{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:52:56Z","timestamp":1777884776368,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100009104","name":"Department of Health Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009104","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["GIA \/2019\/00281\/PRCGIA"],"award-info":[{"award-number":["GIA \/2019\/00281\/PRCGIA"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jcehepatology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical and Experimental Hepatology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jceh.2025.103463","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T08:03:27Z","timestamp":1767945807000},"page":"103463","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Point-of-care Ultrasound (POCUS)-Guided Pragmatic Fluid and Albumin Resuscitation and Hemodynamic Monitoring in Cirrhosis and Septic Shock"],"prefix":"10.1016","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2961-4148","authenticated-orcid":false,"given":"Madhumita","family":"Premkumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3271-0122","authenticated-orcid":false,"given":"Kamal","family":"Kajal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7042-0129","authenticated-orcid":false,"given":"Anand","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manhal","family":"Izzy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akash","family":"Roy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhupendra","family":"Sihag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anand V.","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prerna","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anchal","family":"Sandhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harish","family":"Bhujade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sekar","family":"Loganathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nipun","family":"Verma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3901-6969","authenticated-orcid":false,"given":"Sunil","family":"Taneja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay K.","family":"Duseja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3960-6133","authenticated-orcid":false,"given":"Smita","family":"Divyaveer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6180-3312","authenticated-orcid":false,"given":"Mohammed U.","family":"Ashraf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.P.","family":"Ganesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankur","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Bahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Rajender Reddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jceh.2025.103463_bib1","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1056\/NEJMra2021808","article-title":"The evolving challenge of infections in cirrhosis","volume":"384","author":"Bajaj","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jceh.2025.103463_bib2","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1002\/hep.31884","article-title":"Diagnosis, evaluation, and management of ascites, spontaneous bacterial peritonitis and hepatorenal syndrome: 2021 practice guidance by the American association for the study of liver diseases","volume":"74","author":"Biggins","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jceh.2025.103463_bib3","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/apt.17695","article-title":"Cirrhotic cardiomyopathy influences clinical outcomes and enhances performance of conventional risk prediction models in acute-on-chronic liver failure with severe sepsis","volume":"58","author":"Kajal","year":"2023","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jceh.2025.103463_bib4","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1111\/apt.18016","article-title":"Review article: evaluation and care of the critically ill patient with cirrhosis","volume":"59","author":"Kosuta","year":"2024","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jceh.2025.103463_bib5","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1007\/s00134-016-4500-7","article-title":"Restricting volumes of resuscitation fluid in adults with septic shock after initial management: the CLASSIC randomised, parallel-group, multicentre feasibility trial","volume":"42","author":"Hjortrup","year":"2016","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jceh.2025.103463_bib6","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jhep.2023.02.024","article-title":"Fluid resuscitation in patients with cirrhosis and sepsis: a multidisciplinary perspective","volume":"79","author":"Durand","year":"2023","journal-title":"J Hepatol"},{"key":"10.1016\/j.jceh.2025.103463_bib7","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000517363","article-title":"Albumin infusion in patients with cirrhosis: time for POCUS-enhanced physical examination","volume":"11","author":"Koratala","year":"2021","journal-title":"Cardiorenal Med"},{"key":"10.1016\/j.jceh.2025.103463_bib8","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1177\/0885066620988281","article-title":"Point-of-Care echocardiography and hemodynamic monitoring in cirrhosis and acute-on-chronic liver failure in the COVID-19 era","volume":"36","author":"Premkumar","year":"2021","journal-title":"J Intensive Care Med"},{"key":"10.1016\/j.jceh.2025.103463_bib9","article-title":"Role of point-of-care ultrasound (POCUS) in clinical hepatology","author":"Premkumar","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.jceh.2025.103463_bib10","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/MOT.0b013e32832d927d","article-title":"Intraoperative hemodynamic monitoring during organ transplantation: what is new?","volume":"14","author":"Della","year":"2009","journal-title":"Curr Opin Organ Transplant"},{"key":"10.1016\/j.jceh.2025.103463_bib11","doi-asserted-by":"crossref","first-page":"323","DOI":"10.5603\/AIT.2014.0056","article-title":"Ten good reasons to practice ultrasound in critical care","volume":"46","author":"Lichtenstein","year":"2014","journal-title":"Anaesthesiol Intensive Ther"},{"key":"10.1016\/j.jceh.2025.103463_bib12","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/aas.14074","article-title":"Kinetics of 5% and 20% albumin: a controlled crossover trial in volunteers","volume":"66","author":"Zdolsek","year":"2022","journal-title":"Acta Anaesthesiol Scand"},{"issue":"S","key":"10.1016\/j.jceh.2025.103463_bib13","first-page":"s18","article-title":"Clinical use of albumin","volume":"11","author":"Caraceni","year":"2013","journal-title":"Blood Transfus"},{"key":"10.1016\/j.jceh.2025.103463_bib14","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1186\/s13054-023-04587-3","article-title":"Identification of indications for albumin administration in septic patients with liver cirrhosis","volume":"27","author":"Hu","year":"2023","journal-title":"Crit Care"},{"key":"10.1016\/j.jceh.2025.103463_bib15","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1055\/s-0038-1672139","article-title":"Shock etiologies and fluid management in liver failure","volume":"39","author":"Weiss","year":"2018","journal-title":"Semin Respir Crit Care Med"},{"key":"10.1016\/j.jceh.2025.103463_bib16","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1056\/NEJMoa1305727","article-title":"Albumin replacement in patients with severe sepsis or septic shock","volume":"370","author":"Caironi","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jceh.2025.103463_bib17","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.jhep.2022.03.043","article-title":"A randomized-controlled trial comparing 20% albumin to plasmalyte in patients with cirrhosis and sepsis-induced hypotension [ALPS trial]","volume":"77","author":"Maiwall","year":"2022","journal-title":"J Hepatol"},{"key":"10.1016\/j.jceh.2025.103463_bib18","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s13054-024-04952-w","article-title":"Protocolized reduction of non-resuscitation fluids versus usual care in septic shock patients (REDUSE): a randomized multicentre feasibility trial","volume":"28","author":"Lind\u00e9n","year":"2024","journal-title":"Crit Care"},{"key":"10.1016\/j.jceh.2025.103463_bib19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s13613-024-01347-6","article-title":"Fluid boluses and infusions in the early phase of resuscitation from septic shock and sepsis-induced hypotension: a retrospective report and outcome analysis from a tertiary hospital","volume":"14","author":"Messina","year":"2024","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.jceh.2025.103463_bib20","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.jceh.2025.103463_bib21","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1097\/HEP.0000000000000691","article-title":"Evaluation of terlipressin-related patient outcomes in hepatorenal syndrome-acute kidney injury using point-of-care echocardiography","volume":"79","author":"Premkumar","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.jceh.2025.103463_bib22","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1378\/chest.07-2800","article-title":"Relevance of lung ultrasound in the diagnosis of acute respiratory failure: the BLUE protocol","volume":"134","author":"Lichtenstein","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.jceh.2025.103463_bib23","article-title":"Point-of-Care thoracic ultrasonography in patients with cirrhosis and liver failure","volume":"13","author":"Kajal","year":"2021","journal-title":"Cureus"},{"key":"10.1016\/j.jceh.2025.103463_bib24","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1001\/jama.2016.0289","article-title":"Developing a new definition and assessing new clinical criteria for septic shock: for the third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Shankar-Hari","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.jceh.2025.103463_bib25","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s12072-021-10164-z","article-title":"Comparison of 5% human albumin and normal saline for fluid resuscitation in sepsis induced hypotension among patients with cirrhosis (FRISC study): a randomized controlled trial","volume":"15","author":"Philips","year":"2021","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jceh.2025.103463_bib26","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1055\/a-2515-2783","article-title":"Current Concepts in Fluid Resuscitation and Vasopressor Use in Cirrhosis","volume":"45","author":"Premkumar","year":"2025","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jceh.2025.103463_bib27","doi-asserted-by":"crossref","DOI":"10.1097\/HEP.0000000000001524","article-title":"Point-of-care ultrasound (POCUS)-Guided volume management and the effect of cirrhotic cardiomyopathy on acute kidney injury outcomes in cirrhosis","author":"Premkumar","year":"2025","journal-title":"Hepatology"},{"key":"10.1016\/j.jceh.2025.103463_bib29","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/hep.30875","article-title":"Redefining cirrhotic cardiomyopathy for the modern era","volume":"71","author":"Izzy","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.jceh.2025.103463_bib30","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s13054-020-2819-5","article-title":"Effect of initial infusion rates of fluid resuscitation on outcomes in patients with septic shock: a historical cohort study","volume":"24","author":"Hu","year":"2020","journal-title":"Crit Care"},{"key":"10.1016\/j.jceh.2025.103463_bib31","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1136\/gut.2004.038679","article-title":"Sepsis in cirrhosis: report on the 7th meeting of the international ascites club","volume":"54","author":"Wong","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.jceh.2025.103463_bib32","doi-asserted-by":"crossref","first-page":"369","DOI":"10.5811\/westjem.2020.11.48571","article-title":"Randomized controlled trial of ultrasound-guided fluid resuscitation of sepsis-induced hypoperfusion and septic shock","volume":"22","author":"Musikatavorn","year":"2021","journal-title":"West J Emerg Med"},{"key":"10.1016\/j.jceh.2025.103463_bib33","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000027593","article-title":"Outcomes of septic cirrhosis patients admitted to the intensive care unit: a retrospective cohort study","volume":"100","author":"Chebl","year":"2021","journal-title":"Medicine (Baltim)"},{"issue":"S","key":"10.1016\/j.jceh.2025.103463_bib34","doi-asserted-by":"crossref","first-page":"S163","DOI":"10.1016\/j.jhep.2020.10.024","article-title":"Intensive care management of acute-on-chronic liver failure","volume":"75","author":"Bernal","year":"2021","journal-title":"J Hepatol"},{"key":"10.1016\/j.jceh.2025.103463_bib35","doi-asserted-by":"crossref","first-page":"497","DOI":"10.4254\/wjh.v15.i4.497","article-title":"Emerging concepts in the care of patients with cirrhosis and septic shock","volume":"15","author":"Jimenez","year":"2023","journal-title":"World J Hepatol"},{"key":"10.1016\/j.jceh.2025.103463_bib36","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1159\/000501299","article-title":"Point-of-Care echocardiography unveils misclassification of acute kidney injury as hepatorenal syndrome","volume":"50","author":"Velez","year":"2019","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.jceh.2025.103463_bib37","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1136\/gutjnl-2019-318843","article-title":"Albumin in decompensated cirrhosis: new concepts and perspectives","volume":"69","author":"Bernardi","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.jceh.2025.103463_bib38","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1097\/CCM.0000000000004617","article-title":"Fluid overload and mortality in adult critical care Patients-A systematic review and meta-analysis of observational studies","volume":"48","author":"Messmer","year":"2020","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jceh.2025.103463_bib39","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1056\/NEJMoa2022166","article-title":"A randomized trial of albumin infusions in hospitalized patients with cirrhosis","volume":"384","author":"China","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jceh.2025.103463_bib40","article-title":"Use of albumin infusion for cirrhosis-related complications: an international position statement","volume":"5","author":"Bai","year":"2023","journal-title":"JHEP Rep"},{"key":"10.1016\/j.jceh.2025.103463_bib41","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/00024382-200013010-00009","article-title":"Prevention of early myocardial depression in hyperdynamic endotoxemia in dogs","volume":"13","author":"Wolf\u00e1rd","year":"2000","journal-title":"Shock"},{"key":"10.1016\/j.jceh.2025.103463_bib42","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1002\/lt.26000","article-title":"Cirrhotic cardiomyopathy predicts posttransplant cardiovascular disease: revelations of the new diagnostic criteria","volume":"27","author":"Izzy","year":"2021","journal-title":"Liver Transpl"}],"container-title":["Journal of Clinical and Experimental Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0973688325009636?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0973688325009636?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:37:55Z","timestamp":1777603075000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0973688325009636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S0973688325009636"],"URL":"https:\/\/doi.org\/10.1016\/j.jceh.2025.103463","relation":{},"ISSN":["0973-6883"],"issn-type":[{"value":"0973-6883","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Point-of-care Ultrasound (POCUS)-Guided Pragmatic Fluid and Albumin Resuscitation and Hemodynamic Monitoring in Cirrhosis and Septic Shock","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical and Experimental Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jceh.2025.103463","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Indian National Association for Study of the Liver. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103463"}}