{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:33:43Z","timestamp":1786991623266,"version":"build-2736575974"},"reference-count":28,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003035","name":"Aase and Ejnar Danielsens Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","jcehepatology.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical and Experimental Hepatology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jceh.2024.102424","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T20:20:34Z","timestamp":1728591634000},"page":"102424","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["The FGL-1\/LAG-3 Axis is Associated With Disease Course in Alcohol-associated Hepatitis: A Preliminary Report"],"prefix":"10.1016","volume":"15","author":[{"given":"Lasse","family":"Pedersen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2610-2051","authenticated-orcid":false,"given":"Lotte L.","family":"Eriksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik H.","family":"Brix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Vilstrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bent","family":"Deleuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas D.","family":"Sandahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidsel","family":"St\u00f8y","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jceh.2024.102424_bib1","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1056\/NEJMra0805786","article-title":"Alcoholic hepatitis","volume":"360","author":"Lucey","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jceh.2024.102424_bib2","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.jhep.2010.07.016","article-title":"Incidence and mortality of alcoholic hepatitis in Denmark 1999-2008: a nationwide population based cohort study","volume":"54","author":"Sandahl","year":"2011","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jceh.2024.102424_bib3","article-title":"Alcohol-related liver disease: basic mechanisms and clinical perspectives","volume":"22","author":"Liu","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jceh.2024.102424_bib4","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1053\/j.gastro.2014.10.042","article-title":"Gut\u2013liver Axis in alcoholic liver disease","volume":"148","author":"Szabo","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jceh.2024.102424_bib5","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jhep.2018.10.026","article-title":"Current trials and novel therapeutic targets for alcoholic hepatitis","volume":"70","author":"Singal","year":"2019","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jceh.2024.102424_bib6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41575-018-0099-1","article-title":"Alcohol, liver disease and the gut microbiota","volume":"16","author":"Bajaj","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jceh.2024.102424_bib7","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.gastha.2022.03.005","article-title":"Cirrhosis-based acute-on-chronic liver failure is marked by inflammation and impaired liver regeneration despite Stat3 activation","volume":"1","author":"Lange","year":"2022","journal-title":"Gastro Hep Advances"},{"key":"10.1016\/j.jceh.2024.102424_bib8","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.bbrc.2007.11.069","article-title":"Fibrinogen-like protein 1, a hepatocyte derived protein is an acute phase reactant","volume":"365","author":"Liu","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jceh.2024.102424_bib9","doi-asserted-by":"crossref","first-page":"13335","DOI":"10.1074\/jbc.M806393200","article-title":"Specific expression and regulation of hepassocin in the liver and down-regulation of the correlation of HNF1alpha with decreased levels of hepassocin in human hepatocellular carcinoma","volume":"284","author":"Yu","year":"2009","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jceh.2024.102424_bib10","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/j.cellsig.2014.04.013","article-title":"Hepassocin activates the EGFR\/ERK cascade and induces proliferation of L02 cells through the Src-dependent pathway","volume":"26","author":"Gao","year":"2014","journal-title":"Cell Signal"},{"key":"10.1016\/j.jceh.2024.102424_bib11","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1136\/gut.2008.171124","article-title":"Recombinant human hepassocin stimulates proliferation of hepatocytes in\u00a0vivo and improves survival in rats with fulminant hepatic failure","volume":"59","author":"Li","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.jceh.2024.102424_bib12","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jhep.2015.04.003","article-title":"Hepatic cell proliferation plays a pivotal role in the prognosis of alcoholic hepatitis","volume":"63","author":"Lanthier","year":"2015","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jceh.2024.102424_bib13","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.cell.2018.11.010","article-title":"Fibrinogen-like protein 1 is a major immune inhibitory ligand of LAG-3","volume":"176","author":"Wang","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jceh.2024.102424_bib14","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/imr.12519","article-title":"LAG3 (CD223) as a cancer immunotherapy target","volume":"276","author":"Andrews","year":"2017","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jceh.2024.102424_bib15","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.immuni.2016.05.001","article-title":"Lag-3, tim-3, and TIGIT: Co-inhibitory receptors with specialized functions in immune regulation","volume":"44","author":"Anderson","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.jceh.2024.102424_bib16","first-page":"269","article-title":"LAG-3 in cancer immunotherapy","volume":"344","author":"Goldberg","year":"2011","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.jceh.2024.102424_bib17","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.jhep.2013.06.004","article-title":"The role of hepassocin in the development of non-alcoholic fatty liver disease","volume":"59","author":"Wu","year":"2013","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jceh.2024.102424_bib18","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1038\/s41590-018-0217-9","article-title":"LAG-3 inhibits the activation of CD4(+) T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII","volume":"19","author":"Maruhashi","year":"2018","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jceh.2024.102424_bib19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0741-8329(02)00210-0","article-title":"Role of activated CD8+ T cells in the initiation and continuation of hepatic damage","volume":"27","author":"Jerrells","year":"2002","journal-title":"Alcohol"},{"key":"10.1016\/j.jceh.2024.102424_bib20","doi-asserted-by":"crossref","first-page":"G269","DOI":"10.1152\/ajpgi.00200.2014","article-title":"Cytotoxic T lymphocytes and natural killer cells display impaired cytotoxic functions and reduced activation in patients with alcoholic hepatitis","volume":"308","author":"Stoy","year":"2015","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jceh.2024.102424_bib21","doi-asserted-by":"crossref","DOI":"10.14309\/ctg.0000000000000197","article-title":"Low interleukin-22 binding protein is associated with high mortality in alcoholic hepatitis and modulates interleukin-22 receptor expression","volume":"11","author":"St\u00f8y","year":"2020","journal-title":"Clin Transl Gastroenterol"},{"key":"10.1016\/j.jceh.2024.102424_bib22","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0167-4781(00)00056-7","article-title":"Isolation and characterization of a novel liver-specific gene, hepassocin, upregulated during liver regeneration","volume":"1492","author":"Hara","year":"2000","journal-title":"Biochim Biophys Acta Gene Struct Expr"},{"key":"10.1016\/j.jceh.2024.102424_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222312886","article-title":"Recombinant human HPS protects mice and nonhuman primates from acute liver injury","volume":"22","author":"Yang","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jceh.2024.102424_bib24","article-title":"Protective role of hepassocin against hepatic endoplasmic reticulum stress in mice","volume":"23","author":"Yang","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jceh.2024.102424_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0058084","article-title":"Targeted deletion of fibrinogen like protein 1 reveals a novel role in energy substrate utilization","volume":"8","author":"Demchev","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jceh.2024.102424_bib26","article-title":"LAG3's enigmatic mechanism of action","volume":"11","author":"Graydon","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jceh.2024.102424_bib27","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1158\/2326-6066.CIR-19-0146","article-title":"PD-1 and LAG-3 dominate checkpoint receptor\u2013mediated T-cell inhibition in renal cell carcinoma","volume":"7","author":"Zelba","year":"2019","journal-title":"Cancer Immunol Res"},{"key":"10.1016\/j.jceh.2024.102424_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.632502","article-title":"Soluble TIM3 and its ligands galectin-9 and CEACAM1 are in disequilibrium during alcohol-related liver disease and promote impairment of anti-bacterial immunity","volume":"12","author":"Riva","year":"2021","journal-title":"Front Physiol"}],"container-title":["Journal of Clinical and Experimental Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0973688324010910?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0973688324010910?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T04:53:46Z","timestamp":1735102426000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0973688324010910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S0973688324010910"],"URL":"https:\/\/doi.org\/10.1016\/j.jceh.2024.102424","relation":{},"ISSN":["0973-6883"],"issn-type":[{"value":"0973-6883","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The FGL-1\/LAG-3 Axis is Associated With Disease Course in Alcohol-associated Hepatitis: A Preliminary Report","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical and Experimental Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jceh.2024.102424","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Indian National Association for Study of the Liver. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102424"}}