{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:03:32Z","timestamp":1760130212875,"version":"3.40.3"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Joint Bone Spine"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.jbspin.2012.03.003","type":"journal-article","created":{"date-parts":[[2012,5,9]],"date-time":"2012-05-09T03:07:27Z","timestamp":1336532847000},"page":"188-194","source":"Crossref","is-referenced-by-count":11,"title":["Loss of sympathetic nerve fibers in vital intertrochanteric bone cylinders lateral to osteonecrosis of the femoral head"],"prefix":"10.1016","volume":"80","author":[{"given":"Johannes","family":"Beckmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Kn\u00f6dl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Bauser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Tingart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Grifka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer H.","family":"Straub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbspin.2012.03.003_bib0005","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2106\/00004623-199503000-00018","article-title":"Non-traumatic avascular necrosis of the femoral head","volume":"77","author":"Mont","year":"1995","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0010","doi-asserted-by":"crossref","first-page":"S314","DOI":"10.1097\/00003086-199810001-00032","article-title":"Osteonecrosis of the femoral head. Potential treatment with growth and differentiation factors","author":"Mont","year":"1998","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0015","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/BLO.0b013e3181591c92","article-title":"Osteonecrosis of the hip: novel approaches to evaluation and treatment","volume":"465","author":"Petrigliano","year":"2007","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0020","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/s00508-005-0326-y","article-title":"MRI-controlled analysis of 104 patients with painful bone marrow edema in different joint localizations treated with the prostacyclin analogue iloprost","volume":"117","author":"Meizer","year":"2005","journal-title":"Wien Klin Wochenschr"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0025","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ejrad.2007.03.019","article-title":"Osteonecrosis of the femoral head: etiology, imaging and treatment","volume":"63","author":"Malizos","year":"2007","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0030","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.2106\/JBJS.E.01041","article-title":"Nontraumatic osteonecrosis of the femoral head: ten years later","volume":"88","author":"Mont","year":"2006","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0035","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/jemt.10121","article-title":"Adrenergic regulation of bone metabolism: possible involvement of sympathetic innervation of osteoblastic and osteoclastic cells","volume":"58","author":"Togari","year":"2002","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0040","first-page":"154","article-title":"Osteotropic effects by the neuropeptides calcitonin gene-related peptide, substance P and vasoactive intestinal peptide","volume":"8","author":"Lerner","year":"2008","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0045","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0092-8674(02)01049-8","article-title":"Leptin regulates bone formation via the sympathetic nervous system","volume":"111","author":"Takeda","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0050","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1152\/ajplegacy.1959.197.6.1255","article-title":"Innervation of the vessels of the marrow cavity of certain bones","volume":"197","author":"Weiss","year":"1959","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0055","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/jor.1100150120","article-title":"Calcitonin gene-related peptide, substance P, and tyrosine hydroxylase-immunoreactive innervation of rat bone marrows: an immunohistochemical and ultrastructural investigation on possible efferent and afferent mechanisms","volume":"15","author":"Imai","year":"1997","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0060","first-page":"1252","article-title":"Innervation of bone from healthy and arthritic rats by substance P and calcitonin gene related peptide containing sensory fibers","volume":"19","author":"Hukkanen","year":"1992","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0065","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1080\/00016470052943946","article-title":"Time-dependent sensory nerve ingrowth into a bone conduction chamber","volume":"71","author":"Madsen","year":"2000","journal-title":"Acta Orthop Scand"},{"year":"2009","series-title":"Sobotta \u2013 Atlas of Anatomy","key":"10.1016\/j.jbspin.2012.03.003_bib0070"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0075","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/BF00500282","article-title":"as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation","volume":"310","author":"Lembeck","year":"1979","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0080","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/1523-1747.ep12497872","article-title":"Autonomic neuroeffector junctions \u2013 reflex vasodilatation of the skin","volume":"69","author":"Burnstock","year":"1977","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0085","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1097\/00005344-198710012-00011","article-title":"Clinical pharmacology of vasodilator peptides","volume":"10","author":"Brown","year":"1987","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0090","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1096\/fj.99-1082com","article-title":"The loss of sympathetic nerve fibers in the synovial tissue of patients with rheumatoid arthritis is accompanied by increased norepinephrine release from synovial macrophages","volume":"14","author":"Miller","year":"2000","journal-title":"FASEB J"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0095","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/rheumatology\/kem301","article-title":"Lower density of synovial nerve fibres positive for calcitonin gene-related peptide relative to substance P in rheumatoid arthritis but not in osteoarthritis","volume":"47","author":"Dirmeier","year":"2008","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0100","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/jor.20807","article-title":"Marked loss of sympathetic nerve fibers in chronic Charcot foot of diabetic origin compared to ankle joint osteoarthritis","volume":"27","author":"Koeck","year":"2009","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0105","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1002\/art.1780370701","article-title":"Peripheral and spinal neural mechanisms in arthritis, with particular reference to treatment of inflammation and pain","volume":"37","author":"Konttinen","year":"1994","journal-title":"Arthritis Rheum"},{"year":"1996","series-title":"Neurogenic inflammation.","key":"10.1016\/j.jbspin.2012.03.003_bib0110"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0115","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0031-6997(25)00011-0","article-title":"Alpha 1-adrenergic receptor subtypes, inositol phosphates, and sources of cell Ca2+","volume":"40","author":"Minneman","year":"1988","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0120","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1139\/y95-072","article-title":"Intracellular mechanisms involved in the regulation of vascular smooth muscle tone","volume":"73","author":"Walsh","year":"1995","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0125","doi-asserted-by":"crossref","first-page":"S318","DOI":"10.1067\/mai.2002.129701","article-title":"Variability in beta-adrenergic receptor response in the vasculature: Role of receptor polymorphism","volume":"110","author":"Wood","year":"2002","journal-title":"J Allergy Clin Immunol"},{"year":"2006","series-title":"Goodman & Gilman's the pharmacological basis of therapeutics","key":"10.1016\/j.jbspin.2012.03.003_bib0130"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0135","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1136\/gut.2007.125401","article-title":"Anti-inflammatory role of sympathetic nerves in chronic intestinal inflammation","volume":"57","author":"Straub","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0140","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.rdc.2004.09.003","article-title":"Sympathetic neurotransmitters in joint inflammation","volume":"31","author":"Straub","year":"2005","journal-title":"Rheum Dis Clin North Am"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0145","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1136\/ard.2005.044016","article-title":"Dupuytren's contracture is associated with sprouting of substance P positive nerve fibres and infiltration by mast cells","volume":"65","author":"Schubert","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0150","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1136\/ard.2004.029876","article-title":"Achilles tendinosis is associated with sprouting of substance P positive nerve fibres","volume":"64","author":"Schubert","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0155","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/jor.20498","article-title":"Preponderance of sensory versus sympathetic nerve fibers and increased cellularity in the infrapatellar fat pad in anterior knee pain patients after primary arthroplasty","volume":"26","author":"Lehner","year":"2008","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0160","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1002\/art.20110","article-title":"Increased prevalence of semaphorin 3C, a repellent of sympathetic nerve fibers, in the synovial tissue of patients with rheumatoid arthritis","volume":"50","author":"Miller","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0165","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/ard.2003.016154","article-title":"Low density of sympathetic nerve fibres and increased density of brain derived neurotrophic factor positive cells in RA synovium","volume":"64","author":"Weidler","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0170","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1161\/01.RES.60.3.309","article-title":"Nonadrenergic neural vasodilator mechanisms","volume":"60","author":"Bevan","year":"1987","journal-title":"Circ Res"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0175","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1752-8062.2009.00133.x","article-title":"Synovial inflammation in patients with osteonecrosis of the femoral head","volume":"2","author":"Rabquer","year":"2009","journal-title":"Clin Transl Sci"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0180","first-page":"385","article-title":"Relationship between magnetic resonance imaging and histologic findings by bone biopsy in nontraumatic osteonecrosis of the femoral head","volume":"19","author":"Hauzeur","year":"1992","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0185","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1006\/brbi.2001.0639","article-title":"Norepinephrine, the beta-adrenergic receptor, and immunity","volume":"16","author":"Sanders","year":"2002","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0190","doi-asserted-by":"crossref","first-page":"162","DOI":"10.2106\/JBJS.F.00452","article-title":"Femoral artery constriction by norepinephrine is enhanced by methylprednisolone in a rat model","volume":"88","author":"Drescher","year":"2006","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0195","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.aanat.2009.09.006","article-title":"Enhanced constriction of supplying arteries--a mechanism of femoral head necrosis in Wistar rats?","volume":"192","author":"Drescher","year":"2010","journal-title":"Ann Anat"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0200","first-page":"22","article-title":"Role of impairment of blood supply of the femoral head in the pathogenesis of idiopathic osteonecrosis","author":"Atsumi","year":"1992","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0205","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1186\/ar121","article-title":"Monoarticular antigen-induced arthritis leads to pronounced bilateral upregulation of the expression of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion neurons of rats","volume":"2","author":"Segond von Banchet","year":"2000","journal-title":"Arthritis Res"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0210","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.pain.2009.06.002","article-title":"Experimental arthritis causes tumor necrosis factor-alpha-dependent infiltration of macrophages into rat dorsal root ganglia which correlates with pain-related behavior","volume":"145","author":"Segond von Banchet","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0215","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.brainres.2009.09.012","article-title":"Sympathetic innervation of the spleen in male Brown Norway rats: a longitudinal aging study","volume":"1302","author":"Perez","year":"2009","journal-title":"Brain Res"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0220","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/aja.1001620204","article-title":"Nerve endings in human sympathetic ganglia","volume":"162","author":"Helen","year":"1981","journal-title":"Am J Anat"},{"key":"10.1016\/j.jbspin.2012.03.003_bib0225","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1136\/ard.2009.119701","article-title":"Catecholamine-producing cells in the synovial tissue during arthritis: modulation of sympathetic neurotransmitters as new therapeutic target","volume":"69","author":"Capellino","year":"2010","journal-title":"Ann Rheum Dis"}],"container-title":["Joint Bone Spine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1297319X12000589?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1297319X12000589?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T16:31:16Z","timestamp":1743093076000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1297319X12000589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S1297319X12000589"],"URL":"https:\/\/doi.org\/10.1016\/j.jbspin.2012.03.003","relation":{},"ISSN":["1297-319X"],"issn-type":[{"type":"print","value":"1297-319X"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}