{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:17:51Z","timestamp":1770970671569,"version":"3.50.1"},"reference-count":65,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"EU's 7th framework program"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Joint Bone Spine"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.jbspin.2016.06.010","type":"journal-article","created":{"date-parts":[[2016,9,19]],"date-time":"2016-09-19T18:35:24Z","timestamp":1474310124000},"page":"401-410","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Alarmins firing arthritis: Helpful diagnostic tools and promising therapeutic targets"],"prefix":"10.1016","volume":"84","author":[{"given":"Miha","family":"Lavric","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Auxiliadora","family":"Miranda-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Holzinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Foell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Wittkowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbspin.2016.06.010_bib0330","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/ncprheum0531","article-title":"Mechanisms of disease: a \u2018DAMP\u2019 view of inflammatory arthritis","volume":"3","author":"Foell","year":"2007","journal-title":"Nat Clin Pract Rheumatol"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0335","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bbagrm.2009.11.003","article-title":"The role of HMGB1 in the pathogenesis of rheumatic disease","volume":"1799","author":"Andersson","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0340","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.clim.2012.11.008","article-title":"Phagocyte-derived S100 proteins in autoinflammation: putative role in pathogenesis and usefulness as biomarkers","volume":"147","author":"Kessel","year":"2013","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0345","first-page":"47","article-title":"Heat shock protein 10 (Hsp10) in immune-related diseases: one coin, two sides","volume":"2","author":"Jia","year":"2011","journal-title":"Int J Biochem Mol Biol"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0350","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nri749","article-title":"Roles of heat-shock proteins in innate and adaptive immunity","volume":"2","author":"Srivastava","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0355","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s12192-010-0168-z","article-title":"Hsp40 proteins modulate humoral and cellular immune response in rheumatoid arthritis patients","volume":"15","author":"Tukaj","year":"2010","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0360","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/ar2674","article-title":"Heat shock protein 60 reactive T cells in juvenile idiopathic arthritis: what is new?","volume":"11","author":"Vercoulen","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0365","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/ni.3370","article-title":"Interleukin 33 is a guardian of barriers and a local alarmin","volume":"17","author":"Martin","year":"2016","journal-title":"Nat Immunol"},{"issue":"Suppl 2","key":"10.1016\/j.jbspin.2016.06.010_bib0370","doi-asserted-by":"crossref","first-page":"i101","DOI":"10.1136\/annrheumdis-2011-200589","article-title":"IL-33: a Janus cytokine","volume":"71","author":"Liew","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0375","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/ar2952","article-title":"Mechanisms of inflammation in gout","volume":"12","author":"Busso","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0380","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jbspin.2014.02.009","article-title":"The concept of the inflammasome and its rheumatologic implications","volume":"81","author":"So","year":"2014","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0385","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00296-011-2269-0","article-title":"Fibronectin molecular status determination useful to differentiate between rheumatoid arthritis and systemic lupus erythematosus patients","volume":"33","author":"Przybysz","year":"2013","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0390","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/nrrheum.2015.105","article-title":"Redox distress and genetic defects conspire in systemic autoinflammatory diseases","volume":"11","author":"Varga","year":"2015","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0395","doi-asserted-by":"crossref","first-page":"4324","DOI":"10.4049\/jimmunol.1202045","article-title":"Signaling through purinergic receptors for ATP induces human cutaneous innate and adaptive Th17 responses: implications in the pathogenesis of psoriasis","volume":"190","author":"Killeen","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0400","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/416603a","article-title":"Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors","volume":"416","author":"Leadbetter","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0405","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.addr.2015.10.017","article-title":"Hyaluronan as a therapeutic target in human diseases","volume":"97","author":"Liang","year":"2016","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0410","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature08780","article-title":"Circulating mitochondrial DAMPs cause inflammatory responses to injury","volume":"464","author":"Zhang","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0415","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1002\/art.38369","article-title":"Myeloid-related proteins 8 and 14 contribute to monosodium urate monohydrate crystal-induced inflammation in gout","volume":"66","author":"Holzinger","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0420","doi-asserted-by":"crossref","first-page":"R158","DOI":"10.1186\/ar3898","article-title":"Enhanced interleukin-1beta production of PBMCs from patients with gout after stimulation with Toll-like receptor-2 ligands and urate crystals","volume":"14","author":"Mylona","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0425","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1136\/annrheumdis-2014-206564","article-title":"Soluble uric acid primes TLR-induced proinflammatory cytokine production by human primary cells via inhibition of IL-1Ra","volume":"75","author":"Crisan","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0430","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nrrheum.2015.171","article-title":"Cytokines in rheumatoid arthritis \u2013 shaping the immunological landscape","volume":"12","author":"McInnes","year":"2016","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0435","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nri1593","article-title":"Heat-shock proteins induce T-cell regulation of chronic inflammation","volume":"5","author":"van Eden","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0440","doi-asserted-by":"crossref","first-page":"6435","DOI":"10.4049\/jimmunol.172.10.6435","article-title":"CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis","volume":"172","author":"de Kleer","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0445","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0140-6736(05)66827-4","article-title":"Tolerogenic immune responses to novel T-cell epitopes from heat-shock protein 60 in juvenile idiopathic arthritis","volume":"366","author":"Kamphuis","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0450","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1253\/circj.CJ-13-1505","article-title":"Calgranulins may contribute vascular protection in atherogenesis","volume":"78","author":"Geczy","year":"2014","journal-title":"Circ J"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0455","doi-asserted-by":"crossref","first-page":"538","DOI":"10.2119\/molmed.2014.00183","article-title":"High systemic levels of the cytokine-inducing HMGB1 isoform secreted in severe macrophage activation syndrome","volume":"20","author":"Palmblad","year":"2014","journal-title":"Mol Med"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0460","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/sj.gene.6363861","article-title":"RAGE and arthritis: the G82S polymorphism amplifies the inflammatory response","volume":"3","author":"Hofmann","year":"2002","journal-title":"Genes Immun"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0465","doi-asserted-by":"crossref","first-page":"R105","DOI":"10.1186\/ar4554","article-title":"Genetic variant in IL33 is associated with susceptibility to rheumatoid arthritis","volume":"16","author":"Li","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0470","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1399-0039.1997.tb02838.x","article-title":"Heat shock protein 70 gene polymorphisms in rheumatoid arthritis","volume":"50","author":"Vinasco","year":"1997","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0475","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/acr.22248","article-title":"Validation of relapse risk biomarkers for routine use in patients with juvenile idiopathic arthritis","volume":"66","author":"Rothmund","year":"2014","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0480","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1136\/annrheumdis-2011-200598","article-title":"The Toll-like receptor 4 agonist MRP8\/14 protein complex is a sensitive indicator for disease activity and predicts relapses in systemic-onset juvenile idiopathic arthritis","volume":"71","author":"Holzinger","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0485","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s13075-015-0723-1","article-title":"MRP8\/14 serum levels as a predictor of response to starting and stopping anti-TNF treatment in juvenile idiopathic arthritis","volume":"17","author":"Anink","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0490","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1001\/jama.2010.375","article-title":"Methotrexate withdrawal at 6 vs 12 months in juvenile idiopathic arthritis in remission: a randomized clinical trial","volume":"303","author":"Foell","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0495","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1136\/annrheumdis-2013-203923","article-title":"MRP8\/14 serum levels as a strong predictor of response to biological treatments in patients with rheumatoid arthritis","volume":"74","author":"Choi","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0500","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1136\/ard.2008.103739","article-title":"Calprotectin (a major S100 leucocyte protein) predicts 10-year radiographic progression in patients with rheumatoid arthritis","volume":"69","author":"Hammer","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0505","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1002\/art.24137","article-title":"S100A12 is a novel molecular marker differentiating systemic-onset juvenile idiopathic arthritis from other causes of fever of unknown origin","volume":"58","author":"Wittkowski","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0510","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1136\/annrheumdis-2012-201329","article-title":"Phagocyte-specific S100 proteins and high-sensitivity C reactive protein as biomarkers for a risk-adapted treatment to maintain remission in juvenile idiopathic arthritis: a comparative study","volume":"71","author":"Gerss","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0515","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1093\/rheumatology\/keg385","article-title":"Expression of the pro-inflammatory protein S100A12 (EN-RAGE) in rheumatoid and psoriatic arthritis","volume":"42","author":"Foell","year":"2003","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0520","first-page":"187","article-title":"Preliminary study of high mobility group box chromosomal protein 1(HMGB1) in ankylosing spondylitis patients","volume":"33","author":"Chen","year":"2015","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0525","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3899\/jrheum.090492","article-title":"Increased levels of interleukin 33 in sera and synovial fluid from patients with active rheumatoid arthritis","volume":"37","author":"Matsuyama","year":"2010","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0530","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cyto.2015.10.005","article-title":"Interleukin-33 acts as a transcriptional repressor and extracellular cytokine in fibroblast-like synoviocytes in patients with rheumatoid arthritis","volume":"77","author":"Lee","year":"2016","journal-title":"Cytokine"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0535","doi-asserted-by":"crossref","first-page":"848","DOI":"10.2310\/JIM.0b013e31828deed2","article-title":"Elevated serum level of IL-33 and sST2 in patients with ankylosing spondylitis: associated with disease activity and vascular endothelial growth factor","volume":"61","author":"Li","year":"2013","journal-title":"J Investig Med"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0540","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.1002\/art.20631","article-title":"Proinflammatory S100 proteins in arthritis and autoimmune disease","volume":"50","author":"Foell","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0545","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1189\/jlb.1206730","article-title":"The extra domain A of fibronectin stimulates murine mast cells via toll-like receptor 4","volume":"82","author":"Gondokaryono","year":"2007","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0550","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.3899\/jrheum.120987","article-title":"HMGB1 levels are increased in patients with juvenile idiopathic arthritis, correlate with early onset of disease, and are independent of disease duration","volume":"40","author":"Schierbeck","year":"2013","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0555","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.cyto.2013.03.007","article-title":"Soluble ST2 as a marker of disease activity in systemic juvenile idiopathic arthritis","volume":"62","author":"Ishikawa","year":"2013","journal-title":"Cytokine"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0560","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jbspin.2011.02.011","article-title":"Distinct serum and synovial fluid interleukin (IL)-33 levels in rheumatoid arthritis, psoriatic arthritis and osteoarthritis","volume":"79","author":"Talabot-Ayer","year":"2012","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0565","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1007\/s10753-014-9871-8","article-title":"Identification of potential serum biomarkers for rheumatoid arthritis by high-resolution quantitative proteomic analysis","volume":"37","author":"Cheng","year":"2014","journal-title":"Inflammation"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0570","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1002\/art.27590","article-title":"Protective targeting of high mobility group box chromosomal protein 1 in a spontaneous arthritis model","volume":"62","author":"Ostberg","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0575","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.pharmthera.2013.11.001","article-title":"An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies","volume":"141","author":"Musumeci","year":"2014","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0580","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/j.ajpath.2013.01.032","article-title":"Amelioration of experimental autoimmune encephalomyelitis by the quinoline-3-carboxamide paquinimod: reduced priming of proinflammatory effector CD4(+) T cells","volume":"182","author":"Helmersson","year":"2013","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0585","doi-asserted-by":"crossref","first-page":"5627","DOI":"10.4049\/jimmunol.181.8.5627","article-title":"S-nitrosylated S100A8: novel anti-inflammatory properties","volume":"181","author":"Lim","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0590","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1136\/annrheumdis-2015-eular.3801","article-title":"AB0451 NI-0101, a monoclonal antibody targeting toll like receptor 4 (TLR4) being developed for rheumatoid arthritis (RA) treatment with a potential for personalized medicine","volume":"74","author":"Monnet","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0595","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1002\/art.24916","article-title":"Epitope-specific immunotherapy of rheumatoid arthritis: clinical responsiveness occurs with immune deviation and relies on the expression of a cluster of molecules associated with T cell tolerance in a double-blind, placebo-controlled, pilot phase II trial","volume":"60","author":"Koffeman","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0600","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1172\/JCI66938","article-title":"Amelioration of arthritis through mobilization of peptide-specific CD8+ regulatory T cells","volume":"123","author":"Leavenworth","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0605","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.4049\/jimmunol.164.5.2711","article-title":"A conserved mycobacterial heat shock protein (hsp) 70 sequence prevents adjuvant arthritis upon nasal administration and induces IL-10-producing T cells that cross-react with the mammalian self-hsp70 homologue","volume":"164","author":"Wendling","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0610","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nature13322","article-title":"Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis","volume":"512","author":"Vande Walle","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0615","doi-asserted-by":"crossref","first-page":"264859","DOI":"10.1155\/2014\/264859","article-title":"The emerging role of biotechnological drugs in the treatment of gout","volume":"2014","author":"Cavagna","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0620","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1002\/art.24305","article-title":"Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis","volume":"60","author":"Palmer","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0625","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1136\/annrheumdis-2011-143578","article-title":"Clinical evaluation of the efficacy of the P2X7 purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine","volume":"71","author":"Keystone","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0630","first-page":"S26","article-title":"IMO-3100, an antagonist of Toll-like receptor (TLR) 7 and TLR9, demonstrates clinical activity in psoriasis patients with 4 weeks of treatment in a phase 2a trial","volume":"133","author":"Kimball","year":"2013","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0635","doi-asserted-by":"crossref","first-page":"408242","DOI":"10.1155\/2012\/408242","article-title":"Modulating P2X7 receptor signaling during rheumatoid arthritis: new therapeutic approaches for bisphosphonates","volume":"2012","author":"Baroja-Mazo","year":"2012","journal-title":"J Osteoporos"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0640","doi-asserted-by":"crossref","first-page":"e29539","DOI":"10.1371\/journal.pone.0029539","article-title":"The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes","volume":"6","author":"Coll","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0645","first-page":"S461","article-title":"Novel compound cytokine release inhibitory drug 3 (CRID3) inhibits the NLRP3 inflammasome in rheumatoid arthritis","volume":"66","author":"McGarry","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jbspin.2016.06.010_bib0650","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2014.00001","article-title":"Emerging role of endosomal toll-like receptors in rheumatoid arthritis","volume":"5","author":"Thwaites","year":"2014","journal-title":"Front Immunol"}],"container-title":["Joint Bone Spine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1297319X16301270?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1297319X16301270?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T15:26:49Z","timestamp":1568388409000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1297319X16301270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S1297319X16301270"],"URL":"https:\/\/doi.org\/10.1016\/j.jbspin.2016.06.010","relation":{},"ISSN":["1297-319X"],"issn-type":[{"value":"1297-319X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alarmins firing arthritis: Helpful diagnostic tools and promising therapeutic targets","name":"articletitle","label":"Article Title"},{"value":"Joint Bone Spine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbspin.2016.06.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Soci\u00e9t\u00e9 fran\u00e7aise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}