{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T21:05:41Z","timestamp":1794258341812,"version":"4.9.0"},"reference-count":10,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["530849567"],"award-info":[{"award-number":["530849567"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["554784412"],"award-info":[{"award-number":["554784412"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofcardiologycases.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiology Cases"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jccase.2026.06.011","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T17:28:38Z","timestamp":1783618118000},"page":"177-180","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Managing a mavacamten non-responder in obstructive hypertrophic cardiomyopathy: A case report"],"prefix":"10.1016","volume":"34","author":[{"given":"Smita","family":"Scholtz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Langkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Rudolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Michael","family":"Federspiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasco","family":"Sequeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jccase.2026.06.011_bb0005","doi-asserted-by":"crossref","first-page":"e1239","DOI":"10.1161\/CIR.0000000000001250","article-title":"2024 AHA\/ACC\/AMSSM\/HRS\/PACES\/SCMR Guideline for the management of hypertrophic cardiomyopathy: a report of the American Heart Association\/American College of Cardiology Joint Committee on Clinical Practice Guidelines","volume":"149","author":"Ommen","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.jccase.2026.06.011_bb0010","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1093\/eurheartj\/ehad194","article-title":"2023 ESC Guidelines for the management of cardiomyopathies","volume":"44","author":"Arbelo","year":"2023","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jccase.2026.06.011_bb0015","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1126\/science.aad3456","article-title":"A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic comdiomyopathy in mice","volume":"351","author":"Green","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.jccase.2026.06.011_bb0020","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0140-6736(20)31792-X","article-title":"Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"396","author":"Olivotto","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jccase.2026.06.011_bb0025","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jacc.2022.04.048","article-title":"Myosin inhibition in patients with obstructive hypertrophic cardiomyopathy referred for septal reduction therapy","volume":"80","author":"Desai","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jccase.2026.06.011_bb0030","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.mayocp.2023.11.019","article-title":"Genotype influences mavacamten responsiveness in obstructive hypertrophic cardiomyopathy","volume":"99","author":"Giudicessi","year":"2024","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jccase.2026.06.011_bb0035","doi-asserted-by":"crossref","first-page":"4885","DOI":"10.1038\/s41467-024-47587-9","article-title":"Omecamtiv mecarbil and mavacamten target the same myosin pocket despite opposite effects in heart contraction","volume":"15","author":"Auguin","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.jccase.2026.06.011_bb0040","doi-asserted-by":"crossref","first-page":"2314914121","DOI":"10.1073\/pnas.2314914121","article-title":"Myosin in autoinhibited off state(s), stabilized by mavacamten, can be recruited in response to intropic interventions","volume":"121","author":"Ma","year":"2024","journal-title":"PNAS"},{"key":"10.1016\/j.jccase.2026.06.011_bb0045","first-page":"860","article-title":"Mitral valve interventions for hypertrophic obstructive cardiomyopathy","volume":"40","author":"Shuvy","year":"2024","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.jccase.2026.06.011_bb0050","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s43055-019-0130-8","article-title":"Corrected calculation of the overestimated ejection fraction in valvular heart disease by phase-contrast cardiac magnetic resonance imaging for better prediction of patient morbidity","volume":"51","author":"Yousef","year":"2020","journal-title":"Egypt J Radiol Nucl Med"}],"container-title":["Journal of Cardiology Cases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878540926000721?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878540926000721?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:51:10Z","timestamp":1790819470000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878540926000721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S1878540926000721"],"URL":"https:\/\/doi.org\/10.1016\/j.jccase.2026.06.011","relation":{},"ISSN":["1878-5409"],"issn-type":[{"value":"1878-5409","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Managing a mavacamten non-responder in obstructive hypertrophic cardiomyopathy: A case report","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiology Cases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jccase.2026.06.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Japanese College of Cardiology. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}