{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:58:11Z","timestamp":1792699091085,"version":"4.5.0"},"reference-count":108,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008235","name":"Peking Union Medical College Hospital","doi-asserted-by":"publisher","award":["UHB12595"],"award-info":[{"award-number":["UHB12595"]}],"id":[{"id":"10.13039\/501100008235","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011176","name":"Peking Union Medical College","doi-asserted-by":"publisher","award":["2022002"],"award-info":[{"award-number":["2022002"]}],"id":[{"id":"10.13039\/501100011176","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020437","name":"Beijing Association for Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020437","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences &amp; Peking Union Medical College","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Bone Oncology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jbo.2026.100776","type":"journal-article","created":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T17:31:57Z","timestamp":1781458317000},"page":"100776","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Recent research progress on the etiology and pathogenesis of tumor-induced osteomalacia: A review"],"prefix":"10.1016","volume":"59","author":[{"given":"Shuzhong","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyi","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibo","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jbo.2026.100776_bb0005","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1210\/endrev\/bnac026","article-title":"Tumor-induced Osteomalacia: a comprehensive review","volume":"44","author":"Minisola","year":"2023","journal-title":"Endocr. Rev."},{"issue":"3","key":"10.1016\/j.jbo.2026.100776_bb0010","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1111\/j.1523-1755.2005.00506.x","article-title":"Effect of fibroblast growth factor-23 on phosphate transport in proximal tubules","volume":"68","author":"Baum","year":"2005","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.jbo.2026.100776_bb0015","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41581-019-0189-5","article-title":"FGF23 at the crossroads of phosphate, iron economy and erythropoiesis","volume":"16","author":"Edmonston","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"issue":"3","key":"10.1016\/j.jbo.2026.100776_bb0020","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/joim.13593","article-title":"Global guidance for the recognition, diagnosis, and management of tumor-induced osteomalacia","volume":"293","author":"Jan","year":"2023","journal-title":"J. Intern. Med."},{"issue":"1","key":"10.1016\/j.jbo.2026.100776_bb0025","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/oxfordjournals.qjmed.a066485","article-title":"Osteomalacia with Looser\u2019s nodes (Milkman\u2019s syndrome) due to a raised resistance to vitamin D acquired about the age of 15 years","volume":"16","author":"McCANCE","year":"1947","journal-title":"Q. J. Med."},{"issue":"4","key":"10.1016\/j.jbo.2026.100776_bb0030","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00223-022-01005-8","article-title":"Tumor-induced Osteomalacia: a systematic clinical review of 895 cases","volume":"111","author":"Bosman","year":"2022","journal-title":"Calcif. Tissue Int."},{"issue":"8","key":"10.1016\/j.jbo.2026.100776_bb0035","doi-asserted-by":"crossref","first-page":"e3428","DOI":"10.1210\/clinem\/dgac253","article-title":"Tumor-induced Osteomalacia: a systematic review and individual patient\u2019s data analysis","volume":"107","author":"Rendina","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"11","key":"10.1016\/j.jbo.2026.100776_bb0040","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1007\/s00198-024-07178-2","article-title":"Clinical characteristics and surgical outcomes of vertebral lesions associated with tumor-induced osteomalacia: report of 16 patients and review of the literature","volume":"35","author":"Pang","year":"2024","journal-title":"Osteoporos. Int."},{"issue":"6","key":"10.1016\/j.jbo.2026.100776_bb0045","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1359\/jbmr.2002.17.6.1102","article-title":"Tumors associated with oncogenic osteomalacia express genes important in bone and mineral metabolism","volume":"17","author":"De Beur","year":"2002","journal-title":"J. Bone Miner. Res."},{"issue":"3","key":"10.1016\/j.jbo.2026.100776_bb0050","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1210\/jc.2012-3473","article-title":"Oncogenic osteomalacia due to FGF23-expressing colon adenocarcinoma","volume":"98","author":"Leaf","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.jbo.2026.100776_bb0055","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1172\/JCI18563","article-title":"Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent","volume":"112","author":"Berndt","year":"2003","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.jbo.2026.100776_bb0060","doi-asserted-by":"crossref","DOI":"10.1002\/jbm4.10438","article-title":"A Normal FGF23 does not preclude tumor-induced Osteomalacia","volume":"5","author":"Nandam","year":"2021","journal-title":"JBMR Plus"},{"issue":"45","key":"10.1016\/j.jbo.2026.100776_bb0065","article-title":"Preoperative evaluation and orthopedic surgical strategies for tumor-induced osteomalacia","volume":"28","author":"Liu","year":"2024","journal-title":"J. Bone Oncol."},{"issue":"4","key":"10.1016\/j.jbo.2026.100776_bb0070","first-page":"698","article-title":"Tumor-induced Osteomalacia: a case report of rare disease and literature review","volume":"14","author":"Bansal","year":"2023","journal-title":"South Asian J. Cancer."},{"issue":"3","key":"10.1016\/j.jbo.2026.100776_bb0075","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/jbmr.3903","article-title":"Nonremission and recurrent tumor-induced Osteomalacia: a retrospective study","volume":"35","author":"Li","year":"2020","journal-title":"J. Bone Miner. Res."},{"issue":"8","key":"10.1016\/j.jbo.2026.100776_bb0080","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1210\/clinem\/dgad034","article-title":"Ultra-high performance liquid chromatography-mass spectrometry-based serum metabolomics for early diagnosis of refractory tumor-induced Osteomalacia: a case-control study","volume":"108","author":"Li","year":"2023","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"8","key":"10.1016\/j.jbo.2026.100776_bb0085","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1111\/os.14105","article-title":"Orthopedic surgical treatment of patients with tumor-induced Osteomalacia located in the hip bones: a retrospective analysis of 10years in a single center","volume":"16","author":"Liu","year":"2024","journal-title":"Orthop. Surg."},{"issue":"1","key":"10.1016\/j.jbo.2026.100776_bb0090","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00198-022-06516-6","article-title":"Long-term use of burosumab for the treatment of tumor-induced osteomalacia","volume":"34","author":"Crotti","year":"2023","journal-title":"Osteoporos. Int."},{"issue":"6","key":"10.1016\/j.jbo.2026.100776_bb0095","doi-asserted-by":"crossref","first-page":"ziaf039","DOI":"10.1093\/jbmrpl\/ziaf039","article-title":"Real-world efficacy and safety of burosumab in tumor-induced osteomalacia: case series from an early access program","volume":"9","author":"Cadiou","year":"2025","journal-title":"JBMR Plus"},{"key":"10.1016\/j.jbo.2026.100776_bb0100","doi-asserted-by":"crossref","first-page":"1804013","DOI":"10.3389\/fendo.2026.1804013","article-title":"Burosumab an emerging therapy in TIO: a local clinical survey and a systematic review with individual patient data analysis","volume":"17","author":"Vergatti","year":"2026","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"4","key":"10.1016\/j.jbo.2026.100776_bb0105","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/MED.0000000000000866","article-title":"Recent advances in fibroblast growth factor 23-related hypophosphatemic disorders","volume":"31","author":"Takashi","year":"2024","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"10.1016\/j.jbo.2026.100776_bb0110","doi-asserted-by":"crossref","DOI":"10.1002\/cpt.3468","article-title":"Model-informed approach to recommend Burosumab dosing regimens for Pediatric and adult patients with the ultrarare disease tumor-induced Osteomalacia","author":"Hruska","year":"2024","journal-title":"Clin. Pharmacol. Ther."},{"issue":"11","key":"10.1016\/j.jbo.2026.100776_bb0115","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1002\/jbmr.4900","article-title":"Burosumab improves patient-reported outcomes in adults with tumor-induced Osteomalacia: mixed-methods analysis","volume":"38","author":"Jan de Beur","year":"2023","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.jbo.2026.100776_bb0120","doi-asserted-by":"crossref","DOI":"10.1002\/jbm4.10436","article-title":"Burden of disease in patients with tumor-induced Osteomalacia","volume":"5","author":"Jerkovich","year":"2021","journal-title":"JBMR Plus"},{"issue":"9","key":"10.1016\/j.jbo.2026.100776_bb0125","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1007\/s00198-022-06432-9","article-title":"A literature review to understand the burden of disease in people living with tumour-induced osteomalacia","volume":"33","author":"Minisola","year":"2022","journal-title":"Osteoporos. Int."},{"issue":"7746","key":"10.1016\/j.jbo.2026.100776_bb0130","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0140-6736(72)92844-9","article-title":"Distinctive tumours of bone and soft tissue causing acquired vitamin-D-resistant osteomalacia","volume":"1","author":"Evans","year":"1972","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.jbo.2026.100776_bb0135","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1002\/1097-0142(19870415)59:8<1442::AID-CNCR2820590810>3.0.CO;2-Q","article-title":"Phosphaturic mesenchymal tumors. A polymorphous group causing osteomalacia or rickets","volume":"59","author":"Weidner","year":"1987","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.jbo.2026.100776_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000478-200401000-00001","article-title":"Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: an analysis of 32 cases and a comprehensive review of the literature","volume":"28","author":"Folpe","year":"2004","journal-title":"Am. J. Surg. Pathol."},{"issue":"11","key":"10.1016\/j.jbo.2026.100776_bb0145","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1097\/CM9.0000000000001448","article-title":"Consensus on clinical management of tumor-induced osteomalacia","volume":"134","author":"Jiang","year":"2021","journal-title":"Chin. Med. J."},{"issue":"2","key":"10.1016\/j.jbo.2026.100776_bb0150","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1210\/jc.2004-0357","article-title":"Fibroblast growth factor 7: an inhibitor of phosphate transport derived from oncogenic osteomalacia-causing tumors","volume":"90","author":"Carpenter","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.jbo.2026.100776_bb0155","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.bone.2003.10.005","article-title":"MEPE has the properties of an osteoblastic phosphatonin and minhibin","volume":"34","author":"Rowe","year":"2004","journal-title":"Bone"},{"issue":"10","key":"10.1016\/j.jbo.2026.100776_bb0160","doi-asserted-by":"crossref","first-page":"6120","DOI":"10.1074\/jbc.C500457200","article-title":"Regulation of fibroblast growth factor-23 signaling by klotho","volume":"281","author":"Kurosu","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.jbo.2026.100776_bb0165","doi-asserted-by":"crossref","first-page":"R53","DOI":"10.1530\/ERC-11-0006","article-title":"Tumor-induced osteomalacia","volume":"18","author":"Chong","year":"2011","journal-title":"Endocr. Relat. Cancer"},{"issue":"4","key":"10.1016\/j.jbo.2026.100776_bb0170","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1177\/039139880903200407","article-title":"Fibroblast growth factor 23 (FGF23) and the kidney","volume":"32","author":"Tsagalis","year":"2009","journal-title":"Int. J. Artif. Organs."},{"issue":"3","key":"10.1016\/j.jbo.2026.100776_bb0175","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1359\/JBMR.0301264","article-title":"FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis","volume":"19","author":"Shimada","year":"2004","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jbo.2026.100776_bb0180","doi-asserted-by":"crossref","first-page":"17044","DOI":"10.1038\/nrdp.2017.44","article-title":"Tumour-induced osteomalacia","volume":"3","author":"Minisola","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"4","key":"10.1016\/j.jbo.2026.100776_bb0185","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.afos.2018.12.001","article-title":"Tumor-induced osteomalacia","volume":"4","author":"Yin","year":"2018","journal-title":"Osteoporos Sarcopenia"},{"issue":"11","key":"10.1016\/j.jbo.2026.100776_bb0190","doi-asserted-by":"crossref","first-page":"6500","DOI":"10.1073\/pnas.101545198","article-title":"Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia","volume":"98","author":"Shimada","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"7","key":"10.1016\/j.jbo.2026.100776_bb0195","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1210\/en.2003-1768","article-title":"Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis","volume":"145","author":"Larsson","year":"2004","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.jbo.2026.100776_bb0200","doi-asserted-by":"crossref","first-page":"R23","DOI":"10.1530\/JME-20-0178","article-title":"FGF23 signalling and physiology","volume":"66","author":"Ho","year":"2021","journal-title":"J. Mol. Endocrinol."},{"issue":"12","key":"10.1016\/j.jbo.2026.100776_bb0205","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1097\/CM9.0000000000002690","article-title":"Promotion effect of FGF23 on osteopenia in congenital scoliosis through FGFr3\/TNAP\/OPN pathway","volume":"136","author":"Zhang","year":"2023","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.jbo.2026.100776_bb0210","doi-asserted-by":"crossref","first-page":"8821292","DOI":"10.1155\/2021\/8821292","article-title":"FGF23: a review of its role in mineral metabolism and renal and cardiovascular disease","volume":"2021","author":"Kurpas","year":"2021","journal-title":"Dis. Markers"},{"issue":"8","key":"10.1016\/j.jbo.2026.100776_bb0215","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.3390\/biom13081222","article-title":"Relationship of fibroblast growth factor 23 serum levels with disease characteristics in systemic lupus erythematosus patients","volume":"13","author":"Fern\u00e1ndez-Cladera","year":"2023","journal-title":"Biomolecules"},{"issue":"10455","key":"10.1016\/j.jbo.2026.100776_bb0220","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0140-6736(24)01305-9","article-title":"X-linked hypophosphataemia","volume":"404","author":"Kamenick\u00fd","year":"2024","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.jbo.2026.100776_bb0225","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1006\/bbrc.2000.3696","article-title":"Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain","volume":"277","author":"Yamashita","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.jbo.2026.100776_bb0230","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/81664","article-title":"Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23","volume":"26","author":"ADHR Consortium","year":"2000","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.jbo.2026.100776_bb0235","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000452880","article-title":"Klotho\/FGF23 axis in chronic kidney disease and cardiovascular disease","volume":"3","author":"Lu","year":"2017","journal-title":"Kidney Dis. (Basel)"},{"issue":"453","key":"10.1016\/j.jbo.2026.100776_bb0240","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/249123a0","article-title":"Localisation of a fibroblast growth factor and its effect alone and with hydrocortisone on 3T3 cell growth","volume":"249","author":"Gospodarowicz","year":"1974","journal-title":"Nature"},{"key":"10.1016\/j.jbo.2026.100776_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2024.108669","article-title":"The endocrine FGFs axis: a systemic anti-fibrotic response that could prevent pulmonary fibrogenesis?","volume":"259","author":"Ghanem","year":"2024","journal-title":"Pharmacol. Ther."},{"issue":"5","key":"10.1016\/j.jbo.2026.100776_bb0250","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s11684-019-0711-y","article-title":"The FGF metabolic axis","volume":"13","author":"Li","year":"2019","journal-title":"Front. Med."},{"issue":"4","key":"10.1016\/j.jbo.2026.100776_bb0255","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/MNH.0000000000000895","article-title":"Fibroblast growth factor 23, klotho and heparin","volume":"32","author":"Thomas","year":"2023","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"4","key":"10.1016\/j.jbo.2026.100776_bb0260","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s10238-022-00844-x","article-title":"New concepts in regulation and function of the FGF23","volume":"23","author":"Dastghaib","year":"2023","journal-title":"Clin. Exp. Med."},{"issue":"15","key":"10.1016\/j.jbo.2026.100776_bb0265","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1021\/acs.jcim.2c00633","article-title":"Identification of small-molecule inhibitors of fibroblast growth factor 23 signaling via in silico hot spot prediction and molecular docking to \u03b1-Klotho","volume":"62","author":"Liu","year":"2022","journal-title":"J. Chem. Inf. Model."},{"issue":"10","key":"10.1016\/j.jbo.2026.100776_bb0270","doi-asserted-by":"crossref","DOI":"10.1111\/apha.14220","article-title":"Lessons from Klotho mouse models to understand mineral homeostasis","volume":"240","author":"Grigore","year":"2024","journal-title":"Acta Physiol. (Oxford)"},{"issue":"8","key":"10.1016\/j.jbo.2026.100776_bb0275","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.tibs.2018.05.001","article-title":"Unraveling endocrine FGF Signaling complex to combat metabolic diseases","volume":"43","author":"Luo","year":"2018","journal-title":"Trends Biochem. Sci."},{"issue":"2","key":"10.1016\/j.jbo.2026.100776_bb0280","doi-asserted-by":"crossref","first-page":"332","DOI":"10.7150\/ijms.90195","article-title":"Beneficial effects of physical exercise on the osteo-renal Klotho-FGF-23 axis in chronic kidney disease: a systematic review with meta-analysis","volume":"21","author":"Castillo","year":"2024","journal-title":"Int. J. Med. Sci."},{"issue":"4\u20135","key":"10.1016\/j.jbo.2026.100776_bb0285","first-page":"365","article-title":"Sodium chloride restriction and extracellular fluid volume contraction in hyperphosphatiuric vitamin D resistant rickets in the Lowe syndrome","volume":"30","author":"Van Bierviet","year":"1976","journal-title":"Helv. Paediatr. Acta"},{"issue":"1","key":"10.1016\/j.jbo.2026.100776_bb0290","doi-asserted-by":"crossref","first-page":"120","DOI":"10.14219\/jada.archive.1976.0327","article-title":"Origin, diagnosis, and treatment of the dental manifestations of vitamin D-resistant rickets: review of the literature and report of case","volume":"92","author":"Cohen","year":"1976","journal-title":"J. Am. Dent. Assoc."},{"key":"10.1016\/j.jbo.2026.100776_bb0295","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev.me.27.020176.001145","article-title":"The effects of calcium and phosphorus in hemodialysis","volume":"27","author":"Goldsmith","year":"1976","journal-title":"Annu. Rev. Med."},{"issue":"5","key":"10.1016\/j.jbo.2026.100776_bb0300","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1136\/adc.51.5.360","article-title":"Recessive hypophosphataemic rickets, and possible aetiology of the \u2018vitamin D-resistant\u2019 syndrome","volume":"51","author":"Stamp","year":"1976","journal-title":"Arch. Dis. Child."},{"issue":"12","key":"10.1016\/j.jbo.2026.100776_bb0305","doi-asserted-by":"crossref","first-page":"4667","DOI":"10.1073\/pnas.73.12.4667","article-title":"Hypophosphatemia: mouse model for human familial hypophosphatemic (vitamin D-resistant) rickets","volume":"73","author":"Eicher","year":"1976","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"17","key":"10.1016\/j.jbo.2026.100776_bb0310","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1056\/NEJMoa020881","article-title":"Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia","volume":"348","author":"Jonsson","year":"2003","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.jbo.2026.100776_bb0315","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1677\/joe.1.07059","article-title":"Phosphorylated acidic serine-aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity","volume":"192","author":"Liu","year":"2007","journal-title":"J. Endocrinol."},{"issue":"4","key":"10.1016\/j.jbo.2026.100776_bb0320","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/MNH.0b013e3282fd6e5b","article-title":"PHEX, FGF23, DMP1 and beyond","volume":"17","author":"Strom","year":"2008","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"2","key":"10.1016\/j.jbo.2026.100776_bb0325","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ajhg.2010.01.010","article-title":"Autosomal-recessive hypophosphatemic rickets is associated with an inactivation mutation in the ENPP1 gene","volume":"86","author":"Levy-Litan","year":"2010","journal-title":"Am. J. Hum. Genet."},{"issue":"5","key":"10.1016\/j.jbo.2026.100776_bb0330","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nrendo.2011.218","article-title":"Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism","volume":"8","author":"Quarles","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"issue":"5","key":"10.1016\/j.jbo.2026.100776_bb0335","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002708","article-title":"Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice","volume":"8","author":"Wang","year":"2012","journal-title":"PLoS Genet."},{"issue":"6","key":"10.1016\/j.jbo.2026.100776_bb0340","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1002\/jbmr.1850","article-title":"Exome sequencing reveals FAM20c mutations associated with fibroblast growth factor 23-related hypophosphatemia, dental anomalies, and ectopic calcification","volume":"28","author":"Rafaelsen","year":"2013","journal-title":"J. Bone Miner. Res."},{"issue":"8","key":"10.1016\/j.jbo.2026.100776_bb0345","doi-asserted-by":"crossref","DOI":"10.1002\/jbm4.10190","article-title":"FGF23, hypophosphatemia, and emerging treatments","volume":"3","author":"Imel","year":"2019","journal-title":"JBMR Plus"},{"key":"10.1016\/j.jbo.2026.100776_bb0350","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/872193","article-title":"Soluble \u03b1 -Klotho serum levels in chronic kidney disease","volume":"2015","author":"Rotondi","year":"2015","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.jbo.2026.100776_bb0355","doi-asserted-by":"crossref","DOI":"10.3389\/fragi.2022.931331","article-title":"Pathobiology of the Klotho antiaging protein and therapeutic considerations","volume":"3","author":"Prud\u2019homme","year":"2022","journal-title":"Front. Aging"},{"issue":"1\u20133","key":"10.1016\/j.jbo.2026.100776_bb0360","first-page":"143","article-title":"Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane","volume":"565","author":"Imura","year":"2004","journal-title":"FEBS Lett."},{"issue":"7689","key":"10.1016\/j.jbo.2026.100776_bb0365","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature25451","article-title":"\u03b1-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling","volume":"553","author":"Chen","year":"2018","journal-title":"Nature"},{"issue":"7966","key":"10.1016\/j.jbo.2026.100776_bb0370","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/s41586-023-06155-9","article-title":"Structural basis for FGF hormone signalling","volume":"618","author":"Chen","year":"2023","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.jbo.2026.100776_bb0375","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/mc.22131","article-title":"Regulation of HIF-1 alpha by the proprotein convertases furin and PC7 in human squamous carcinoma cells","volume":"54","author":"Fu","year":"2015","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.jbo.2026.100776_bb0380","doi-asserted-by":"crossref","first-page":"16011","DOI":"10.1038\/boneres.2016.11","article-title":"The hypoxia-inducible factor-1\u03b1 activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia","volume":"4","author":"Zhang","year":"2016","journal-title":"Bone Res."},{"issue":"46","key":"10.1016\/j.jbo.2026.100776_bb0385","doi-asserted-by":"crossref","first-page":"E1146","DOI":"10.1073\/pnas.1110905108","article-title":"Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice","volume":"108","author":"Farrow","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6","key":"10.1016\/j.jbo.2026.100776_bb0390","doi-asserted-by":"crossref","first-page":"F1170","DOI":"10.1152\/ajprenal.00072.2005","article-title":"\u201cPhosphatonins\u201d and the regulation of phosphorus homeostasis","volume":"289","author":"Berndt","year":"2005","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"1","key":"10.1016\/j.jbo.2026.100776_bb0395","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1006\/geno.2000.6235","article-title":"MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia","volume":"67","author":"Rowe","year":"2000","journal-title":"Genomics"},{"issue":"1","key":"10.1016\/j.jbo.2026.100776_bb0400","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1523-1755.2004.00355.x","article-title":"The phosphatonin pathway: new insights in phosphate homeostasis","volume":"65","author":"Schiavi","year":"2004","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.jbo.2026.100776_bb0405","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1210\/jc.2004-0357","article-title":"Fibroblast growth factor 7: an inhibitor of phosphate transport derived from oncogenic osteomalacia-causing tumors","volume":"90","author":"Carpenter","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"11","key":"10.1016\/j.jbo.2026.100776_bb0410","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1359\/jbmr.060719","article-title":"Secreted frizzled-related protein 4 is a negative regulator of peak BMD in SAMP6 mice","volume":"21","author":"Nakanishi","year":"2006","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.jbo.2026.100776_bb0415","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s00223-025-01394-6","article-title":"Exploring the role of FGF7 in tumor-induced Osteomalacia. Clinic-pathologic analysis in a patient with a sino-nasal phosphaturic mesenchymal tumor","volume":"116","author":"Colangelo","year":"2025","journal-title":"Calcif. Tissue Int."},{"issue":"6","key":"10.1016\/j.jbo.2026.100776_bb0420","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1359\/jbmr.2002.17.6.1102","article-title":"Tumors associated with oncogenic osteomalacia express genes important in bone and mineral metabolism","volume":"17","author":"De Beur","year":"2002","journal-title":"J. Bone Miner. Res."},{"issue":"8","key":"10.1016\/j.jbo.2026.100776_bb0425","doi-asserted-by":"crossref","DOI":"10.1002\/jbm4.10661","article-title":"Infigratinib reduces fibroblast growth factor 23 (FGF23) and increases blood phosphate in tumor-induced Osteomalacia","volume":"6","author":"Hartley","year":"2022","journal-title":"JBMR Plus"},{"issue":"8","key":"10.1016\/j.jbo.2026.100776_bb0430","first-page":"9422","article-title":"Fibroblast growth factor receptor 1 (FGFR1) expression in phosphaturic mesenchymal tumors","volume":"8","author":"Tajima","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.jbo.2026.100776_bb0435","article-title":"Ectopic expression of Klotho in fibroblast growth factor 23 (FGF23)-producing tumors that cause tumor-induced rickets\/osteomalacia (TIO)","volume":"10","author":"Kinoshita","year":"2019","journal-title":"Bone Rep."},{"issue":"3","key":"10.1016\/j.jbo.2026.100776_bb0440","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.path.2025.01.002","article-title":"Phosphaturic mesenchymal tumors: histologic mimics and updates","volume":"18","author":"Su","year":"2025","journal-title":"Surg. Pathol. Clin."},{"issue":"5","key":"10.1016\/j.jbo.2026.100776_bb0445","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1210\/clinem\/dgab885","article-title":"Serum metabolomics reveals dysregulation and diagnostic potential of oxylipins in tumor-induced Osteomalacia","volume":"107","author":"Gong","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jbo.2026.100776_bb0450","doi-asserted-by":"crossref","DOI":"10.1210\/clinem\/dgad034","article-title":"UPLC-MS based serum metabolomics for early diagnosis of refractory tumor-induced osteomalacia: a case-control study","author":"Li","year":"2023","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"9","key":"10.1016\/j.jbo.2026.100776_bb0455","doi-asserted-by":"crossref","first-page":"4931","DOI":"10.1111\/jcmm.14991","article-title":"Mutational landscape and genetic signatures of cell-free DNA in tumour-induced osteomalacia","volume":"24","author":"Wu","year":"2020","journal-title":"J. Cell. Mol. Med."},{"issue":"23","key":"10.1016\/j.jbo.2026.100776_bb0460","doi-asserted-by":"crossref","first-page":"11418","DOI":"10.1073\/pnas.1815166116","article-title":"Activation of unliganded FGF receptor by extracellular phosphate potentiates proteolytic protection of FGF23 by its O-glycosylation","volume":"116","author":"Takashi","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jbo.2026.100776_bb0465","article-title":"Skeletal FGFR1 signaling is necessary for regulation of serum phosphate level by FGF23 and normal life span","volume":"27","author":"Takashi","year":"2021","journal-title":"Biochem. Biophys. Rep."},{"issue":"4","key":"10.1016\/j.jbo.2026.100776_bb0470","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/path.4465","article-title":"Identification of a novel FN1-FGFR1 genetic fusion as a frequent event in phosphaturic mesenchymal tumour","volume":"235","author":"Lee","year":"2015","journal-title":"J. Pathol."},{"issue":"11","key":"10.1016\/j.jbo.2026.100776_bb0475","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1038\/modpathol.2016.137","article-title":"Characterization of FN1-FGFR1 and novel FN1-FGF1 fusion genes in a large series of phosphaturic mesenchymal tumors","volume":"29","author":"Lee","year":"2016","journal-title":"Mod. Pathol."},{"issue":"10","key":"10.1016\/j.jbo.2026.100776_bb0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.modpat.2023.100266","article-title":"RNA sequencing reveals novel oncogenic fusions and depicts detailed fusion transcripts of FN1-FGFR1 in phosphaturic mesenchymal tumors","volume":"36","author":"Liu","year":"2023","journal-title":"Mod. Pathol."},{"issue":"12","key":"10.1016\/j.jbo.2026.100776_bb0485","doi-asserted-by":"crossref","DOI":"10.1016\/j.modpat.2023.100336","article-title":"Klotho overexpression is frequently associated with upstream rearrangements in fusion-negative Phosphaturic mesenchymal Tumors of bone and sinonasal tract","volume":"36","author":"Lee","year":"2023","journal-title":"Mod. Pathol."},{"issue":"12","key":"10.1016\/j.jbo.2026.100776_bb0490","doi-asserted-by":"crossref","first-page":"5358","DOI":"10.1210\/en.2005-0777","article-title":"Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice","volume":"146","author":"Perwad","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.jbo.2026.100776_bb0495","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2025.117640","article-title":"Integrating single-cell and bulk transcriptome analysis of fibroblast growth factor 23 (FGF23)-producing mesenchymal tumors reveals molecular basis of its secretory phenotype","volume":"201","author":"Gronskaia","year":"2025","journal-title":"Bone"},{"issue":"10","key":"10.1016\/j.jbo.2026.100776_bb0500","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1210\/clinem\/dgae886","article-title":"Glucose metabolic abnormalities and their interaction with defective phosphate homeostasis in tumor-induced Osteomalacia","volume":"110","author":"Zhou","year":"2025","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.jbo.2026.100776_bb0505","doi-asserted-by":"crossref","first-page":"e397","DOI":"10.1210\/clinem\/dgae183","article-title":"A retrospective cohort of tumor-induced osteomalacia and case series of malignant disease","volume":"110","author":"Hoong","year":"2025","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"10","key":"10.1016\/j.jbo.2026.100776_bb0510","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1007\/s00198-025-07527-9","article-title":"Postoperative outcome and clinical management of tumor-induced osteomalacia: a single-center retrospective cohort study on 117 patients","volume":"36","author":"Shan","year":"2025","journal-title":"Osteoporos. Int."},{"issue":"9","key":"10.1016\/j.jbo.2026.100776_bb0515","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1210\/clinem\/dgae911","article-title":"Prognostic factors for refractory outcome in localizing TIO: experience in a tertiary center","volume":"110","author":"Hoong","year":"2025","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.jbo.2026.100776_bb0520","article-title":"Malignant Phosphaturic mesenchymal tumor with lung metastasis","volume":"18","author":"Arsoy Sahin","year":"2026","journal-title":"Cureus"},{"issue":"12","key":"10.1016\/j.jbo.2026.100776_bb0525","doi-asserted-by":"crossref","DOI":"10.1002\/ccr3.8283","article-title":"Transformation of a long-standing phosphaturic tumor-inducing osteomalacia into malignancy","volume":"11","author":"Malagon-Rangel","year":"2023","journal-title":"Clin. Case Reports"},{"issue":"3","key":"10.1016\/j.jbo.2026.100776_bb0530","doi-asserted-by":"crossref","first-page":"e1006","DOI":"10.1210\/clinem\/dgad690","article-title":"Clinical characteristics of malignant Phosphaturic mesenchymal tumor causing tumor-induced Osteomalacia","volume":"109","author":"Abate","year":"2024","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"11","key":"10.1016\/j.jbo.2026.100776_bb0535","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1210\/clinem\/dgad297","article-title":"Tumor-induced Osteomalacia in patients with malignancy: a Meta-analysis and systematic review of case reports","volume":"108","author":"Bouraima","year":"2023","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"12","key":"10.1016\/j.jbo.2026.100776_bb0540","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1007\/s00198-025-07686-9","article-title":"A nomogram for predicting surgery outcome of tumor-induced osteomalacia: a case-control study","volume":"36","author":"Li","year":"2025","journal-title":"Osteoporos. Int."}],"container-title":["Journal of Bone Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212137426000382?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212137426000382?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T02:39:19Z","timestamp":1785897559000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212137426000382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":108,"alternative-id":["S2212137426000382"],"URL":"https:\/\/doi.org\/10.1016\/j.jbo.2026.100776","relation":{},"ISSN":["2212-1374"],"issn-type":[{"value":"2212-1374","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recent research progress on the etiology and pathogenesis of tumor-induced osteomalacia: A review","name":"articletitle","label":"Article Title"},{"value":"Journal of Bone Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbo.2026.100776","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"100776"}}