{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T09:17:17Z","timestamp":1784279837721,"version":"3.55.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jcehepatology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical and Experimental Hepatology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jceh.2023.08.010","type":"journal-article","created":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T02:13:46Z","timestamp":1694225626000},"page":"101274","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Neutrophil Gelatinase\u2013associated Lipocalin Predicts Short-term Outcomes in Decompensated Cirrhosis With Acute Kidney Injury"],"prefix":"10.1016","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7579-6822","authenticated-orcid":false,"given":"Kshitiz","family":"Sharan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9841-8768","authenticated-orcid":false,"given":"Anand","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyavati","family":"Rana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itish","family":"Patnaik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6641-2505","authenticated-orcid":false,"given":"Rohit","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jceh.2023.08.010_bib1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.cgh.2010.11.038","article-title":"Renal dysfunction is the most important independent predictor of mortality in cirrhotic patients with spontaneous bacterial peritonitis","volume":"9","author":"Tandon","year":"2011","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jceh.2023.08.010_bib2","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1002\/hep.25735","article-title":"Association of AKI with mortality and complications in hospitalized patients with cirrhosis","volume":"57","author":"Belcher","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jceh.2023.08.010_bib3","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1053\/j.gastro.2010.07.043","article-title":"Prognostic importance of the cause of renal failure in patients with cirrhosis","volume":"140","author":"Mart\u00edn\u2013Llah\u00ed","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jceh.2023.08.010_bib4","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1590\/s0004-2803.201800000-71","article-title":"Recommendations of the Brazilian Society of Hepatology for the management of acute kidney injury in patients with cirrhosis","volume":"55","author":"Terra","year":"2018","journal-title":"Arq Gastroenterol"},{"key":"10.1016\/j.jceh.2023.08.010_bib5","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.jhep.2011.10.016","article-title":"Renal failure and cirrhosis: a systematic review of mortality and prognosis","volume":"56","author":"Fede","year":"2012","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jceh.2023.08.010_bib6","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/gastro\/gox009","article-title":"Renal dysfunction in cirrhosis: acute kidney injury and the hepatorenal syndrome","volume":"5","author":"Bucsics","year":"2017","journal-title":"Gastroenterol Rep"},{"key":"10.1016\/j.jceh.2023.08.010_bib7","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.jhep.2009.11.025","article-title":"The evaluation of renal function and disease in patients with cirrhosis","volume":"52","author":"Francoz","year":"2010","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jceh.2023.08.010_bib8","series-title":"Brenner and Rector's the Kidney","article-title":"Laboratory assessment of kidney disease: glomerular filtration rate, urinalysis, and proteinuria","author":"Krishnan","year":"2020"},{"key":"10.1016\/j.jceh.2023.08.010_bib9","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.jhep.2016.05.025","article-title":"Kidney biomarkers in cirrhosis","volume":"65","author":"Francoz","year":"2016","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jceh.2023.08.010_bib10","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1053\/j.gastro.2013.02.042","article-title":"Acute-on chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis","volume":"144","author":"Moreau","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jceh.2023.08.010_bib11","doi-asserted-by":"crossref","first-page":"c179","DOI":"10.1159\/000339789","article-title":"KDIGO clinical practice guidelines for acute kidney injury","volume":"120","author":"Khwaja","year":"2012","journal-title":"Nephron Clin Pract"},{"key":"10.1016\/j.jceh.2023.08.010_bib12","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.jhep.2019.07.002","article-title":"News in pathophysiology, definition and classification of hepatorenal syndrome: a step beyond the International Club of Ascites (ICA) consensus document","volume":"71","author":"Angeli","year":"2019","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jceh.2023.08.010_bib13","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1681\/ASN.2007080913","article-title":"Acute tubular necrosis is a syndrome of physiologic and pathologic dissociation","volume":"19","author":"Rosen","year":"2008","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.jceh.2023.08.010_bib14","first-page":"85","article-title":"Acute kidney injury: definition, pathophysiology and clinical phenotypes","volume":"37","author":"Makris","year":"2016","journal-title":"Clin Biochem Rev"},{"key":"10.1016\/j.jceh.2023.08.010_bib15","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jhep.2012.03.015","article-title":"Urinary neutrophil gelatinase-associated lipocalin as biomarker in the differential diagnosis of impairment of kidney function in cirrhosis","volume":"57","author":"Fagundes","year":"2012","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jceh.2023.08.010_bib16","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1053\/jhep.2001.22172","article-title":"A\u00a0model to predict survival in patients with end-stage liver disease","volume":"33","author":"Kamath","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.jceh.2023.08.010_bib17","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/liv.12683","article-title":"CLIF-SOFA scoring system accurately predicts short-term mortality in acutely decompensated patients with alcoholic cirrhosis: a retrospective analysis","volume":"35","author":"Lee","year":"2015","journal-title":"Liver Int"},{"key":"10.1016\/j.jceh.2023.08.010_bib18","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S1097-2765(02)00708-6","article-title":"The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition","volume":"10","author":"Goetz","year":"2002","journal-title":"Mol Cell"},{"key":"10.1016\/j.jceh.2023.08.010_bib19","first-page":"526","article-title":"Neutrophil gelatinase-associated lipocalin","volume":"16","author":"Haase","year":"2010","journal-title":"Curr Opin Crit Care"},{"key":"10.1016\/j.jceh.2023.08.010_bib20","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ccc.2010.12.003","article-title":"Neutrophil gelatinase\u2013associated lipocalin (NGAL) as a biomarker for early acute kidney injury","volume":"27","author":"Shemin","year":"2011","journal-title":"Crit Care Clin"},{"key":"10.1016\/j.jceh.2023.08.010_bib21","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/apha.12054","article-title":"Neutrophil gelatinase-associated lipocalin: pathophysiology and clinical applications","volume":"207","author":"Singer","year":"2013","journal-title":"Acta Physiol"},{"key":"10.1016\/j.jceh.2023.08.010_bib22","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.1097\/01.ASN.0000145013.44578.45","article-title":"Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin","volume":"15","author":"Mishra","year":"2004","journal-title":"Am Soc Nephrol"},{"key":"10.1016\/j.jceh.2023.08.010_bib23","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/hep.510240527","article-title":"Transjugular renal biopsy in the treatment of patients with cirrhosis and renal abnormalities","volume":"24","author":"Jouet","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.jceh.2023.08.010_bib24","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/ki.2013.78","article-title":"Bile cast nephropathy is a common pathologic finding for kidney injury associated with severe liver dysfunction","volume":"84","author":"Van Slambrouck","year":"2013","journal-title":"Kidney Int"},{"key":"10.1016\/j.jceh.2023.08.010_bib25","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1478-3231.2009.02182.x","article-title":"The spectrum of renal lesions in patients with cirrhosis: a clinicopathological study","volume":"30","author":"Trawal\u00e9","year":"2010","journal-title":"Liver Int"},{"key":"10.1016\/j.jceh.2023.08.010_bib26","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/hep.26980","article-title":"TRIBE-AKI Consortium. Kidney biomarkers and differential diagnosis of patients with cirrhosis and acute kidney injury","volume":"60","author":"Belcher","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jceh.2023.08.010_bib27","doi-asserted-by":"crossref","DOI":"10.14309\/ctg.0000000000000359","article-title":"Urinary NGAL as a diagnostic and prognostic marker for acute kidney injury in cirrhosis: a prospective study","volume":"12","author":"Allegretti","year":"2021","journal-title":"Clin Transl Gastroenterol"},{"key":"10.1016\/j.jceh.2023.08.010_bib28","doi-asserted-by":"crossref","first-page":"391","DOI":"10.4103\/ijn.IJN_254_19","article-title":"Utility of Urinary Neutrophil gelatinase associated lipocalin (NGAL) in decompensated cirrhosis","volume":"30","author":"Reddy","year":"2020","journal-title":"Indian J Nephrol"},{"key":"10.1016\/j.jceh.2023.08.010_bib29","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1002\/jgh3.12377","article-title":"Urinary neutrophil gelatinase-associated lipocalin determines short-term mortality and type of acute kidney injury in cirrhosis","volume":"4","author":"Rathi","year":"2020","journal-title":"JGH Open"},{"key":"10.1016\/j.jceh.2023.08.010_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12876-015-0372-5","article-title":"Urine neutrophil gelatinase-associated lipocalin: a diagnostic and prognostic marker for acute kidney injury (AKI) in hospitalized cirrhotic patients with AKI-prone conditions","volume":"15","author":"Treeprasertsuk","year":"2015","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.jceh.2023.08.010_bib31","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.cgh.2016.11.035","article-title":"Urine interleukin 18 and lipocalin 2 are biomarkers of acute tubular necrosis in patients with cirrhosis: a systematic review and meta-analysis","volume":"15","author":"Puthumana","year":"2017","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jceh.2023.08.010_bib32","doi-asserted-by":"crossref","first-page":"337","DOI":"10.5935\/0101-2800.20120022","article-title":"Early initiation of dialysis: mortality and renal function recovery in acute kidney injury patients","volume":"34","author":"Nascimento","year":"2012","journal-title":"Braz J Nephrol"},{"key":"10.1016\/j.jceh.2023.08.010_bib33","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s001340050956","article-title":"Outcome in post-traumatic acute renal failure when continuous renal replacement therapy is applied early vs. late","volume":"25","author":"Gettings","year":"1999","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jceh.2023.08.010_bib34","doi-asserted-by":"crossref","first-page":"744","DOI":"10.7326\/0003-4819-137-9-200211050-00010","article-title":"Diagnosis and treatment of acute tubular necrosis","volume":"137","author":"Esson","year":"2002","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jceh.2023.08.010_bib35","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/liv.12232","article-title":"Neutrophil gelatinase-associated lipocalin in prediction of mortality in patients with hepatorenal syndrome: a prospective observational study","volume":"34","author":"Gungor","year":"2014","journal-title":"Liver Int"},{"key":"10.1016\/j.jceh.2023.08.010_bib36","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/nep.13226","article-title":"Biomarkers for acute kidney injury in decompensated cirrhosis: a prospective study","volume":"24","author":"Jaques","year":"2019","journal-title":"Nephrol"},{"key":"10.1016\/j.jceh.2023.08.010_bib37","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1007\/s10620-012-2180-x","article-title":"Urinary neutrophil gelatinase-associated lipocalin predicts mortality and identifies acute kidney injury in cirrhosis","volume":"57","author":"Verna","year":"2012","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jceh.2023.08.010_bib38","doi-asserted-by":"crossref","first-page":"155","DOI":"10.5604\/01.3001.0012.7907","article-title":"Serum NGAL is superior to cystatin C in predicting the prognosis of acute-on-chronic liver failure","volume":"18","author":"Lu","year":"2019","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.jceh.2023.08.010_bib39","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s12072-015-9653-x","article-title":"AKI in patients with acute on chronic liver failure is different from acute decompensation of cirrhosis","volume":"9","author":"Maiwall","year":"2015","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jceh.2023.08.010_bib40","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/aas.12427","article-title":"Predictive value of NGAL for use of renal replacement therapy in patients with severe sepsis","volume":"59","author":"Hjortrup","year":"2015","journal-title":"Acta Anaesthesiolog Scand"},{"key":"10.1016\/j.jceh.2023.08.010_bib41","doi-asserted-by":"crossref","first-page":"665","DOI":"10.2215\/CJN.04010907","article-title":"Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study","volume":"3","author":"Bennett","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.jceh.2023.08.010_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12882-020-01799-5","article-title":"Serum levels of neutrophil Gelatinase associated Lipocalin (NGAL) predicts hemodialysis after coronary angiography in high risk patients with acute coronary syndrome","volume":"21","author":"Reyes","year":"2020","journal-title":"BMC Nephrol"}],"container-title":["Journal of Clinical and Experimental Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0973688323006953?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0973688323006953?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T06:10:57Z","timestamp":1760854257000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0973688323006953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S0973688323006953"],"URL":"https:\/\/doi.org\/10.1016\/j.jceh.2023.08.010","relation":{},"ISSN":["0973-6883"],"issn-type":[{"value":"0973-6883","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neutrophil Gelatinase\u2013associated Lipocalin Predicts Short-term Outcomes in Decompensated Cirrhosis With Acute Kidney Injury","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical and Experimental Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jceh.2023.08.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Indian National Association for Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101274"}}