{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:01:17Z","timestamp":1791860477156,"version":"4.3.4"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010109","name":"Medizinische Universit\u00e4t Graz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010109","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Bone Oncology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jbo.2026.100785","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T23:08:53Z","timestamp":1783984133000},"page":"100785","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Targeting the Hippo\/YAP-TAZ pathway increases X-ray sensitivity in chondrosarcoma spheroids and is associated with autophagic disruption"],"prefix":"10.1016","volume":"59","author":[{"given":"Birgit","family":"Lohberger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Gl\u00e4nzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Kaltenegger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Kolb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbo.2026.100785_bb0005","series-title":"World Health Organization Classification of Tumours of Soft Tissue and Bone","first-page":"264","author":"Fletcher","year":"2013"},{"issue":"3","key":"10.1016\/j.jbo.2026.100785_bb0010","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1302\/0301-620X.101B3.BJJ-2018-0881.R1","article-title":"Locally recurrent chondrosarcoma of the pelvis and limbs can only be controlled by wide local excision","volume":"101-B","author":"Laitinen","year":"2019","journal-title":"Bone Joint J."},{"issue":"22 Suppl","key":"10.1016\/j.jbo.2026.100785_bb0015","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/BRS.0b013e3181b969ac","article-title":"Challenges of local recurrence and cure in low grade malignant tumors of the spine","volume":"34","author":"Boriani","year":"2009","journal-title":"Spine (Phila Pa 1976)"},{"issue":"10","key":"10.1016\/j.jbo.2026.100785_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13102390","article-title":"Chondrosarcoma-from molecular pathology to novel therapies","volume":"13","author":"Zaj\u0105c","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.jbo.2026.100785_bb0025","first-page":"120","article-title":"Latest developments in targeted biological therapies in the management of chordoma and chondrosarcoma","volume":"15","author":"Biczo","year":"2025","journal-title":"Glob. Spine J."},{"issue":"3","key":"10.1016\/j.jbo.2026.100785_bb0030","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1042\/CS20201474","article-title":"The hippo pathway in cancer: YAP\/TAZ and TEAD as therapeutic targets in cancer","volume":"136","author":"Cunningham","year":"2022","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.jbo.2026.100785_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbo.2022.100419","article-title":"Targeting the IGF\/PI3K\/mTOR pathway and AXL\/YAP1\/TAZ pathways in primary bone cancer","volume":"33","author":"Truong","year":"2022","journal-title":"J. Bone Oncol."},{"issue":"4","key":"10.1016\/j.jbo.2026.100785_bb0040","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3892\/ol.2021.12964","article-title":"Photosensitizer verteporfin inhibits the growth of YAP- and TAZ-dominant gastric cancer cells by suppressing the anti-apoptotic protein Survivin in a light-independent manner","volume":"22","author":"Hasegawa","year":"2021","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jbo.2026.100785_bb0045","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.926780","article-title":"Verteporfin promotes the apoptosis and inhibits the proliferation, migration, and invasion of cervical cancer cells by downregulating SULT2B1 expression","volume":"26","author":"Yin","year":"2020","journal-title":"Med. Sci. Monit."},{"issue":"1","key":"10.1016\/j.jbo.2026.100785_bb0050","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s11033-025-10264-1","article-title":"Targeting breast cancer stem cells in ER-positive breast cancer by repurposing the benzoporphyrin derivative verteporfin as a YAP\/TAZ small molecule inhibitor","volume":"52","author":"Talukdar","year":"2025","journal-title":"Mol. Biol. Rep."},{"issue":"1","key":"10.1016\/j.jbo.2026.100785_bb0055","doi-asserted-by":"crossref","DOI":"10.1111\/eos.13034","article-title":"Efficacy of metformin and verteporfin treatment alone or in combination in a murine head and neck cancer xenograft model","volume":"133","author":"Shan","year":"2025","journal-title":"Eur. J. Oral Sci."},{"issue":"12","key":"10.1016\/j.jbo.2026.100785_bb0060","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.3390\/cancers12123847","article-title":"The YAP\/TEAD Axis as a new therapeutic target in osteosarcoma: effect of Verteporfin and CA3 on primary tumor growth","volume":"12","author":"Morice","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"8","key":"10.1016\/j.jbo.2026.100785_bb0065","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.3390\/cells11081361","article-title":"Verteporfin inhibits the progression of spontaneous osteosarcoma caused by Trp53 and Rb1 deficiency in Ctsk-expressing cells via impeding hippo pathway","volume":"11","author":"Li","year":"2022","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.jbo.2026.100785_bb0070","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41389-020-00294-8","article-title":"YAP\/TAZ inhibition reduces metastatic potential of Ewing sarcoma cells","volume":"10","author":"Bierbaumer","year":"2021","journal-title":"Oncogenesis"},{"key":"10.1016\/j.jbo.2026.100785_bb0075","first-page":"624","article-title":"Photodynamic therapy with verteporfin (Visudyne): impact on ophthalmology and visual sciences","volume":"41","author":"Bressler","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"13","key":"10.1016\/j.jbo.2026.100785_bb0080","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.2217\/fon-2019-0035","article-title":"A brief review: some compounds targeting YAP against malignancies","volume":"15","author":"Tang","year":"2019","journal-title":"Future Oncol."},{"issue":"1","key":"10.1016\/j.jbo.2026.100785_bb0085","doi-asserted-by":"crossref","first-page":"24116","DOI":"10.1038\/s41598-021-03529-9","article-title":"Activation of efficient DNA repair mechanisms after photon and proton irradiation of human chondrosarcoma cells","volume":"11","author":"Lohberger","year":"2021","journal-title":"Sci. Rep."},{"issue":"19","key":"10.1016\/j.jbo.2026.100785_bb0090","doi-asserted-by":"crossref","first-page":"11464","DOI":"10.3390\/ijms231911464","article-title":"Cellular and molecular biological alterations after photon, proton, and carbon ions irradiation in human chondrosarcoma cells linked with high-quality physics data","volume":"23","author":"Lohberger","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.jbo.2026.100785_bb0095","doi-asserted-by":"crossref","first-page":"542","DOI":"10.4161\/auto.4600","article-title":"How to interpret LC3 immunoblotting","volume":"3","author":"Mizushima","year":"2007","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.jbo.2026.100785_bb0100","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3390\/cancers10030081","article-title":"Targeting the hippo pathway and cancer through the TEAD family of transcription factors","volume":"10","author":"Holden","year":"2018","journal-title":"Cancers (Basel)"},{"issue":"8","key":"10.1016\/j.jbo.2026.100785_bb0105","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/s41556-018-0142-z","article-title":"YAP\/TAZ upstream signals and downstream responses","volume":"20","author":"Totaro","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jbo.2026.100785_bb0110","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.freeradbiomed.2018.08.038","article-title":"Reactive oxygen species, aging and articular cartilage homeostasis","volume":"132","author":"Bolduc","year":"2019","journal-title":"Free Radic. Biol. Med."},{"issue":"20","key":"10.1016\/j.jbo.2026.100785_bb0115","doi-asserted-by":"crossref","first-page":"13355","DOI":"10.1074\/jbc.M900843200","article-title":"TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition","volume":"284","author":"Zhang","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.jbo.2026.100785_bb0120","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/s41392-022-01191-9","article-title":"The Hippo signalling pathway and its implications in human health and diseases","volume":"7","author":"Fu","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.jbo.2026.100785_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/gad.274027.115","article-title":"Mechanisms of Hippo pathway regulation","volume":"30","author":"Meng","year":"2016","journal-title":"Genes Dev."},{"key":"10.1016\/j.jbo.2026.100785_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2019.108813","article-title":"Verteporfin exhibits anti-proliferative activity in embryonal and alveolar rhabdomyosarcoma cell lines","volume":"312","author":"Sanna","year":"2019","journal-title":"Chem. Biol. Interact."},{"issue":"15","key":"10.1016\/j.jbo.2026.100785_bb0135","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.3390\/cells11152262","article-title":"Autophagy: a key regulator of homeostasis and disease: an overview of molecular mechanisms and modulators","volume":"11","author":"G\u00f3mez-Virgilio","year":"2022","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.jbo.2026.100785_bb0140","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.7150\/ijbs.95122","article-title":"Autophagy in its (proper) context: molecular basis, biological relevance, pharmacological modulation, and lifestyle medicine","volume":"20","author":"Ortega","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"9","key":"10.1016\/j.jbo.2026.100785_bb0145","doi-asserted-by":"crossref","first-page":"381","DOI":"10.5483\/BMBRep.2024-0101","article-title":"Nuclear structures and their emerging roles in cell differentiation and development","volume":"57","author":"Cha","year":"2024","journal-title":"BMB Rep."},{"issue":"1","key":"10.1016\/j.jbo.2026.100785_bb0150","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13578-021-00570-z","article-title":"Is targeting autophagy mechanism in cancer a good approach? The possible double-edge sword effect","volume":"11","author":"Lim","year":"2021","journal-title":"Cell Biosci."},{"issue":"1","key":"10.1016\/j.jbo.2026.100785_bb0155","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40170-022-00285-w","article-title":"Metabolic flux analysis of 3D spheroids reveals significant differences in glucose metabolism from matched 2D cultures of colorectal cancer and pancreatic ductal adenocarcinoma cell lines","volume":"10","author":"Tidwell","year":"2022","journal-title":"Cancer Metab."},{"issue":"21","key":"10.1016\/j.jbo.2026.100785_bb0160","first-page":"2003","article-title":"Oxidative stress, mitochondrial damage and neurodegenerative diseases","volume":"8","author":"Guo","year":"2013","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.jbo.2026.100785_bb0165","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/327167","article-title":"Mitochondrial dysfunction induces formation of lipid droplets as a generalized response to stress","volume":"2013","author":"Lee","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"5","key":"10.1016\/j.jbo.2026.100785_bb0170","doi-asserted-by":"crossref","DOI":"10.1038\/oncsis.2016.33","article-title":"Targeting survivin as a potential new treatment for chondrosarcoma of bone","volume":"5","author":"de Jong","year":"2016","journal-title":"Oncogenesis"},{"issue":"11","key":"10.1016\/j.jbo.2026.100785_bb0175","doi-asserted-by":"crossref","first-page":"6179","DOI":"10.3390\/ijms25116179","article-title":"DNA-PKcs inhibition sensitizes human chondrosarcoma cells to carbon ion irradiation via cell cycle arrest and telomere capping disruption","volume":"25","author":"Lohberger","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"38","key":"10.1016\/j.jbo.2026.100785_bb0180","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1038\/onc.2014.427","article-title":"c-MYC is a radiosensitive locus in human breast cells","volume":"34","author":"Wade","year":"2015","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.jbo.2026.100785_bb0185","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1038\/s41467-020-16926-x","article-title":"DNA double-strand breaks induce H2Ax phosphorylation domains in a contact-dependent manner","volume":"11","author":"Collins","year":"2020","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.jbo.2026.100785_bb0190","doi-asserted-by":"crossref","first-page":"jcs260698","DOI":"10.1242\/jcs.260698","article-title":"Live-cell tracking of \u03b3-H2AX kinetics reveals the distinct modes of ATM and DNA-PK in the immediate response to DNA damage","volume":"136","author":"Trakarnphornsombat","year":"2023","journal-title":"J. Cell Sci."},{"issue":"1","key":"10.1016\/j.jbo.2026.100785_bb0195","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1158\/1541-7786.9.2.1","article-title":"Mdm2 in the response to radiation","volume":"2","author":"Perry","year":"2004","journal-title":"Mol. Cancer Res."}],"container-title":["Journal of Bone Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212137426000473?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212137426000473?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T12:17:53Z","timestamp":1786018673000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212137426000473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":39,"alternative-id":["S2212137426000473"],"URL":"https:\/\/doi.org\/10.1016\/j.jbo.2026.100785","relation":{},"ISSN":["2212-1374"],"issn-type":[{"value":"2212-1374","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting the Hippo\/YAP-TAZ pathway increases X-ray sensitivity in chondrosarcoma spheroids and is associated with autophagic disruption","name":"articletitle","label":"Article Title"},{"value":"Journal of Bone Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbo.2026.100785","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"100785"}}