{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:27:31Z","timestamp":1787696851923,"version":"build-2784847793"},"reference-count":60,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Joint Bone Spine"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1016\/j.jbspin.2008.11.002","type":"journal-article","created":{"date-parts":[[2009,2,14]],"date-time":"2009-02-14T15:32:27Z","timestamp":1234625547000},"page":"234-240","source":"Crossref","is-referenced-by-count":31,"title":["Bone tissue and hyperhomocysteinemia"],"prefix":"10.1016","volume":"76","author":[{"given":"R\u00e9gis","family":"Levasseur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbspin.2008.11.002_bib1","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1161\/01.STR.15.6.1012","article-title":"Moderate homocysteinemia\u2014a possible risk factor for arteriosclerotic cerebrovascular disease","volume":"15","author":"Brattstrom","year":"1984","journal-title":"Stroke"},{"key":"10.1016\/j.jbspin.2008.11.002_bib2","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.revmed.2005.09.018","volume":"27","author":"Ducros","year":"2006","journal-title":"Rev Med Intern"},{"key":"10.1016\/j.jbspin.2008.11.002_bib3","first-page":"1","article-title":"The natural history of homocystinuria due to cystathionine beta-synthase deficiency","volume":"37","author":"Mudd","year":"1985","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jbspin.2008.11.002_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1651-2227.1985.tb10147.x","article-title":"Homocystinuria. Clinical, biochemical and genetic aspects of cystathionine beta-synthase and its deficiency in man","volume":"321","author":"Skovby","year":"1985","journal-title":"Acta Paediatr Scand Suppl"},{"key":"10.1016\/j.jbspin.2008.11.002_bib5","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1079\/PHN2001159","article-title":"MTHFR gene polymorphism, homocysteine and cardiovascular disease","volume":"4","author":"Cortese","year":"2001","journal-title":"Public Health Nutr"},{"key":"10.1016\/j.jbspin.2008.11.002_bib6","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1093\/ndt\/gfh620","article-title":"The C677T methylenetetrahydrofolate reductase gene mutation does not influence cardiovascular risk in the dialysis population: results of a multicentre prospective study","volume":"20","author":"Aucella","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.jbspin.2008.11.002_bib7","first-page":"CD000951","article-title":"Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis","author":"Ortiz","year":"2000","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jbspin.2008.11.002_bib8","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1093\/rheumatology\/41.6.658","article-title":"Homocysteine and folate status in methotrexate-treated patients with rheumatoid arthritis","volume":"41","author":"van Ede","year":"2002","journal-title":"Rheumatology (Oxford)"},{"issue":"Suppl. 1","key":"10.1016\/j.jbspin.2008.11.002_bib9","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1038\/sj.cdd.4401451","article-title":"Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease","volume":"11","author":"Austin","year":"2004","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jbspin.2008.11.002_bib10","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1515\/CCLM.2007.038","article-title":"Plasma homocysteine cutoff values for venous thrombosis","volume":"45","author":"Castanon","year":"2007","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.jbspin.2008.11.002_bib11","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.autrev.2007.03.008","article-title":"Hyperhomocysteinemia, inflammation and autoimmunity","volume":"6","author":"Lazzerini","year":"2007","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jbspin.2008.11.002_bib12","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.jbspin.2007.07.022","article-title":"Severe atherosclerosis in rheumatoid arthritis and hyperhomocysteinemia: is there a link?","volume":"75","author":"El Bouchti","year":"2008","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.jbspin.2008.11.002_bib13","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1093\/ajcn\/82.3.636","article-title":"Homocysteine and folate as risk factors for dementia and Alzheimer's disease","volume":"82","author":"Ravaglia","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jbspin.2008.11.002_bib14","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1056\/NEJMc066569","article-title":"Folate deficiency and plasma homocysteine during increased oxidative stress","volume":"357","author":"Rogers","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jbspin.2008.11.002_bib15","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1055\/s-0037-1615951","article-title":"High prevalence of the I278T mutation of the human cystathionine beta-synthase detected by a novel screening application","volume":"85","author":"Linnebank","year":"2001","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jbspin.2008.11.002_bib16","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1136\/bmj.313.7064.1037","article-title":"Delay in diagnosis of homocystinuria: retrospective study of consecutive patients","volume":"313","author":"Cruysberg","year":"1996","journal-title":"BMJ"},{"key":"10.1016\/j.jbspin.2008.11.002_bib17","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1302\/0301-620X.54B2.277","article-title":"Homocystinuria and Marfan's syndrome. A comparison","volume":"54","author":"Brenton","year":"1972","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.jbspin.2008.11.002_bib18","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1001\/jama.1965.03090090017003","article-title":"Homocystinuria. Studies of 20 families with 38 affected members","volume":"193","author":"Schimke","year":"1965","journal-title":"JAMA"},{"key":"10.1016\/j.jbspin.2008.11.002_bib19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/BF02263573","article-title":"Homocystinuria: studies on cystathionine beta-synthase, S-adenosylmethionine synthetase and cystathionase activities in skin fibroblasts","volume":"4","author":"Bittles","year":"1981","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.jbspin.2008.11.002_bib20","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0009-8981(73)90429-4","article-title":"The reaction of homocysteine with aldehyde: an explanation of the collagen defects in homocystinuria","volume":"45","author":"Jackson","year":"1973","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jbspin.2008.11.002_bib21","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0925-4439(95)00119-0","article-title":"Evidence for McKusick's hypothesis of deficient collagen cross-linking in patients with homocystinuria","volume":"1315","author":"Lubec","year":"1996","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jbspin.2008.11.002_bib22","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1056\/NEJMoa032546","article-title":"Homocysteine levels and the risk of osteoporotic fracture","volume":"350","author":"van Meurs","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jbspin.2008.11.002_bib23","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1073\/pnas.92.5.1585","article-title":"Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia","volume":"92","author":"Watanabe","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jbspin.2008.11.002_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ar.a.20145","article-title":"Cystathionine beta synthase deficiency affects mouse endochondral ossification","volume":"282","author":"Robert","year":"2005","journal-title":"Anat Rec A Discov Mol Cell Evol Biol"},{"key":"10.1016\/j.jbspin.2008.11.002_bib25","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1373\/clinchem.2007.086272","article-title":"Experimental hyperhomocysteinemia reduces bone quality in rats","volume":"53","author":"Herrmann","year":"2007","journal-title":"Clin Chem"},{"key":"10.1016\/j.jbspin.2008.11.002_bib26","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1373\/clinchem.2005.053363","article-title":"Increased osteoclast activity in the presence of increased homocysteine concentrations","volume":"51","author":"Herrmann","year":"2005","journal-title":"Clin Chem"},{"key":"10.1016\/j.jbspin.2008.11.002_bib27","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.bone.2007.06.005","article-title":"Stimulation of osteoclast activity by low B-vitamin concentrations","volume":"41","author":"Herrmann","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.jbspin.2008.11.002_bib28","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2474-4-2","article-title":"Chemical and biomechanical characterization of hyperhomocysteinemic bone disease in an animal model","volume":"4","author":"Masse","year":"2003","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.jbspin.2008.11.002_bib29","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1079\/BJN19940196","article-title":"Vitamin B6 deficiency experimentally-induced bone and joint disorder: microscopic, radiographic and biochemical evidence","volume":"71","author":"Masse","year":"1994","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jbspin.2008.11.002_bib30","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/8756-3282(96)00072-5","article-title":"Pyridoxine deficiency affects biomechanical properties of chick tibial bone","volume":"18","author":"Masse","year":"1996","journal-title":"Bone"},{"key":"10.1016\/j.jbspin.2008.11.002_bib31","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.bone.2006.03.004","article-title":"Homocysteine enhances apoptosis in human bone marrow stromal cells","volume":"39","author":"Kim","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.jbspin.2008.11.002_bib32","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1359\/jbmr.060406","article-title":"Homocysteine enhances bone resorption by stimulation of osteoclast formation and activity through increased intracellular ROS generation","volume":"21","author":"Koh","year":"2006","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jbspin.2008.11.002_bib33","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s00223-006-0035-1","article-title":"Degree of mineralization-related collagen crosslinking in the femoral neck cancellous bone in cases of hip fracture and controls","volume":"79","author":"Saito","year":"2006","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jbspin.2008.11.002_bib34","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1056\/NEJMoa032739","article-title":"Homocysteine as a predictive factor for hip fracture in older persons","volume":"350","author":"McLean","year":"2004","journal-title":"N Engl J Med"},{"issue":"6 Suppl","key":"10.1016\/j.jbspin.2008.11.002_bib35","doi-asserted-by":"crossref","first-page":"1726S","DOI":"10.1093\/jn\/136.6.1726S","article-title":"The many facets of hyperhomocysteinemia: studies from the Framingham cohorts","volume":"136","author":"Selhub","year":"2006","journal-title":"J Nutr"},{"key":"10.1016\/j.jbspin.2008.11.002_bib36","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.bone.2005.01.011","article-title":"Homocysteine as a predictive factor for hip fracture in stroke patients","volume":"36","author":"Sato","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.jbspin.2008.11.002_bib37","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.amjmed.2005.01.052","article-title":"Homocysteine as a predictive factor for hip fracture in elderly women with Parkinson's disease","volume":"118","author":"Sato","year":"2005","journal-title":"Am J Med"},{"key":"10.1016\/j.jbspin.2008.11.002_bib38","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1001\/jama.293.9.1082","article-title":"Effect of folate and mecobalamin on hip fractures in patients with stroke: a randomized controlled trial","volume":"293","author":"Sato","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.jbspin.2008.11.002_bib39","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1359\/jbmr.070210","article-title":"Plasma homocysteine, folate, and vitamin B 12 and the risk of hip fracture: the hordaland homocysteine study","volume":"22","author":"Gjesdal","year":"2007","journal-title":"J Bone Miner Res"},{"issue":"7","key":"10.1016\/j.jbspin.2008.11.002_bib40","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1365-2036.2007.03260.x","article-title":"Hyperhomocysteinaemia is associated with osteoporosis in patients with Crohn's disease","volume":"25","author":"Roblin","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jbspin.2008.11.002_bib41","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.seizure.2006.10.001","article-title":"Homocysteine and bone loss in epilepsy","volume":"16","author":"Elliott","year":"2007","journal-title":"Seizure"},{"key":"10.1016\/j.jbspin.2008.11.002_bib42","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1007\/s00198-007-0393-1","article-title":"Homocysteine and fracture risk in postmenopausal women: the OFELY study","volume":"18","author":"Perier","year":"2007","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jbspin.2008.11.002_bib43","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1359\/jbmr.061003","article-title":"Associations between homocysteine, bone turnover, BMD, mortality, and fracture risk in elderly women","volume":"22","author":"Gerdhem","year":"2007","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jbspin.2008.11.002_bib44","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1093\/gerona\/60.11.1458","article-title":"Folate, but not homocysteine, predicts the risk of fracture in elderly persons","volume":"60","author":"Ravaglia","year":"2005","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.jbspin.2008.11.002_bib45","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s002230010038","article-title":"Association of methylenetetrahydrofolate reductase (MTHFR) polymorphism with bone mineral density in postmenopausal Japanese women","volume":"66","author":"Miyao","year":"2000","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jbspin.2008.11.002_bib46","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bone.2005.08.005","article-title":"MTHFR c.677C>T polymorphism as an independent predictor of peak bone mass in Danish men\u2014results from the Odense Androgen Study","volume":"38","author":"Abrahamsen","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.jbspin.2008.11.002_bib47","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.bone.2006.09.031","article-title":"Association of the methylenetetrahydrofolate reductase C677T polymorphism and fracture risk in Chinese postmenopausal women","volume":"40","author":"Hong","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.jbspin.2008.11.002_bib48","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00198-004-1704-4","article-title":"Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with osteoporotic vertebral fractures, but is a weak predictor of BMD","volume":"16","author":"Villadsen","year":"2005","journal-title":"Osteoporos Int"},{"issue":"6 Suppl","key":"10.1016\/j.jbspin.2008.11.002_bib49","doi-asserted-by":"crossref","first-page":"1731S","DOI":"10.1093\/jn\/136.6.1731S","article-title":"The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with disease","volume":"136","author":"Refsum","year":"2006","journal-title":"J Nutr"},{"key":"10.1016\/j.jbspin.2008.11.002_bib50","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1359\/jbmr.2003.18.4.723","article-title":"A common methylenetetrahydrofolate reductase (C677T) polymorphism is associated with low bone mineral density and increased fracture incidence after menopause: longitudinal data from the Danish osteoporosis prevention study","volume":"18","author":"Abrahamsen","year":"2003","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jbspin.2008.11.002_bib51","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00198-003-1584-z","article-title":"Evidence for an association of methylene tetrahydrofolate reductase polymorphism C677T and an increased risk of fractures: results from a population-based Danish twin study","volume":"15","author":"Bathum","year":"2004","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jbspin.2008.11.002_bib52","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.bone.2004.04.018","article-title":"Association of plasma folate, plasma total homocysteine, but not methylenetetrahydrofolate reductase C667T polymorphism, with bone mineral density in postmenopausal Iranian women: a cross-sectional study","volume":"35","author":"Golbahar","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.jbspin.2008.11.002_bib53","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.bone.2004.05.018","article-title":"Methylenetetrahydrofolate reductase polymorphism interacts with riboflavin intake to influence bone mineral density","volume":"35","author":"Macdonald","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.jbspin.2008.11.002_bib54","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.bone.2004.12.014","article-title":"Are effects of MTHFR (C677T) genotype on BMD confined to women with low folate and riboflavin intake? Analysis of food records from the Danish osteoporosis prevention study","volume":"36","author":"Abrahamsen","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.jbspin.2008.11.002_bib55","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1001\/archinte.166.1.88","article-title":"Plasma total homocysteine level and bone mineral density: the Hordaland Homocysteine Study","volume":"166","author":"Gjesdal","year":"2006","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jbspin.2008.11.002_bib56","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.bone.2006.10.008","article-title":"The association of homocysteine and its determinants MTHFR genotype, folate, vitamin B12 and vitamin B6 with bone mineral density in postmenopausal British women","volume":"40","author":"Baines","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.jbspin.2008.11.002_bib57","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1359\/JBMR.0301261","article-title":"Association of a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate status","volume":"19","author":"McLean","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jbspin.2008.11.002_bib58","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1093\/gerona\/62.4.434","article-title":"Relationship of homocysteine levels to quadriceps strength, gait speed, and late-life disability in older adults","volume":"62","author":"Kuo","year":"2007","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.jbspin.2008.11.002_bib59","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1515\/CCLM.2005.195","article-title":"Relation between homocysteine and biochemical bone turnover markers and bone mineral density in peri- and post-menopausal women","volume":"43","author":"Herrmann","year":"2005","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.jbspin.2008.11.002_bib60","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s11926-007-0027-9","article-title":"Not just calcium and vitamin D: other nutritional considerations in osteoporosis","volume":"9","author":"Kitchin","year":"2007","journal-title":"Curr Rheumatol Rep"}],"container-title":["Joint Bone Spine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1297319X08003539?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1297319X08003539?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,10]],"date-time":"2024-03-10T15:30:19Z","timestamp":1710084619000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1297319X08003539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S1297319X08003539"],"URL":"https:\/\/doi.org\/10.1016\/j.jbspin.2008.11.002","relation":{},"ISSN":["1297-319X"],"issn-type":[{"value":"1297-319X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}