{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T04:00:51Z","timestamp":1780977651998,"version":"3.54.1"},"reference-count":14,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Bone Oncology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jbo.2026.100757","type":"journal-article","created":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T23:28:19Z","timestamp":1774826899000},"page":"100757","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Letter to the Editor regarding \u201cQuestionable indication for postoperative radiotherapy after surgery for metastases of the major long bones\u201d: A cautionary note on methodology and analysis"],"prefix":"10.1016","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4696-9434","authenticated-orcid":false,"given":"Shing Fung","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel A.","family":"Finkelstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Hoskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Rades","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Oldenburger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy A.","family":"Balboni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel E.","family":"Roos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Kreder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric L.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Khoury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristopher","family":"Dennis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candice","family":"Johnstone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara R.","family":"Alcorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"Charles B.","family":"Simone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Willmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne M.","family":"van der Velden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"Spa\u0142ek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvette M.","family":"van der Linden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Kazmierska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaus","family":"Andratschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily J.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenny","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond C.H.","family":"Yau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengji","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenfeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Yee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XinXin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin P.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.L.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian W.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung Ming","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Rembielak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo N.","family":"Marta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilios","family":"Vassiliou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saverio","family":"Caini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry C.Y.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbo.2026.100757_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbo.2026.100746","article-title":"Questionable indication for postoperative radiotherapy after surgery for metastases of the major long bones: a single-centre cohort study of 552 fractures\/526 patients","volume":"57","author":"Ehne","year":"2026","journal-title":"J. Bone Oncol."},{"key":"10.1016\/j.jbo.2026.100757_b0010","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2147\/CLEP.S129879","article-title":"Confounding in observational studies based on large health care databases: problems and potential solutions \u2013 a primer for the clinician","volume":"9","author":"N\u00f8rgaard","year":"2017","journal-title":"CLEP"},{"key":"10.1016\/j.jbo.2026.100757_b0015","doi-asserted-by":"crossref","DOI":"10.1177\/1073274818789355","article-title":"Immortal time bias in observational studies of time-to-event outcomes: assessing effects of postmastectomy radiation therapy using the National Cancer Database","volume":"25","author":"Agarwal","year":"2018","journal-title":"Cancer Control"},{"key":"10.1016\/j.jbo.2026.100757_b0020","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13014-020-01740-y","article-title":"Delayed postoperative radiotherapy increases the incidence of radiographic local tumor progression before radiotherapy and leads to poor prognosis in spinal metastases","volume":"16","author":"Gong","year":"2021","journal-title":"Radiat. Oncol."},{"key":"10.1016\/j.jbo.2026.100757_b0025","series-title":"Radiobiology for the Radiologist","author":"Hall","year":"2018"},{"key":"10.1016\/j.jbo.2026.100757_b0030","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3109\/17453679108999232","article-title":"Cement interface temperature in hip arthroplasty","volume":"62","author":"Toksvig-Larsen","year":"1991","journal-title":"Acta Orthop. Scand."},{"key":"10.1016\/j.jbo.2026.100757_b0035","doi-asserted-by":"crossref","first-page":"11651","DOI":"10.3390\/app142411651","article-title":"Polymethyl Methacrylate Bone Cement Polymerization Induced thermal Necrosis at the Cement\u2013Bone Interface: a Narrative Review","volume":"14","author":"Szoradi","year":"2024","journal-title":"Appl. Sci."},{"key":"10.1016\/j.jbo.2026.100757_b0040","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3892\/mco.2024.2764","article-title":"The impact of metal implants on the dose and clinical outcome of radiotherapy (Review)","volume":"21","author":"Liang","year":"2024","journal-title":"Mol. Clin. Oncol."},{"key":"10.1016\/j.jbo.2026.100757_b0045","doi-asserted-by":"crossref","first-page":"4536","DOI":"10.3390\/app15084536","article-title":"Impact of metallic implants on dose distribution in radiotherapy with electrons, photons, protons, and very-high-energy beams","volume":"15","author":"Bedri","year":"2025","journal-title":"Appl. Sci."},{"key":"10.1016\/j.jbo.2026.100757_b0050","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.radonc.2016.07.009","article-title":"Lack of clinical evidence for postoperative radiotherapy after surgical fixation of impending or actual pathologic fractures in the long bones in patients with cancer; a systematic review","volume":"121","author":"Willeumier","year":"2016","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.jbo.2026.100757_b0070","article-title":"Should postoperative radiation for long bone metastases cover part or all of the orthopedic hardware? Results of a large retrospective analysis","volume":"6","author":"Rosen","year":"2021","journal-title":"Adv. Radiat. Oncol."},{"key":"10.1016\/j.jbo.2026.100757_b0055","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.radonc.2022.06.002","article-title":"ESTRO ACROP guidelines for external beam radiotherapy of patients with complicated bone metastases","volume":"173","author":"Oldenburger","year":"2022","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.jbo.2026.100757_b0060","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.prro.2024.04.018","article-title":"External Beam Radiation Therapy for Palliation of Symptomatic Bone Metastases: an ASTRO Clinical Practice Guideline","volume":"14","author":"Alcorn","year":"2024","journal-title":"Pract. Radiat. Oncol."},{"key":"10.1016\/j.jbo.2026.100757_b0065","unstructured":"The PORTRAIT trial Post-operative radiotherapy in surgically treated bone metastases - NIHR Funding and Awards, (n.d.). https:\/\/www.fundingawards.nihr.ac.uk\/award\/NIHR159676 (accessed February 22, 2026)."}],"container-title":["Journal of Bone Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212137426000199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212137426000199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T03:38:38Z","timestamp":1780976318000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212137426000199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":14,"alternative-id":["S2212137426000199"],"URL":"https:\/\/doi.org\/10.1016\/j.jbo.2026.100757","relation":{},"ISSN":["2212-1374"],"issn-type":[{"value":"2212-1374","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Letter to the Editor regarding \u201cQuestionable indication for postoperative radiotherapy after surgery for metastases of the major long bones\u201d: A cautionary note on methodology and analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Bone Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbo.2026.100757","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"100757"}}