{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T23:24:16Z","timestamp":1793057056741,"version":"4.5.0"},"reference-count":143,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T00:00:00Z","timestamp":1445212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","cysticfibrosisjournal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cystic Fibrosis"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.jcf.2015.09.008","type":"journal-article","created":{"date-parts":[[2015,10,21]],"date-time":"2015-10-21T01:08:33Z","timestamp":1445389713000},"page":"147-157","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":119,"title":["Cystic fibrosis in young children: A review of disease manifestation, progression, and response to early treatment"],"prefix":"10.1016","volume":"15","author":[{"given":"Donald R.","family":"VanDevanter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Kahle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy K.","family":"O\u2019Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slaven","family":"Sikirica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Hodgkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcf.2015.09.008_bb0005","series-title":"2012 Annual Data Report to the Center Directors","author":"CFF Patient Registry","year":"2013"},{"key":"10.1016\/j.jcf.2015.09.008_bb0010","series-title":"Annual Data Report 2013","author":"UK Cystic Fibrosis Registry","year":"2014"},{"issue":"4922","key":"10.1016\/j.jcf.2015.09.008_bb0015","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1126\/science.2772657","article-title":"Identification of the cystic fibrosis gene: chromosome walking and jumping","volume":"245","author":"Rommens","year":"1989","journal-title":"Science"},{"issue":"4922","key":"10.1016\/j.jcf.2015.09.008_bb0020","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1126\/science.2475911","article-title":"Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA","volume":"245","author":"Riordan","year":"1989","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.jcf.2015.09.008_bb0025","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/0092-8674(92)90155-6","article-title":"Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)","volume":"68","author":"Bear","year":"1992","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.jcf.2015.09.008_bb0030","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.prrv.2012.05.003","article-title":"The impact of newborn screening and earlier intervention on the clinical course of cystic fibrosis","volume":"13","author":"Dijk","year":"2012","journal-title":"Paediatr Respir Rev"},{"issue":"4","key":"10.1016\/j.jcf.2015.09.008_bb0035","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.jpedsurg.2012.02.019","article-title":"A review of pathophysiology and management of fetuses and neonates with meconium ileus for the pediatric surgeon","volume":"47","author":"Carlyle","year":"2012","journal-title":"J Pediatr Surg"},{"issue":"5-6","key":"10.1016\/j.jcf.2015.09.008_bb0040","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1515\/jpem-2012-0012","article-title":"Growth failure in children with cystic fibrosis","volume":"25","author":"Scaparrotta","year":"2012","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0045","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S2213-2600(13)70026-2","article-title":"Early lung disease in cystic fibrosis","volume":"1","author":"Grasemann","year":"2013","journal-title":"Lancet Respir Med"},{"issue":"3","key":"10.1016\/j.jcf.2015.09.008_bb0050","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/MOP.0b013e328360dbf5","article-title":"Cystic fibrosis in the era of genomic medicine","volume":"25","author":"Milla","year":"2013","journal-title":"Curr Opin Pediatr"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0055","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1183\/09031936.00108212","article-title":"Early intervention studies in infants and preschool children with cystic fibrosis: are we ready?","volume":"42","author":"Stick","year":"2013","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jcf.2015.09.008_bb0060","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.1513\/AnnalsATS.201312-444LD","article-title":"Cystic fibrosis: NHLBI workshop on the primary prevention of chronic lung diseases","volume":"11 Suppl. 3","author":"Pittman","year":"2014","journal-title":"Ann Am Thorac Soc"},{"issue":"10","key":"10.1016\/j.jcf.2015.09.008_bb0065","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1164\/rccm.201410-1929ED","article-title":"Narrowing in on early cystic fibrosis lung disease","volume":"190","author":"Zemanick","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcf.2015.09.008_bb0070","author":"United Nations"},{"issue":"3","key":"10.1016\/j.jcf.2015.09.008_bb0075","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/hmg\/2.3.219","article-title":"Cell-specific localization of CFTR mRNA shows developmentally regulated expression in human fetal tissues","volume":"2","author":"Tizzano","year":"1993","journal-title":"Hum Mol Genet"},{"issue":"4","key":"10.1016\/j.jcf.2015.09.008_bb0080","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1165\/ajrcmb.10.4.7510983","article-title":"Regional expression of CFTR in developing human respiratory tissues","volume":"10","author":"Tizzano","year":"1994","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0085","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1203\/00006450-199408000-00002","article-title":"Immunohistochemical localization of cystic fibrosis transmembrane conductance regulator in human fetal airway and digestive mucosa","volume":"36","author":"Gaillard","year":"1994","journal-title":"Pediatr Res"},{"issue":"3","key":"10.1016\/j.jcf.2015.09.008_bb0090","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/ppul.22586","article-title":"Evaluation of the intestinal current measurement method as a diagnostic test for cystic fibrosis","volume":"48","author":"Cohen-Cymberknoh","year":"2013","journal-title":"Pediatr Pulmonol"},{"issue":"6","key":"10.1016\/j.jcf.2015.09.008_bb0095","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1136\/thx.2009.123422","article-title":"Measurement of nasal potential difference in young children with an equivocal sweat test following newborn screening for cystic fibrosis","volume":"65","author":"Sermet-Gaudelus","year":"2010","journal-title":"Thorax"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0100","first-page":"141","article-title":"Pathological confirmation of foetal cystic fibrosis following prenatal diagnosis","volume":"38","author":"Damjanovich","year":"1990","journal-title":"Acta Morphol Hung"},{"key":"10.1016\/j.jcf.2015.09.008_bb0105","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jcf.2013.12.006","article-title":"Neonates with cystic fibrosis have a reduced nasal liquid pH; a small pilot study","volume":"13","author":"Abou Alaiwa","year":"2014","journal-title":"J Cyst Fibros"},{"issue":"10","key":"10.1016\/j.jcf.2015.09.008_bb0110","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1164\/rccm.201004-0643OC","article-title":"Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children","volume":"182","author":"Meyerholz","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"10.1016\/j.jcf.2015.09.008_bb0115","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1136\/thx.2005.054643","article-title":"Inducible NO synthase expression is low in airway epithelium from young children with cystic fibrosis","volume":"61","author":"Moeller","year":"2006","journal-title":"Thorax"},{"issue":"5","key":"10.1016\/j.jcf.2015.09.008_bb0120","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/ppul.20010","article-title":"Quantitative cytokine gene expression in CF airway","volume":"37","author":"Muhlebach","year":"2004","journal-title":"Pediatr Pulmonol"},{"issue":"4","key":"10.1016\/j.jcf.2015.09.008_bb0125","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1067\/mai.2001.118516","article-title":"Distinct pattern of immune cell population in the lung of human fetuses with cystic fibrosis","volume":"108","author":"Hubeau","year":"2001","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0130","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1136\/thorax.56.2.151","article-title":"Exhaled nitric oxide is reduced in infants with cystic fibrosis","volume":"56","author":"Elphick","year":"2001","journal-title":"Thorax"},{"issue":"4","key":"10.1016\/j.jcf.2015.09.008_bb0135","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1203\/01.pdr.0000238242.39881.64","article-title":"Exhaled nitric oxide differentiates airway diseases in the first two years of life","volume":"60","author":"Gabriele","year":"2006","journal-title":"Pediatr Res"},{"issue":"4","key":"10.1016\/j.jcf.2015.09.008_bb0140","first-page":"1075","article-title":"Early pulmonary inflammation in infants with cystic fibrosis","volume":"151","author":"Khan","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.jcf.2015.09.008_bb0145","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1164\/ajrccm.160.1.9808096","article-title":"Quantitation of inflammatory responses to bacteria in young cystic fibrosis and control patients","volume":"160","author":"Muhlebach","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0150","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1164\/rccm.200901-0069OC","article-title":"Lung disease at diagnosis in infants with cystic fibrosis detected by newborn screening","volume":"180","author":"Sly","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"issue":"7","key":"10.1016\/j.jcf.2015.09.008_bb0155","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1002\/ppul.21434","article-title":"Bronchoscopy in cystic fibrosis infants diagnosed by newborn screening","volume":"46","author":"Stafler","year":"2011","journal-title":"Pediatr Pulmonol"},{"issue":"10","key":"10.1016\/j.jcf.2015.09.008_bb0160","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1373\/clinchem.2007.087650","article-title":"Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients","volume":"53","author":"McMorran","year":"2007","journal-title":"Clin Chem"},{"issue":"3","key":"10.1016\/j.jcf.2015.09.008_bb0165","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1183\/09031936.00178508","article-title":"Alveolar macrophages and CC chemokines are increased in children with cystic fibrosis","volume":"34","author":"Brennan","year":"2009","journal-title":"Eur Respir J"},{"issue":"5","key":"10.1016\/j.jcf.2015.09.008_bb0170","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/ppul.1144","article-title":"Early pulmonary infection, inflammation, and clinical outcomes in infants with cystic fibrosis","volume":"32","author":"Rosenfeld","year":"2001","journal-title":"Pediatr Pulmonol"},{"issue":"3","key":"10.1016\/j.jcf.2015.09.008_bb0175","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/ppul.10336","article-title":"Longitudinal evaluation of bronchopulmonary disease in children with cystic fibrosis","volume":"36","author":"Farrell","year":"2003","journal-title":"Pediatr Pulmonol"},{"issue":"22","key":"10.1016\/j.jcf.2015.09.008_bb0180","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1001\/jama.287.22.2958","article-title":"Respiratory infections with Pseudomonas aeruginosa in children with cystic fibrosis: early detection by serology and assessment of risk factors","volume":"287","author":"West","year":"2002","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.jcf.2015.09.008_bb0185","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jpeds.2012.12.042","article-title":"Distribution of early structural lung changes due to cystic fibrosis detected with chest computed tomography","volume":"163","author":"Mott","year":"2013","journal-title":"J Pediatr"},{"issue":"8","key":"10.1016\/j.jcf.2015.09.008_bb0190","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1164\/rccm.201309-1659OC","article-title":"Magnetic resonance imaging detects changes in structure and perfusion, and response to therapy in early cystic fibrosis lung disease","volume":"189","author":"Wielputz","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"issue":"8","key":"10.1016\/j.jcf.2015.09.008_bb0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023932","article-title":"Air trapping on chest CT is associated with worse ventilation distribution in infants with cystic fibrosis diagnosed following newborn screening","volume":"6","author":"Hall","year":"2011","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0200","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1148\/radiology.213.2.r99nv04537","article-title":"Cystic fibrosis: CT assessment of lung involvement in children and adults","volume":"213","author":"Helbich","year":"1999","journal-title":"Radiology"},{"issue":"11","key":"10.1016\/j.jcf.2015.09.008_bb0205","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1007\/s00247-005-1541-4","article-title":"Comparison of quiet breathing and controlled ventilation in the high-resolution CT assessment of airway disease in infants with cystic fibrosis","volume":"35","author":"Long","year":"2005","journal-title":"Pediatr Radiol"},{"issue":"21","key":"10.1016\/j.jcf.2015.09.008_bb0210","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1056\/NEJMoa1301725","article-title":"Risk factors for bronchiectasis in children with cystic fibrosis","volume":"368","author":"Sly","year":"2013","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0215","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jpeds.2003.09.026","article-title":"Structural airway abnormalities in infants and young children with cystic fibrosis","volume":"144","author":"Long","year":"2004","journal-title":"J Pediatr"},{"issue":"9","key":"10.1016\/j.jcf.2015.09.008_bb0220","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1164\/rccm.200412-1665OC","article-title":"High-resolution computed tomography imaging of airway disease in infants with cystic fibrosis","volume":"172","author":"Martinez","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.jcf.2015.09.008_bb0225","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1159\/000067458","article-title":"Early detection of lung disease and its association with the nutritional status, genetic background and life events in patients with cystic fibrosis","volume":"67","author":"Kraemer","year":"2000","journal-title":"Respiration"},{"issue":"4","key":"10.1016\/j.jcf.2015.09.008_bb0230","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/S0022-3476(05)83534-6","article-title":"Relationship of genotype to early pulmonary function in infants with cystic fibrosis identified through neonatal screening","volume":"122","author":"Mohon","year":"1993","journal-title":"J Pediatr"},{"issue":"3","key":"10.1016\/j.jcf.2015.09.008_bb0235","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1164\/rccm.200407-895OC","article-title":"Multiple-breath washout as a marker of lung disease in preschool children with cystic fibrosis","volume":"171","author":"Aurora","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"11","key":"10.1016\/j.jcf.2015.09.008_bb0240","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1164\/rccm.200303-347OC","article-title":"Serial lung function and responsiveness in cystic fibrosis during early childhood","volume":"169","author":"Nielsen","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"issue":"10","key":"10.1016\/j.jcf.2015.09.008_bb0245","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3109\/02770903.2013.834507","article-title":"Opening interrupter technique in pre-school children with chronic respiratory diseases: a perspective case-control study in the diagnosis of airway hyperesponsiveness","volume":"50","author":"Vitaliti","year":"2013","journal-title":"J Asthma"},{"issue":"10","key":"10.1016\/j.jcf.2015.09.008_bb0250","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1136\/thoraxjnl-2012-201747","article-title":"Lung function is abnormal in 3-month-old infants with cystic fibrosis diagnosed by newborn screening","volume":"67","author":"Hoo","year":"2012","journal-title":"Thorax"},{"issue":"6","key":"10.1016\/j.jcf.2015.09.008_bb0255","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1203\/00006450-199812000-00016","article-title":"Genotype-phenotype association in infants with cystic fibrosis at the time of diagnosis","volume":"44","author":"Kraemer","year":"1998","journal-title":"Pediatr Res"},{"issue":"10","key":"10.1016\/j.jcf.2015.09.008_bb0260","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1136\/thoraxjnl-2013-204023","article-title":"Evolution of lung function during the first year of life in newborn screened cystic fibrosis infants","volume":"69","author":"Nguyen","year":"2014","journal-title":"Thorax"},{"issue":"4","key":"10.1016\/j.jcf.2015.09.008_bb0265","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1136\/thoraxjnl-2013-204176","article-title":"Is chest CT useful in newborn screened infants with cystic fibrosis at 1year of age?","volume":"69","author":"Thia","year":"2014","journal-title":"Thorax"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0270","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1164\/ajrccm\/144.2.344","article-title":"Assessment of airway responsiveness in infants with cystic fibrosis","volume":"144","author":"Ackerman","year":"1991","journal-title":"Am Rev Respir Dis"},{"issue":"3","key":"10.1016\/j.jcf.2015.09.008_bb0275","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jcf.2011.12.003","article-title":"Determining presence of lung disease in young children with cystic fibrosis: lung clearance index, oxygen saturation and cough frequency","volume":"11","author":"Bakker","year":"2012","journal-title":"J Cyst Fibros"},{"issue":"8","key":"10.1016\/j.jcf.2015.09.008_bb0280","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1164\/rccm.201109-1631OC","article-title":"Early cystic fibrosis lung disease detected by bronchoalveolar lavage and lung clearance index","volume":"185","author":"Belessis","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"10.1016\/j.jcf.2015.09.008_bb0285","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.jcf.2011.07.006","article-title":"Long-term course of lung clearance index between infancy and school-age in cystic fibrosis subjects","volume":"10","author":"Kieninger","year":"2011","journal-title":"J Cyst Fibros"},{"issue":"12","key":"10.1016\/j.jcf.2015.09.008_bb0290","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1164\/rccm.200804-551OC","article-title":"Lung function in infants with cystic fibrosis diagnosed by newborn screening","volume":"178","author":"Linnane","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.jcf.2015.09.008_bb0295","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1136\/thx.2006.068262","article-title":"Early detection of cystic fibrosis lung disease: multiple-breath washout versus raised volume tests","volume":"62","author":"Lum","year":"2007","journal-title":"Thorax"},{"issue":"10","key":"10.1016\/j.jcf.2015.09.008_bb0300","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1164\/rccm.2202041","article-title":"Relative ability of full and partial forced expiratory maneuvers to identify diminished airway function in infants with cystic fibrosis","volume":"166","author":"Ranganathan","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"issue":"8","key":"10.1016\/j.jcf.2015.09.008_bb0305","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1164\/rccm.200309-1344OC","article-title":"The evolution of airway function in early childhood following clinical diagnosis of cystic fibrosis","volume":"169","author":"Ranganathan","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.jcf.2015.09.008_bb0310","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1159\/000357075","article-title":"Multiple breath washout is feasible in the clinical setting and detects abnormal lung function in infants and young children with cystic fibrosis","volume":"87","author":"Stahl","year":"2014","journal-title":"Respiration"},{"issue":"6","key":"10.1016\/j.jcf.2015.09.008_bb0315","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/ppul.21589","article-title":"Lung function distinguishes preschool children with CF from healthy controls in a multi-center setting","volume":"47","author":"Kerby","year":"2012","journal-title":"Pediatr Pulmonol"},{"issue":"1","key":"10.1016\/j.jcf.2015.09.008_bb0320","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1164\/rccm.200111-056OC","article-title":"Spirometry in 3- to 6-year-old children with cystic fibrosis","volume":"166","author":"Marostica","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"issue":"10","key":"10.1016\/j.jcf.2015.09.008_bb0325","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1002\/ppul.22519","article-title":"Risk factors for onset of persistent respiratory symptoms in children with cystic fibrosis","volume":"47","author":"McColley","year":"2012","journal-title":"Pediatr Pulmonol"},{"issue":"1","key":"10.1016\/j.jcf.2015.09.008_bb0330","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1164\/rccm.201011-1892OC","article-title":"Infection, inflammation, and lung function decline in infants with cystic fibrosis","volume":"184","author":"Pillarisetti","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0335","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1378\/chest.06-1351","article-title":"Spirometry in early childhood in cystic fibrosis patients","volume":"131","author":"Vilozni","year":"2007","journal-title":"Chest"},{"issue":"6","key":"10.1016\/j.jcf.2015.09.008_bb0340","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.jcf.2013.04.005","article-title":"Evidence of diminished FEV1 and FVC in 6-year-olds followed in the European cystic fibrosis patient registry, 2007\u20132009","volume":"12","author":"VanDevanter","year":"2013","journal-title":"J Cyst Fibros"},{"issue":"12","key":"10.1016\/j.jcf.2015.09.008_bb0345","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1002\/ppul.20930","article-title":"Lung function in 3-5-year-old children with cystic fibrosis","volume":"43","author":"Mayer","year":"2008","journal-title":"Pediatr Pulmonol"},{"issue":"7","key":"10.1016\/j.jcf.2015.09.008_bb0350","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1136\/thorax.57.7.596","article-title":"Relationship between nutritional status and lung function in cystic fibrosis: cross sectional and longitudinal analyses from the German CF quality assurance (CFQA) project","volume":"57","author":"Steinkamp","year":"2002","journal-title":"Thorax"},{"issue":"6","key":"10.1016\/j.jcf.2015.09.008_bb0355","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/(SICI)1099-0496(199812)26:6<371::AID-PPUL1>3.0.CO;2-N","article-title":"Severe viral respiratory infections in infants with cystic fibrosis","volume":"26","author":"Armstrong","year":"1998","journal-title":"Pediatr Pulmonol"},{"issue":"3","key":"10.1016\/j.jcf.2015.09.008_bb0360","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1542\/peds.2004-2599","article-title":"Neonatal screening for cystic fibrosis does not affect time to first infection with Pseudomonas aeruginosa","volume":"118","author":"Baussano","year":"2006","journal-title":"Pediatrics"},{"issue":"3","key":"10.1016\/j.jcf.2015.09.008_bb0365","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1086\/318075","article-title":"Longitudinal assessment of Pseudomonas aeruginosa in young children with cystic fibrosis","volume":"183","author":"Burns","year":"2001","journal-title":"J Infect Dis"},{"issue":"7","key":"10.1016\/j.jcf.2015.09.008_bb0370","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1164\/ajrccm.165.7.2010139","article-title":"Inflammation, infection, and pulmonary function in infants and young children with cystic fibrosis","volume":"165","author":"Dakin","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0375","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1183\/09031936.00043108","article-title":"Acquisition and eradication of P. aeruginosa in young children with cystic fibrosis","volume":"33","author":"Douglas","year":"2009","journal-title":"Eur Respir J"},{"issue":"3","key":"10.1016\/j.jcf.2015.09.008_bb0380","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1542\/peds.103.3.619","article-title":"Effects of viral lower respiratory tract infection on lung function in infants with cystic fibrosis","volume":"103","author":"Hiatt","year":"1999","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0385","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0022-3476(05)80729-2","article-title":"Early bacteriologic, immunologic, and clinical courses of young infants with cystic fibrosis identified by neonatal screening","volume":"119","author":"Abman","year":"1991","journal-title":"J Pediatr"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0390","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1136\/thx.2004.026419","article-title":"Correlation of forced oscillation technique in preschool children with cystic fibrosis with pulmonary inflammation","volume":"60","author":"Brennan","year":"2005","journal-title":"Thorax"},{"issue":"1","key":"10.1016\/j.jcf.2015.09.008_bb0395","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1164\/ajrccm.156.1.9609090","article-title":"Surfactant composition in infants and young children with cystic fibrosis","volume":"156","author":"Hull","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"10.1016\/j.jcf.2015.09.008_bb0400","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jcf.2011.01.003","article-title":"Prevalence and histopathology of chronic polypoid sinusitis in pediatric patients with cystic fibrosis","volume":"10","author":"Schraven","year":"2011","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2015.09.008_bb0405","article-title":"Pulmonary exacerbations and parent-reported outcomes in children <6years with cystic fibrosis","author":"Brumback","year":"2014","journal-title":"Pediatr Pulmonol"},{"issue":"5","key":"10.1016\/j.jcf.2015.09.008_bb0410","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.jpeds.2011.05.005","article-title":"Socioeconomic status and the likelihood of antibiotic treatment for signs and symptoms of pulmonary exacerbation in children with cystic fibrosis","volume":"159","author":"Schechter","year":"2011","journal-title":"J Pediatr"},{"issue":"4","key":"10.1016\/j.jcf.2015.09.008_bb0415","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jcf.2012.11.011","article-title":"Changing thresholds and incidence of antibiotic treatment of cystic fibrosis pulmonary exacerbations, 1995\u20132005","volume":"12","author":"VanDevanter","year":"2013","journal-title":"J Cyst Fibros"},{"issue":"10","key":"10.1016\/j.jcf.2015.09.008_bb0420","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/ejhg.2010.80","article-title":"Notable contribution of large CFTR gene rearrangements to the diagnosis of cystic fibrosis in fetuses with bowel anomalies","volume":"18","author":"de Becdelievre","year":"2010","journal-title":"Eur J Hum Genet"},{"issue":"5","key":"10.1016\/j.jcf.2015.09.008_bb0425","first-page":"778","article-title":"Sonographically detected hyperechoic fetal bowel: significance and implications for pregnancy management","volume":"80","author":"Dicke","year":"1992","journal-title":"Obstet Gynecol"},{"issue":"12","key":"10.1016\/j.jcf.2015.09.008_bb0430","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1136\/jcp.43.12.1014","article-title":"Abnormal fucosylation of ileal mucus in cystic fibrosis: I. A histochemical study using peroxidase labelled lectins","volume":"43","author":"Thiru","year":"1990","journal-title":"J Clin Pathol"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0435","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0087796","article-title":"Disrupted intestinal microbiota and intestinal inflammation in children with cystic fibrosis and its restoration with Lactobacillus GG: a randomised clinical trial","volume":"9","author":"Bruzzese","year":"2014","journal-title":"PLoS ONE"},{"issue":"4 Pt 1","key":"10.1016\/j.jcf.2015.09.008_bb0440","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0022-3476(05)82478-3","article-title":"Pancreatic insufficiency, growth, and nutrition in infants identified by newborn screening as having cystic fibrosis","volume":"120","author":"Bronstein","year":"1992","journal-title":"J Pediatr"},{"issue":"11","key":"10.1016\/j.jcf.2015.09.008_bb0445","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1111\/j.1651-2227.1997.tb14836.x","article-title":"Failure to thrive: the earliest feature of cystic fibrosis in infants diagnosed by neonatal screening","volume":"86","author":"Giglio","year":"1997","journal-title":"Acta Paediatr"},{"issue":"1","key":"10.1016\/j.jcf.2015.09.008_bb0450","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/00005176-199107000-00010","article-title":"Evaluation of growth and changes in body composition following neonatal diagnosis of cystic fibrosis","volume":"13","author":"Greer","year":"1991","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"3","key":"10.1016\/j.jcf.2015.09.008_bb0455","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1136\/adc.69.3.366","article-title":"Measurement of fat digestion in early life using a stable isotope breath test","volume":"69","author":"McClean","year":"1993","journal-title":"Arch Dis Child"},{"issue":"4","key":"10.1016\/j.jcf.2015.09.008_bb0460","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.jpeds.2012.10.008","article-title":"Evolution of pancreatic function during the first year in infants with cystic fibrosis","volume":"162","author":"O'Sullivan","year":"2013","journal-title":"J Pediatr"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0465","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/00005176-200502000-00022","article-title":"Early decline of pancreatic function in cystic fibrosis patients with class 1 or 2 CFTR mutations","volume":"40","author":"Walkowiak","year":"2005","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"5","key":"10.1016\/j.jcf.2015.09.008_bb0470","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1056\/NEJM199002013220505","article-title":"Pancreatic function in infants identified as having cystic fibrosis in a neonatal screening program","volume":"322","author":"Waters","year":"1990","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.jcf.2015.09.008_bb0475","doi-asserted-by":"crossref","first-page":"F1","DOI":"10.1136\/fn.80.1.F1","article-title":"Clinical outcomes of newborn screening for cystic fibrosis","volume":"80","author":"Waters","year":"1999","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"5","key":"10.1016\/j.jcf.2015.09.008_bb0480","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/j.1442-200X.2009.02855.x","article-title":"Protein-energy malnutrition as the first manifestation of cystic fibrosis in infancy","volume":"51","author":"Fustik","year":"2009","journal-title":"Pediatr Int"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0485","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1136\/adc.81.2.125","article-title":"Retrospective review of cystic fibrosis presenting as infantile liver disease","volume":"81","author":"Shapira","year":"1999","journal-title":"Arch Dis Child"},{"issue":"6","key":"10.1016\/j.jcf.2015.09.008_bb0490","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.jcf.2009.08.006","article-title":"Evaluation of salt supplementation in CF infants","volume":"8","author":"Coates","year":"2009","journal-title":"J Cyst Fibros"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0495","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jpeds.2012.01.052","article-title":"Prevalence of hyponatremia at diagnosis and factors associated with the longitudinal variation in serum sodium levels in infants with cystic fibrosis","volume":"161","author":"Guimar\u00e3es","year":"2012","journal-title":"J Pediatr"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0500","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1203\/00006450-200008000-00022","article-title":"Abnormalities in zinc homeostasis in young infants with cystic fibrosis","volume":"48","author":"Krebs","year":"2000","journal-title":"Pediatr Res"},{"issue":"3","key":"10.1016\/j.jcf.2015.09.008_bb0505","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/ajcn\/54.3.578","article-title":"Nutritional status of infants with cystic fibrosis associated with early diagnosis and intervention","volume":"54","author":"Marcus","year":"1991","journal-title":"Am J Clin Nutr"},{"issue":"1-2","key":"10.1016\/j.jcf.2015.09.008_bb0510","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1440-1754.2008.01432.x","article-title":"Vitamin D in infants with cystic fibrosis diagnosed by newborn screening","volume":"45","author":"Neville","year":"2009","journal-title":"J Paediatr Child Health"},{"issue":"5","key":"10.1016\/j.jcf.2015.09.008_bb0515","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1093\/ajcn\/63.5.746","article-title":"Effect of linoleic acid intake on growth of infants with cystic fibrosis","volume":"63","author":"van Egmond","year":"1996","journal-title":"Am J Clin Nutr"},{"issue":"3 Suppl","key":"10.1016\/j.jcf.2015.09.008_bb0520","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1016\/j.jpeds.2005.08.034","article-title":"Complications associated with symptomatic diagnosis in infants with cystic fibrosis","volume":"147","author":"Accurso","year":"2005","journal-title":"J Pediatr"},{"issue":"5","key":"10.1016\/j.jcf.2015.09.008_bb0525","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1067\/mpd.2002.123284","article-title":"Energy metabolism in infants with cystic fibrosis","volume":"140","author":"Bines","year":"2002","journal-title":"J Pediatr"},{"issue":"14","key":"10.1016\/j.jcf.2015.09.008_bb0530","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1056\/NEJM199710023371403","article-title":"Nutritional benefits of neonatal screening for cystic fibrosis","volume":"337","author":"Farrell","year":"1997","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.jcf.2015.09.008_bb0535","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jpeds.2005.04.031","article-title":"Gestational and neonatal characteristics of children with cystic fibrosis: a cohort study","volume":"147","author":"Festini","year":"2005","journal-title":"J Pediatr"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0540","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1136\/adc.72.2.150","article-title":"Disproportionate head growth retardation in cystic fibrosis","volume":"72","author":"Ghosal","year":"1995","journal-title":"Arch Dis Child"},{"issue":"5","key":"10.1016\/j.jcf.2015.09.008_bb0545","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2223\/1221","article-title":"Cystic fibrosis at a Brazilian center of excellence: clinical and laboratory characteristics of 104 patients and their association with genotype and disease severity","volume":"80","author":"Alvarez","year":"2004","journal-title":"J Pediatr (Rio J)"},{"issue":"6","key":"10.1016\/j.jcf.2015.09.008_bb0550","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1164\/rccm.200911-1646OC","article-title":"Lung clearance index at 4years predicts subsequent lung function in children with cystic fibrosis","volume":"183","author":"Aurora","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"issue":"7","key":"10.1016\/j.jcf.2015.09.008_bb0555","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/ppul.20842","article-title":"Improved pulmonary and growth outcomes in cystic fibrosis by newborn screening","volume":"43","author":"Collins","year":"2008","journal-title":"Pediatr Pulmonol"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0560","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S1569-1993(03)00023-7","article-title":"Growth in prepubertal children with cystic fibrosis, homozygous for the Delta F508 mutation","volume":"2","author":"Keller","year":"2003","journal-title":"J Cyst Fibros"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0565","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/apa.12462","article-title":"The relationship between body growth and pulmonary function in children with cystic fibrosis","volume":"103","author":"Woestenenk","year":"2014","journal-title":"Acta Paediatr"},{"issue":"6","key":"10.1016\/j.jcf.2015.09.008_bb0570","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1080\/03014469000001262","article-title":"Early childhood growth in patients with cystic fibrosis","volume":"17","author":"Byard","year":"1990","journal-title":"Ann Hum Biol"},{"issue":"3","key":"10.1016\/j.jcf.2015.09.008_bb0575","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1136\/adc.75.3.191","article-title":"Head growth in cystic fibrosis following early diagnosis by neonatal screening","volume":"75","author":"Ghosal","year":"1996","journal-title":"Arch Dis Child"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0580","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1183\/09031936.06.00071005","article-title":"Exhaled nitric oxide is not reduced in infants with cystic fibrosis","volume":"27","author":"Franklin","year":"2006","journal-title":"Eur Respir J"},{"issue":"5","key":"10.1016\/j.jcf.2015.09.008_bb0585","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1164\/rccm.200401-132OC","article-title":"Elastic properties of the respiratory system in infants with cystic fibrosis","volume":"170","author":"Tepper","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.jcf.2015.09.008_bb0590","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/ppul.20994","article-title":"Longitudinal assessment of lung function from infancy to childhood in patients with cystic fibrosis","volume":"44","author":"Harrison","year":"2009","journal-title":"Pediatr Pulmonol"},{"issue":"6","key":"10.1016\/j.jcf.2015.09.008_bb0595","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1067\/mpd.2003.152","article-title":"Growth and nutritional indexes in early life predict pulmonary function in cystic fibrosis","volume":"142","author":"Konstan","year":"2003","journal-title":"J Pediatr"},{"issue":"1","key":"10.1016\/j.jcf.2015.09.008_bb0600","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1164\/rccm.200710-1599OC","article-title":"Lung function from infancy to the preschool years after clinical diagnosis of cystic fibrosis","volume":"178","author":"Kozlowska","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcf.2015.09.008_bb0605","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/ppul.22894","article-title":"Early childhood wheezing is associated with lower lung function in cystic fibrosis","volume":"49","author":"Ren","year":"2014","journal-title":"Pediatr Pulmonol"},{"issue":"12","key":"10.1016\/j.jcf.2015.09.008_bb0610","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1002\/ppul.21311","article-title":"Pulmonary outcome prediction (POP) tools for cystic fibrosis patients","volume":"45","author":"VanDevanter","year":"2010","journal-title":"Pediatr Pulmonol"},{"issue":"1","key":"10.1016\/j.jcf.2015.09.008_bb0615","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jcf.2009.10.004","article-title":"Pulmonary outcome differences in U.S. and French cystic fibrosis cohorts diagnosed through newborn screening","volume":"9","author":"Walsh","year":"2010","journal-title":"J Cyst Fibros"},{"issue":"6","key":"10.1016\/j.jcf.2015.09.008_bb0620","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1136\/thoraxjnl-2011-200912","article-title":"Progression of early structural lung disease in young children with cystic fibrosis assessed using CT","volume":"67","author":"Mott","year":"2012","journal-title":"Thorax"},{"issue":"6","key":"10.1016\/j.jcf.2015.09.008_bb0625","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1183\/09031936.00138412","article-title":"Association of lung function, chest radiographs and clinical features in infants with cystic fibrosis","volume":"42","author":"Rosenfeld","year":"2013","journal-title":"Eur Respir J"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0630","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1183\/09031936.00051406","article-title":"Radiological and functional changes over 3years in young children with cystic fibrosis","volume":"30","author":"Terheggen-Lagro","year":"2007","journal-title":"Eur Respir J"},{"issue":"5","key":"10.1016\/j.jcf.2015.09.008_bb0635","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0022-3476(99)70059-4","article-title":"Prospective, long-term study of fat-soluble vitamin status in children with cystic fibrosis identified by newborn screen","volume":"135","author":"Feranchak","year":"1999","journal-title":"J Pediatr"},{"issue":"6","key":"10.1016\/j.jcf.2015.09.008_bb0640","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0022-3476(98)70147-7","article-title":"Low plasma zinc concentrations in young infants with cystic fibrosis","volume":"133","author":"Krebs","year":"1998","journal-title":"J Pediatr"},{"key":"10.1016\/j.jcf.2015.09.008_bb0645","first-page":"1","article-title":"Effect of equipment dead space on multiple breath washout measures","author":"Benseler","year":"2015","journal-title":"Respirology"},{"issue":"7","key":"10.1016\/j.jcf.2015.09.008_bb0650","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1136\/thoraxjnl-2012-202342","article-title":"Prospective evaluation of respiratory exacerbations in children with cystic fibrosis from newborn screening to 5years of age","volume":"68","author":"Byrnes","year":"2013","journal-title":"Thorax"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0655","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/ppul.1950160204","article-title":"Longitudinal evaluation of pulmonary function in infants and very young children with cystic fibrosis","volume":"16","author":"Tepper","year":"1993","journal-title":"Pediatr Pulmonol"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0660","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/ppul.10127","article-title":"Pseudomonas aeruginosa and other predictors of mortality and morbidity in young children with cystic fibrosis","volume":"34","author":"Emerson","year":"2002","journal-title":"Pediatr Pulmonol"},{"issue":"7","key":"10.1016\/j.jcf.2015.09.008_bb0665","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1136\/thx.50.7.712","article-title":"Long term prognosis of patients with cystic fibrosis in relation to early detection by neonatal screening and treatment in a cystic fibrosis centre","volume":"50","author":"Dankert-Roelse","year":"1995","journal-title":"Thorax"},{"issue":"3 Suppl","key":"10.1016\/j.jcf.2015.09.008_bb0670","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1016\/j.jpeds.2005.08.002","article-title":"Neonatal screening for cystic fibrosis is beneficial even in the context of modern treatment","volume":"147","author":"Sims","year":"2005","journal-title":"J Pediatr"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0675","doi-asserted-by":"crossref","first-page":"e348","DOI":"10.1542\/peds.2011-0567","article-title":"Comparison of the US and Australian cystic fibrosis registries: the impact of newborn screening","volume":"129","author":"Martin","year":"2012","journal-title":"Pediatrics"},{"issue":"5","key":"10.1016\/j.jcf.2015.09.008_bb0680","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1159\/000055856","article-title":"Neonatal screening for cystic fibrosis: long-term clinical balance","volume":"1","author":"Mastella","year":"2001","journal-title":"Pancreatology"},{"issue":"1","key":"10.1016\/j.jcf.2015.09.008_bb0685","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1542\/peds.107.1.1","article-title":"Early diagnosis of cystic fibrosis through neonatal screening prevents severe malnutrition and improves long-term growth","volume":"107","author":"Farrell","year":"2001","journal-title":"Pediatrics"},{"issue":"5","key":"10.1016\/j.jcf.2015.09.008_bb0690","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/ppul.10259","article-title":"Comparing the clinical evolution of cystic fibrosis screened neonatally to that of cystic fibrosis diagnosed from clinical symptoms: a 10-year retrospective study in a French region (Brittany)","volume":"35","author":"Siret","year":"2003","journal-title":"Pediatr Pulmonol"},{"issue":"3 Suppl","key":"10.1016\/j.jcf.2015.09.008_bb0695","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1016\/j.jpeds.2005.08.014","article-title":"The survival advantage of patients with cystic fibrosis diagnosed through neonatal screening: evidence from the United States Cystic Fibrosis Foundation registry data","volume":"147","author":"Lai","year":"2005","journal-title":"J Pediatr"},{"issue":"3","key":"10.1016\/j.jcf.2015.09.008_bb0700","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.jpeds.2012.08.040","article-title":"Better nutritional status in early childhood is associated with improved clinical outcomes and survival in patients with cystic fibrosis","volume":"162","author":"Yen","year":"2013","journal-title":"J Pediatr"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0705","doi-asserted-by":"crossref","first-page":"163","DOI":"10.4155\/cli.11.174","article-title":"Outcome measures for clinical trials assessing treatment of cystic fibrosis lung disease","volume":"2","author":"VanDevanter","year":"2012","journal-title":"Clin Invest"},{"issue":"2","key":"10.1016\/j.jcf.2015.09.008_bb0710","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1001\/archpedi.1938.01980140114013","article-title":"Cystic fibrosis of the pancreas and its relation to celiac disease: a clinical and pathologic study","volume":"56","author":"Andersen","year":"1938","journal-title":"Am J Dis Child"},{"issue":"6","key":"10.1016\/j.jcf.2015.09.008_bb0715","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.jpeds.2014.06.061","article-title":"Improvements in lung function and height among cohorts of 6-year-olds with cystic fibrosis from 1994 to 2012","volume":"165","author":"VanDevanter","year":"2014","journal-title":"J Pediatr"}],"container-title":["Journal of Cystic Fibrosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199315002167?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199315002167?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T15:15:07Z","timestamp":1567264507000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569199315002167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":143,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S1569199315002167"],"URL":"https:\/\/doi.org\/10.1016\/j.jcf.2015.09.008","relation":{},"ISSN":["1569-1993"],"issn-type":[{"value":"1569-1993","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cystic fibrosis in young children: A review of disease manifestation, progression, and response to early treatment","name":"articletitle","label":"Article Title"},{"value":"Journal of Cystic Fibrosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcf.2015.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}