{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:51:00Z","timestamp":1791996660567,"version":"4.4.0"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Bone Oncology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jbo.2026.100794","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T23:41:09Z","timestamp":1786146069000},"page":"100794","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Association between serum preptin levels and bone metastasis in newly diagnosed prostate cancer: a prospective exploratory study"],"prefix":"10.1016","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5720-8254","authenticated-orcid":false,"given":"Burcu","family":"G\u00fclba\u011fc\u0131","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Akda\u011f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"G\u00fcl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice","family":"Halis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra Ozen","family":"Engin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hac\u0131 \u0130brahim","family":"\u00c7imen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lhan","family":"Hac\u0131bekiro\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jbo.2026.100794_bb0005","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1080\/07853890802244142","article-title":"Circulating preptin levels in normal, impaired glucose tolerance, and type 2 diabetic subjects","volume":"41","author":"Yang","year":"2009","journal-title":"Ann. Med."},{"issue":"9","key":"10.1016\/j.jbo.2026.100794_bb0010","doi-asserted-by":"crossref","DOI":"10.3390\/metabo13090991","article-title":"Preptin: a new bone metabolic parameter?","volume":"13","author":"Ungureanu","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.jbo.2026.100794_bb0015","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3109\/08977194.2013.770392","article-title":"Effects and differentiation activity of IGF-I, IGF-II, insulin and preptin on human primary bone cells","volume":"31","author":"Bosetti","year":"2013","journal-title":"Growth Factors"},{"key":"10.1016\/j.jbo.2026.100794_bb0020","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2474-14-49","article-title":"Lower circulating preptin levels in male patients with osteoporosis are correlated with bone mineral density and bone formation","volume":"14","author":"Li","year":"2013","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.jbo.2026.100794_bb0025","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/789174","article-title":"Insulin resistance and cancer risk: an overview of the pathogenetic mechanisms","volume":"2012","author":"Arcidiacono","year":"2012","journal-title":"Exp. Diabetes Res."},{"issue":"12","key":"10.1016\/j.jbo.2026.100794_bb0030","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/nrc2536","article-title":"Insulin and insulin-like growth factor signalling in neoplasia","volume":"8","author":"Pollak","year":"2008","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.jbo.2026.100794_bb0035","doi-asserted-by":"crossref","first-page":"126","DOI":"10.5005\/jp-journals-10054-0302","article-title":"Exploring the role of preptin, adropin, and apelin in the development of breast cancer: a narrative review","volume":"30","author":"Tyagi","year":"2026","journal-title":"Indian J. Med. Biochem."},{"issue":"3","key":"10.1016\/j.jbo.2026.100794_bb0040","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s10068-022-01233-6","article-title":"Recent advances of bioactive proteins\/ polypeptides in the treatment of breast cancer","volume":"32","author":"Li","year":"2023","journal-title":"Food Sci. Biotechnol."},{"issue":"6","key":"10.1016\/j.jbo.2026.100794_bb0045","doi-asserted-by":"crossref","first-page":"465","DOI":"10.5489\/cuaj.117","article-title":"Management of skeletal-related events in patients with advanced prostate cancer and bone metastases: incorporating new agents into clinical practice","volume":"6","author":"So","year":"2012","journal-title":"Can. Urol. Assoc. J."},{"issue":"1","key":"10.1016\/j.jbo.2026.100794_bb0050","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-020-00105-1","article-title":"Molecular mechanisms and clinical management of cancer bone metastasis","volume":"8","author":"Wang","year":"2020","journal-title":"Bone Res."},{"key":"10.1016\/j.jbo.2026.100794_bb0055","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.urology.2024.04.043","article-title":"Poor bone mineral density is associated with increased risk of urological bone metastases","volume":"192","author":"Bowling","year":"2024","journal-title":"Urology"},{"issue":"3","key":"10.1016\/j.jbo.2026.100794_bb0060","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.0429","article-title":"Association of bone metastasis with early-stage breast cancer in women with and without precancer osteoporosis according to osteoporosis therapy status","volume":"2","author":"Chen","year":"2019","journal-title":"JAMA Netw. Open"},{"issue":"12","key":"10.1016\/j.jbo.2026.100794_bb0065","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1002\/jbmr.3618","article-title":"Understanding the bone in cancer metastasis","volume":"33","author":"Fornetti","year":"2018","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.jbo.2026.100794_bb0075","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S1096-6374(02)00121-1","article-title":"The role of insulin-like growth factor-II in cancer growth and progression evidenced by the use of ribozymes and prostate cancer progression models","volume":"13","author":"Guo","year":"2003","journal-title":"Growth Hormon. IGF Res."},{"issue":"2","key":"10.1016\/j.jbo.2026.100794_bb0080","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.eururo.2005.08.022","article-title":"IGF-II serum levels increase discrimination between benign prostatic hyperplasia and prostate cancer and improve the predictive value of PSA in clinical staging","volume":"49","author":"Trojan","year":"2006","journal-title":"Eur. Urol."},{"issue":"4","key":"10.1016\/j.jbo.2026.100794_bb0085","doi-asserted-by":"crossref","DOI":"10.3390\/life11040341","article-title":"Is Preptin a new bone metabolism parameter in hemodialysis patients?","volume":"11","author":"Ka\u0142u\u017cna","year":"2021","journal-title":"Life"},{"issue":"5","key":"10.1016\/j.jbo.2026.100794_bb0090","first-page":"367","article-title":"Circulating serum preptin levels in women with polycystic ovary syndrome: a systematic review and meta-analysis","volume":"21","author":"Bahreiny","year":"2023","journal-title":"Int. J. Reprod. BioMed."}],"container-title":["Journal of Bone Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212137426000564?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212137426000564?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:31:28Z","timestamp":1791995488000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212137426000564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":17,"alternative-id":["S2212137426000564"],"URL":"https:\/\/doi.org\/10.1016\/j.jbo.2026.100794","relation":{},"ISSN":["2212-1374"],"issn-type":[{"value":"2212-1374","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between serum preptin levels and bone metastasis in newly diagnosed prostate cancer: a prospective exploratory study","name":"articletitle","label":"Article Title"},{"value":"Journal of Bone Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbo.2026.100794","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"100794"}}