{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:06:19Z","timestamp":1790111179566,"version":"4.0.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofcardiovascularct.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiovascular Computed Tomography"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.jcct.2023.04.005","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T16:32:13Z","timestamp":1683131533000},"page":"261-268","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Quantification of extracellular volume with cardiac computed tomography in patients with dilated cardiomyopathy"],"prefix":"10.1016","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8261-4529","authenticated-orcid":false,"given":"Andrea","family":"Baggiano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1443-5788","authenticated-orcid":false,"given":"Edoardo","family":"Conte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Spiritigliozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima","family":"Mushtaq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5271-4353","authenticated-orcid":false,"given":"Andrea","family":"Annoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8181-154X","authenticated-orcid":false,"given":"Maria Ludovica","family":"Carerj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7675-0578","authenticated-orcid":false,"given":"Francesco","family":"Cilia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7156-0636","authenticated-orcid":false,"given":"Fabio","family":"Fazzari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Formenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Frappampina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0309-6231","authenticated-orcid":false,"given":"Laura","family":"Fusini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7689-0594","authenticated-orcid":false,"given":"Margherita","family":"Gaudenzi Asinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Junod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elisabetta","family":"Mancini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0696-1625","authenticated-orcid":false,"given":"Valentina","family":"Mantegazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1581-6742","authenticated-orcid":false,"given":"Riccardo","family":"Maragna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Marchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4040-6112","authenticated-orcid":false,"given":"Marco","family":"Penso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8479-122X","authenticated-orcid":false,"given":"Luigi","family":"Tassetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0624-0588","authenticated-orcid":false,"given":"Alessandra","family":"Volpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Baessato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1718-9949","authenticated-orcid":false,"given":"Marco","family":"Guglielmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexia","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4815-9427","authenticated-orcid":false,"given":"Chiara","family":"Rovera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Andreini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark G.","family":"Rabbat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7133-4401","authenticated-orcid":false,"given":"Andrea Igoren","family":"Guaricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Pepi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Pontone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcct.2023.04.005_bib1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11886-018-0961-3","article-title":"Myocardial extracellular volume quantification by cardiovascular magnetic resonance and computed tomography","volume":"20","author":"Scully","year":"2018","journal-title":"Curr Cardiol Rep"},{"key":"10.1016\/j.jcct.2023.04.005_bib2","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcct.2023.04.005_bib3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1161\/CIRCRESAHA.116.303577","article-title":"The biological basis for cardiac repair after myocardial infarction: from inflammation to fibrosis","volume":"119","author":"Prabhu","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.jcct.2023.04.005_bib4","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1136\/heart.89.10.1255","article-title":"Interstitial fibrosis in the dilated non-ischaemic myocardium","volume":"89","author":"Brooks","year":"2003","journal-title":"Heart"},{"key":"10.1016\/j.jcct.2023.04.005_bib5","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1016\/j.jacc.2019.01.061","article-title":"Moving beyond the sarcomere to explain heterogeneity in hypertrophic cardiomyopathy: JACC review topic of the week","volume":"73","author":"Maron","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcct.2023.04.005_bib6","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1016\/j.jacc.2019.08.1061","article-title":"Prognostic value of repeating cardiac magnetic resonance in patients with acute myocarditis","volume":"74","author":"Aquaro","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcct.2023.04.005_bib7","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1161\/CIRCRESAHA.117.310221","article-title":"Inflammatory cardiomyopathic syndromes","volume":"121","author":"Trachtenberg","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.jcct.2023.04.005_bib8","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1161\/CIRCULATIONAHA.111.089409","article-title":"Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short-term mortality","volume":"126","author":"Wong","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jcct.2023.04.005_bib9","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.jacc.2018.11.042","article-title":"Effects of sacubitril\/valsartan on biomarkers of extracellular matrix regulation in patients with HFrEF","volume":"73","author":"Zile","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcct.2023.04.005_bib10","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1056\/NEJM199908193410806","article-title":"Hormones and hemodynamics in heart failure","volume":"341","author":"Schrier","year":"1999","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcct.2023.04.005_bib11","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1161\/CIRCULATIONAHA.109.924167","article-title":"Comparative evaluation of left and right ventricular endomyocardial biopsy: differences in complication rate and diagnostic performance","volume":"122","author":"Yilmaz","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jcct.2023.04.005_bib12","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/eurjhf\/hfp050","article-title":"Patterns of late gadolinium enhancement are associated with ventricular stiffness in patients with advanced non-ischaemic dilated cardiomyopathy","volume":"11","author":"Choi","year":"2009","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jcct.2023.04.005_bib13","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/mrm.20110","article-title":"Modified Look-Locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart","volume":"52","author":"Messroghli","year":"2004","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jcct.2023.04.005_bib14","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1016\/j.jcmg.2021.07.029","article-title":"The future of cardiac magnetic resonance clinical trials","volume":"15","author":"Rabbat","year":"2022","journal-title":"JACC Cardiovasc Imag"},{"key":"10.1016\/j.jcct.2023.04.005_bib15","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12968-016-0308-4","article-title":"Cardiac T1 Mapping and Extracellular Volume (ECV) in clinical practice: a comprehensive review","volume":"18","author":"Haaf","year":"2016","journal-title":"J\u00a0Cardiovasc Magn Reson"},{"key":"10.1016\/j.jcct.2023.04.005_bib16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/00004424-198303000-00015","article-title":"Human pharmacokinetics of iohexol. A new nonionic contrast medium","volume":"18","author":"Olsson","year":"1983","journal-title":"Invest Radiol"},{"key":"10.1016\/j.jcct.2023.04.005_bib17","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1148\/radiol.13130130","article-title":"Measurement of myocardial extracellular volume fraction by using equilibrium contrast-enhanced CT: validation against histologic findings","volume":"269","author":"Bandula","year":"2013","journal-title":"Radiology"},{"key":"10.1016\/j.jcct.2023.04.005_bib18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/ehjci\/jex310","article-title":"Training in cardiac computed tomography: EACVI certification process","volume":"19","author":"Pontone","year":"2018","journal-title":"Eur Heart J Cardiovasc Imag"},{"key":"10.1016\/j.jcct.2023.04.005_bib19","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/ehjci\/jeab293","article-title":"Clinical applications of cardiac computed tomography: a consensus paper of the European Association of Cardiovascular Imaging-part I","volume":"23","author":"Pontone","year":"2022","journal-title":"Eur Heart J Cardiovasc Imag"},{"key":"10.1016\/j.jcct.2023.04.005_bib20","doi-asserted-by":"crossref","first-page":"e136","DOI":"10.1093\/ehjci\/jeab292","article-title":"Clinical applications of cardiac computed tomography: a consensus paper of the European Association of Cardiovascular Imaging-part II","volume":"23","author":"Pontone","year":"2022","journal-title":"Eur Heart J Cardiovasc Imag"},{"key":"10.1016\/j.jcct.2023.04.005_bib21","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1148\/radiol.12112458","article-title":"Interstitial myocardial fibrosis assessed as extracellular volume fraction with low-radiation-dose cardiac CT","volume":"264","author":"Nacif","year":"2012","journal-title":"Radiology"},{"key":"10.1016\/j.jcct.2023.04.005_bib22","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.jcct.2015.07.001","article-title":"Extracellular volume quantification by dynamic equilibrium cardiac computed tomography in cardiac amyloidosis","volume":"9","author":"Treibel","year":"2015","journal-title":"J\u00a0Cardiovasc Comput Tomogr"},{"key":"10.1016\/j.jcct.2023.04.005_bib23","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1016\/j.jcmg.2020.05.029","article-title":"Identifying cardiac amyloid in aortic stenosis: ECV quantification by CT in TAVR patients","volume":"13","author":"Scully","year":"2020","journal-title":"JACC Cardiovasc Imag"},{"key":"10.1016\/j.jcct.2023.04.005_bib24","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jcmg.2022.08.005","article-title":"Comprehensive evaluation of left ventricle dysfunction by a new computed tomography scanner: the E-PLURIBUS study","volume":"16","author":"Andreini","year":"2023","journal-title":"JACC Cardiovasc Imag"},{"key":"10.1016\/j.jcct.2023.04.005_bib25","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1161\/hc0402.102975","article-title":"Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association","volume":"105","author":"Cerqueira","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jcct.2023.04.005_bib26","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00441-016-2431-9","article-title":"Cardiac fibrosis in myocardial infarction-from repair and remodeling to regeneration","volume":"365","author":"Talman","year":"2016","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jcct.2023.04.005_bib27","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1161\/CIRCULATIONAHA.109.930636","article-title":"Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis: preliminary validation in humans","volume":"122","author":"Flett","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jcct.2023.04.005_bib28","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jcmg.2019.03.026","article-title":"Noncontrast magnetic resonance for the diagnosis of cardiac amyloidosis","volume":"13","author":"Baggiano","year":"2020","journal-title":"JACC Cardiovasc Imag"},{"key":"10.1016\/j.jcct.2023.04.005_bib29","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jacc.2017.05.053","article-title":"Magnetic resonance in transthyretin cardiac amyloidosis","volume":"70","author":"Martinez-Naharro","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcct.2023.04.005_bib30","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.jcmg.2018.02.006","article-title":"Native T1 and extracellular volume in transthyretin amyloidosis","volume":"12","author":"Martinez-Naharro","year":"2019","journal-title":"JACC Cardiovasc Imag"},{"key":"10.1016\/j.jcct.2023.04.005_bib31","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1007\/s00330-020-07650-7","article-title":"Prognostic value of myocardial extracellular volume fraction evaluation based on cardiac magnetic resonance T1 mapping with T1 long and short in hypertrophic cardiomyopathy","volume":"31","author":"Li","year":"2021","journal-title":"Eur Radiol"},{"key":"10.1016\/j.jcct.2023.04.005_bib32","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1016\/j.jacc.2016.02.054","article-title":"Assessing myocardial extracellular volume by T1 mapping to distinguish hypertrophic cardiomyopathy from athlete's heart","volume":"67","author":"Swoboda","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jcct.2023.04.005_bib33","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jcmg.2019.03.017","article-title":"Extracellular volume associates with outcomes more strongly than native or post-contrast myocardial T1","volume":"13","author":"Treibel","year":"2020","journal-title":"JACC Cardiovasc Imag"},{"key":"10.1016\/j.jcct.2023.04.005_bib34","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1016\/j.jcmg.2020.07.045","article-title":"Prognostic value of computed tomography-derived extracellular volume in TAVR patients with low-flow low-gradient aortic stenosis","volume":"13","author":"Tamarappoo","year":"2020","journal-title":"JACC Cardiovasc Imag"},{"key":"10.1016\/j.jcct.2023.04.005_bib35","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.ijcard.2018.05.027","article-title":"Extracellular volume quantitation using dual-energy CT in patients with heart failure: comparison with 3T cardiac MR","volume":"268","author":"Wang","year":"2018","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jcct.2023.04.005_bib36","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jcct.2019.12.032","article-title":"Investigation of myocardial extracellular volume fraction in heart failure patients using iodine map with rapid-kV switching dual-energy CT: segmental comparison with MRI T1 mapping","volume":"14","author":"Ohta","year":"2020","journal-title":"J\u00a0Cardiovasc Comput Tomogr"},{"key":"10.1016\/j.jcct.2023.04.005_bib37","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/RLI.0000000000000851","article-title":"Extracellular volume quantification with cardiac late enhancement scanning using dual-source photon-counting detector CT","volume":"57","author":"Mergen","year":"2022","journal-title":"Invest Radiol"},{"key":"10.1016\/j.jcct.2023.04.005_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.CIR.82.1.1","article-title":"Understanding the coronary circulation through studies at the microvascular level","volume":"82","author":"Marcus","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.jcct.2023.04.005_bib39","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1161\/hc0502.102964","article-title":"Dynamic changes in three-dimensional architecture and vascular volume of transmural coronary microvasculature\u00a0between\u00a0diastolic- and systolic-arrested rat hearts","volume":"105","author":"Toyota","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jcct.2023.04.005_bib40","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jcmg.2015.11.002","article-title":"T1 mapping by CMR imaging: from histological validation to clinical implication","volume":"9","author":"Kammerlander","year":"2016","journal-title":"JACC Cardiovasc Imag"}],"container-title":["Journal of Cardiovascular Computed Tomography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934592523001181?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934592523001181?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T14:04:54Z","timestamp":1761833094000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1934592523001181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S1934592523001181"],"URL":"https:\/\/doi.org\/10.1016\/j.jcct.2023.04.005","relation":{},"ISSN":["1934-5925"],"issn-type":[{"value":"1934-5925","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantification of extracellular volume with cardiac computed tomography in patients with dilated cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiovascular Computed Tomography","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcct.2023.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}