{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T07:44:57Z","timestamp":1790495097914,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["cysticfibrosisjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cystic Fibrosis"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.jcf.2014.03.006","type":"journal-article","created":{"date-parts":[[2014,4,13]],"date-time":"2014-04-13T16:30:12Z","timestamp":1397406612000},"page":"564-571","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Bronchiectases at early chest computed tomography in children with cystic fibrosis are associated with increased risk of subsequent pulmonary exacerbations and chronic pseudomonas infection"],"prefix":"10.1016","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3071-4456","authenticated-orcid":false,"given":"Carla-Federica","family":"Bortoluzzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Volpi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciro","family":"D'Orazio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harm A.W.M.","family":"Tiddens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Loeve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Tridello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2758-7062","authenticated-orcid":false,"given":"Baroukh M.","family":"Assael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jcf.2014.03.006_bb0005","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1136\/thx.2007.077784","article-title":"Multiple-breath inert gas washout and spirometry versus structural lung disease in cystic fibrosis","volume":"63","author":"Gustafsson","year":"2008","journal-title":"Thorax"},{"issue":"1","key":"10.1016\/j.jcf.2014.03.006_bb0010","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1183\/09031936.03.00006603","article-title":"Progressive damage on high resolution computed tomography despite stable lung function in cystic fibrosis","volume":"23","author":"de Jong","year":"2004","journal-title":"Eur Respir J"},{"issue":"5","key":"10.1016\/j.jcf.2014.03.006_bb0015","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.jpeds.2009.05.005","article-title":"Bronchiectasis in infants and preschool children diagnosed with cystic fibrosis after newborn screening","volume":"155","author":"Stick","year":"2009","journal-title":"J Pediatr"},{"issue":"1","key":"10.1016\/j.jcf.2014.03.006_bb0020","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0033-8389(05)70009-9","article-title":"Bronchiectasis","volume":"36","author":"Hansell","year":"1998","journal-title":"Radiol Clin North Am"},{"issue":"3","key":"10.1016\/j.jcf.2014.03.006_bb0025","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1183\/09031936.00051512","article-title":"Chest computed tomography: a validated surrogate endpoint of cystic fibrosis lung disease?","volume":"42","author":"Loeve","year":"2012","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1016\/j.jcf.2014.03.006_bb0030","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jpeds.2004.02.038","article-title":"High-resolution computed tomography in young patients with cystic fibrosis: distribution of abnormalities and correlation with pulmonary function tests","volume":"145","author":"Brody","year":"2004","journal-title":"J Pediatr"},{"issue":"1","key":"10.1016\/j.jcf.2014.03.006_bb0035","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1378\/chest.10-1152","article-title":"Bronchiectasis and pulmonary exacerbations in children and young adults with cystic fibrosis","volume":"140","author":"Loeve","year":"2011","journal-title":"Chest"},{"issue":"10","key":"10.1016\/j.jcf.2014.03.006_bb0040","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1164\/rccm.201111-2065OC","article-title":"Chest computed tomography scores are predictive of survival in patients with cystic fibrosis awaiting lung transplantation","volume":"185","author":"Loeve","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.jcf.2014.03.006_bb0045","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1183\/09031936.00137612","article-title":"Impact of bronchiectasis and trapped air on quality of life and exacerbations in cystic fibrosis","volume":"42","author":"Tepper","year":"2013","journal-title":"Eur Respir J"},{"issue":"7","key":"10.1016\/j.jcf.2014.03.006_bb0050","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1164\/rccm.201105-0816OC","article-title":"Chest computed tomography scores of severity are associated with future lung disease progression in children with cystic fibrosis","volume":"184","author":"Sanders","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.jcf.2014.03.006_bb0055","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/ppul.10127","article-title":"Pseudomonas aeruginosa and other predictors of mortality and morbidity in young children with cystic fibrosis","volume":"34","author":"Emerson","year":"2002","journal-title":"Pediatr Pulmonol"},{"issue":"Suppl. 1","key":"10.1016\/j.jcf.2014.03.006_bb0060","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00228-010-0922-2","article-title":"Endpoints in respiratory diseases","volume":"67","author":"de Benedictis","year":"2011","journal-title":"Eur J Clin Pharmacol"},{"issue":"4","key":"10.1016\/j.jcf.2014.03.006_bb0065","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1513\/pats.200611-178HT","article-title":"An overview of endpoints for cystic fibrosis clinical trials: one size does not fit all","volume":"4","author":"Rosenfeld","year":"2007","journal-title":"Proc Am Thorac Soc"},{"issue":"3","key":"10.1016\/j.jcf.2014.03.006_bb0070","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1067\/mpd.2001.117288","article-title":"Defining a pulmonary exacerbation in cystic fibrosis","volume":"139","author":"Rosenfeld","year":"2001","journal-title":"J Pediatr"},{"issue":"9","key":"10.1016\/j.jcf.2014.03.006_bb0075","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1164\/rccm.200407-989OC","article-title":"Computed tomography correlates with pulmonary exacerbations in children with cystic fibrosis","volume":"172","author":"Brody","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"Suppl. 6","key":"10.1016\/j.jcf.2014.03.006_bb0080","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1016\/j.jpeds.2009.09.001","article-title":"Cystic Fibrosis Foundation evidence-based guidelines for management of infants with cystic fibrosis","volume":"155","author":"Borowitz","year":"2009","journal-title":"J Pediatr"},{"issue":"9","key":"10.1016\/j.jcf.2014.03.006_bb0085","first-page":"513","article-title":"Flow resistance of airways and pulmonary flow resistance in children and juveniles. Normal values and their significance for the evaluation of airway obstruction","volume":"32","author":"Zapletal","year":"1977","journal-title":"Cesk Pediatr"},{"issue":"1","key":"10.1016\/j.jcf.2014.03.006_bb0090","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1569-1993(02)00141-8","article-title":"Evaluation of a new definition for chronic Pseudomonas aeruginosa infection in cystic fibrosis patients","volume":"2","author":"Lee","year":"2003","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2014.03.006_bb0095","series-title":"Encyclopedia of measurement and statistics","article-title":"Correlation coefficient","author":"Chung","year":"2007"},{"issue":"5","key":"10.1016\/j.jcf.2014.03.006_bb0100","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1001\/jama.293.5.581","article-title":"Longitudinal development of mucoid Pseudomonas aeruginosa infection and lung disease progression in children with cystic fibrosis","volume":"293","author":"Li","year":"2005","journal-title":"Jama"},{"issue":"4","key":"10.1016\/j.jcf.2014.03.006_bb0105","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/aje\/153.4.345","article-title":"Predictive 5-year survivorship model of cystic fibrosis","volume":"153","author":"Liou","year":"2001","journal-title":"Am J Epidemiol"},{"issue":"4","key":"10.1016\/j.jcf.2014.03.006_bb0110","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/ppul.21374","article-title":"Pulmonary exacerbations are associated with subsequent FEV1 decline in both adults and children with cystic fibrosis","volume":"46","author":"Sanders","year":"2011","journal-title":"Pediatr Pulmonol"},{"issue":"6","key":"10.1016\/j.jcf.2014.03.006_bb0115","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1067\/mpd.2001.118570","article-title":"A two-year randomized, placebo-controlled trial of dornase alfa in young patients with cystic fibrosis with mild lung function abnormalities","volume":"139","author":"Quan","year":"2001","journal-title":"J Pediatr"},{"issue":"6","key":"10.1016\/j.jcf.2014.03.006_bb0120","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s13244-013-0288-y","article-title":"Radiography, tomosynthesis, CT and MRI in the evaluation of pulmonary cystic fibrosis: an untangling review of the multitude of scoring systems","volume":"4","author":"Vult von Steyern","year":"2013","journal-title":"Insights Imaging"},{"key":"10.1016\/j.jcf.2014.03.006_bb0125","first-page":"10","article-title":"Lung clearance index predicts pulmonary exacerbations in young patients with cystic fibrosis","author":"Vermeulen","year":"2013","journal-title":"Thorax"},{"issue":"11","key":"10.1016\/j.jcf.2014.03.006_bb0130","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1002\/ppul.21107","article-title":"Cystic fibrosis HRCT scores correlate strongly with Pseudomonas infection","volume":"44","author":"Robinson","year":"2009","journal-title":"Pediatr Pulmonol"},{"issue":"2","key":"10.1016\/j.jcf.2014.03.006_bb0135","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1148\/radiol.2522081882","article-title":"Association between mucoid Pseudomonas infection and bronchiectasis in children with cystic fibrosis","volume":"252","author":"Farrell","year":"2009","journal-title":"Radiology"},{"issue":"2","key":"10.1016\/j.jcf.2014.03.006_bb0140","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1001\/jama.2011.954","article-title":"Effect of bronchoalveolar lavage-directed therapy on Pseudomonas aeruginosa infection and structural lung injury in children with cystic fibrosis: a randomized trial","volume":"306","author":"Wainwright","year":"2011","journal-title":"Jama"},{"issue":"5","key":"10.1016\/j.jcf.2014.03.006_bb0145","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.jcf.2012.12.003","article-title":"Association between Staphylococcus aureus alone or combined with Pseudomonas aeruginosa and the clinical condition of patients with cystic fibrosis","volume":"12","author":"Hubert","year":"2012","journal-title":"J Cyst Fibros"}],"container-title":["Journal of Cystic Fibrosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199314000757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199314000757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T19:57:53Z","timestamp":1538683073000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569199314000757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S1569199314000757"],"URL":"https:\/\/doi.org\/10.1016\/j.jcf.2014.03.006","relation":{},"ISSN":["1569-1993"],"issn-type":[{"value":"1569-1993","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bronchiectases at early chest computed tomography in children with cystic fibrosis are associated with increased risk of subsequent pulmonary exacerbations and chronic pseudomonas infection","name":"articletitle","label":"Article Title"},{"value":"Journal of Cystic Fibrosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcf.2014.03.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}