{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T17:04:58Z","timestamp":1782320698530,"version":"3.54.5"},"reference-count":43,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Joint Bone Spine"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.jbspin.2016.09.006","type":"journal-article","created":{"date-parts":[[2016,12,3]],"date-time":"2016-12-03T19:31:31Z","timestamp":1480793491000},"page":"553-556","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"title":["Long noncoding RNAs in osteoarthritis"],"prefix":"10.1016","volume":"84","author":[{"given":"Shi-de","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-han","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-sheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-hua","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbspin.2016.09.006_bib0220","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.3892\/etm.2015.2434","article-title":"Osteopontin inhibits HIF-2\u03b1 mRNA expression in osteoarthritic chondrocytes","volume":"9","author":"Cheng","year":"2015","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0225","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.bone.2005.08.007","article-title":"Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis","volume":"38","author":"Hayami","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0230","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1007\/s00296-014-3036-9","article-title":"Association of osteopontin with osteoarthritis","volume":"34","author":"Cheng","year":"2014","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0235","doi-asserted-by":"crossref","first-page":"3e25","DOI":"10.1016\/j.berh.2005.09.007","article-title":"Osteoarthritis: epidemiology","volume":"20","author":"Arden","year":"2006","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0240","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.joca.2013.03.018","article-title":"The epidemiology and impact of pain in osteoarthritis","volume":"21","author":"Neogi","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0245","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.joca.2012.11.012","article-title":"Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)","volume":"21","author":"Berenbaum","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0250","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1089\/1549168041552964","article-title":"Aging theories of primary osteoarthritis: from epidemiology to molecular biology","volume":"7","author":"Aigner","year":"2004","journal-title":"Rejuvenation Res"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0255","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0212-6567(14)70038-1","article-title":"Symptoms, localizations: knee, hip, hands, spine, other localizations","volume":"46","author":"Mart\u00edn","year":"2014","journal-title":"Aten Primaria"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0260","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1126\/science.274.5288.740","article-title":"Evidence-based health policylessons from the Global Burden of Disease Study","volume":"274","author":"Murray","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0265","first-page":"646","article-title":"Burden of major musculoskeletal conditions","volume":"81","author":"Woolf","year":"2003","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0270","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0212-6567(14)70037-X","article-title":"Definition, etiology, classification and presentation forms","volume":"46","author":"Garriga","year":"2014","journal-title":"Aten Primaria"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mcna.2008.08.009","article-title":"Etiopathogenesis of osteoarthritis","volume":"93","author":"Brandt","year":"2009","journal-title":"Med Clin North Am"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0280","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/jphp.12196","article-title":"Osteoarthritis of the hand I: aetiology and pathogenesis, risk factors, investigation and diagnosis","volume":"66","author":"Leung","year":"2014","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0285","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.joca.2014.03.004","article-title":"The hallmarks of osteoarthritis and the potential to develop personalised disease modifying pharmacological therapeutics","volume":"22","author":"Tonge","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0290","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0212-6567(14)70043-5","article-title":"Treatment of patients with osteoarthritis","volume":"46","author":"Vargas Negr\u00edn","year":"2014","journal-title":"Aten Primaria"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0295","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.joca.2010.01.013","article-title":"OARSI recommendations for the management of hip and knee osteoarthritis: Part III: changes in evidence following systematic cumulative update of research published through January 2009","volume":"18","author":"Zhang","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0300","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","article-title":"Osteoarthritis","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0305","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1749-6632.2002.tb04239.x","article-title":"Neuropeptides in experimental and degenerative arthritis","volume":"966","author":"Niissalo","year":"2002","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0310","doi-asserted-by":"crossref","first-page":"356893","DOI":"10.1155\/2015\/356893","article-title":"The long noncoding RNA MEG3 is downregulated and inversely associated with VEGF levels in osteoarthritis","volume":"2015","author":"Su","year":"2015","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0315","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1073\/pnas.1222643110","article-title":"Long noncoding RNAs regulate adipogenesis","volume":"110","author":"Sun","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0320","doi-asserted-by":"crossref","first-page":"R17","DOI":"10.1093\/hmg\/ddl046","article-title":"Non-coding RNA","volume":"15","author":"Mattick","year":"2006","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0325","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1002\/jor.22718","article-title":"A long non-coding RNA, GAS5, plays a critical role in the regulation of miR-21 during osteoarthritis","volume":"32","author":"Song","year":"2014","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0330","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/abbs\/gmt117","article-title":"Long non-coding RNA HOTAIR in carcinogenesis and metastasis","volume":"46","author":"Zhang","year":"2014","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0335","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrg2521","article-title":"Long non-coding RNAs: insights into functions","volume":"10","author":"Mercer","year":"2009","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0340","doi-asserted-by":"crossref","first-page":"925","DOI":"10.4161\/rna.24604","article-title":"On the classification of long non-coding RNAs","volume":"10","author":"Ma","year":"2013","journal-title":"RNA Biol"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0345","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1093\/nar\/gks967","article-title":"Long non-coding RNAs function annotation: a global prediction method based on bi-colored networks","volume":"41","author":"Guo","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0350","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.coi.2013.12.001","article-title":"Long noncoding RNAs in innate and adaptive immunity","volume":"26","author":"Fitzgerald","year":"2014","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0355","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.cell.2009.02.006","article-title":"Evolution and functions of long noncoding RNAs","volume":"136","author":"Ponting","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0360","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1476-4598-10-38","article-title":"The functional role of long non-coding RNA in human carcinomas","volume":"10","author":"Gibb","year":"2011","journal-title":"Mol Cancer"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0365","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1096\/fj.14-260323","article-title":"Noncoding RNAs, cytokines, and inflammation-related diseases","volume":"29","author":"Marques-Rocha","year":"2015","journal-title":"FASEB J"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0370","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1002\/art.38309","article-title":"Long noncoding RNA related to cartilage injury promotes chondrocyte extracellular matrix degradation in osteoarthritis","volume":"66","author":"Liu","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0375","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.joca.2014.12.001","article-title":"Expression profile of long noncoding RNAs in cartilage from knee osteoarthritis patients","volume":"23","author":"Fu","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0380","doi-asserted-by":"crossref","first-page":"200e4","DOI":"10.1016\/j.maturitas.2011.12.001","article-title":"Genetics and epigenetics of osteoarthritis","volume":"71","author":"Reynard","year":"2012","journal-title":"Maturitas"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0385","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/art.39520","article-title":"Long intergenic noncoding RNAs mediate the human chondrocyte inflammatory response and are differentially expressed in osteoarthritis cartilage","volume":"68","author":"Pearson","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0390","doi-asserted-by":"crossref","first-page":"902e6","DOI":"10.1042\/BST20120020","article-title":"Long non-coding RNAs and human disease","volume":"40","author":"Harries","year":"2012","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0395","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/os.12147","article-title":"Identification of long noncoding RNA associated with osteoarthritis in humans","volume":"6","author":"Xing","year":"2014","journal-title":"Orthop Surg"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0400","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.gene.2016.04.016","article-title":"Upregulation of lncRNA HOTAIR contributes to IL-1\u03b2-induced MMP overexpression and chondrocytes apoptosis in temporomandibular joint osteoarthritis","volume":"586","author":"Zhang","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0405","article-title":"Global molecular changes in a tibial compression induced ACL rupture model of post-traumatic osteoarthritis","author":"Chang","year":"2016","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0410","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/jor.23046","article-title":"PCGEM1 stimulates proliferation of osteoarthritic synoviocytes by acting as a sponge for miR-770","volume":"34","author":"Kang","year":"2016","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0415","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1016\/j.cellsig.2013.08.034","article-title":"Two non-coding RNAs, MicroRNA-101 and HOTTIP contribute cartilage integrity by epigenetic and homeotic regulation of integrin-\u03b11","volume":"25","author":"Kim","year":"2013","journal-title":"Cell Signal"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0420","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/S0140-6736(11)60243-2","article-title":"Osteoarthritis: an update with relevance for clinical practice","volume":"377","author":"Bijlsma","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0425","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/1759720X13514669","article-title":"Targeting the synovial angiogenesis as a novel treatment approach to osteoarthritis","volume":"6","author":"Henrotin","year":"2014","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"10.1016\/j.jbspin.2016.09.006_bib0430","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s00109-012-0895-y","article-title":"Regulation of H19 and its encoded microRNA-675 in osteoarthritis and under anabolic and catabolic in vitro conditions","volume":"90","author":"Steck","year":"2012","journal-title":"J Mol Med (Berl)"}],"container-title":["Joint Bone Spine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1297319X16301610?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1297319X16301610?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T02:27:49Z","timestamp":1536200869000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1297319X16301610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S1297319X16301610"],"URL":"https:\/\/doi.org\/10.1016\/j.jbspin.2016.09.006","relation":{},"ISSN":["1297-319X"],"issn-type":[{"value":"1297-319X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long noncoding RNAs in osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Joint Bone Spine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbspin.2016.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Soci\u00e9t\u00e9 fran\u00e7aise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}