{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T16:06:26Z","timestamp":1779379586645,"version":"3.53.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Joint Bone Spine"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.jbspin.2012.10.022","type":"journal-article","created":{"date-parts":[[2012,12,12]],"date-time":"2012-12-12T02:16:13Z","timestamp":1355278573000},"page":"380-385","source":"Crossref","is-referenced-by-count":26,"title":["The usefulness of computer-aided joint space analysis in the assessment of rheumatoid arthritis"],"prefix":"10.1016","volume":"80","author":[{"given":"Alexander","family":"Pfeil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane M.","family":"Renz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Hansch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Kainberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansgar","family":"Malich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunter","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"B\u00f6ttcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbspin.2012.10.022_bib0005","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1136\/ard.2010.138461","article-title":"2010 rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"69","author":"Aletaha","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0010","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1136\/ard.2007.076463","article-title":"Optimal use of methotrexate: the advantages of tight control","volume":"66","author":"Bijlsma","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0015","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1136\/ard.2008.092668","article-title":"Optimal dosage and route of administration of methotrexate in rheumatoid arthritis: a systematic review of the literature","volume":"68","author":"Visser","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0020","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1136\/ard.2008.092932","article-title":"IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial","volume":"67","author":"Emery","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0025","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1136\/ard.2009.119222","article-title":"Continued inhibition of structural damage over 2 years in patients with rheumatoid arthritis treated with rituximab in combination with methotrexate","volume":"69","author":"Cohen","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0030","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/acr.20423","article-title":"The value of digital X-ray radiogrammetry in the assessment of inflammatory bone loss in rheumatoid arthritis","volume":"63","author":"Pfeil","year":"2011","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0035","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/art.20775","article-title":"Presentation and analysis of data on radiographic outcome in clinical trials","volume":"52","author":"van der Heijde","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0040","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/art.1780380704","article-title":"Joint space measurement in hand radiographs using computerized image analysis","volume":"38","author":"James","year":"1995","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0045","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1002\/1529-0131(200006)43:6<1378::AID-ANR23>3.0.CO;2-H","article-title":"Computed-based methods for measuring joint space and estimating erosion volume in the finger and wrist joints of patients with rheumatoid arthritis","volume":"43","author":"Sharp","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0050","first-page":"937","article-title":"Quantitative microfocal radiography detects changes in OA knee joint space width in patients in placebo-controlled trial of NSAID therapy","volume":"22","author":"Buckland-Wright","year":"1995","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0055","first-page":"265","article-title":"Quantitative measurement of erosion growth and joint space loss in rheumatoid arthritis hand radiographs","volume":"23","author":"Higss","year":"1996","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0060","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3109\/03009748909095032","article-title":"Computerized assessment of radiological changes of the hand in rheumatic diseases","volume":"18","author":"Allander","year":"1989","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0065","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1118\/1.598983","article-title":"Neutral network based algorithm to quantify joint space width in joints of the hand for arthritis assessment","volume":"27","author":"Duryea","year":"2000","journal-title":"Med Phys"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0070","first-page":"6144","article-title":"Detection of joint space narrowing in hand radiographs","author":"Kauffman","year":"2006","journal-title":"Med Imaging Image Process"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0075","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/01.rli.0000191594.76235.a0","article-title":"Computerized quantification of joint space narrowing and periarticular demineralization in patients with rheumatoid arthritis based on digital X-ray radiogrammetry","volume":"41","author":"B\u00f6ttcher","year":"2006","journal-title":"Invest Radiol"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0080","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s10278-006-0263-y","article-title":"Computerized digital imaging techniques provided by digital radiogrammetry as new diagnostic tool in rheumatoid arthritis","volume":"19","author":"B\u00f6ttcher","year":"2006","journal-title":"J Digit Imaging"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0085","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1148\/radiol.2452061281","article-title":"An automatic model-based system for joint space measurements on hand radiographs: initial experience","volume":"245","author":"Peloschek","year":"2007","journal-title":"Radiology"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0090","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s00256-007-0304-8","article-title":"Computer-aided joint space analysis of the metacarpal-phalangeal and proximal-interphalangeal finger joint\u00a0\u2013\u00a0normative age-related and gender specific data","volume":"36","author":"Pfeil","year":"2007","journal-title":"Skeletal Radiol"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0095","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s10278-007-9031-x","article-title":"Normative reference values of joint space width estimated by Computer-aided joint space analysis (CAJSA): the distal-interphalangeal joint","volume":"21","author":"Pfeil","year":"2008","journal-title":"J Digit Imaging"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0100","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1136\/ard.16.4.494","article-title":"Radiological assessment of osteoarthrosis","volume":"16","author":"Kellgren","year":"1957","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0105","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"Arnett","year":"1988","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0110","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1002\/art.1780281203","article-title":"How many joints in the hands and wrist should be included in a score of radiologic abnormalities used to assess rheumatoid arthritis?","volume":"28","author":"Sharp","year":"1985","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0115","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.acra.2007.01.032","article-title":"Computer-aided joint space analysis (CAJSA) of the proximal-interphalangeal joint\u00a0\u2013\u00a0normative age-related and gender specific data","volume":"14","author":"Pfeil","year":"2007","journal-title":"Acad Radiol"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0120","doi-asserted-by":"crossref","first-page":"717","DOI":"10.3899\/jrheum.080651","article-title":"Implementation of Z-scores as an age- and gender-independent parameter for estimating joint space widths in rheumatoid arthritis","volume":"36","author":"Pfeil","year":"2009","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0125","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.1002\/art.21606","article-title":"Digital X-ray radiogrammetry combined with semi-automated analysis of joint space distances as a new diagnostic approach in rheumatoid arthritis\u00a0\u2013\u00a0a cross-sectional and longitudinal study","volume":"52","author":"B\u00f6ttcher","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0130","first-page":"31","article-title":"Radiographic hand joint space width assessed by computer is a sensitive measure of change in early rheumatoid arthritis","volume":"31","author":"Angwin","year":"2004","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0135","first-page":"655","article-title":"Irreversible physical disability in rheumatoid arthritis is determined by cartilage damage rather than bone destruction","volume":"69","author":"Smolen","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0140","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1093\/rheumatology\/38.10.941","article-title":"Reliability and sensitivity to change of a simplification of the Sharp\/van der Heijde radiological assessment in rheumatoid arthritis","volume":"38","author":"Van der Heijde","year":"1999","journal-title":"Rheumatology"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0145","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1136\/ard.2007.072785","article-title":"Reliability and sensitivity to change of the simple erosion narrowing score compared with the Sharp\/van der Heijde method for scoring radiographs in rheumatoid arthritis","volume":"67","author":"Dias","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0150","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1002\/art.21802","article-title":"Performance of an automated computer-based scoring method to assess joint space narrowing in rheumatoid arthritis. A longitudinal study","volume":"54","author":"Finckh","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0155","first-page":"1062","article-title":"Variability of precision in scoring radiographic abnormalities in rheumatoid arthritis by experienced readers","volume":"31","author":"Sharp","year":"2004","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0160","first-page":"874","article-title":"Computer-based methods for measurement of joint space width: Update of an ongoing OMERACT Project","volume":"34","author":"Sharp","year":"2007","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0165","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.jbspin.2011.07.011","article-title":"Reproducibility and influence of hand rotation on computer-aided joint space analysis","volume":"79","author":"Pfeil","year":"2012","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0170","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00296-008-0682-9","article-title":"Effects of leflunomide and methotrexate in rheumatoid arthritis detected by digital X-ray radiogrammetry and computer-aided joint space analysis","volume":"29","author":"Pfeil","year":"2009","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.jbspin.2012.10.022_bib0175","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ejrad.2009.05.053","article-title":"Computational radiology in skeletal radiography","volume":"72","author":"Peloschek","year":"2009","journal-title":"Eur J Radiol"}],"container-title":["Joint Bone Spine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1297319X12002941?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1297319X12002941?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T08:05:37Z","timestamp":1540022737000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1297319X12002941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S1297319X12002941"],"URL":"https:\/\/doi.org\/10.1016\/j.jbspin.2012.10.022","relation":{},"ISSN":["1297-319X"],"issn-type":[{"value":"1297-319X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]}}}