{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:05:07Z","timestamp":1792263907367,"version":"4.4.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jcehepatology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical and Experimental Hepatology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.jceh.2021.08.010","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T06:35:02Z","timestamp":1629268502000},"page":"336-342","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Rifaximin Vs. Norfloxacin for Spontaneous Bacterial Peritonitis Prophylaxis: A Randomized Controlled Trial"],"prefix":"10.1016","volume":"12","author":[{"given":"Dibya L.","family":"Praharaj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhumita","family":"Premkumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nipun","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Taneja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Duseja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radha K.","family":"Dhiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jceh.2021.08.010_bib1","first-page":"1","article-title":"Antibiotics for prophylaxis of spontaneous bacterial peritonitis: systematic review & Bayesian network meta-analysis","author":"Soni","year":"2020","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jceh.2021.08.010_bib2","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/s41395-018-0168-7","article-title":"Daily norfloxacin vs. weekly ciprofloxacin to prevent spontaneous bacterial peritonitis: a randomized controlled trial","volume":"113","author":"Yim","year":"2018","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jceh.2021.08.010_bib3","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1136\/gut.2004.038679","article-title":"Sepsis in cirrhosis: report on the 7th meeting of the international ascites club","volume":"54","author":"Wong","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.jceh.2021.08.010_bib4","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jhep.2018.03.024","article-title":"EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis","volume":"69","year":"2018","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jceh.2021.08.010_bib5","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/apt.14361","article-title":"Systematic review with meta-analysis: rifaximin for the prophylaxis of spontaneous bacterial peritonitis","volume":"46","author":"Goel","year":"2017","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jceh.2021.08.010_bib6","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1097\/MEG.0000000000001446","article-title":"Norfloxacin, ciprofloxacin, trimethoprim\u2013sulfamethoxazole, and rifaximin for the prevention of spontaneous bacterial peritonitis: a network meta-analysis","volume":"31","author":"Wang","year":"2019","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.jceh.2021.08.010_bib7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/MOG.0b013e328333dc8d","article-title":"Rifaximin: a unique gastrointestinalselective antibiotic for enteric diseases","volume":"26","author":"Koo","year":"2010","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.jceh.2021.08.010_bib8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.7326\/0003-4819-117-3-215","article-title":"The serum-ascites albumin gradient is superior\u00a0to the exudate-transudate concept in the differential\u00a0diagnosis of ascites","volume":"117","author":"Runyon","year":"1992","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jceh.2021.08.010_bib9","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.jhep.2010.05.004","article-title":"EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis","volume":"53","year":"2010","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jceh.2021.08.010_bib10","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s12072-019-09946-3","article-title":"Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update","volume":"13","author":"Sarin","year":"2019","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jceh.2021.08.010_bib11","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1097\/MEG.0000000000000724","article-title":"Randomized-controlled trial of rifaximin versus norfloxacin for secondary prophylaxis of spontaneous bacterial peritonitis","volume":"28","author":"Elfert","year":"2016","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.jceh.2021.08.010_bib12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ajme.2015.09.002","article-title":"Rifaximin: a reasonable alternative for norfloxacin in the prevention of spontaneous bacterial peritonitis in patients with HCV-related liver cirrhosis","volume":"52","author":"Shamseya","year":"2016","journal-title":"Alexandria J Med"},{"key":"10.1016\/j.jceh.2021.08.010_bib13","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/apt.12797","article-title":"Prevalence and in-hospital mortality trends of infections among patients with cirrhosis: a nationwide study of hospitalised patients in the United States","volume":"40","author":"Singal","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jceh.2021.08.010_bib14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/hep.1840080107","article-title":"Recurrence of spontaneous bacterial peritonitis in cirrhosis: frequency and predictive factors","volume":"8","author":"Tit\u00f3","year":"1988","journal-title":"Hepatology"},{"key":"10.1016\/j.jceh.2021.08.010_bib15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/apt.12803","article-title":"Systematic review with meta-analysis: the effects of rifaximin in hepatic encephalopathy","volume":"40","author":"Kimer","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jceh.2021.08.010_bib16","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s12072-015-9688-z","article-title":"Efficacy and safety of alternating norfloxacin and rifaximin as primary prophylaxis for spontaneous bacterial peritonitis in cirrhotic ascites: a prospective randomized open-label comparative multicenter study","volume":"10","author":"Assem","year":"2016","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jceh.2021.08.010_bib17","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/j.1469-0691.2004.00997.x","article-title":"Influence of rifaximin treatment on the susceptibility of intestinal Gram-negative flora and enterococci","volume":"10","author":"DuPont","year":"2004","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jceh.2021.08.010_bib18","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1097\/MEG.0000000000000940","article-title":"Rifaximin for the prevention of spontaneous bacterial peritonitis and hepatorenal syndrome in cirrhosis: a systematic review and meta-analysis","volume":"29","author":"Kamal","year":"2017","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.jceh.2021.08.010_bib19","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/MCG.0b013e3182506dbb","article-title":"The role of rifaximin in the primary prophylaxis of spontaneous bacterial peritonitis in patients with liver cirrhosis","volume":"46","author":"Hanouneh","year":"2012","journal-title":"J\u00a0Clin Gastroenterol"}],"container-title":["Journal of Clinical and Experimental Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0973688321002152?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0973688321002152?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T06:09:09Z","timestamp":1760854149000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0973688321002152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S0973688321002152"],"URL":"https:\/\/doi.org\/10.1016\/j.jceh.2021.08.010","relation":{},"ISSN":["0973-6883"],"issn-type":[{"value":"0973-6883","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rifaximin Vs. Norfloxacin for Spontaneous Bacterial Peritonitis Prophylaxis: A Randomized Controlled Trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical and Experimental Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jceh.2021.08.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Indian National Association for Study of the Liver. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}