{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:53:13Z","timestamp":1791204793729,"version":"4.2.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Joint Bone Spine"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1016\/j.jbspin.2007.04.004","type":"journal-article","created":{"date-parts":[[2007,7,12]],"date-time":"2007-07-12T13:28:11Z","timestamp":1184246891000},"page":"571-576","source":"Crossref","is-referenced-by-count":82,"title":["The inflammasome, autoinflammatory diseases, and gout"],"prefix":"10.1016","volume":"74","author":[{"given":"Virginie","family":"P\u00e9trilli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Martinon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbspin.2007.04.004_bib1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0952-7915(00)00124-2","article-title":"TNFRSF1A mutations and autoinflammatory syndromes","volume":"12","author":"Galon","year":"2000","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jbspin.2007.04.004_bib2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0092-8674(00)80721-7","article-title":"Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes","volume":"97","author":"McDermott","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.jbspin.2007.04.004_bib3","doi-asserted-by":"crossref","first-page":"e297","DOI":"10.1371\/journal.pmed.0030297","article-title":"A proposed classification of the immunological diseases","volume":"3","author":"McGonagle","year":"2006","journal-title":"PLoS Med"},{"key":"10.1016\/j.jbspin.2007.04.004_bib4","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1097\/bor.0000174210.78449.6b","article-title":"Familial autoinflammatory diseases: genetics, pathogenesis and treatment","volume":"17","author":"Stojanov","year":"2005","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.jbspin.2007.04.004_bib5","first-page":"583","article-title":"Phase I study of recombinant human interleukin-1 beta (rhIL-1 beta) in patients with bone marrow failure","volume":"14","author":"Nemunaitis","year":"1994","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jbspin.2007.04.004_bib6","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1182\/blood.V83.12.3473.3473","article-title":"Phase I study of recombinant interleukin-1 beta in patients undergoing autologous bone marrow transplant for acute myelogenous leukemia","volume":"83","author":"Nemunaitis","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.jbspin.2007.04.004_bib7","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3109\/10428199309145750","article-title":"Interleukin-1: biological effects in human hematopoiesis","volume":"9","author":"Crown","year":"1993","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.jbspin.2007.04.004_bib8","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.4049\/jimmunol.135.5.3205","article-title":"The role of IL 1 in the antigen-specific activation of murine class II-restricted T lymphocyte clones","volume":"135","author":"McKean","year":"1985","journal-title":"J Immunol"},{"key":"10.1016\/j.jbspin.2007.04.004_bib9","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1161\/01.ATV.18.8.1292","article-title":"Interleukin-1beta induces tissue- and cell type-specific expression of adhesion\u00a0molecules in vivo","volume":"18","author":"Tamaru","year":"1998","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jbspin.2007.04.004_bib10","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00024382-199702000-00006","article-title":"Endothelial structural integrity is maintained during endotoxic shock in an interleukin-1 type 1 receptor knockout mouse","volume":"7","author":"Sutton","year":"1997","journal-title":"Shock"},{"key":"10.1016\/j.jbspin.2007.04.004_bib11","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.4049\/jimmunol.143.10.3309","article-title":"Migration of neutrophils across endothelial monolayers is stimulated by treatment of the monolayers with interleukin-1 or tumor necrosis factor-alpha","volume":"143","author":"Furie","year":"1989","journal-title":"J Immunol"},{"key":"10.1016\/j.jbspin.2007.04.004_bib12","doi-asserted-by":"crossref","first-page":"S460","DOI":"10.1097\/01.CCM.0000185500.11080.91","article-title":"Interleukin-1beta","volume":"33","author":"Dinarello","year":"2005","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jbspin.2007.04.004_bib13","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1172\/JCI117842","article-title":"Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor necrosis factor-alpha, and lipopolysaccharide","volume":"95","author":"Feng","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jbspin.2007.04.004_bib14","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/sj.bjp.0701152","article-title":"Effect of interleukin-1 beta, tumour necrosis factor-alpha and interferon-gamma on the induction of cyclo-oxygenase-2 in cultured human airway smooth muscle cells","volume":"121","author":"Pang","year":"1997","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jbspin.2007.04.004_bib15","first-page":"S1","article-title":"The IL-1 family and inflammatory diseases","volume":"20","author":"Dinarello","year":"2002","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jbspin.2007.04.004_bib16","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0304-4165(88)90008-6","article-title":"Recombinant human interleukin-1 stimulates human articular cartilage to undergo resorption and human chondrocytes to produce both tissue- and urokinase-type plasminogen activator","volume":"967","author":"Campbell","year":"1988","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jbspin.2007.04.004_bib17","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1172\/JCI112350","article-title":"Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells","volume":"77","author":"Dayer","year":"1986","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jbspin.2007.04.004_bib18","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/rheumatology\/kei171","article-title":"Chondroprotective drugs in degenerative joint diseases","volume":"45","author":"Verbruggen","year":"2006","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.jbspin.2007.04.004_bib19","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.1073\/pnas.86.14.5227","article-title":"Identification of a monocyte specific pre-interleukin 1 beta convertase activity","volume":"86","author":"Kostura","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jbspin.2007.04.004_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/sj.jid.5700819","article-title":"Activation of the IL-1b-processing inflammasome is involved in contact hypersensitivity","author":"Watanabe","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jbspin.2007.04.004_bib21","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/0014-5793(89)81376-6","article-title":"Activation of interleukin-1 beta by a co-induced protease","volume":"247","author":"Black","year":"1989","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jbspin.2007.04.004_bib22","doi-asserted-by":"crossref","first-page":"21657","DOI":"10.1016\/S0021-9258(18)54687-1","article-title":"Mechanism-based inactivation of alanine racemase by 3-halovinylglycines","volume":"266","author":"Thornberry","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jbspin.2007.04.004_bib23","doi-asserted-by":"crossref","first-page":"S370","DOI":"10.1086\/374751","article-title":"Interleukin-18 and host defense against infection","volume":"187","author":"Dinarello","year":"2003","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jbspin.2007.04.004_bib24","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.immuni.2005.09.015","article-title":"IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines","volume":"23","author":"Schmitz","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.jbspin.2007.04.004_bib25","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/sj.cdd.4402038","article-title":"Inflammatory caspases and inflammasomes: master switches of inflammation","volume":"14","author":"Martinon","year":"2007","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jbspin.2007.04.004_bib26","doi-asserted-by":"crossref","first-page":"3433","DOI":"10.4049\/jimmunol.155.7.3433","article-title":"IL-1 beta converting enzyme (ICE) is not required for apoptosis induced by lymphokine deprivation in an IL-2-dependent T cell line","volume":"155","author":"Vasilakos","year":"1995","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jbspin.2007.04.004_bib27","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0092-8674(95)90490-5","article-title":"Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock","volume":"80","author":"Li","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.jbspin.2007.04.004_bib28","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1126\/science.7535475","article-title":"Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme","volume":"267","author":"Kuida","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.jbspin.2007.04.004_bib29","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol Cell"},{"key":"10.1016\/j.jbspin.2007.04.004_bib30","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nrm1019","article-title":"NALPs: a novel protein family involved in inflammation","volume":"4","author":"Tschopp","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jbspin.2007.04.004_bib31","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1074-7613(04)00046-9","article-title":"NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle\u2013Wells autoinflammatory disorder","volume":"20","author":"Agostini","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.jbspin.2007.04.004_bib32","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.immuni.2006.02.004","article-title":"Critical role for NALP3\/CIAS1\/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1","volume":"24","author":"Sutterwala","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.jbspin.2007.04.004_bib33","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature04515","article-title":"Cryopyrin activates the inflammasome in response to toxins and ATP","volume":"40","author":"Mariathasan","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jbspin.2007.04.004_bib34","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nature04517","article-title":"Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin\/Nalp3","volume":"440","author":"Kanneganti","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jbspin.2007.04.004_bib35","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1182\/asheducation-2005.1.74","article-title":"Hereditary periodic Fever syndromes","author":"Kastner","year":"2005","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.jbspin.2007.04.004_bib36","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1097\/ACI.0b013e3280109b57","article-title":"Recent advances in the molecular pathogenesis of hereditary recurrent fevers","volume":"6","author":"Masters","year":"2006","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jbspin.2007.04.004_bib37","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3109\/03009748709102523","article-title":"A chronic, infantile, neurological, cutaneous and articular (CINCA) syndrome. A specific entity analysed in 30 patients","volume":"66","author":"Prieur","year":"1987","journal-title":"Scand J Rheumatol Suppl"},{"key":"10.1016\/j.jbspin.2007.04.004_bib38","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1086\/341357","article-title":"Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes","volume":"71","author":"Feldmann","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jbspin.2007.04.004_bib39","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/ng756","article-title":"Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle\u2013Wells syndrome","volume":"29","author":"Hoffman","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.jbspin.2007.04.004_bib40","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/01.bor.0000209435.89720.7c","article-title":"New insights into gout epidemiology","volume":"18","author":"Mikuls","year":"2006","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.jbspin.2007.04.004_bib41","doi-asserted-by":"crossref","first-page":"9412","DOI":"10.1073\/pnas.86.23.9412","article-title":"Urate oxidase: primary structure and evolutionary implications","volume":"86","author":"Wu","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jbspin.2007.04.004_bib42","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/BF00163854","article-title":"Two independent mutational events in the loss of urate oxidase during hominoid evolution","volume":"34","author":"Wu","year":"1992","journal-title":"J Mol Evol"},{"key":"10.1016\/j.jbspin.2007.04.004_bib43","first-page":"341","article-title":"Gout: epidemiology and lifestyle choices","volume":"17","author":"Choi","year":"2005","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.jbspin.2007.04.004_bib44","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1001\/archinte.165.7.742","article-title":"Obesity, weight change, hypertension, diuretic use, and risk of gout in men: the health professionals follow-up study","volume":"165","author":"Choi","year":"2005","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jbspin.2007.04.004_bib45","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1002\/art.1780340716","article-title":"Monocyte-derived neutrophil chemotactic factor\/interleukin-8 is a potential mediator of crystal-induced inflammation","volume":"34","author":"Terkeltaub","year":"1991","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jbspin.2007.04.004_bib46","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1084\/jem.182.6.2019","article-title":"Inflammatory microcrystals differentially regulate the secretion of macrophage inflammatory protein 1 and interleukin 8 by human neutrophils: a possible mechanism of neutrophil recruitment to sites of inflammation in synovitis","volume":"182","author":"Hachicha","year":"1995","journal-title":"J Exp Med"},{"key":"10.1016\/j.jbspin.2007.04.004_bib47","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1172\/JCI115142","article-title":"Urate crystals stimulate production of tumor necrosis factor alpha from human blood monocytes and synovial cells. Cytokine mRNA and protein kinetics, and cellular distribution","volume":"87","author":"di Giovine","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jbspin.2007.04.004_bib48","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.jbspin.2006.03.006","article-title":"Colchicine today","volume":"73","author":"Niel","year":"2006","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.jbspin.2007.04.004_bib49","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nature01991","article-title":"Molecular identification of a danger signal that alerts the immune system to dying cells","volume":"425","author":"Shi","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jbspin.2007.04.004_bib50","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jbspin.2007.04.004_bib51","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1172\/JCI29404","article-title":"Gout: new insights into an old disease","volume":"116","author":"Martinon","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jbspin.2007.04.004_bib52","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1172\/JCI28075","article-title":"MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals","volume":"116","author":"Chen","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jbspin.2007.04.004_bib53","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1016\/S0140-6736(04)17401-1","article-title":"Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist","volume":"364","author":"Hoffman","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.jbspin.2007.04.004_bib54","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/art.20033","article-title":"Spectrum of clinical features in Muckle\u2013Wells syndrome and response to anakinra","volume":"50","author":"Hawkins","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jbspin.2007.04.004_bib55","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1056\/NEJM200306193482523","article-title":"Interleukin-1-receptor antagonist in the Muckle\u2013Wells syndrome","volume":"348","author":"Hawkins","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jbspin.2007.04.004_bib56","doi-asserted-by":"crossref","first-page":"R28","DOI":"10.1186\/ar2143","article-title":"A pilot study of IL-1 inhibition by anakinra in acute gout","volume":"9","author":"So","year":"2007","journal-title":"Arthritis Res Ther"}],"container-title":["Joint Bone Spine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1297319X07001959?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1297319X07001959?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T09:07:27Z","timestamp":1683968847000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1297319X07001959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S1297319X07001959"],"URL":"https:\/\/doi.org\/10.1016\/j.jbspin.2007.04.004","relation":{},"ISSN":["1297-319X"],"issn-type":[{"value":"1297-319X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}