{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:01:30Z","timestamp":1780567290649,"version":"3.54.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Joint Bone Spine"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.jbspin.2012.03.008","type":"journal-article","created":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T23:04:12Z","timestamp":1336518252000},"page":"38-43","source":"Crossref","is-referenced-by-count":45,"title":["Anti-cyclic citrullinated peptide (anti-CCP) antibody in juvenile idiopathic arthritis (JIA): Correlations with disease activity and severity of joint damage (a multicenter trial)"],"prefix":"10.1016","volume":"80","author":[{"given":"Aziza","family":"Omar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihab","family":"Abo-Elyoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan","family":"Hussein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Nabih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda","family":"Atwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzan","family":"Gad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser","family":"Emad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbspin.2012.03.008_bib0005","first-page":"569417","article-title":"Secondary osteoporosis in patients with juvenile idiopathic arthritis","volume":"20","author":"Brabnikova Maresova","year":"2011","journal-title":"J Osteoporos"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0010","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1001\/jama.294.13.1722","article-title":"JAMA patient page. Juvenile idiopathic arthritis","volume":"294","author":"Ringold","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0015","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s11926-008-0027-4","article-title":"Rheumatoid factors and anticyclic citrullinated peptide antibodies in pediatric rheumatology","volume":"10","author":"Syed","year":"2008","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0020","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S0140-6736(00)80045-8","article-title":"Juvenile chronic arthritis","volume":"351","author":"Woo","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0025","first-page":"1975","article-title":"Pediatric rheumatology in the United Kingdom: data from the British Pediatric Rheumatology Group National Diagnostic Register","volume":"23","author":"Symmons","year":"1996","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0030","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1191\/096120398678920659","article-title":"Anticardiolipin antibodies in childhood rheumatic disorders","volume":"7","author":"Gedalia","year":"1998","journal-title":"Lupus"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0035","first-page":"375","article-title":"Clinical significance of anticardiolipin antibodies in juvenile idiopathic arthritis","volume":"17","author":"Serra","year":"1999","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0040","first-page":"101","article-title":"Estimation of anticardiolipin antibodies, anti-b2 glycoprotein I antibodies and lupus anticoagulant in a prospective longitudinal study of children with juvenile idiopathic arthritis","volume":"20","author":"Avcin","year":"2002","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0045","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1136\/ard.51.3.350","article-title":"Antiperinuclear factor in juvenile rheumatoid arthritis","volume":"51","author":"Nesher","year":"1992","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0050","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1136\/ard.52.11.785","article-title":"Occurrence of antiperinuclear, antikeratin, and anti-RA33 antibodies in juvenile chronic arthritis","volume":"52","author":"Gabay","year":"1993","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0055","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1399-3038.1995.tb00277.x","article-title":"Antiperinuclear factor in the diagnosis of juvenile rheumatoid arthritis","volume":"6","author":"el-Gamal","year":"1995","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0060","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0022-3476(99)70212-X","article-title":"Antiperinuclear factor and antibodies to the stratum corneum of rat esophagus in juvenile idiopathic arthritis","volume":"134","author":"Serra","year":"1999","journal-title":"J Pediatr"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0065","first-page":"470","article-title":"Anti-keratin antibodies in patients with juvenile idiopathic arthritis","volume":"19","author":"Hromadn\u00edkov\u00e1","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0070","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1136\/ard.61.7.608","article-title":"Prevalence and clinical significance of anti-cyclic citrullinated peptide antibodies in juvenile idiopathic arthritis","volume":"61","author":"Avcin","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0075","doi-asserted-by":"crossref","unstructured":"Gheita TA, Bassyouni IH, Emad Y, et al. Elevated BAFF (BLyS) and APRIL in juvenile idiopathic arthritis patients: relation to clinical manifestations and disease activity. Joint Bone Spine 2011; doi:10.1016\/j.jbspin.2011.05.019.","DOI":"10.1016\/j.jbspin.2011.05.019"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0080","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty","year":"2004","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0085","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/art.24516","article-title":"Paediatric Rheumatology International Trials Organisation. Development and validation of a composite disease activity score for juvenile idiopathic arthritis","volume":"61","author":"Consolaro","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0090","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/art.1780140605","article-title":"Methods of scoring the progression of radiologic changes in rheumatoid arthritis. Correlation of radiologic, clinical and laboratory abnormalities","volume":"14","author":"Sharp","year":"1971","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0095","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.jbspin.2010.09.002","article-title":"Current treatments for juvenile idiopathic arthritis","volume":"77","author":"Quartier","year":"2010","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0100","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jbspin.2011.02.001","article-title":"Prevalence of overweight among Moroccan children and adolescents with juvenile idiopathic arthritis","volume":"78","author":"Amine","year":"2011","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0105","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1136\/ard.23.4.302","article-title":"A new serum factor in patients with rheumatoid arthritis; the antiperinuclear factor","volume":"23","author":"Nienhuis","year":"1964","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0110","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1136\/bmj.2.6182.97","article-title":"Anti-keratin antibodies in rheumatoid arthritis","volume":"2","author":"Young","year":"1979","journal-title":"Br Med J"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0115","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1172\/JCI116713","article-title":"The cytokeratin filament-aggregating protein filaggrin is the target of the so-called antikeratin antibodies, autoantibodies specific for rheumatoid arthritis","volume":"92","author":"Simon","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0120","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1172\/JCI117969","article-title":"The antiperinuclear factor and the so-called antikeratin antibodies are the same rheumatoid arthritis-specific autoantibodies","volume":"95","author":"Sebbag","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0125","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/1529-0131(200001)43:1<155::AID-ANR20>3.0.CO;2-3","article-title":"The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide","volume":"43","author":"Schellekens","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0130","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1136\/ard.2004.035089","article-title":"A comparison of the diagnostic accuracy and prognostic value of the first and second anti-cyclic citrullinated peptides (CCP1 and CCP2) autoantibody tests for rheumatoid arthritis","volume":"64","author":"van Gaalen","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0135","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/art.27584","article-title":"2010 rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"62","author":"Aletaha","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0140","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s12098-010-0006-4","article-title":"Anti-cyclic citrullinated peptide antibodies in juvenile idiopathic arthritis","volume":"77","author":"Gupta","year":"2010","journal-title":"Indian J Pediatr"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0145","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1080\/08820130802438057","article-title":"Anti-cyclic citrullinated peptide antibodies in patients with juvenile idiopathic arthritis","volume":"37","author":"Habib","year":"2008","journal-title":"Immunol Invest"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0150","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1080\/03009740510026634","article-title":"Anti-cyclic citrullinated peptide: diagnostic and prognostic values in juvenile idiopathic arthritis and rheumatoid arthritis in a Chinese population","volume":"34","author":"Kwok","year":"2005","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0155","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1136\/ard.2003.019331","article-title":"Diagnostic accuracy of anti-cyclic citrullinated peptide antibodies in juvenile idiopathic arthritis","volume":"63","author":"Kasap\u00e7opur","year":"2004","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0160","first-page":"825","article-title":"Anti-cyclic citrullinated peptide (anti-CCP) antibodies in children with juvenile idiopathic arthritis","volume":"30","author":"van Rossum","year":"2003","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0165","first-page":"449","article-title":"The diagnostic value of anti-cyclic citrullinated peptide (CCP) antibodies in children with Juvenile Idiopathic Arthritis","volume":"24","author":"Brunner","year":"2006","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jbspin.2012.03.008_bib0170","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/RHU.0b013e31823a4d0a","article-title":"Anti-cyclic citrullinated Peptide antibodies in adult patients with juvenile idiopathic arthritis","volume":"17","author":"Skare","year":"2011","journal-title":"J Clin Rheumatol"}],"container-title":["Joint Bone Spine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1297319X12000632?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1297319X12000632?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T10:25:04Z","timestamp":1542968704000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1297319X12000632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S1297319X12000632"],"URL":"https:\/\/doi.org\/10.1016\/j.jbspin.2012.03.008","relation":{},"ISSN":["1297-319X"],"issn-type":[{"value":"1297-319X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}