{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T22:02:46Z","timestamp":1769551366481,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Joint Bone Spine"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1016\/j.jbspin.2004.12.012","type":"journal-article","created":{"date-parts":[[2005,6,30]],"date-time":"2005-06-30T16:08:00Z","timestamp":1120147680000},"page":"527-532","source":"Crossref","is-referenced-by-count":88,"title":["Where Do T Cells Stand in Rheumatoid Arthritis?"],"prefix":"10.1016","volume":"72","author":[{"given":"Catherine","family":"Fournier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbspin.2004.12.012_bib1","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/art.1780330602","article-title":"How important are T cells in chronic rheumatoid synovitis?","volume":"33","author":"Firestein","year":"1990","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jbspin.2004.12.012_bib2","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/art.502","article-title":"How important are T cells in chronic rheumatoid synovitis? II. T cell-independent mechanisms from beginning to end","volume":"46","author":"Firestein","year":"2002","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jbspin.2004.12.012_bib3","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/art.1780350702","article-title":"The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis","volume":"35","author":"Panayi","year":"1992","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jbspin.2004.12.012_bib4","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S1471-4906(00)01841-X","article-title":"Thymic function and peripheral T-cell homeostasis in rheumatoid arthritis","volume":"22","author":"Goronzy","year":"2001","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jbspin.2004.12.012_bib5","first-page":"281","article-title":"Autoantigens and immune pathways in rheumatoid arthritis","volume":"22","author":"Corrigall","year":"2002","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.jbspin.2004.12.012_bib6","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S1471-4906(01)01976-7","article-title":"Post-translational protein modifications in antigen recognition and autoimmunity","volume":"22","author":"Doyle","year":"2001","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jbspin.2004.12.012_bib7","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1126\/science.291.5512.2370","article-title":"Glycosylation and the immune system","volume":"291","author":"Rudd","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.jbspin.2004.12.012_bib8","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1002\/art.20316","article-title":"Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis","volume":"50","author":"Van Gaalen","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jbspin.2004.12.012_bib9","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.4049\/jimmunol.166.6.4177","article-title":"The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha- and beta-chains of fibrin","volume":"166","author":"Masson-Bessiere","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.jbspin.2004.12.012_bib10","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1146\/annurev.immunol.14.1.397","article-title":"Role of cytokines in rheumatoid arthritis","volume":"14","author":"Feldmann","year":"1996","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jbspin.2004.12.012_bib11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1600-065X.1998.tb01218.x","article-title":"Heat-shock protein T-cell epitopes trigger a spreading regulatory control in a diversified arthritogenic T-cell response","volume":"164","author":"Van Eden","year":"1998","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jbspin.2004.12.012_bib12","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1136\/ard.46.9.691","article-title":"Experimental autoimmune arthritis in mice. I. Homologous type II collagen is responsible for self-perpetuating chronic polyarthritis","volume":"46","author":"Boissier","year":"1987","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jbspin.2004.12.012_bib13","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.4049\/jimmunol.162.2.1018","article-title":"Mice lacking mature T and B lymphocytes develop arthritic lesions after immunization with type II collagen","volume":"162","author":"Plows","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.jbspin.2004.12.012_bib14","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1002\/eji.1830251206","article-title":"Processing and presentation of type II collagen, a fibrillar autoantigen, by H-2q antigen-presenting cells","volume":"25","author":"Manoury-Schwartz","year":"1995","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jbspin.2004.12.012_bib15","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1002\/eji.1830270623","article-title":"Conversion in vivo from an early dominant Th0\/Th1 response to a Th2 phenotype during the development of collagen-induced arthritis","volume":"27","author":"Doncarli","year":"1997","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jbspin.2004.12.012_bib16","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1002\/eji.1830250508","article-title":"Biphasic effect of interferon-gamma in murine collagen-induced arthritis","volume":"25","author":"Boissier","year":"1995","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jbspin.2004.12.012_bib17","doi-asserted-by":"crossref","first-page":"5501","DOI":"10.4049\/jimmunol.158.11.5501","article-title":"High susceptibility to collagen-induced arthritis in mice lacking IFN-gamma receptors","volume":"158","author":"Manoury-Schwartz","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.jbspin.2004.12.012_bib18","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/35046102","article-title":"T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma","volume":"408","author":"Takayanagi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jbspin.2004.12.012_bib19","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1002\/eji.1830261020","article-title":"Attenuation of collagen-induced arthritis in mice by treatment with vector cells engineered to secrete interleukin-13","volume":"26","author":"Bessis","year":"1996","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jbspin.2004.12.012_bib20","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.4049\/jimmunol.160.11.5213","article-title":"Adenovirus-mediated transfer of viral IL-10 gene inhibits murine collagen-induced arthritis","volume":"160","author":"Apparailly","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.jbspin.2004.12.012_bib21","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1002\/(SICI)1521-4141(199911)29:11<3636::AID-IMMU3636>3.0.CO;2-3","article-title":"A recurrent valpha17\/vbeta10 TCR-expressing T cell clone is involved in the pathogenicity of collagen-induced arthritis in DBA\/1 mice","volume":"29","author":"Doncarli","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jbspin.2004.12.012_bib22","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1084\/jem.185.6.1113","article-title":"An HLA-DR1 transgene confers susceptibility to collagen-induced arthritis elicited with human type II collagen","volume":"18","author":"Rosloniec","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jbspin.2004.12.012_bib23","doi-asserted-by":"crossref","first-page":"7574","DOI":"10.1073\/pnas.95.13.7574","article-title":"Definition of MHC and T cell receptor contacts in the HLA-DR4 restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice","volume":"95","author":"Andersson","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jbspin.2004.12.012_bib24","doi-asserted-by":"crossref","first-page":"9960","DOI":"10.1073\/pnas.132254199","article-title":"Predominant selection of T cells specific for the glycosylated collagen type II epitope (263-270) in humanized transgenic mice and in rheumatoid arthritis","volume":"99","author":"Backlund","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jbspin.2004.12.012_bib25","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0092-8674(00)81989-3","article-title":"Organ-specific disease provoked by systemic autoimmunity","volume":"87","author":"Kouskoff","year":"1996","journal-title":"Cell."},{"key":"10.1016\/j.jbspin.2004.12.012_bib26","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S1074-7613(00)80045-X","article-title":"From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins","volume":"10","author":"Korganow","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.jbspin.2004.12.012_bib27","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1126\/science.286.5445.1732","article-title":"Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme","volume":"286","author":"Matsumoto","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.jbspin.2004.12.012_bib28","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/ni772","article-title":"How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease","volume":"3","author":"Matsumoto","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jbspin.2004.12.012_bib29","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/nature02119","article-title":"Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice","volume":"426","author":"Sakaguchi","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jbspin.2004.12.012_bib30","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1172\/JCI200421795","article-title":"Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice","volume":"114","author":"Hata","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbspin.2004.12.012_bib31","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1172\/JCI22651","article-title":"The T cell cometh: interplay between adaptive immunity and cytokine networks in rheumatoid arthritis","volume":"114","author":"Firestein","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbspin.2004.12.012_bib32","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4049\/jimmunol.155.3.1151","article-title":"Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases","volume":"155","author":"Sakaguchi","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.jbspin.2004.12.012_bib33","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1002\/art.11063","article-title":"CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis","volume":"48","author":"Morgan","year":"2003","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jbspin.2004.12.012_bib34","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/immu.200390024","article-title":"Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis","volume":"33","author":"Cao","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jbspin.2004.12.012_bib35","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1084\/jem.20040165","article-title":"Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy","volume":"200","author":"Ehrenstein","year":"2004","journal-title":"J. Exp. Med."}],"container-title":["Joint Bone Spine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1297319X05000825?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1297319X05000825?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T13:52:49Z","timestamp":1706363569000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1297319X05000825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["S1297319X05000825"],"URL":"https:\/\/doi.org\/10.1016\/j.jbspin.2004.12.012","relation":{},"ISSN":["1297-319X"],"issn-type":[{"value":"1297-319X","type":"print"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}