{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:12:39Z","timestamp":1760919159057,"version":"build-2065373602"},"reference-count":12,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jcehepatology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical and Experimental Hepatology"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.jceh.2017.03.009","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T14:30:35Z","timestamp":1489588235000},"page":"93-96","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy and Safety of Sofosbuvir-Based Direct Acting Antivirals for Hepatitis C in Septuagenarians and Octogenarians"],"prefix":"10.1016","volume":"7","author":[{"given":"Heather S.","family":"Snyder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bilal","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Humberto C.","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satheesh","family":"Nair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjaya K.","family":"Satapathy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jceh.2017.03.009_bib0065","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1002\/hep.26141","article-title":"Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence","volume":"57","author":"Mohd Hanafiah","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jceh.2017.03.009_bib0070","doi-asserted-by":"crossref","first-page":"293","DOI":"10.7326\/M13-1133","article-title":"Chronic hepatitis C virus infection in the United States, National Health and Nutrition Examination Survey 2003 to 2010","volume":"160","author":"Denniston","year":"2014","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jceh.2017.03.009_bib0075","doi-asserted-by":"crossref","first-page":"817","DOI":"10.7326\/0003-4819-157-9-201211060-00529","article-title":"Hepatitis C virus testing of persons born during 1945\u20131965: recommendations from the Centers for Disease Control and Prevention","volume":"157","author":"Smith","year":"2012","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jceh.2017.03.009_bib0080","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.jhep.2013.11.014","article-title":"The changing epidemiology of hepatitis C virus infection in the United States: National Health and Nutrition Examination Survey 2001 through 2010","volume":"60","author":"Ditah","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.jceh.2017.03.009_bib0085","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1002\/hep.28425","article-title":"Safety and efficacy of ledipasvir\/sofosbuvir for the treatment of genotype 1 hepatitis C in subjects aged 65 years or older","volume":"63","author":"Saab","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jceh.2017.03.009_bib0090","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1053\/jlts.2003.50073","article-title":"Projecting future complications of chronic hepatitis C in the United States","volume":"9","author":"Davis","year":"2003","journal-title":"Liver Transpl"},{"key":"10.1016\/j.jceh.2017.03.009_bib0095","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1055\/s-2000-9258","article-title":"Fibrosis in patients with chronic hepatitis C: detection and significance","volume":"20","author":"Poynard","year":"2000","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jceh.2017.03.009_bib0100","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/S0168-8278(01)00062-9","article-title":"Long-term beneficial effects in sustained responders to interferon-alfa therapy for chronic hepatitis C","volume":"34","author":"Bruno","year":"2001","journal-title":"J Hepatol"},{"key":"10.1016\/j.jceh.2017.03.009_bib0105","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1016\/j.dld.2015.01.036","article-title":"Sofosbuvir-based all-oral treatment for elderly chronic hepatitis C patients: a cost-effectiveness analysis","volume":"47S","author":"Ciaccio","year":"2015","journal-title":"Dig Liver Dis"},{"issue":"suppl","key":"10.1016\/j.jceh.2017.03.009_bib0110","first-page":"256A","article-title":"The use of all oral regimens for treatment of chronic hepatitis C (CHC) coupled with birth cohort screening is highly cost effective: the health and economic impact on the U.S. population [Abstract]","volume":"60","author":"Younossi","year":"2014","journal-title":"Hepatology"},{"issue":"suppl","key":"10.1016\/j.jceh.2017.03.009_bib0115","first-page":"233A","article-title":"Projected health and economic impact of hepatitis C on the United States Medicare system from 2010 to 2024 [Abstract]","volume":"60","author":"Rein","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jceh.2017.03.009_bib0120","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.antiviral.2016.10.012","article-title":"Effectiveness and safety of sofosbuvir plus ribavirin for HCV genotype 2 patients 65 and over with or without cirrhosis","volume":"136","author":"Ogawa","year":"2016","journal-title":"Antiviral Res"}],"container-title":["Journal of Clinical and Experimental Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0973688316304637?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0973688316304637?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T06:03:31Z","timestamp":1760853811000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0973688316304637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S0973688316304637"],"URL":"https:\/\/doi.org\/10.1016\/j.jceh.2017.03.009","relation":{},"ISSN":["0973-6883"],"issn-type":[{"type":"print","value":"0973-6883"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and Safety of Sofosbuvir-Based Direct Acting Antivirals for Hepatitis C in Septuagenarians and Octogenarians","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical and Experimental Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jceh.2017.03.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 INASL.","name":"copyright","label":"Copyright"}]}}