{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:33:37Z","timestamp":1790624017763,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":731,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100014555","name":"Murdoch Children's Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014555","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001232","name":"Royal Australasian College of Physicians","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001232","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009968","name":"Amt der Tiroler Landesregierung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001247","name":"Thoracic Society of Australia and New Zealand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001247","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL116211"],"award-info":[{"award-number":["HL116211"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GNT1043768"],"award-info":[{"award-number":["GNT1043768"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001186","name":"Australian Cystic Fibrosis Research Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001186","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003327","name":"Cooperative Research Centres, Australian Government Department of Industry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003327","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cysticfibrosisjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cystic Fibrosis"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.jcf.2018.12.003","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T22:13:06Z","timestamp":1545343986000},"page":"646-652","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Differences in the lower airway microbiota of infants with and without cystic fibrosis"],"prefix":"10.1016","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3479-4470","authenticated-orcid":false,"given":"Katherine B.","family":"Frayman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine M.","family":"Wylie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Carzino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie D.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Ferkol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Grimwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Storch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarath C.","family":"Ranganathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6285","key":"10.1016\/j.jcf.2018.12.003_bb0005","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1126\/science.aad9378","article-title":"How colonization by microbiota in early life shapes the immune system","volume":"352","author":"Gensollen","year":"2016","journal-title":"Science"},{"issue":"21","key":"10.1016\/j.jcf.2018.12.003_bb0010","doi-asserted-by":"crossref","first-page":"3887","DOI":"10.1002\/1873-3468.12353","article-title":"Impact of micro-environmental changes on respiratory tract infections caused by intracellular bacteria","volume":"590","author":"Shima","year":"2016","journal-title":"FEBS Lett"},{"issue":"11","key":"10.1016\/j.jcf.2018.12.003_bb0015","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1002\/ppul.23782","article-title":"The airway microbiota in early cystic fibrosis lung disease","volume":"52","author":"Frayman","year":"2017","journal-title":"Pediatr Pulmonol"},{"issue":"21","key":"10.1016\/j.jcf.2018.12.003_bb0020","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1056\/NEJMoa1301725","article-title":"Risk factors for bronchiectasis in children with cystic fibrosis","volume":"368","author":"Sly","year":"2013","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.jcf.2018.12.003_bb0025","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/ppul.20294","article-title":"Lower airway inflammation in infants with cystic fibrosis detected by newborn screening","volume":"40","author":"Armstrong","year":"2005","journal-title":"Pediatr Pulmonol"},{"issue":"4 Pt 1","key":"10.1016\/j.jcf.2018.12.003_bb0030","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1164\/ajrccm.156.4.96-11058","article-title":"Lower airway inflammation in infants and young children with cystic fibrosis","volume":"156","author":"Armstrong","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.jcf.2018.12.003_bb0035","first-page":"1075","article-title":"Early pulmonary inflammation in infants with cystic fibrosis","volume":"151","author":"Khan","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.jcf.2018.12.003_bb0040","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1164\/rccm.201509-1759OC","article-title":"Development of the nasopharyngeal microbiota in infants with cystic fibrosis","volume":"193","author":"Prevaes","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"issue":"8","key":"10.1016\/j.jcf.2018.12.003_bb0045","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S2213-2600(16)30081-9","article-title":"Group oboSs. The nasal microbiota in infants with cystic fibrosis in the first year of life: a prospective cohort study","volume":"4","author":"Mika","year":"2016","journal-title":"Lancet Respir Med"},{"issue":"4","key":"10.1016\/j.jcf.2018.12.003_bb0050","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/ppul.23953","article-title":"In children, the microbiota of the nasopharynx and brochoalveolar lavage fluid are both similar and different","volume":"53","author":"Kloepfer","year":"2018","journal-title":"Pediatr Pulmonol"},{"issue":"1","key":"10.1016\/j.jcf.2018.12.003_bb0055","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s40168-016-0182-1","article-title":"The microbiota in bronchoalveolar lavage from young children with chronic lung disease includes taxa present in both the oropharynx and nasopharynx","volume":"4","author":"Marsh","year":"2016","journal-title":"Microbiome"},{"issue":"3","key":"10.1016\/j.jcf.2018.12.003_bb0060","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02235-2016","article-title":"Concordance between upper and lower airway microbiota in infants with cystic fibrosis","volume":"49","author":"Prevaes","year":"2017","journal-title":"Eur Respir J"},{"issue":"5","key":"10.1016\/j.jcf.2018.12.003_bb0065","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00832-2017","article-title":"Airway microbiota across age and disease spectrum in cystic fibrosis","volume":"50","author":"Zemanick","year":"2017","journal-title":"Eur Respir J"},{"issue":"12","key":"10.1016\/j.jcf.2018.12.003_bb0070","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1136\/thoraxjnl-2016-209279","article-title":"The lower airway microbiota in early cystic fibrosis lung disease: a longitudinal analysis","volume":"72","author":"Frayman","year":"2017","journal-title":"Thorax"},{"issue":"2","key":"10.1016\/j.jcf.2018.12.003_bb0075","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1183\/09031936.01.17202810","article-title":"Interlobar differences in bronchoalveolar lavage fluid from children with cystic fibrosis","volume":"17","author":"Gutierrez","year":"2001","journal-title":"Eur Respir J"},{"issue":"5","key":"10.1016\/j.jcf.2018.12.003_bb0080","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/(SICI)1099-0496(199605)21:5<267::AID-PPUL1>3.0.CO;2-K","article-title":"Bronchoalveolar lavage or oropharyngeal cultures to identify lower respiratory pathogens in infants with cystic fibrosis","volume":"21","author":"Armstrong","year":"1996","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jcf.2018.12.003_bb0085","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature11234","article-title":"Structure, function and diversity of the healthy human microbiome","volume":"486","author":"Human Microbiome Project Consortium","year":"2012","journal-title":"Nature"},{"issue":"16","key":"10.1016\/j.jcf.2018.12.003_bb0090","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1128\/AEM.00062-07","article-title":"Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy","volume":"73","author":"Wang","year":"2007","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.jcf.2018.12.003_bb0095","series-title":"R: A language and environment for statistical computing","author":"Core Team","year":"2017"},{"key":"10.1016\/j.jcf.2018.12.003_bb0100","series-title":"Community Ecology Package","author":"Okansen","year":"2018"},{"issue":"12","key":"10.1016\/j.jcf.2018.12.003_bb0105","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/nmeth.2658","article-title":"Differential abundance analysis for microbial marker-gene surveys","volume":"10","author":"Paulson","year":"2013","journal-title":"Nat Methods"},{"issue":"5","key":"10.1016\/j.jcf.2018.12.003_bb0110","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/cid\/cir399","article-title":"Inflammatory responses to individual microorganisms in the lungs of children with cystic fibrosis","volume":"53","author":"Gangell","year":"2011","journal-title":"Clin Infect Dis"},{"issue":"1","key":"10.1016\/j.jcf.2018.12.003_bb0115","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1164\/rccm.201011-1892OC","article-title":"Infection, inflammation, and lung function decline in infants with cystic fibrosis","volume":"184","author":"Pillarisetti","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"issue":"10","key":"10.1016\/j.jcf.2018.12.003_bb0120","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1164\/rccm.201407-1277OC","article-title":"Early respiratory infection is associated with reduced spirometry in children with cystic fibrosis","volume":"190","author":"Ramsey","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"10.1016\/j.jcf.2018.12.003_bb0125","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1183\/09031936.00138412","article-title":"Association of lung function, chest radiographs and clinical features in infants with cystic fibrosis","volume":"42","author":"Rosenfeld","year":"2013","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1016\/j.jcf.2018.12.003_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006798","article-title":"Initial acquisition and succession of the cystic fibrosis lung microbiome is associated with disease progression in infants and preschool children","volume":"14","author":"Muhlebach","year":"2018","journal-title":"PLoS Pathog"},{"issue":"10","key":"10.1016\/j.jcf.2018.12.003_bb0135","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1513\/AnnalsATS.201702-121OC","article-title":"CF. A. Association of antibiotics, airway microbiome and inflammation in infants with cystic fibrosis","volume":"14","author":"Pittman","year":"2017","journal-title":"Ann Am Thorac Soc"},{"issue":"11","key":"10.1016\/j.jcf.2018.12.003_bb0140","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1164\/rccm.201407-1240OC","article-title":"Early respiratory microbiota composition determines bacterial succession patterns and respiratory health in children","volume":"190","author":"Biesbroek","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.jcf.2018.12.003_bb0145","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.jaci.2014.12.1909","article-title":"Dynamics of the nasal microbiota in infancy: a prospective cohort study","volume":"135","author":"Mika","year":"2015","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"10.1016\/j.jcf.2018.12.003_bb0150","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.chom.2015.03.008","article-title":"The Infant Nasopharyngeal Microbiome Impacts Severity of lower respiratory Infection and risk of Asthma Development","volume":"17","author":"Teo","year":"2015","journal-title":"Cell Host Microbe"}],"container-title":["Journal of Cystic Fibrosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156919931830941X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156919931830941X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T21:41:31Z","timestamp":1761601291000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156919931830941X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S156919931830941X"],"URL":"https:\/\/doi.org\/10.1016\/j.jcf.2018.12.003","relation":{},"ISSN":["1569-1993"],"issn-type":[{"value":"1569-1993","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differences in the lower airway microbiota of infants with and without cystic fibrosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Cystic Fibrosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcf.2018.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 European Cystic Fibrosis Society. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}