{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T15:00:18Z","timestamp":1778166018879,"version":"3.51.4"},"reference-count":22,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jcehepatology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical and Experimental Hepatology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.jceh.2021.06.021","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T11:54:56Z","timestamp":1625226896000},"page":"732-738","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Herbal Immune Booster-Induced Liver Injury in the COVID-19 Pandemic - A Case Series"],"prefix":"10.1016","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0005-2508","authenticated-orcid":false,"given":"Aabha","family":"Nagral","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2622-8655","authenticated-orcid":false,"given":"Kunal","family":"Adhyaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omkar S.","family":"Rudra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Gharat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonal","family":"Bhandare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jceh.2021.06.021_bib1","unstructured":"https:\/\/covid19.who.int\/."},{"key":"10.1016\/j.jceh.2021.06.021_bib2","series-title":"Coronavirus | in Rush for \u2018immunity\u2019, Ayurveda Supplements Have an Untested Run","author":"Koshy","year":"2020"},{"key":"10.1016\/j.jceh.2021.06.021_bib3","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3390\/ijms17020224","article-title":"Hepatotoxicity by drugs: the most common implicated agents","volume":"17","author":"Bj\u00f6rnsson","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jceh.2021.06.021_bib4","doi-asserted-by":"crossref","first-page":"574","DOI":"10.4254\/wjh.v12.i9.574","article-title":"Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs","volume":"12","author":"Philips","year":"2020","journal-title":"World J Hepatol"},{"key":"10.1016\/j.jceh.2021.06.021_bib5","doi-asserted-by":"crossref","DOI":"10.1007\/s12072-021-10144-3","article-title":"Asia pacific association of study of liver. Drug induced liver injury: asia pacific association of study of liver consensus guidelines","author":"Devarbhavi","year":"2021","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jceh.2021.06.021_bib6","unstructured":"https:\/\/herbs.indianmedicinalplants.info\/index.php\/61-guduci-tinospora-cordifolia."},{"key":"10.1016\/j.jceh.2021.06.021_bib7","doi-asserted-by":"crossref","first-page":"147","DOI":"10.35946\/arcr.v38.2.01","article-title":"Alcoholic liver disease: pathogenesis and current management","volume":"38","author":"Osna","year":"2017","journal-title":"Alcohol Res"},{"key":"10.1016\/j.jceh.2021.06.021_bib8","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0168-8278(99)80297-9","article-title":"International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis","volume":"31","author":"Alvarez","year":"1999","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jceh.2021.06.021_bib9","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3390\/ijms17010014","article-title":"RUCAM in drug and herb induced liver injury: the update","volume":"17","author":"Danan","year":"2015","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jceh.2021.06.021_bib10","unstructured":"https:\/\/www.ayush.gov.in\/."},{"key":"10.1016\/j.jceh.2021.06.021_bib11","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4103\/0253-7613.42302","article-title":"Immunomodulatory effect of Tinospora cordifolia extract in human immuno-deficiency virus positive patients","volume":"40","author":"Kalikar","year":"2008","journal-title":"Indian J Pharmacol"},{"key":"10.1016\/j.jceh.2021.06.021_bib12","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s00253-018-9488-1","article-title":"Green synthesis of silver nanoparticles from medicinal plants and evaluation of their antiviral potential against chikungunya virus","volume":"103","author":"Sharma","year":"2019","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.jceh.2021.06.021_bib13","first-page":"5","article-title":"Immunotherapy with Tinospora cordifolia: a new lead in the management of obstructive jaundice","volume":"12","author":"Rege","year":"1993","journal-title":"Indian J Gastroenterol"},{"key":"10.1016\/j.jceh.2021.06.021_bib14","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12906-021-03251-z","article-title":"Case series and review of Ayurvedic medication induced liver injury","volume":"21","author":"Karousatos","year":"2021","journal-title":"BMC Complement Med Ther"},{"key":"10.1016\/j.jceh.2021.06.021_bib15","doi-asserted-by":"crossref","first-page":"324","DOI":"10.5604\/16652681.1235471","article-title":"Prospective Indian study of DILI with confirmed causality using the roussel Uclaf causality assessment method (RUCAM): a report of excellence","volume":"16","author":"Teschke","year":"2017","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.jceh.2021.06.021_bib16","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1007\/s10620-011-1611-4","article-title":"Drug-induced autoimmune-like hepatitis","volume":"56","author":"Czaja","year":"2011","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jceh.2021.06.021_bib17","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1002\/hep.23588","article-title":"Drug-induced autoimmune hepatitis: clinical characteristics and prognosis","volume":"51","author":"Bj\u00f6rnsson","year":"2010","journal-title":"Hepatol Baltim Md"},{"key":"10.1016\/j.jceh.2021.06.021_bib18","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/hep.23696","article-title":"Standardization of nomenclature and causality assessment in drug-induced liver injury: summary of a clinical research workshop","volume":"52","author":"Fontana","year":"2010","journal-title":"Hepatol Baltim Md"},{"key":"10.1016\/j.jceh.2021.06.021_bib19","article-title":"Use of natural compounds, chitin and tinosporin for the treatment of the targeted viruses (retroviruses) (HIV-1, HIV-2) all subgroups, HTLV and other viral disease","author":"Chetan","year":"2010","journal-title":"Indian patent App"},{"key":"10.1016\/j.jceh.2021.06.021_bib20","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0378-8741(97)00086-X","article-title":"Immunopotentiating compounds from Tinospora cordifolia","volume":"58","author":"Kapil","year":"1997","journal-title":"J\u00a0Ethnopharmacol"},{"key":"10.1016\/j.jceh.2021.06.021_bib21","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0378-8741(86)90025-5","article-title":"Immunomodulating agents of plant origin. I: preliminary screening","volume":"18","author":"Atal","year":"1986","journal-title":"J\u00a0Ethnopharmacol"},{"key":"10.1016\/j.jceh.2021.06.021_bib22","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jhep.2012.09.009","article-title":"Relapse is almost universal after withdrawal of immunosuppressive medication in patients with autoimmune hepatitis in remission","volume":"58","author":"van Gerven","year":"2013","journal-title":"J\u00a0Hepatol"}],"container-title":["Journal of Clinical and Experimental Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0973688321001651?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0973688321001651?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T06:06:55Z","timestamp":1760854015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0973688321001651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S0973688321001651"],"URL":"https:\/\/doi.org\/10.1016\/j.jceh.2021.06.021","relation":{},"ISSN":["0973-6883"],"issn-type":[{"value":"0973-6883","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Herbal Immune Booster-Induced Liver Injury in the COVID-19 Pandemic - A Case Series","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical and Experimental Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jceh.2021.06.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Indian National Association for Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}