{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:46:32Z","timestamp":1790934392920,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Joint Bone Spine"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.jbspin.2010.03.011","type":"journal-article","created":{"date-parts":[[2010,5,11]],"date-time":"2010-05-11T08:02:22Z","timestamp":1273564942000},"page":"306-312","source":"Crossref","is-referenced-by-count":59,"title":["Sex hormone-binding globulin in osteoporosis"],"prefix":"10.1016","volume":"77","author":[{"given":"Emmanuel","family":"Hopp\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Bouvard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Royer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Audran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick","family":"Legrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbspin.2010.03.011_bib1","first-page":"212","article-title":"Testosterone binding globulin in human plasma","volume":"101","author":"Mercier","year":"1966","journal-title":"Int Cong Excerpta Med"},{"key":"10.1016\/j.jbspin.2010.03.011_bib2","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1210\/jcem-26-12-1399","article-title":"Electrophoretic evidence for the presence of an estrogen-binding \u03b2-globulin in human plasma","volume":"26","author":"Rosenbaum","year":"1966","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jbspin.2010.03.011_bib3","first-page":"457","article-title":"The serum transport of steroid hormones","volume":"38","author":"Siiteri","year":"1982","journal-title":"Recent Prog Horm Res"},{"key":"10.1016\/j.jbspin.2010.03.011_bib4","series-title":"Testicular development: structure and function.","first-page":"291","article-title":"Bidirectional release of a Sertoli cell product, androgen-binding protein, into the blood and seminiferous tubule","author":"Gunsalus","year":"1980"},{"key":"10.1016\/j.jbspin.2010.03.011_bib5","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1210\/en.137.2.686","article-title":"Sex steroid binding protein exerts a negative control on estradiol action in MCF-7 cells (human breast cancer) through cyclic adenosine 3\u2019,5\u2019-monophosphate and protein kinase A","volume":"137","author":"Fortunati","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.jbspin.2010.03.011_bib6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.mce.2004.11.005","article-title":"Sex hormone-binding globulin antagonizes the antiapoptotic effect of estradiol in breast cancer cells","volume":"230","author":"Catalano","year":"2005","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.jbspin.2010.03.011_bib7","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF03343547","article-title":"Sex hormone-binding globulin: not only a transport protein. What news is around the corner?","volume":"22","author":"Fortunati","year":"1999","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.jbspin.2010.03.011_bib8","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1210\/en.2008-1289","article-title":"Peroxisome-proliferator receptor gamma represses hepatic sex hormone-binding globulin expression","volume":"150","author":"Selva","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.jbspin.2010.03.011_bib9","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1210\/jcem-58-5-915","article-title":"Plasma sex hormone-binding globulin levels decrease during the second decade of life irrespective of pubertal status","volume":"58","author":"Cunningham","year":"1984","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jbspin.2010.03.011_bib10","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1210\/jcem-34-4-730","article-title":"Testosterone secretion and metabolism in male senescence","volume":"34","author":"Vermeulen","year":"1972","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jbspin.2010.03.011_bib11","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1210\/jc.76.2.283","article-title":"Interrelation between plasma sex hormone-binding globulin and plasma insulin in healthy adult women: the Telecom study","volume":"76","author":"Preziosi","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jbspin.2010.03.011_bib12","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1210\/edrv-11-1-80","article-title":"The functions of corticosteroid-binding globulin and sex hormone-binding globulin: recent advances","volume":"11","author":"Rosner","year":"1990","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jbspin.2010.03.011_bib13","first-page":"222","article-title":"Impact of combined and progestogen-only contraceptives on bone mineral density","volume":"769","author":"Sarfati","year":"2009","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.jbspin.2010.03.011_bib14","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/j.1365-2265.1986.tb03287.x","article-title":"Sex hormone binding globulin in women with anorexia nervosa","volume":"24","author":"Estour","year":"1986","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.jbspin.2010.03.011_bib15","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1530\/eje.0.1430657","article-title":"Anthropometric, computed tomography and fat cell data in an obese population: relationship with insulin, leptin, tumor necrosis factor-alpha, sex hormone-binding globulin and sex hormones","volume":"143","author":"Garaulet","year":"2000","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.jbspin.2010.03.011_bib16","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0960-0760(03)00268-1","article-title":"Comparative studies on the regulation of insulin-like growth factor-binding protein-1 (IGFBP-1) and sex hormone-binding globulin (SHBG) production by insulin and insulin-like growth factors in human hepatoma cells","volume":"86","author":"Kalme","year":"2003","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.jbspin.2010.03.011_bib17","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1046\/j.1365-2265.2001.01361.x","article-title":"Plasma leptin concentrations are associated with bone mineral density and the presence of vertebral fractures in postmenopausal women","volume":"55","author":"Yamauchi","year":"2001","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.jbspin.2010.03.011_bib18","first-page":"60","article-title":"Determinants of sex hormone-binding globulin concentrations in a cross-sectional study of healthy men randomly selected","volume":"11","author":"Gomez","year":"2007","journal-title":"J Nutr Health Ageing"},{"key":"10.1016\/j.jbspin.2010.03.011_bib19","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1359\/jbmr.2000.15.7.1405","article-title":"Hormonal and biochemical parameters and osteoporotic fractures in elderly men","volume":"15","author":"Center","year":"2000","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jbspin.2010.03.011_bib20","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s10549-008-0031-4","article-title":"Molecular mechanisms of the D327N SHBG protective role on breast cancer development after estrogen exposure","volume":"114","author":"Costantino","year":"2009","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.jbspin.2010.03.011_bib21","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1158\/1055-9965.EPI-06-0689","article-title":"Variant in sex hormone-binding globulin gene and the risk of prostate cancer","volume":"16","author":"Berndt","year":"2007","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.jbspin.2010.03.011_bib22","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1210\/jc.2002-020557","article-title":"The biological variation of testosterone and sex hormone-binding globulin (SHBG) in polycystic ovarian syndrome: implications for SHBG as a surrogate marker of insulin resistance","volume":"88","author":"Jayagopal","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jbspin.2010.03.011_bib23","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1210\/jc.77.1.56","article-title":"Decreased sex hormone-binding globulin predicts noninsulin-dependent diabetes mellitus in women but not in men","volume":"77","author":"Haffner","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jbspin.2010.03.011_bib24","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.metabol.2006.06.017","article-title":"Low sex hormone-binding globulin is associated with the metabolic syndrome in post-menopausal women","volume":"55","author":"Weinberg","year":"2006","journal-title":"Metabolism"},{"key":"10.1016\/j.jbspin.2010.03.011_bib25","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1161\/01.CIR.0000157697.54255.CE","article-title":"Sex hormone-binding globulin and the free androgen index are related to cardiovascular risk factors in multiethnic premenopausal and perimenopausal women enrolled in the Study of Women Across the Nation (SWAN)","volume":"111","author":"Sutton-Tyrell","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jbspin.2010.03.011_bib26","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1161\/01.CIR.0000091114.36254.F3","article-title":"Sex hormone levels and risk of cardiovascular events in postmenopausal women","volume":"108","author":"Rexrode","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jbspin.2010.03.011_bib27","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jbspin.2005.02.005","article-title":"Aromatase and regulation of bone remodeling","volume":"73","author":"Ribot","year":"2006","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.jbspin.2010.03.011_bib28","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1210\/jc.83.7.2239","article-title":"Associations between low levels of serum estradiol, bone density, and fractures among elderly women: the study of osteoporotic fractures","volume":"83","author":"Ettinger","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jbspin.2010.03.011_bib29","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S8756-3282(01)00584-1","article-title":"Association between endogenous hormones and sex hormone-binding globulin and bone turnover in older women; study of osteoporotic fractures","volume":"29","author":"Chapurlat","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.jbspin.2010.03.011_bib30","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1056\/NEJM199809103391104","article-title":"Endogenous hormones and the risk of hip and vertebral fractures among older women. Study of Osteoporotic Fractures Research Group","volume":"339","author":"Cummings","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jbspin.2010.03.011_bib31","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jbspin.2004.04.004","article-title":"Androgens and bone metabolism","volume":"72","author":"Alexandre","year":"2005","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.jbspin.2010.03.011_bib32","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1210\/jc.87.4.1443","article-title":"Clinical review 144: estrogen and the male skeleton","volume":"87","author":"Khosla","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jbspin.2010.03.011_bib33","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00223-007-9035-z","article-title":"Circulating sex steroids, sex hormone-binding globulin, and longitudinal changes in forearm bone mineral density in postmenopausal women and men: the Troms\u00f8 study","volume":"81","author":"Bj\u00f8rnerem","year":"2007","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jbspin.2010.03.011_bib34","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1002\/jbmr.5650100806","article-title":"Vitamin D status and sex hormone binding globulin: determinants of bone turnover and bone mineral density in elderly women","volume":"10","author":"Ooms","year":"1995","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jbspin.2010.03.011_bib35","doi-asserted-by":"crossref","first-page":"4954","DOI":"10.1210\/jc.2004-0434","article-title":"Endogenous levels of serum estradiol and sex hormone binding globulin determine bone mineral density, bone remodeling, the rate of bone loss, and response to treatment with estrogen in elderly women","volume":"89","author":"Rapuri","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jbspin.2010.03.011_bib36","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1172\/JCI119701","article-title":"Sex steroids and bone mass in older men. Positive associations with serum estrogens and negative associations with androgens","volume":"100","author":"Slemenda","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jbspin.2010.03.011_bib37","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.1210\/jc.84.10.3626","article-title":"Hormonal and biochemical parameters in the determination of osteoporosis in elderly men","volume":"84","author":"Center","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jbspin.2010.03.011_bib38","doi-asserted-by":"crossref","first-page":"5327","DOI":"10.1210\/jc.2003-030736","article-title":"Longitudinal association between sex hormone levels, bone loss, and bone turnover in elderly men","volume":"88","author":"Gennari","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jbspin.2010.03.011_bib39","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1359\/jbmr.1998.13.7.1167","article-title":"Hormonal predictors of bone loss in elderly women: a prospective study. The Study of Osteoporotic Fractures Research Group","volume":"13","author":"Stone","year":"1998","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jbspin.2010.03.011_bib40","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1172\/JCI118382","article-title":"Sex steroids, bone mass, and bone loss. A prospective study of pre-, peri-, and postmenopausal women","volume":"97","author":"Slemenda","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jbspin.2010.03.011_bib41","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1359\/JBMR.050404","article-title":"Free testosterone is a positive, whereas free estradiol is a negative, predictor of cortical bone size in young Swedish men: the GOOD study","volume":"20","author":"Lorentzon","year":"2005","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jbspin.2010.03.011_bib42","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1210\/jc.2006-0893","article-title":"Sex hormone status may modulate rate of expansion of proximal femur diameter in older women alongside other skeletal regulators","volume":"92","author":"Kaptoge","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jbspin.2010.03.011_bib43","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1359\/jbmr.2000.15.9.1835","article-title":"Serum estradiol and sex hormone-binding globulin and the risk of hip fracture in elderly women: the EPIDOS study","volume":"15","author":"Chapurlat","year":"2000","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jbspin.2010.03.011_bib44","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1359\/jbmr.2000.15.8.1526","article-title":"Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: the OFELY study","volume":"15","author":"Garnero","year":"2000","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jbspin.2010.03.011_bib45","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S8756-3282(01)00478-1","article-title":"Osteoporosis in men: a potential role for the sex hormone binding globulin","volume":"29","author":"Legrand","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.jbspin.2010.03.011_bib46","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.bone.2004.01.024","article-title":"Sex hormone-binding globulin, estradiol, and bone turnover markers in male osteoporosis","volume":"34","author":"Lormeau","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.jbspin.2010.03.011_bib47","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.1210\/jc.2003-032187","article-title":"Serum estradiol, testosterone, and sex hormone-binding globulin as regulators of peak bone mass and bone turnover rate in young Finnish men","volume":"89","author":"V\u00e4lim\u00e4ki","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jbspin.2010.03.011_bib48","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1365-2265.1989.tb01274.x","article-title":"Sex hormone binding globulin in postmenopausal women: a predictor of osteoporosis superior to endogenous oestrogens","volume":"31","author":"Van Hemert","year":"1989","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.jbspin.2010.03.011_bib49","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1210\/jc.85.1.219","article-title":"Low levels of estradiol are associated with vertebral fractures in older men, but not women: the Rancho Bernardo Study","volume":"85","author":"Barrett-Connor","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jbspin.2010.03.011_bib50","first-page":"s447","article-title":"Serum sex hormone-binding globulin level to predict osteoporosis severity","volume":"23","author":"Hopp\u00e9","year":"2008","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jbspin.2010.03.011_bib51","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/PL00004174","article-title":"Predictors of fractures in elderly women","volume":"11","author":"Tromp","year":"2000","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jbspin.2010.03.011_bib52","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1210\/jc.2002-022041","article-title":"Endogenous sex hormones, sex hormone-binding globulin, and the risk of incident vertebral fractures in elderly men and women: the Rotterdam Study","volume":"89","author":"Goderie-Plomp","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jbspin.2010.03.011_bib53","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1210\/jc.2007-2358","article-title":"Associations of serum sex hormone-binding globulin and sex hormone concentrations with hip fracture risk in postmenopausal women","volume":"93","author":"Lee","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jbspin.2010.03.011_bib54","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1530\/EJE-07-0032","article-title":"A prospective study of sex steroids, sex hormone-binding globulin, and non-vertebral fractures in women and men: the Tromso Study","volume":"157","author":"Bj\u00f8rnerem","year":"2007","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.jbspin.2010.03.011_bib55","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00198-004-1674-6","article-title":"Prediction of incident osteoporotic fractures in elderly women using the free estradiol index","volume":"16","author":"Devine","year":"2005","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jbspin.2010.03.011_bib56","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1359\/jbmr.080518","article-title":"Older men with low serum estradiol and high serum SHBG have an increased risk of fractures","volume":"23","author":"Mellstr\u00f6m","year":"2008","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jbspin.2010.03.011_bib57","first-page":"s79","article-title":"Post-fracture mortality in men: contributions of sex hormones and bone mineral density as risk factors","volume":"23","author":"Nguyen","year":"2008","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jbspin.2010.03.011_bib58","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1001\/archinternmed.2007.2","article-title":"Endogenous sex hormones and incident fracture risk in older men: the Dubbo Osteoporosis Epidemiology Study","volume":"14","author":"Meier","year":"2008","journal-title":"Arch Intern Med"}],"container-title":["Joint Bone Spine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1297319X10000692?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1297319X10000692?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T02:22:52Z","timestamp":1544494972000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1297319X10000692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S1297319X10000692"],"URL":"https:\/\/doi.org\/10.1016\/j.jbspin.2010.03.011","relation":{},"ISSN":["1297-319X"],"issn-type":[{"value":"1297-319X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}