{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T13:34:47Z","timestamp":1776951287779,"version":"3.51.4"},"reference-count":23,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T00:00:00Z","timestamp":1483920000000},"content-version":"vor","delay-in-days":739,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR000454"],"award-info":[{"award-number":["UL1TR000454"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["FDA RO1FD003527"],"award-info":[{"award-number":["FDA RO1FD003527"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["HSR&D IIR 07-138"],"award-info":[{"award-number":["HSR&D IIR 07-138"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["PHILLI12A0"],"award-info":[{"award-number":["PHILLI12A0"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["U01 DK1U01DK098246"],"award-info":[{"award-number":["U01 DK1U01DK098246"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["CFFSTECEN07A0"],"award-info":[{"award-number":["CFFSTECEN07A0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cysticfibrosisjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cystic Fibrosis"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.jcf.2014.06.004","type":"journal-article","created":{"date-parts":[[2014,7,4]],"date-time":"2014-07-04T00:00:12Z","timestamp":1404432012000},"page":"135-141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Disposition index identifies defective beta-cell function in cystic fibrosis subjects with normal glucose tolerance"],"prefix":"10.1016","volume":"14","author":[{"given":"L.","family":"Merjaneh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.S.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.A.","family":"Stecenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcf.2014.06.004_bb0005","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.2337\/dc09-0586","article-title":"Cystic fibrosis\u2013related diabetes: current trends in prevalence, incidence, and mortality","volume":"32","author":"Moran","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcf.2014.06.004_bb0010","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/ppul.1142","article-title":"Presence of cystic fibrosis-related diabetes mellitus is tightly linked to poor lung function in patients with cystic fibrosis: data from the European Epidemiologic Registry of Cystic Fibrosis","volume":"32","author":"Koch","year":"2001","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jcf.2014.06.004_bb0015","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jpeds.2004.12.039","article-title":"Epidemiology of cystic fibrosis-related diabetes","volume":"146","author":"Marshall","year":"2005","journal-title":"J Pediatr"},{"key":"10.1016\/j.jcf.2014.06.004_bb0020","unstructured":"Milla CE, Warwick WJ, Moran A. Trends in pulmonary function in patients with cystic fibrosis correlate with the degree of glucose intolerance at baseline. Am J Respiratory and Critical Care Medicine."},{"key":"10.1016\/j.jcf.2014.06.004_bb0025","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2337\/dc09-1215","article-title":"Diabetes as a determinant of mortality in cystic fibrosis","volume":"33","author":"Chamnan","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcf.2014.06.004_bb0030","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/BF01957574","article-title":"Influence of the development of diabetes mellitus on clinical status in patients with cystic fibrosis","volume":"151","author":"Lanng","year":"1992","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jcf.2014.06.004_bb0035","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1651-2227.1994.tb13156.x","article-title":"Diabetes mellitus in cystic fibrosis: effect of insulin therapy on lung function and infections","volume":"83","author":"Lanng","year":"1994","journal-title":"Acta Paediatr"},{"issue":"12","key":"10.1016\/j.jcf.2014.06.004_bb0040","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.2337\/dc10-1768","volume":"33","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcf.2014.06.004_bb0045","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1464-5491.2004.01219.x","article-title":"Conventional measures underestimate glycaemia in cystic fibrosis patients","volume":"21","author":"Dobson","year":"2004","journal-title":"Diabet Med"},{"issue":"2","key":"10.1016\/j.jcf.2014.06.004_bb0050","doi-asserted-by":"crossref","first-page":"292","DOI":"10.2337\/dc10-1604","article-title":"Elevation of 1-hour plasma glucose during oral glucose tolerance testing is associated with worse pulmonary function in cystic fibrosis","volume":"34","author":"Brodsky","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcf.2014.06.004_bb0055","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.2337\/diab.42.11.1663","article-title":"Quantification of the relationship between insulin sensitivity and B-cell function in human subjects: evidence for a hyperbolic function","volume":"42","author":"Kahn","year":"1993","journal-title":"Diabetes"},{"key":"10.1016\/j.jcf.2014.06.004_bb0060","doi-asserted-by":"crossref","first-page":"776","DOI":"10.2337\/dc08-1478","article-title":"Oral Disposition Index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels","volume":"32","author":"Utzschneider","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcf.2014.06.004_bb0065","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.2337\/diacare.26.11.3160","article-title":"Follow- up report on the diagnosis of diabetes mellitus","volume":"26","author":"Genuth","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcf.2014.06.004_bb0070","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1172\/JCI110398","article-title":"Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and B-cell glucose sensitivity from the response to intravenous glucose","volume":"68","author":"Bergman","year":"1981","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jcf.2014.06.004_bb0075","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1055\/s-2008-1062723","article-title":"Continuous glucose monitoring in cystic fibrosis patients according to the glucose tolerance","volume":"40","author":"Moreau","year":"2008","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.jcf.2014.06.004_bb0080","first-page":"00106","article-title":"Predictors for future cystic fibrosis-related diabetes by oral glucose tolerance test","volume":"13","author":"Schmid","year":"2013","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2014.06.004_bb0085","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.2337\/dc08-0225","article-title":"One-hour plasma glucose concentration and the metabolic syndrome identify subjects at high risk for future type 2 diabetes","volume":"31","author":"Abdul-Ghani","year":"2008","journal-title":"Diabetes Care"},{"issue":"6","key":"10.1016\/j.jcf.2014.06.004_bb0090","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.jpeds.2007.05.012","article-title":"Glucose tolerance, insulin secretion, and insulin sensitivity in children and adolescents with cystic fibrosis and no prior history of diabetes","volume":"151","author":"Elder","year":"2007","journal-title":"J Pediatr"},{"key":"10.1016\/j.jcf.2014.06.004_bb0095","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1046\/j.1464-5491.2002.00666.x","article-title":"Cystic fibrosis-related diabetes: the role of peripheral insulin resistance and beta-cell dysfunction","volume":"19","author":"Yung","year":"2002","journal-title":"Diabet Med"},{"issue":"4","key":"10.1016\/j.jcf.2014.06.004_bb0100","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.jpeds.2007.09.025","article-title":"Glucose tolerance and insulin secretion, morbidity, and death in patients with cystic fibrosis","volume":"152","author":"Bismuth","year":"2008","journal-title":"J Pediatr"},{"key":"10.1016\/j.jcf.2014.06.004_bb0105","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1007\/s00125-007-0819-5","article-title":"Within-subject variability of measures of beta cell function derived from a 2h OGTT: implications for research studies","volume":"50","author":"Utzschneider","year":"2007","journal-title":"Diabetologia"},{"issue":"6","key":"10.1016\/j.jcf.2014.06.004_bb0110","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.jcf.2009.08.007","article-title":"Validation of insulin secretion indices in cystic fibrosis patients","volume":"8","author":"Hammana","year":"2009","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2014.06.004_bb0115","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1210\/jc.2010-2813","article-title":"Surrogate estimates of insulin sensitivity in obese youth along the spectrum of glucose tolerance from normal to prediabetes to diabetes","volume":"96","author":"George","year":"2011","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of Cystic Fibrosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199314001532?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199314001532?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T21:38:41Z","timestamp":1761601121000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569199314001532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S1569199314001532"],"URL":"https:\/\/doi.org\/10.1016\/j.jcf.2014.06.004","relation":{},"ISSN":["1569-1993"],"issn-type":[{"value":"1569-1993","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disposition index identifies defective beta-cell function in cystic fibrosis subjects with normal glucose tolerance","name":"articletitle","label":"Article Title"},{"value":"Journal of Cystic Fibrosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcf.2014.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}