{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T21:33:25Z","timestamp":1786484005342,"version":"build-2736575974"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008322","name":"CSL Behring LLC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006251","name":"Universit\u00e9 de Bordeaux","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006251","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jcehepatology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical and Experimental Hepatology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jceh.2026.103545","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T06:17:14Z","timestamp":1775197034000},"page":"103545","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Alpha-1 Antitrypsin Deficiency Alleles in Non-Cirrhotic Hepatocellular Carcinoma: Insights from a Multicenter French Cohort"],"prefix":"10.1016","volume":"16","author":[{"given":"Aur\u00e9lie","family":"Beaufr\u00e8re","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Leon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3304-2106","authenticated-orcid":false,"given":"Marie","family":"Decreaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5401-3767","authenticated-orcid":false,"given":"Laurent","family":"Possenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9409-2887","authenticated-orcid":false,"given":"Manon","family":"Evain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Coilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6728-9246","authenticated-orcid":false,"given":"Carolin V.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zo\u00e9","family":"Feurer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6120-1098","authenticated-orcid":false,"given":"Marie-Fran\u00e7oise","family":"Odou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malika","family":"Balduyck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Payanc\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai M.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulette","family":"Bioulac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fr\u00e9d\u00e9ric","family":"Blanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Le Bail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Guettier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Amintas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9233-4152","authenticated-orcid":false,"given":"Marion","family":"Bouchecareilh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jceh.2026.103545_bib1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41572-020-00240-3","article-title":"Hepatocellular carcinoma","volume":"7","author":"Llovet","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jceh.2026.103545_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jviscsurg.2010.12.012","article-title":"Hepatocellular cancer in the non-cirrhotic liver","volume":"148","author":"Alkofer","year":"2011","journal-title":"J Vis Surg"},{"key":"10.1016\/j.jceh.2026.103545_bib3","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1053\/j.gastro.2004.09.020","article-title":"Alcohol and hepatocellular carcinoma","volume":"127","author":"Morgan","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jceh.2026.103545_bib4","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgast-2018-000260","article-title":"Alcohol and hepatocellular carcinoma","volume":"6","author":"Matsushita","year":"2019","journal-title":"BMJ Open Gastroenterol"},{"key":"10.1016\/j.jceh.2026.103545_bib5","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1056\/NEJMra1910234","article-title":"Alpha(1)-Antitrypsin deficiency","volume":"382","author":"Strnad","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jceh.2026.103545_bib6","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1055\/a-2122-7674","article-title":"Pediatric and adult liver disease in Alpha-1 antitrypsin deficiency","volume":"43","author":"Ruiz","year":"2023","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jceh.2026.103545_bib7","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.jhep.2021.11.022","article-title":"Alpha-1 antitrypsin deficiency: a re-surfacing adult liver disorder","volume":"76","author":"Fromme","year":"2022","journal-title":"J Hepatol"},{"key":"10.1016\/j.jceh.2026.103545_bib8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1177\/1753465812457113","article-title":"Prevalence of alpha1-antitrypsin deficiency alleles PI\u2217S and PI\u2217Z worldwide and effective screening for each of the five phenotypic classes PI\u2217MS, PI\u2217MZ, PI\u2217SS, PI\u2217SZ, and PI\u2217ZZ: a comprehensive review","volume":"6","author":"de Serres","year":"2012","journal-title":"Ther Adv Respir Dis"},{"key":"10.1016\/j.jceh.2026.103545_bib9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1183\/09031936.06.00062305","article-title":"Estimated numbers and prevalence of PI\u2217S and PI\u2217Z alleles of alpha1-antitrypsin deficiency in European countries","volume":"27","author":"Blanco","year":"2006","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jceh.2026.103545_bib10","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0954-6111(98)90278-5","article-title":"Alpha 1-antitrypsin deficiency in Europe: geographical distribution of Pi types S and Z","volume":"92","author":"Hutchison","year":"1998","journal-title":"Respir Med"},{"key":"10.1016\/j.jceh.2026.103545_bib11","article-title":"Alpha-1 antitrypsin deficiency-mediated liver toxicity: why do some patients do poorly? What do we know So far? Chronic","volume":"7","author":"Bouchecareilh","year":"2020","journal-title":"Obstr Pulm Dis"},{"key":"10.1016\/j.jceh.2026.103545_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.51","article-title":"alpha1-Antitrypsin deficiency","volume":"2","author":"Greene","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jceh.2026.103545_bib13","article-title":"Cancer risk in severe alpha-1 antitrypsin deficiency: the importance of early identification","volume":"60","author":"Hiller","year":"2022","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jceh.2026.103545_bib14","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00535-019-01548-y","article-title":"Liver disease in adults with severe alpha-1-antitrypsin deficiency","volume":"54","author":"Tanash","year":"2019","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.jceh.2026.103545_bib15","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/joim.20016","article-title":"Alpha-1 antitrypsin deficiency associated with increased risks of skin cancer, leukemia, and hepatic cancer: a nationwide cohort study","volume":"296","author":"Korsbaek","year":"2024","journal-title":"J Intern Med"},{"key":"10.1016\/j.jceh.2026.103545_bib16","article-title":"PiSS Alpha-1 antitrypsin deficiency: a clinical risk variant?","author":"Fraughen","year":"2023","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jceh.2026.103545_bib17","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s12931-024-02879-y","article-title":"Risk of lung disease in the PI\u2217SS genotype of alpha-1 antitrypsin: an EARCO research project","volume":"25","author":"Martin","year":"2024","journal-title":"Respir Res"},{"key":"10.1016\/j.jceh.2026.103545_bib18","doi-asserted-by":"crossref","first-page":"376","DOI":"10.5152\/TurkThoracJ.2022.22001","article-title":"Pulmonary function and respiratory diseases in different genotypes of Alpha-1 antitrypsin deficiency","volume":"23","author":"Hernandez Perez","year":"2022","journal-title":"Turk Thorac J"},{"key":"10.1016\/j.jceh.2026.103545_bib19","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2147\/COPD.S448593","article-title":"Alpha-1 antitrypsin gene variants in patients without severe deficiency diagnosed with pulmonary emphysema on chest CT","volume":"19","author":"Lavina","year":"2024","journal-title":"Int J Chronic Obstr Pulm Dis"},{"key":"10.1016\/j.jceh.2026.103545_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/cells12121663","article-title":"Increased prevalence of Alpha-1-Antitrypsin deficiency in patients with biliary tract cancer and its associated clinicopathological features","volume":"12","author":"Cornillet","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.jceh.2026.103545_bib21","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/his.13975","article-title":"The 2019 WHO classification of tumours of the digestive system","volume":"76","author":"Nagtegaal","year":"2020","journal-title":"Histopathology"},{"key":"10.1016\/j.jceh.2026.103545_bib22","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1002\/hep.25889","article-title":"Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients","volume":"56","author":"Bedossa","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jceh.2026.103545_bib23","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/apt.70183","article-title":"Underdiagnosis of Alpha-1 antitrypsin deficiency in cirrhotic liver transplant candidates: findings from a multicenter retrospective study","volume":"62","author":"Evain","year":"2025","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jceh.2026.103545_bib24","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1165\/rcmb.2017-0179OC","article-title":"Characterization of novel missense variants of SERPINA1 gene causing Alpha-1 antitrypsin deficiency","volume":"58","author":"Matamala","year":"2018","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jceh.2026.103545_bib25","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/s41588-025-02125-1","article-title":"Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency","volume":"57","author":"Brzozowska","year":"2025","journal-title":"Nat Genet"},{"key":"10.1016\/j.jceh.2026.103545_bib26","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/liv.12504","article-title":"Alpha-1-antitrypsin deficiency: from genoma to liver disease. PiZ mouse as model for the development of liver pathology in human","volume":"35","author":"Giovannoni","year":"2015","journal-title":"Liver Int"},{"key":"10.1016\/j.jceh.2026.103545_bib27","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1136\/gutjnl-2020-323729","article-title":"Hepatobiliary phenotypes of adults with alpha-1 antitrypsin deficiency","volume":"71","author":"Fromme","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.jceh.2026.103545_bib28","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1002\/hep.20118","article-title":"Analyses of hepatocellular proliferation in a mouse model of alpha-1-antitrypsin deficiency","volume":"39","author":"Rudnick","year":"2004","journal-title":"Hepatology"}],"container-title":["Journal of Clinical and Experimental Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0973688326000770?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0973688326000770?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T21:12:18Z","timestamp":1786482738000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0973688326000770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0973688326000770"],"URL":"https:\/\/doi.org\/10.1016\/j.jceh.2026.103545","relation":{},"ISSN":["0973-6883"],"issn-type":[{"value":"0973-6883","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alpha-1 Antitrypsin Deficiency Alleles in Non-Cirrhotic Hepatocellular Carcinoma: Insights from a Multicenter French Cohort","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical and Experimental Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jceh.2026.103545","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Indian National Association for Study of the Liver. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103545"}}