{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T00:27:32Z","timestamp":1793924852022,"version":"4.8.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jcehepatology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical and Experimental Hepatology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jceh.2026.103549","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T15:09:40Z","timestamp":1776352180000},"page":"103549","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rishyagandha Induced Possible Autoimmune-like Liver Injury in an Elderly Couple With Diabetes Mellitus"],"prefix":"10.1016","volume":"16","author":[{"given":"Sayan","family":"Malakar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1057-5110","authenticated-orcid":false,"given":"Srikanth","family":"Kothalkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4012-0428","authenticated-orcid":false,"given":"Piyush","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uday C.","family":"Ghoshal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jceh.2026.103549_bib1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0031-9422(02)00727-6","article-title":"Withanolides from Withania coagulans","volume":"63","author":"ur-Rahman","year":"2003","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jceh.2026.103549_bib2","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.3390\/pharmaceutics15041057","article-title":"Ashwagandha (Withania somnifera)-Current Research on the Health-Promoting Activities: A Narrative Review","volume":"15","author":"Mikulska","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jceh.2026.103549_bib3","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.2174\/1389557518666171129164056","article-title":"Natural Bioactive New Withanolides","volume":"20","author":"Xu","year":"2020","journal-title":"Mini Rev Med Chem"},{"key":"10.1016\/j.jceh.2026.103549_bib4","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/0031-9422(95)00429-B","article-title":"Antifungal steroidal lactones from Withania coagulance","volume":"40","author":"Choudhary","year":"1995","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jceh.2026.103549_bib5","doi-asserted-by":"crossref","first-page":"6534","DOI":"10.1016\/j.bmcl.2008.10.050","article-title":"Coagulanolide, a withanolide from Withania coagulans fruits and antihyperglycemic activity","volume":"18","author":"Maurya","year":"2008","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.jceh.2026.103549_bib6","doi-asserted-by":"crossref","first-page":"507","DOI":"10.4103\/0974-8520.96124","article-title":"A clinical study on the effect of Rishyagandha (Withania coagulans) in the management of Prameha (Type II Diabetes Mellitus)","volume":"32","author":"Upadhyay","year":"2011","journal-title":"Ayu"},{"key":"10.1016\/j.jceh.2026.103549_bib7","doi-asserted-by":"crossref","first-page":"3921","DOI":"10.3390\/ijerph20053921","article-title":"Liver Dangers of Herbal Products: A Case Report of Ashwagandha-Induced Liver Injury","volume":"20","author":"Lubarska","year":"2023","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.jceh.2026.103549_bib8","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000270","article-title":"Ashwagandha-induced liver injury-A case series from India and literature review","volume":"7","author":"Philips","year":"2023","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jceh.2026.103549_bib9","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1002\/hep4.1904","article-title":"Tinospora Cordifolia (Giloy)-Induced Liver Injury During the COVID-19 Pandemic-Multicenter Nationwide Study From India","volume":"6","author":"Kulkarni","year":"2022","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jceh.2026.103549_bib10","article-title":"Tinospora cordifolia (Guduchi\/Giloy)-Induced Liver Injury: A Case Review","volume":"15","author":"Nnamani","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.jceh.2026.103549_bib11","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/s12072-021-10144-3","article-title":"Asia Pacific Association of Study of Liver. Drug-induced liver injury: Asia Pacific Association of Study of Liver consensus guidelines","volume":"15","author":"Devarbhavi","year":"2021","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jceh.2026.103549_bib12","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jceh.2020.08.008","article-title":"Outcomes and Predictors of Mortality in Patients With Drug-Induced Liver Injury at a Tertiary Hospital in South India: A Single-Centre Experience","volume":"11","author":"Sunil Kumar","year":"2021","journal-title":"J Clin Exp Hepatol"},{"key":"10.1016\/j.jceh.2026.103549_bib13","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.jceh.2020.11.002","article-title":"The Indian Network of Drug-Induced Liver Injury: Etiology, Clinical Features, Outcome and Prognostic Markers in 1288 Patients","volume":"11","author":"Devarbhavi","year":"2021","journal-title":"J Clin Exp Hepatol"},{"key":"10.1016\/j.jceh.2026.103549_bib14","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.jceh.2021.06.021","article-title":"Herbal Immune Booster-Induced Liver Injury in the COVID-19 Pandemic - A Case Series","volume":"11","author":"Nagral","year":"2021","journal-title":"J Clin Exp Hepatol"},{"key":"10.1016\/j.jceh.2026.103549_bib15","article-title":"Different Course And Management of Khat-Induced Autoimmune Hepatitis: Report On Three Cases","volume":"11","author":"Someili","year":"2024","journal-title":"Eur J Case Rep Intern Med"},{"key":"10.1016\/j.jceh.2026.103549_bib16","doi-asserted-by":"crossref","first-page":"150","DOI":"10.4254\/wjh.v6.i3.150","article-title":"Khat (Catha Edulis) as a possible cause of autoimmune hepatitis","volume":"6","author":"Riyaz","year":"2014","journal-title":"World J Hepatol"},{"key":"10.1016\/j.jceh.2026.103549_bib17","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1478-3231.2005.01088.x","article-title":"An unusual form of autoimmune hepatitis in young Somalian men","volume":"25","author":"D'Souza","year":"2005","journal-title":"Liver Int"},{"key":"10.1016\/j.jceh.2026.103549_bib18","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2022-251852","article-title":"Immune-mediated herb-induced liver injury: a potential association with herbal artemisinin use as supported by the updated RUCAM","volume":"16","author":"Mathavan","year":"2023","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.jceh.2026.103549_bib19","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000024045","article-title":"Herb-induced autoimmune-like hepatitis associated with Xiang-tian-guo (Swietenia macrophylla seeds): A case report and literature review","volume":"100","author":"Shao","year":"2021","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jceh.2026.103549_bib20","article-title":"Drug-induced autoimmune-like hepatitis","volume":"23","author":"Garc\u00eda-Cort\u00e9s","year":"2024","journal-title":"Clin Liver Dis (Hoboken)"},{"key":"10.1016\/j.jceh.2026.103549_bib21","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/naaq.10358","article-title":"Withania coagulans root powder effect on growth, hematology, digestive enzyme activity, antioxidant status, serum immune response, and tolerance against Aeromonas hydrophila in common carp","volume":"86","author":"Afzal","year":"2024","journal-title":"N Am J Aquac"},{"key":"10.1016\/j.jceh.2026.103549_bib22","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1080\/14786419.2022.2089139","article-title":"Withania coagulans fruit extract: a possible useful additive in ameliorating growth and immunity of Labeo rohita (Hamilton, 1822)","volume":"37","author":"Fazio","year":"2023","journal-title":"Nat Prod Res"},{"key":"10.1016\/j.jceh.2026.103549_bib23","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.3390\/ijms18091954","article-title":"Autoimmune(-Like)\" Drug and Herb Induced Liver Injury: New Insights into Molecular Pathogenesis","volume":"18","author":"Sebode","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jceh.2026.103549_bib24","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.crtox.2021.02.002","article-title":"DNA damage by Withanone as a potential cause of liver toxicity observed for herbal products of Withania somnifera (Ashwagandha)","volume":"2","author":"Siddiqui","year":"2021","journal-title":"Curr Res Toxicol"},{"key":"10.1016\/j.jceh.2026.103549_bib25","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1055\/s-0034-1375958","article-title":"Hepatotoxicity induced by herbal and dietary supplements","volume":"34","author":"Navarro","year":"2014","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jceh.2026.103549_bib26","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.3748\/wjg.v28.i24.2654","article-title":"Drug-induced autoimmune hepatitis: A minireview","volume":"28","author":"Tan","year":"2022","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jceh.2026.103549_bib27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/10773525.2018.1447880","article-title":"Toxic metals in ayurvedic preparations from a public health lead poisoning cluster investigation","volume":"23","author":"Mikulski","year":"2017","journal-title":"Int J Occup Environ Health"},{"key":"10.1016\/j.jceh.2026.103549_bib28","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1179\/2049396715Y.0000000009","article-title":"A cluster of lead poisoning among consumers of Ayurvedic medicine","volume":"21","author":"Breeher","year":"2015","journal-title":"Int J Occup Environ Health"},{"key":"10.1016\/j.jceh.2026.103549_bib29","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1248\/cpb.c12-00264","article-title":"Leishmanicidal active withanolides from a pakistani medicinal plant, Withania coagulans","volume":"60","author":"Kuroyanagi","year":"2012","journal-title":"Chem Pharm Bull (Tokyo)"}],"container-title":["Journal of Clinical and Experimental Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0973688326000812?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0973688326000812?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T23:54:49Z","timestamp":1793922889000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0973688326000812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0973688326000812"],"URL":"https:\/\/doi.org\/10.1016\/j.jceh.2026.103549","relation":{},"ISSN":["0973-6883"],"issn-type":[{"value":"0973-6883","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rishyagandha Induced Possible Autoimmune-like Liver Injury in an Elderly Couple With Diabetes Mellitus","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical and Experimental Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jceh.2026.103549","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Indian National Association for Study of the Liver. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103549"}}