{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:26:16Z","timestamp":1780471576336,"version":"3.54.1"},"reference-count":52,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Joint Bone Spine"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.jbspin.2010.01.013","type":"journal-article","created":{"date-parts":[[2010,5,17]],"date-time":"2010-05-17T06:22:33Z","timestamp":1274077353000},"page":"399-404","source":"Crossref","is-referenced-by-count":14,"title":["Mseleni joint disease: A potential model of epigenetic chondrodysplasia"],"prefix":"10.1016","volume":"77","author":[{"given":"Victoria E.","family":"Gibbon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Harington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clem B.","family":"Penny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Fredlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7651","key":"10.1016\/j.jbspin.2010.01.013_bib1","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0140-6736(70)92444-X","article-title":"Unusual hip disease in remote part of Zululand","volume":"295","author":"Wittman","year":"1970","journal-title":"Lancet"},{"key":"10.1016\/j.jbspin.2010.01.013_bib2","first-page":"2173","article-title":"Mseleni joint disease: background and prevalence","volume":"47","author":"Fellingham","year":"1973","journal-title":"S Afr Med J"},{"key":"10.1016\/j.jbspin.2010.01.013_bib3","first-page":"360","article-title":"Mseleni joint disease: population genetic studies","volume":"70","author":"Nurse","year":"1974","journal-title":"S Afr J Sci"},{"key":"10.1016\/j.jbspin.2010.01.013_bib4","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/ije\/14.2.276","article-title":"Mseleni joint disease in 1981: decreased prevalence rates, wider geographical location than before, and socioeconomic impact of an endemic osteoarthrosis in an underdeveloped community in South Africa","volume":"14","author":"Yach","year":"1985","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jbspin.2010.01.013_bib5","first-page":"2225","article-title":"Mseleni joint disease: food and water supplies","volume":"47","author":"Lubbe","year":"1973","journal-title":"S Afr Med J"},{"key":"10.1016\/j.jbspin.2010.01.013_bib6","first-page":"2366","article-title":"Mseleni joint disease:a radiological study of two affected families","volume":"47","author":"Lockitch","year":"1973","journal-title":"S Afr Med J"},{"key":"10.1016\/j.jbspin.2010.01.013_bib7","first-page":"2283","article-title":"Mseleni joint disease: the pilot clinical survey","volume":"47","author":"Lockitch","year":"1973","journal-title":"S Afr Med J"},{"key":"10.1016\/j.jbspin.2010.01.013_bib8","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0046-8177(85)80059-9","article-title":"Pathological features of the femoral head in Mseleni disease","volume":"16","author":"Sokoloff","year":"1985","journal-title":"Hum Pathol"},{"key":"10.1016\/j.jbspin.2010.01.013_bib9","first-page":"15","article-title":"Distinct types of hip disorder in Mseleni joint disease","volume":"69","author":"Solomon","year":"1986","journal-title":"S Afr Med J"},{"key":"10.1016\/j.jbspin.2010.01.013_bib10","first-page":"445","article-title":"Mseleni joint disease \u2013 a manganese deficiency?","volume":"60","author":"Fincham","year":"1981","journal-title":"S Afr Med J"},{"key":"10.1016\/j.jbspin.2010.01.013_bib11","first-page":"473","article-title":"Osteopenia of the pelvis associated with Mseleni joint disease","volume":"72","author":"Schnitzler","year":"1987","journal-title":"S Afr Med J"},{"key":"10.1016\/j.jbspin.2010.01.013_bib12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/8756-3282(88)90023-3","article-title":"Histomorphometric analysis of osteopenia associated with endemic osteoarthritis (Mseleni joint disease)","volume":"9","author":"Schnitzler","year":"1988","journal-title":"Bone"},{"key":"10.1016\/j.jbspin.2010.01.013_bib13","first-page":"369","article-title":"Mycotoxicological investigations on maize and groundnuts from the endemic area of Mseleni joint disease in Kwazulu","volume":"69","author":"Marasas","year":"1986","journal-title":"S Afr Med J"},{"key":"10.1016\/j.jbspin.2010.01.013_bib14","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/art.1780070105","article-title":"The clinical course of Kashin-Beck disease","volume":"7","author":"Nesterov","year":"1964","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jbspin.2010.01.013_bib15","first-page":"75","article-title":"Heritable disorders of the skeleton in Southern Africa: genetic and orthopaedic implications","volume":"20","author":"Beighton","year":"1992","journal-title":"Trans Coll Med S Afr"},{"key":"10.1016\/j.jbspin.2010.01.013_bib16","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/BF03372604","article-title":"Handigodu disease: a radiological study","volume":"23","author":"Agarwal","year":"1994","journal-title":"Skeletal Radiol"},{"key":"10.1016\/j.jbspin.2010.01.013_bib17","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/(SICI)1096-8628(19971112)72:4<435::AID-AJMG12>3.0.CO;2-S","article-title":"Mseleni and Handigodu familial osteoarthropathies: syndromic identity?","volume":"72","author":"Agarwal","year":"1997","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.jbspin.2010.01.013_bib18","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.cca.2008.05.017","article-title":"Metabolic status of magnesium and ceruloplasmin in Handigodu Joint Disease: A variety of spondylo epi (meta) physeal dysplasia","volume":"395","author":"Badadani","year":"2008","journal-title":"Clinica Chimica Acta"},{"key":"10.1016\/j.jbspin.2010.01.013_bib19","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/ajmg.1320460607","article-title":"Brachydactylous dwarfs of Mseleni","volume":"46","author":"Viljoen","year":"1993","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.jbspin.2010.01.013_bib20","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0049-0172(99)80003-1","article-title":"Rheumatic diseases in North America's Indigenous Peoples","volume":"28","author":"Peschken","year":"1999","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.jbspin.2010.01.013_bib21","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1093\/rheumatology\/37.5.585","article-title":"Mseleni joint disease: social priorities","volume":"37","author":"Waller","year":"1998","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.jbspin.2010.01.013_bib22","first-page":"78","article-title":"Mseleni joint disease progress","volume":"38","author":"Bateman","year":"2000","journal-title":"S Afr J Sci"},{"key":"10.1016\/j.jbspin.2010.01.013_bib23","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1046\/j.1365-2389.1997.00124.x","article-title":"Soil and human health: a review","volume":"48","author":"Oliver","year":"1997","journal-title":"Eur J Soil Sci"},{"key":"10.1016\/j.jbspin.2010.01.013_bib24","series-title":"Geology and health: closing the gap","first-page":"151","article-title":"Soil nutrient deficiencies in an area of endemic osteoarthritis (Mseleni Joint Disease) and dwarfism in Maputaland, South Africa","author":"Ceruti","year":"2003"},{"key":"10.1016\/j.jbspin.2010.01.013_bib25","unstructured":"Ceruti PO. Crushed rock and clay amelioration of a nutrient deficient, sandy soil or Maputaland. MSc thesis, Department of Geological Sciences, University of Cape Town June 1999: i-109."},{"key":"10.1016\/j.jbspin.2010.01.013_bib26","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.quaint.2006.10.028","article-title":"Soil chronosequence development in dunes on the southeast African coastal plain, Maputaland, South Africa","volume":"162-163","author":"Botha","year":"2007","journal-title":"Quat Int"},{"key":"10.1016\/j.jbspin.2010.01.013_bib27","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.quascirev.2008.01.017","article-title":"The luminescence chronology of dune development on the Maputaland coastal plain, southeast Africa","volume":"27","author":"Porat","year":"2008","journal-title":"Quat Sci Rev"},{"issue":"24","key":"10.1016\/j.jbspin.2010.01.013_bib28","first-page":"920","article-title":"Something fishy about Mseleni joint disease","volume":"60","author":"Mackenzie","year":"1981","journal-title":"S Afr Med J"},{"key":"10.1016\/j.jbspin.2010.01.013_bib29","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0140-6736(86)90671-9","article-title":"Mseleni joint disease","author":"Fincham","year":"1986","journal-title":"Lancet"},{"key":"10.1016\/j.jbspin.2010.01.013_bib30","first-page":"51","article-title":"Mseleni joint disease Part I. An animal model?","volume":"67","author":"Fincham","year":"1985","journal-title":"S Afr Med J"},{"key":"10.1016\/j.jbspin.2010.01.013_bib31","first-page":"740","article-title":"Mseleni joint disease Part II. Low serum calcium and magnesium levels in women","volume":"70","author":"Fincham","year":"1986","journal-title":"S Afr Med J"},{"key":"10.1016\/j.jbspin.2010.01.013_bib32","first-page":"2331","article-title":"Mseleni joint disease: biochemical survey","volume":"47","author":"Burger","year":"1973","journal-title":"S Afr Med J"},{"key":"10.1016\/j.jbspin.2010.01.013_bib33","first-page":"956","article-title":"Mseleni joint disease- a molecular genetic approach to defining the aetiology","volume":"86","author":"Ballo","year":"1996","journal-title":"S Afr Med J"},{"key":"10.1016\/j.jbspin.2010.01.013_bib34","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.berh.2008.02.001","article-title":"Cartilage in normal and osteoarthritis conditions","volume":"22","author":"Martel-Pelletier","year":"2008","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.jbspin.2010.01.013_bib35","first-page":"317","article-title":"Proteoglycans of articular cartilage in Mseleni joint disease","volume":"71","author":"Sweet","year":"1987","journal-title":"S Afr Med J"},{"key":"10.1016\/j.jbspin.2010.01.013_bib36","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/art.1780300316","article-title":"Mseleni disease serum is not harmful to cultured chondrocytes","volume":"30","author":"Changelong","year":"1987","journal-title":"Arthritis Rheum"},{"issue":"8458","key":"10.1016\/j.jbspin.2010.01.013_bib37","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/S0140-6736(85)90666-X","article-title":"Slow virus in Mseleni joint disease?","volume":"2","author":"Nurse","year":"1985","journal-title":"Lancet"},{"key":"10.1016\/j.jbspin.2010.01.013_bib38","first-page":"75","article-title":"Lymphocytes from the site of disease suggest adenovirus is one cause of persistent or recurrent inflammatory arthritis","volume":"20","author":"Ford","year":"1993","journal-title":"J Rheum"},{"key":"10.1016\/j.jbspin.2010.01.013_bib39","unstructured":"McGlashan N. Mseleni joint disease in Zululand: the borreliosis hypothesis. In: Palagiano C, De Saintis G, Cardillo MC, editors. Atti del Quinto Seminario Internazionale di Geografia medica (Roma, 1-2 dicembre 1994) 1995. p. 462\u20134."},{"key":"10.1016\/j.jbspin.2010.01.013_bib40","first-page":"552","article-title":"Mseleni joint disease: an hypothesis and research agendum","volume":"88","author":"McGlashan","year":"1992","journal-title":"S Afr J Sci"},{"key":"10.1016\/j.jbspin.2010.01.013_bib41","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0035-9203(97)90388-6","article-title":"Mseleni joint disease: not a borreliosis","volume":"91","author":"McGlashan","year":"1997","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.jbspin.2010.01.013_bib42","unstructured":"Mann D. Aspects of the social effects of Mseleni joint disease: in second Carnegie inquiry into poverty and development in Southern Africa, Cape Town. Conference paper no. 191. 1984:1\u201313."},{"key":"10.1016\/j.jbspin.2010.01.013_bib43","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3109\/03790798709166189","article-title":"Prevalence of motor impairment and disability in a rural community in Kwazulu","volume":"8","author":"McLaren","year":"1987","journal-title":"Int Rehabil Med"},{"issue":"8453","key":"10.1016\/j.jbspin.2010.01.013_bib44","first-page":"483","article-title":"Mseleni joint disease","volume":"2","author":"Editorial","year":"1985","journal-title":"Lancet"},{"key":"10.1016\/j.jbspin.2010.01.013_bib45","first-page":"403","article-title":"Does epigenetics play a role in the pathology of osteoarthritis?","volume":"88-B","author":"Yamada","year":"2006","journal-title":"J Bone Joint Surg"},{"key":"10.1016\/j.jbspin.2010.01.013_bib46","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.joca.2006.07.002","article-title":"DNA methylation in osteoarthritic chondrocytes: a new molecular target","volume":"15","author":"Roach","year":"2008","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.jbspin.2010.01.013_bib47","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/jor.20799","article-title":"Cellular and epigenetic features of a young healthy and a young osteoarthritic cartilage compared with aged control and OA cartilage. 1","volume":"27","author":"da Silva","year":"2009","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jbspin.2010.01.013_bib48","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1136\/ard.2007.069377","article-title":"Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention","volume":"66","author":"Iliopoulos","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jbspin.2010.01.013_bib49","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00296-008-0744-z","article-title":"Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation","volume":"29","author":"Cheung","year":"2009","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.jbspin.2010.01.013_bib50","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/ar2500","article-title":"Epigenetic modifications in rheumatoid arthritis","volume":"10","author":"Strietholt","year":"2008","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jbspin.2010.01.013_bib51","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1101\/gad.10.13.1580","article-title":"Bone morphogenetic proteins: multifunctional regulators of vertebrate development","volume":"10","author":"Hogan","year":"1996","journal-title":"Genes Dev"},{"key":"10.1016\/j.jbspin.2010.01.013_bib52","series-title":"Human osteology","author":"White","year":"2000"}],"container-title":["Joint Bone Spine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1297319X10001004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1297319X10001004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T04:53:30Z","timestamp":1544504010000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1297319X10001004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S1297319X10001004"],"URL":"https:\/\/doi.org\/10.1016\/j.jbspin.2010.01.013","relation":{},"ISSN":["1297-319X"],"issn-type":[{"value":"1297-319X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}