{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T14:52:08Z","timestamp":1781967128790,"version":"3.54.5"},"reference-count":23,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jcehepatology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical and Experimental Hepatology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jceh.2026.103521","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T07:48:40Z","timestamp":1771832920000},"page":"103521","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hepatic and Extra-hepatic Outcomes of Classical Galactosemia in Infants: A Longitudinal Observational Study"],"prefix":"10.1016","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1319-4222","authenticated-orcid":false,"given":"Nitu","family":"Kumari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2015-4069","authenticated-orcid":false,"given":"Moinak S.","family":"Sarma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0902-4140","authenticated-orcid":false,"given":"Anshu","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0584-1100","authenticated-orcid":false,"given":"Surender K.","family":"Yachha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ujjal","family":"Poddar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrita","family":"Mathias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jceh.2026.103521_bib1","doi-asserted-by":"crossref","first-page":"968","DOI":"10.3390\/biom12070968","article-title":"Galactosemia: biochemistry, molecular genetics, newborn screening, and treatment","volume":"12","author":"Succoio","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.jceh.2026.103521_bib2","doi-asserted-by":"crossref","first-page":"43885","DOI":"10.1074\/jbc.R300025200","article-title":"Structure and function of enzymes of the leloir pathway for galactose metabolism","volume":"278","author":"Holden","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jceh.2026.103521_bib3","first-page":"79","article-title":"Newborn screening for galactosemia in the United States: looking back, looking around, and looking ahead","volume":"15","author":"Pyhtila","year":"2015","journal-title":"JIMD Rep"},{"key":"10.1016\/j.jceh.2026.103521_bib4","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s00431-019-03328-5","article-title":"Metabolic liver diseases presenting with neonatal cholestasis: at the crossroad between old and new paradigms","volume":"178","author":"Moreira-Silva","year":"2019","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jceh.2026.103521_bib5","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10545-010-9213-4","article-title":"Voice disorders in children with classic galactosemia","volume":"34(2)","author":"Potter","year":"2011","journal-title":"J Inher Metab Dis"},{"key":"10.1016\/j.jceh.2026.103521_bib6","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/ajcn\/76.2.442","article-title":"Calcium and zinc absorption from lactose-containing and lactose-free infant formulas","volume":"76","author":"Abrams","year":"2002","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jceh.2026.103521_bib7","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1080\/07315724.2001.10719038","article-title":"Absorbability and cost effectiveness in calcium supplementation","volume":"20","author":"Heaney","year":"2001","journal-title":"J Am Coll Nutr"},{"key":"10.1016\/j.jceh.2026.103521_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/tropej\/fmu079","article-title":"Challenges in the diagnosis and management of neonatal sepsis","volume":"61","author":"Zea-Vera","year":"2015","journal-title":"J Trop Pediatr"},{"key":"10.1016\/j.jceh.2026.103521_bib9","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.jhep.2015.06.019","article-title":"Safety, Complications and outcome of large volume paracentesis with or without albumin therapy in children with severe ascites due to liver disease","volume":"63","author":"Sen Sarma","year":"2015","journal-title":"J Hepatol"},{"key":"10.1016\/j.jceh.2026.103521_bib10","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.jhep.2015.05.022","article-title":"Expanding consensus in portal hypertension: report of the baveno VI consensus workshop: stratifying risk and individualizing care for portal hypertension","volume":"63","author":"de Franchis","year":"2015","journal-title":"J Hepatol"},{"key":"10.1016\/j.jceh.2026.103521_bib11","first-page":"203","article-title":"Classical galactosemia among Indian children: presentation and outcome from a pediatric gastroenterology center","volume":"53","author":"SenSarma","year":"2016","journal-title":"Indian Pediatr"},{"key":"10.1016\/j.jceh.2026.103521_bib12","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s13312-014-0375-2","article-title":"Management of neonatal cholestasis: consensus statement of the pediatric gastroenterology chapter of Indian academy of pediatrics","volume":"51","author":"Bhatia","year":"2014","journal-title":"Indian Pediatr"},{"key":"10.1016\/j.jceh.2026.103521_bib13","first-page":"26","article-title":"Neonatal cholestasis syndrome due to galactosemia","volume":"15","author":"Kumar","year":"1996","journal-title":"Ind J Gastroenterol"},{"key":"10.1016\/j.jceh.2026.103521_bib14","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13023-019-1047-z","article-title":"The natural history of classic galactosemia: lessons from the GalNet registry","volume":"14","author":"Rubio-Gozalbo","year":"2019","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.jceh.2026.103521_bib15","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1159\/000153463","article-title":"Polymorphism of erythrocyte Galactose-1-Phosphate Uridyl-Transferase in Italy: segregation analysis in 693 families","volume":"34","author":"Vaccaro","year":"1984","journal-title":"Hum Hered"},{"key":"10.1016\/j.jceh.2026.103521_bib16","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/0003-9861(78)90351-X","article-title":"Effect of galactose on free radical reactions of polymorphonuclear leukocytes","volume":"188","author":"Litchfield","year":"1978","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jceh.2026.103521_bib17","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1056\/NEJM197710132971510","article-title":"Sepsis due to Escherichia coli in neonates with galactosemia","volume":"297","author":"Levy","year":"1977","journal-title":"New Eng J Med"},{"key":"10.1016\/j.jceh.2026.103521_bib18","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10545-016-9990-5","article-title":"Galactosemia network (GalNet). International clinical guideline for the management of classical galactosemia: diagnosis, treatment, and follow-up","volume":"40","author":"Welling","year":"2017","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.jceh.2026.103521_bib19","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10545-017-0029-3","article-title":"Sweet and sour; an update on classic galactosemia","volume":"40","author":"Cohello","year":"2017","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.jceh.2026.103521_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ymgme.2023.107708","article-title":"Long-term complications in classic galactosemia are not progressive","volume":"140","author":"Smith","year":"2023","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.jceh.2026.103521_bib21","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00431-006-0255-4","article-title":"Growth in treated classical galactosemia patients","volume":"166","author":"Panis","year":"2007","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jceh.2026.103521_bib22","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cca.2012.09.017","article-title":"Biochemical and molecular characterization of GALT gene from Indian galactosemia patients: identification of 10 novel mutations and their structural and functional implications","volume":"414","author":"Singh","year":"2012","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jceh.2026.103521_bib23","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1007\/BF01800204","article-title":"Long-term prognosis in galactosaemia: results of a survey of 350 cases","volume":"13","author":"Waggoner","year":"1990","journal-title":"J Inherit Metab Dis"}],"container-title":["Journal of Clinical and Experimental Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0973688326000538?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0973688326000538?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T14:34:11Z","timestamp":1781966051000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0973688326000538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S0973688326000538"],"URL":"https:\/\/doi.org\/10.1016\/j.jceh.2026.103521","relation":{},"ISSN":["0973-6883"],"issn-type":[{"value":"0973-6883","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatic and Extra-hepatic Outcomes of Classical Galactosemia in Infants: A Longitudinal Observational Study","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical and Experimental Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jceh.2026.103521","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Indian National Association for Study of the Liver. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103521"}}