{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T14:52:57Z","timestamp":1770562377642,"version":"3.49.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T00:00:00Z","timestamp":1632528000000},"content-version":"am","delay-in-days":359,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Joint Bone Spine"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.jbspin.2020.04.013","type":"journal-article","created":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T23:16:54Z","timestamp":1589152614000},"page":"483-486","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Infliximab induces clinical resolution of sacroiliitis that coincides with increased circulating FOXP3+ T cells in a patient with IPEX syndrome"],"prefix":"10.1016","volume":"87","author":[{"given":"Gilles","family":"Boschetti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marine","family":"Sarfati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Fabien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Flouri\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Lachaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Nancey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabienne","family":"Coury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbspin.2020.04.013_bib0095","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/83713","article-title":"The immune dysregulation, polyen-docrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3","volume":"27","author":"Bennett","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.jbspin.2020.04.013_bib0100","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.jaci.2017.10.041","article-title":"Long-term follow-up of IPEX syndrome patients after different therapeutic strategies: an international multicenter retrospective study","volume":"141","author":"Barzaghi","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jbspin.2020.04.013_bib0105","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/S0022-3476(05)81999-7","article-title":"Familial autoimmune enteropathy with circulating anti-bullous pemphigoid antibodies and chronic autoimmune hepatitis","volume":"125","author":"Lachaux","year":"1994","journal-title":"J Pediatr"},{"key":"10.1016\/j.jbspin.2020.04.013_bib0110","first-page":"856","article-title":"Flow cytometry characterization of epithelial cells released in the watery stools of a patient with autoimmune enteropathy","volume":"90","author":"Lachaux","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jbspin.2020.04.013_bib0115","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s004280050277","article-title":"Autoimmune enteropathy in infants. Pathological study of the disease in two familial cases","volume":"433","author":"Lachaux","year":"1998","journal-title":"Virchows Arch"},{"key":"10.1016\/j.jbspin.2020.04.013_bib0120","doi-asserted-by":"crossref","first-page":"6034","DOI":"10.1210\/jc.2003-031080","article-title":"Mutational analysis of the FOXP3 gene and evidence for genetic heterogeneity in the immune dysregulation, polyendocrinopathy, enteropathy syndrome","volume":"88","author":"Owen","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jbspin.2020.04.013_bib0125","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1016\/j.clinre.2015.03.006","article-title":"Long-term disease course in a patient with severe neonatal IPEX syndrome","volume":"39","author":"Duclaux-Loras","year":"2015","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"10.1016\/j.jbspin.2020.04.013_bib0130","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/nyas.13011","article-title":"From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation","volume":"1417","author":"Bacchetta","year":"2018","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jbspin.2020.04.013_bib0135","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.berh.2014.10.018","article-title":"The role of the gut and microbes in the pathogenesis of spondyloarthritis","volume":"28","author":"Asquith","year":"2014","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.jbspin.2020.04.013_bib0140","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.it.2012.11.002","article-title":"Differentiation and function of Foxp3(+) effector regulatory T cells","volume":"34","author":"Cretney","year":"2013","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jbspin.2020.04.013_bib0145","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/ibd.21308","article-title":"Therapy with anti-TNF\u03b1 antibody enhances number and function of Foxp3(+) regulatory T cells in inflammatory bowel diseases","volume":"17","author":"Boschetti","year":"2011","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jbspin.2020.04.013_bib0150","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1097\/MIB.0000000000000554","article-title":"Restoration of Foxp3+ regulatory T-cell subsets and Foxp3- Type 1 regulatory-like T cells in inflammatory bowel diseases during anti-tumor necrosis factor therapy","volume":"21","author":"Li","year":"2015","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jbspin.2020.04.013_bib0155","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1084\/jem.20151255","article-title":"Anti-TNF drives regulatory T cell expansion by paradoxically promoting membrane TNF-TNF-RII binding in rheumatoid arthritis","volume":"213","author":"Nguyen","year":"2016","journal-title":"J Exp Med"},{"key":"10.1016\/j.jbspin.2020.04.013_bib0160","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.4049\/jimmunol.1003224","article-title":"CD4+ FOXP3+ Treg in human autoimmunity: more than a numbers game","volume":"187","author":"Long","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.jbspin.2020.04.013_bib0165","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/BOR.0b013e32836202dc","article-title":"Dendritic cells and regulatory T cells in spondyloarthritis","volume":"25","author":"Wright","year":"2013","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.jbspin.2020.04.013_bib0170","doi-asserted-by":"crossref","first-page":"R335","DOI":"10.1186\/ar1192","article-title":"CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease","volume":"6","author":"Cao","year":"2004","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jbspin.2020.04.013_bib0175","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.3899\/jrheum.110377","article-title":"Synovial and peripheral blood CD4+ FoxP3+ T cells in spondyloarthritis","volume":"38","author":"Appel","year":"2011","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jbspin.2020.04.013_bib0180","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1186\/ar3257","article-title":"Reduced immunomodulation potential of bone marrow-derived mesenchymal stem cells induced CCR4+ CCR6+ Th\/Treg cell subset imbalance in ankylosing spondylitis","volume":"13","author":"Wu","year":"2011","journal-title":"Arthritis Res Ther"}],"container-title":["Joint Bone Spine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1297319X20300786?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1297319X20300786?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T16:26:42Z","timestamp":1761150402000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1297319X20300786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S1297319X20300786"],"URL":"https:\/\/doi.org\/10.1016\/j.jbspin.2020.04.013","relation":{},"ISSN":["1297-319X"],"issn-type":[{"value":"1297-319X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Infliximab induces clinical resolution of sacroiliitis that coincides with increased circulating FOXP3+ T cells in a patient with IPEX syndrome","name":"articletitle","label":"Article Title"},{"value":"Joint Bone Spine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbspin.2020.04.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Soci\u00e9t\u00e9 fran\u00e7aise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}