{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:14:02Z","timestamp":1791252842138,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jcehepatology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical and Experimental Hepatology"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.jceh.2014.05.004","type":"journal-article","created":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T09:16:27Z","timestamp":1402046187000},"page":"S80-S89","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"special_numbering":"S3","title":["Treatment Algorithms for Managing Hepatocellular Carcinoma"],"prefix":"10.1016","volume":"4","author":[{"given":"Vivek A.","family":"Saraswat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Shetty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jceh.2014.05.004_bib1","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/hep.510280322","article-title":"A\u00a0new prognostic system for hepatocellular carcinoma: a retrospective study of 435 patients","volume":"28","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.jceh.2014.05.004_bib2","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.jhep.2011.12.001","article-title":"EASL\u2013EORTC clinical practice guidelines: management of hepatocellular carcinoma","volume":"56","year":"2012","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jceh.2014.05.004_bib3","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/1097-0142(19850815)56:4<918::AID-CNCR2820560437>3.0.CO;2-E","article-title":"Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients","volume":"56","author":"Okuda","year":"1985","journal-title":"Cancer"},{"key":"10.1016\/j.jceh.2014.05.004_bib4","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/bjs.1800600817","article-title":"Transection of the oesophagus for bleeding oesophageal varices","volume":"60","author":"Pugh","year":"1973","journal-title":"Br J Surg"},{"key":"10.1016\/j.jceh.2014.05.004_bib5","series-title":"AJCC Cancer Staging Handbook","year":"2010"},{"key":"10.1016\/j.jceh.2014.05.004_bib6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0168-8278(99)80173-1","article-title":"A\u00a0new prognostic classification for predicting survival in patients with hepatocellular carcinoma. Groupe d'Etude et de Traitement du Carcinome H\u00e9patocellulaire","volume":"31","author":"Chevret","year":"1999","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jceh.2014.05.004_bib7","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1002\/cncr.10384","article-title":"Construction of the Chinese University prognostic index for hepatocellular carcinoma and comparison with the TNM staging system, the Okuda staging system, and the Cancer of the Liver Italian Program staging system: a study based on 926 patients","volume":"94","author":"Leung","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.jceh.2014.05.004_bib8","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.ejso.2004.05.003","article-title":"The Japanese integrated staging score using liver damage grade for hepatocellular carcinoma in patients after hepatectomy","volume":"30","author":"Nanashima","year":"2004","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.jceh.2014.05.004_bib9","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1159\/000173428","article-title":"Validation of a new prognostic staging system for hepatocellular carcinoma: a comparison of the biomarker-combined Japan Integrated Staging Score, the conventional Japan Integrated Staging Score and the BALAD Score","volume":"75","author":"Kitai","year":"2008","journal-title":"Oncol"},{"key":"10.1016\/j.jceh.2014.05.004_bib10","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1055\/s-2007-1007122","article-title":"Prognosis of hepatocellular carcinoma: the BCLC staging classification","volume":"19","author":"Llovet","year":"1999","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jceh.2014.05.004_bib11","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1093\/jnci\/djn134","article-title":"Design and endpoints of clinical trials in hepatocellular carcinoma","volume":"100","author":"Llovet","year":"2008","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.jceh.2014.05.004_bib12","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.1200\/JCO.2010.28.7805","article-title":"Hepatocellular carcinoma: consensus recommendations of the National Cancer Institute Clinical Trials Planning Meeting","volume":"28","author":"Thomas","year":"2010","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.jceh.2014.05.004_bib13","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/hep.24199","volume":"53","author":"Bruix","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.jceh.2014.05.004_bib14","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/hep.20636","article-title":"Prognosis of hepatocellular carcinoma: comparison of 7 staging systems in an American cohort","volume":"41","author":"Marrero","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jceh.2014.05.004_bib15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1055\/s-0030-1247131","article-title":"Molecular classification and novel targets in hepatocellular carcinoma: recent advancements","volume":"30","author":"Hohida","year":"2010","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jceh.2014.05.004_bib16","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1016\/S1470-2045(11)70175-9","article-title":"OLT for HCC Consensus Group. Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report","volume":"13","author":"Clavien","year":"2012","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jceh.2014.05.004_bib17","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1002\/hep.510280511","article-title":"Early hepatocellular carcinoma as an entity with a high rate of surgical cure","volume":"28","author":"Takayama","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.jceh.2014.05.004_bib18","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1053\/j.gastro.2009.06.003","article-title":"A\u00a0system of classifying microvascular invasion to predict outcome after resection in patients with hepatocellular carcinoma","volume":"137","author":"Roayaie","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jceh.2014.05.004_bib19","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1002\/hep.25832","article-title":"Hepatic resection for hepatocellular carcinoma <2 cm in diameter","volume":"57","author":"Roayaie","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jceh.2014.05.004_bib20","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/hep.21933","article-title":"Sustained complete response and complications rates after radiofrequency ablation of very early hepatocellular carcinoma in cirrhosis: is resection still the treatment of choice?","volume":"47","author":"Livraghi","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jceh.2014.05.004_bib21","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1056\/NEJM199603143341104","article-title":"Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis","volume":"334","author":"Mazzaferro","year":"1996","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jceh.2014.05.004_bib22","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1200\/JCO.2002.20.6.1527","article-title":"Simplified staging for hepatocellular carcinoma","volume":"20","author":"Vauthey","year":"2002","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.jceh.2014.05.004_bib23","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/jnci\/92.3.205","article-title":"New guidelines to evaluate the response to treatment in solid tumors (RECIST Guidelines)","volume":"92","author":"Therasse","year":"2000","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.jceh.2014.05.004_bib24","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1055\/s-0030-1247132","article-title":"Modified RECIST (mRECIST) assessment for hepatocellular carcinoma","volume":"30","author":"Lencioni","year":"2010","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jceh.2014.05.004_bib25","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1016\/j.transproceed.2007.05.073","article-title":"First-line liver resection and salvage liver transplantation are increasing therapeutic strategies for patients with hepatocellular carcinoma and child a cirrhosis","volume":"39","author":"Vennarecci","year":"2007","journal-title":"Transplant Proc"},{"issue":"suppl 7","key":"10.1016\/j.jceh.2014.05.004_bib26","doi-asserted-by":"crossref","first-page":"vii41","DOI":"10.1093\/annonc\/mds225","article-title":"Hepatocellular carcinoma: ESMO-ESDO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"23","author":"Verslype","year":"2012","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jceh.2014.05.004_bib27","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s12262-011-0387-2","article-title":"Liver transplantation for HCC: a review","volume":"74","author":"Kakodkar","year":"2012","journal-title":"Indian J Surg"},{"key":"10.1016\/j.jceh.2014.05.004_bib28","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/lt.21023","article-title":"Hepatectomy vs. liver transplantation: a combination rather than an opposition","volume":"13","author":"Belghiti","year":"2007","journal-title":"Liver Transpl"},{"key":"10.1016\/j.jceh.2014.05.004_bib29","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1111\/j.1600-6143.2008.02229.x","article-title":"Liver transplantation for recurrent hepatocellular carcinoma on cirrhosis after liver resection: University of Bologna experience","volume":"8","author":"Del Gaudio","year":"2008","journal-title":"Am J Transpl"},{"key":"10.1016\/j.jceh.2014.05.004_bib30","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00535-008-2244-z","article-title":"Evidence-based clinical practice guidelines for hepatocellular carcinoma in Japan: the J-HCC Guidelines","volume":"44","author":"Kokudo","year":"2009","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1016\/j.jceh.2014.05.004_bib31","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1159\/000327577","article-title":"Management of hepatocellular carcinoma in Japan: consensus-based clinical practice guidelines proposed by the Japan Society of Hepatology (JSH) 2010 updated version","volume":"29","author":"Kudo","year":"2011","journal-title":"Dig Dis"},{"key":"10.1016\/j.jceh.2014.05.004_bib32","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1097\/00029330-200810020-00008","article-title":"Early liver retransplantation versus late liver retransplantation: analysis of a single-centre experience","volume":"121","author":"Chen","year":"2008","journal-title":"Chin Med J Engl"},{"key":"10.1016\/j.jceh.2014.05.004_bib33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1477-7819-8-55","article-title":"Repeat hepatectomy for recurrent hepatocellular carcinoma: a local experience and a systematic review","volume":"8","author":"Zhou","year":"2010","journal-title":"World J Surg Oncol"},{"key":"10.1016\/j.jceh.2014.05.004_bib34","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/PL00009956","article-title":"Results of surgical treatment for recurrent hepatocellular carcinoma: comparison of outcome among patients with multicentric carcinogenesis, intrahepatic metastasis, and extrahepatic recurrence","volume":"5","author":"Arii","year":"1998","journal-title":"J\u00a0Hepatobiliary Pancreat Surg"},{"key":"10.1016\/j.jceh.2014.05.004_bib35","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/01.sla.0000201480.65519.b8","article-title":"A\u00a0prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma","volume":"243","author":"Chen","year":"2006","journal-title":"Ann Surg"},{"key":"10.1016\/j.jceh.2014.05.004_bib36","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jhep.2004.11.042","article-title":"Treatment of hepatocellular carcinoma in compensated cirrhosis with radiofrequency thermal ablation (RFTA): a prospective study","volume":"42","author":"Camma","year":"2005","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jceh.2014.05.004_bib37","doi-asserted-by":"crossref","first-page":"S275","DOI":"10.2214\/AJR.04.1573","article-title":"Radiofrequency ablation of recurrent hepatocellular carcinoma after hepatectomy: therapeutic efficacy on early- and late-phase recurrence","volume":"186","author":"Yang","year":"2006","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.jceh.2014.05.004_bib38","first-page":"1359","article-title":"Second laparoscopic resection for recurrent hepatocellular carcinoma after initial laparoscopic hepatectomy: case report","volume":"122","author":"Liang","year":"2009","journal-title":"Chin Med J Engl"},{"key":"10.1016\/j.jceh.2014.05.004_bib39","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1053\/jhep.2001.24233","article-title":"Increased risk of tumor seeding after percutaneous radiofrequency ablation for single hepatocellular carcinoma","volume":"33","author":"Llovet","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.jceh.2014.05.004_bib40","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1053\/jhep.2003.50473","article-title":"Adjuvant intra-arterial injection of iodine-131-labeled lipiodol after resection of hepatocellular carcinoma","volume":"38","author":"Boucher","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.jceh.2014.05.004_bib41","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jvir.2008.10.021","article-title":"Does post-embolization fever after chemo-embolization have prognostic significance for survival in patients with unresectable hepatocellular carcinoma?","volume":"20","author":"Shim","year":"2009","journal-title":"J\u00a0Vasc Interv Radiol"},{"key":"10.1016\/j.jceh.2014.05.004_bib42","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1097\/COC.0b013e3181967da0","article-title":"Efficacy and safety of transarterial chemoembolization in recurrent hepatocellular carcinoma after curative surgical resection","volume":"32","author":"Choi","year":"2009","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.jceh.2014.05.004_bib43","unstructured":"Charing Ching Ning Chong and Paul Bo San Lai. Treatment strategy for recurrent hepatocellular carcinoma. www.intechopen.com\/download\/pdf\/27581."},{"key":"10.1016\/j.jceh.2014.05.004_bib44","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1470-2045(08)70285-7","article-title":"Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial","volume":"10","author":"Cheng","year":"2009","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jceh.2014.05.004_bib45","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.suronc.2011.01.005","article-title":"Exploring the role of resection of extrahepatic metastases from hepatocellular carcinoma","volume":"21","author":"Chua","year":"2012","journal-title":"Surg Oncol"},{"key":"10.1016\/j.jceh.2014.05.004_bib46","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1111\/j.1365-2036.2011.04634.x","article-title":"Meta-analysis: the efficacy of anti-viral therapy in prevention of recurrence after curative treatment of chronic hepatitis B-related hepatocellular carcinoma","volume":"33","author":"Wong","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jceh.2014.05.004_bib47","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/SLA.0b013e3181571047","article-title":"Adjuvant intra-arterial iodine-131-labeled lipiodol for resectable hepatocellular carcinoma: a prospective randomized trial update on 5-year and 10-year survival","volume":"247","author":"Lau","year":"2008","journal-title":"Ann Surg"}],"container-title":["Journal of Clinical and Experimental Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0973688314003004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0973688314003004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T06:02:26Z","timestamp":1760853746000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0973688314003004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":47,"alternative-id":["S0973688314003004"],"URL":"https:\/\/doi.org\/10.1016\/j.jceh.2014.05.004","relation":{},"ISSN":["0973-6883"],"issn-type":[{"value":"0973-6883","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment Algorithms for Managing Hepatocellular Carcinoma","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical and Experimental Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jceh.2014.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 INASL. Published by Elsevier, a division of Reed Elsevier India, Pvt. Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}