{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T13:18:06Z","timestamp":1779196686753,"version":"3.51.4"},"reference-count":73,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":731,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100012423","name":"Children's Healthcare of Atlanta","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012423","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI130504"],"award-info":[{"award-number":["R21AI130504"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR071384"],"award-info":[{"award-number":["R01AR071384"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5K08AR063668"],"award-info":[{"award-number":["5K08AR063668"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006939","name":"Emory University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006939","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["438903"],"award-info":[{"award-number":["438903"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cysticfibrosisjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cystic Fibrosis"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.jcf.2018.12.010","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T17:43:57Z","timestamp":1547142237000},"page":"636-645","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Systemic levels of anti-PAD4 autoantibodies correlate with airway obstruction in cystic fibrosis"],"prefix":"10.1016","volume":"18","author":[{"given":"Ruchi","family":"Yadav","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae-goon","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Michelle","family":"Kahlenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"S. Louis","family":"Bridges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oluwadamilola","family":"Oni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanwen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arlene","family":"Stecenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9742-4955","authenticated-orcid":false,"given":"Bal\u00e1zs","family":"Rada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcf.2018.12.010_bb0005","doi-asserted-by":"crossref","first-page":"15010","DOI":"10.1038\/nrdp.2015.10","article-title":"Cystic fibrosis","volume":"1","author":"Ratjen","year":"2015","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"10.1016\/j.jcf.2018.12.010_bb0010","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01910-2017","article-title":"Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis","volume":"51","author":"Dittrich","year":"2018","journal-title":"Eur Respir J"},{"issue":"6","key":"10.1016\/j.jcf.2018.12.010_bb0015","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1067\/mpd.2002.129847","article-title":"Induced sputum inflammatory measures correlate with lung function in children with cystic fibrosis","volume":"141","author":"Sagel","year":"2002","journal-title":"J Pediatr"},{"issue":"5","key":"10.1016\/j.jcf.2018.12.010_bb0020","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1378\/chest.129.5.1148","article-title":"Pulmonary function is negatively correlated with sputum inflammatory markers and cough clearability in subjects with cystic fibrosis but not those with chronic bronchitis","volume":"129","author":"Kim","year":"2006","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.jcf.2018.12.010_bb0025","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1183\/09031936.93.03010019","article-title":"The origin of DNA associated with mucus glycoproteins in cystic fibrosis sputum","volume":"3","author":"Lethem","year":"1990","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1016\/j.jcf.2018.12.010_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ppul.1950190102","article-title":"Sputum peroxidase activity correlates with the severity of lung disease in cystic fibrosis","volume":"19","author":"Regelmann","year":"1995","journal-title":"Pediatr Pulmonol"},{"issue":"9","key":"10.1016\/j.jcf.2018.12.010_bb0035","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1164\/rccm.201203-0507OC","article-title":"Sputum biomarkers of inflammation and lung function decline in children with cystic fibrosis","volume":"186","author":"Sagel","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcf.2018.12.010_bb0040","doi-asserted-by":"crossref","first-page":"408935","DOI":"10.1155\/2015\/408935","article-title":"Free DNA in cystic fibrosis airway fluids correlates with airflow obstruction","volume":"2015","author":"Marcos","year":"2015","journal-title":"Mediators Inflamm"},{"issue":"5663","key":"10.1016\/j.jcf.2018.12.010_bb0045","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.jcf.2018.12.010_bb0050","doi-asserted-by":"crossref","first-page":"4728","DOI":"10.4049\/jimmunol.1301589","article-title":"Release of cystic fibrosis airway inflammatory markers from Pseudomonas aeruginosa-stimulated human neutrophils involves NADPH oxidase-dependent extracellular DNA trap formation","volume":"192","author":"Yoo","year":"2014","journal-title":"J Immunol"},{"issue":"2","key":"10.1016\/j.jcf.2018.12.010_bb0055","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.imlet.2014.03.003","article-title":"NET formation induced by Pseudomonas aeruginosa cystic fibrosis isolates measured as release of myeloperoxidase-DNA and neutrophil elastase-DNA complexes","volume":"160","author":"Yoo","year":"2014","journal-title":"Immunol Lett"},{"issue":"2","key":"10.1016\/j.jcf.2018.12.010_bb0060","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jcf.2011.09.008","article-title":"Ultrastructural characterization of cystic fibrosis sputum using atomic force and scanning electron microscopy","volume":"11","author":"Manzenreiter","year":"2012","journal-title":"J Cyst Fibros"},{"issue":"12","key":"10.1016\/j.jcf.2018.12.010_bb0065","doi-asserted-by":"crossref","first-page":"e28526","DOI":"10.1371\/journal.pone.0028526","article-title":"Neutrophil elastase enhances sputum solubilization in cystic fibrosis patients receiving DNase therapy","volume":"6","author":"Papayannopoulos","year":"2011","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.jcf.2018.12.010_bb0070","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1084\/jem.20100239","article-title":"PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps","volume":"207","author":"Li","year":"2010","journal-title":"J Exp Med"},{"issue":"2","key":"10.1016\/j.jcf.2018.12.010_bb0075","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1083\/jcb.200806072","article-title":"Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation","volume":"184","author":"Wang","year":"2009","journal-title":"J Cell Biol"},{"issue":"3","key":"10.1016\/j.jcf.2018.12.010_bb0080","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1136\/annrheumdis-2013-203844","article-title":"Citrullination of autoantigens implicates NETosis in the induction of autoimmunity","volume":"73","author":"Dwivedi","year":"2014","journal-title":"Ann Rheum Dis"},{"issue":"12","key":"10.1016\/j.jcf.2018.12.010_bb0085","doi-asserted-by":"crossref","first-page":"6488","DOI":"10.4049\/jimmunol.1203215","article-title":"Pseudogout-associated inflammatory calcium pyrophosphate dihydrate microcrystals induce formation of neutrophil extracellular traps","volume":"190","author":"Pang","year":"2013","journal-title":"J Immunol"},{"issue":"3","key":"10.1016\/j.jcf.2018.12.010_bb0090","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nchembio.1735","article-title":"Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation","volume":"11","author":"Lewis","year":"2015","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.jcf.2018.12.010_bb0095","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3389\/fimmu.2012.00307","article-title":"PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures","volume":"3","author":"Leshner","year":"2012","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.jcf.2018.12.010_bb0100","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1038\/s41467-018-06263-5","article-title":"Chromatin swelling drives neutrophil extracellular trap release","volume":"9","author":"Neubert","year":"2018","journal-title":"Nat Commun"},{"issue":"17","key":"10.1016\/j.jcf.2018.12.010_bb0105","doi-asserted-by":"crossref","first-page":"e88912","DOI":"10.1172\/jci.insight.88912","article-title":"The role for neutrophil extracellular traps in cystic fibrosis autoimmunity","volume":"1","author":"Skopelja","year":"2016","journal-title":"JCI Insight"},{"issue":"9","key":"10.1016\/j.jcf.2018.12.010_bb0110","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1002\/art.1780400928","article-title":"Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus","volume":"40","author":"Hochberg","year":"1997","journal-title":"Arthritis Rheum"},{"issue":"112","key":"10.1016\/j.jcf.2018.12.010_bb0115","doi-asserted-by":"crossref","DOI":"10.3791\/52779","article-title":"High throughput measurement of extracellular DNA release and quantitative NET formation in human neutrophils in vitro","author":"Sil","year":"2016","journal-title":"J Vis Exp"},{"issue":"1","key":"10.1016\/j.jcf.2018.12.010_bb0120","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/BOR.0000000000000452","article-title":"Rheumatoid arthritis and citrullination","volume":"30","author":"Darrah","year":"2018","journal-title":"Curr Opin Rheumatol"},{"issue":"9","key":"10.1016\/j.jcf.2018.12.010_bb0125","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.autrev.2018.02.014","article-title":"ACPA mediates the interplay between innate and adaptive immunity in rheumatoid arthritis","volume":"17","author":"Dong","year":"2018","journal-title":"Autoimmun Rev"},{"issue":"3","key":"10.1016\/j.jcf.2018.12.010_bb0130","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nrrheum.2018.10","article-title":"The B cell response to citrullinated antigens in the development of rheumatoid arthritis","volume":"14","author":"Scherer","year":"2018","journal-title":"Nat Rev Rheumatol"},{"issue":"11","key":"10.1016\/j.jcf.2018.12.010_bb0135","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.autrev.2018.06.006","article-title":"Neutrophils: novel key players in Rheumatoid Arthritis. Current and future therapeutic targets","volume":"17","author":"Cecchi","year":"2018","journal-title":"Autoimmun Rev"},{"issue":"6","key":"10.1016\/j.jcf.2018.12.010_bb0140","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1084\/jem.152.6.1720","article-title":"Human autoantibodies that react with both cell nuclei and plasma membranes display specificity for the octamer of histones H2A, H2B, H3, and H4 in high salt","volume":"152","author":"Rekvig","year":"1980","journal-title":"J Exp Med"},{"issue":"7","key":"10.1016\/j.jcf.2018.12.010_bb0145","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1093\/cid\/ciy215","article-title":"Changing rates of chronic Pseudomonas aeruginosa infections in cystic fibrosis: a population-based cohort study","volume":"67","author":"Crull","year":"2018","journal-title":"Clin Infect Dis"},{"issue":"6","key":"10.1016\/j.jcf.2018.12.010_bb0150","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s10096-016-2621-0","article-title":"Staphylococcus aureus and Pseudomonas aeruginosa co-infection is associated with cystic fibrosis-related diabetes and poor clinical outcomes","volume":"35","author":"Limoli","year":"2016","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"6 Pt 2","key":"10.1016\/j.jcf.2018.12.010_bb0155","first-page":"e38","article-title":"Current and emerging comorbidities in cystic fibrosis","volume":"46","author":"Ronan","year":"2017","journal-title":"Presse Med"},{"issue":"2","key":"10.1016\/j.jcf.2018.12.010_bb0160","doi-asserted-by":"crossref","first-page":"498","DOI":"10.3390\/biom4020498","article-title":"Decoding F508del misfolding in cystic fibrosis","volume":"4","author":"Wang","year":"2014","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.jcf.2018.12.010_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cei.13041","article-title":"Self-dsDNA in the pathogenesis of systemic lupus erythematosus","volume":"191","author":"Bai","year":"2018","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"10.1016\/j.jcf.2018.12.010_bb0170","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1189\/jlb.5BT0615-247R","article-title":"At the Bench: Neutrophil extracellular traps (NETs) highlight novel aspects of innate immune system involvement in autoimmune diseases","volume":"99","author":"Grayson","year":"2016","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jcf.2018.12.010_bb0175","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/978-1-4939-0326-9_11","article-title":"Detection of SLE antigens in neutrophil extracellular traps (NETs)","volume":"1134","author":"Carmona-Rivera","year":"2014","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jcf.2018.12.010_bb0180","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3389\/fimmu.2016.00485","article-title":"NETosis as source of Autoantigens in Rheumatoid Arthritis","volume":"7","author":"Corsiero","year":"2016","journal-title":"Front Immunol"},{"issue":"11","key":"10.1016\/j.jcf.2018.12.010_bb0185","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.autrev.2017.09.012","article-title":"Neutrophil extracellular traps (NETs) in autoimmune diseases: a comprehensive review","volume":"16","author":"Lee","year":"2017","journal-title":"Autoimmun Rev"},{"issue":"2","key":"10.1016\/j.jcf.2018.12.010_bb0190","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/00365540600951259","article-title":"Serum myeloperoxidase in cystic fibrosis patients receiving systemic antibiotics","volume":"39","author":"Kohlhoff","year":"2007","journal-title":"Scand J Infect Dis"},{"issue":"3","key":"10.1016\/j.jcf.2018.12.010_bb0195","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1001-9294(15)30048-1","article-title":"Serum Myeloperoxidase Level in Systemic Lupus Erythematosus","volume":"30","author":"Bai","year":"2015","journal-title":"Chin Med Sci J"},{"issue":"1","key":"10.1016\/j.jcf.2018.12.010_bb0200","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.lfs.2014.09.012","article-title":"Increased levels of serum myeloperoxidase in patients with active rheumatoid arthritis","volume":"117","author":"Wang","year":"2014","journal-title":"Life Sci"},{"issue":"6","key":"10.1016\/j.jcf.2018.12.010_bb0205","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.jcf.2016.10.009","article-title":"Biomarkers for cystic fibrosis drug development","volume":"15","author":"Muhlebach","year":"2016","journal-title":"J Cyst Fibros"},{"issue":"3","key":"10.1016\/j.jcf.2018.12.010_bb0210","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1164\/ajrccm\/144.3_Pt_1.580","article-title":"Human neutrophil elastase and elastase\/alpha 1-antiprotease complex in cystic fibrosis. Comparison with interstitial lung disease and evaluation of the effect of intravenously administered antibiotic therapy","volume":"144","author":"Meyer","year":"1991","journal-title":"Am Rev Respir Dis"},{"issue":"8","key":"10.1016\/j.jcf.2018.12.010_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182587","article-title":"Neutrophil extracellular trap (NET) levels in human plasma are associated with active TB","volume":"12","author":"Schechter","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jcf.2018.12.010_bb0220","series-title":"Neutrophil Extracellular Traps in Children with Meningococcal Sepsis. Pediatr Crit Care Med","author":"Hoppenbrouwers","year":"2018"},{"issue":"2","key":"10.1016\/j.jcf.2018.12.010_bb0225","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/1756-185X.13226","article-title":"Increased levels of neutrophil extracellular trap remnants in the serum of patients with rheumatoid arthritis","volume":"21","author":"Wang","year":"2018","journal-title":"Int J Rheum Dis"},{"issue":"2","key":"10.1016\/j.jcf.2018.12.010_bb0230","article-title":"Circulating Level of Neutrophil Extracellular Traps is not a Useful Biomarker for Assessing disease activity in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis","volume":"11","author":"Wang","year":"2016","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jcf.2018.12.010_bb0235","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1159\/000444853","article-title":"Elevated Levels of Total Cell-Free DNA in Maternal Serum Samples Arise from the Generation of Neutrophil Extracellular Traps","volume":"40","author":"Sur Chowdhury","year":"2016","journal-title":"Fetal Diagn Ther"},{"issue":"5","key":"10.1016\/j.jcf.2018.12.010_bb0240","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1084\/jem.177.5.1367","article-title":"Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus","volume":"177","author":"Mohan","year":"1993","journal-title":"J Exp Med"},{"issue":"73","key":"10.1016\/j.jcf.2018.12.010_bb0245","doi-asserted-by":"crossref","first-page":"73ra19","DOI":"10.1126\/scitranslmed.3001180","article-title":"Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus","volume":"3","author":"Lande","year":"2011","journal-title":"Sci Transl Med"},{"issue":"1","key":"10.1016\/j.jcf.2018.12.010_bb0250","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/rheumatology\/keh414","article-title":"Localization of peptidylarginine deiminase 4 (PADI4) and citrullinated protein in synovial tissue of rheumatoid arthritis","volume":"44","author":"Chang","year":"2005","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"10.1016\/j.jcf.2018.12.010_bb0255","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1189\/jlb.70.1.46","article-title":"Immunocytochemical localization of peptidylarginine deiminase in human eosinophils and neutrophils","volume":"70","author":"Asaga","year":"2001","journal-title":"J Leukoc Biol"},{"issue":"4","key":"10.1016\/j.jcf.2018.12.010_bb0260","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1136\/ard.2003.012211","article-title":"Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages","volume":"63","author":"Vossenaar","year":"2004","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"10.1016\/j.jcf.2018.12.010_bb0265","first-page":"616","article-title":"Protein arginine deiminase 4 (PAD4): current understanding and future therapeutic potential","volume":"12","author":"Jones","year":"2009","journal-title":"Curr Opin Drug Discov Devel"},{"issue":"3","key":"10.1016\/j.jcf.2018.12.010_bb0270","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.autrev.2009.06.002","article-title":"Peptidylarginine deiminase 4 and citrullination in health and disease","volume":"9","author":"Anzilotti","year":"2010","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jcf.2018.12.010_bb0275","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3389\/fimmu.2012.00360","article-title":"Activation of PAD4 in NET formation","volume":"3","author":"Rohrbach","year":"2012","journal-title":"Front Immunol"},{"issue":"12","key":"10.1016\/j.jcf.2018.12.010_bb0280","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1002\/art.39313","article-title":"Release of active peptidyl arginine deiminases by neutrophils can explain production of extracellular citrullinated autoantigens in rheumatoid arthritis synovial fluid","volume":"67","author":"Spengler","year":"2015","journal-title":"Arthritis Rheumatol"},{"issue":"5","key":"10.1016\/j.jcf.2018.12.010_bb0285","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1007\/s00296-010-1765-y","article-title":"Anti-PAD4 autoantibodies in rheumatoid arthritis: levels in serum over time and impact on PAD4 activity as measured with a small synthetic substrate","volume":"32","author":"Pollmann","year":"2012","journal-title":"Rheumatol Int"},{"issue":"2","key":"10.1016\/j.jcf.2018.12.010_bb0290","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.autrev.2017.11.023","article-title":"Clinical and immunological aspects of anti-peptidylarginine deiminase type 4 (anti-PAD4) autoantibodies in rheumatoid arthritis","volume":"17","author":"Reyes-Castillo","year":"2018","journal-title":"Autoimmun Rev"},{"issue":"7","key":"10.1016\/j.jcf.2018.12.010_bb0295","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1002\/art.23596","article-title":"Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritis","volume":"58","author":"Harris","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"9","key":"10.1016\/j.jcf.2018.12.010_bb0300","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.3899\/jrheum.130293","article-title":"Prevalence of anti-peptidylarginine deiminase type 4 antibodies in rheumatoid arthritis and unaffected first-degree relatives in indigenous north American Populations","volume":"40","author":"Ferucci","year":"2013","journal-title":"J Rheumatol"},{"issue":"6","key":"10.1016\/j.jcf.2018.12.010_bb0305","first-page":"969","article-title":"Prevalence and significance of anti-peptidylarginine deiminase 4 antibodies in rheumatoid arthritis","volume":"35","author":"Zhao","year":"2008","journal-title":"J Rheumatol"},{"issue":"1","key":"10.1016\/j.jcf.2018.12.010_bb0310","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13075-018-1533-z","article-title":"Smoking is not linked to the development of anti-peptidylarginine deiminase 4 autoantibodies in rheumatoid arthritis","volume":"20","author":"Cappelli","year":"2018","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"10.1016\/j.jcf.2018.12.010_bb0315","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/s13075-016-1126-7","article-title":"Association of anti-peptidyl arginine deiminase antibodies with radiographic severity of rheumatoid arthritis in African Americans","volume":"18","author":"Navarro-Millan","year":"2016","journal-title":"Arthritis Res Ther"},{"issue":"9","key":"10.1016\/j.jcf.2018.12.010_bb0320","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1002\/art.27570","article-title":"Autoimmunity to peptidyl arginine deiminase type 4 precedes clinical onset of rheumatoid arthritis","volume":"62","author":"Kolfenbach","year":"2010","journal-title":"Arthritis Rheum"},{"issue":"6","key":"10.1016\/j.jcf.2018.12.010_bb0325","doi-asserted-by":"crossref","first-page":"e98794","DOI":"10.1371\/journal.pone.0098794","article-title":"Association of cross-reactive antibodies targeting peptidyl-arginine deiminase 3 and 4 with rheumatoid arthritis-associated interstitial lung disease","volume":"9","author":"Giles","year":"2014","journal-title":"PLoS One"},{"issue":"186","key":"10.1016\/j.jcf.2018.12.010_bb0330","doi-asserted-by":"crossref","first-page":"186ra65","DOI":"10.1126\/scitranslmed.3005370","article-title":"Erosive rheumatoid arthritis is associated with antibodies that activate PAD4 by increasing calcium sensitivity","volume":"5","author":"Darrah","year":"2013","journal-title":"Sci Transl Med"},{"issue":"1","key":"10.1016\/j.jcf.2018.12.010_bb0335","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/imm.12582","article-title":"Mucosal-associated invariant T cells in autoimmunity, immune-mediated diseases and airways disease","volume":"148","author":"Hinks","year":"2016","journal-title":"Immunology"},{"key":"10.1016\/j.jcf.2018.12.010_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(15)60357-9","article-title":"Multidimensional endotypes of asthma: topological data analysis of cross-sectional clinical, pathological, and immunological data","volume":"385","author":"Hinks","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.jcf.2018.12.010_bb0345","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2017.10.008","article-title":"\u201cNETtling\u201d the host: breaking of tolerance in chronic inflammation and chronic infection","volume":"88","author":"Skopelja-Gardner","year":"2018","journal-title":"J Autoimmun"},{"issue":"11","key":"10.1016\/j.jcf.2018.12.010_bb0350","doi-asserted-by":"crossref","first-page":"e1005987","DOI":"10.1371\/journal.ppat.1005987","article-title":"Swimming Motility Mediates the Formation of Neutrophil Extracellular Traps Induced by Flagellated Pseudomonas aeruginosa","volume":"12","author":"Floyd","year":"2016","journal-title":"PLoS Pathog"},{"issue":"1","key":"10.1016\/j.jcf.2018.12.010_bb0355","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens6010010","article-title":"Interactions between Neutrophils and Pseudomonas aeruginosa in Cystic Fibrosis","volume":"6","author":"Rada","year":"2017","journal-title":"Pathogens"},{"issue":"3","key":"10.1016\/j.jcf.2018.12.010_bb0360","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1189\/jlb.0709517","article-title":"Infections and autoimmunity: the multifaceted relationship","volume":"87","author":"Sfriso","year":"2010","journal-title":"J Leukoc Biol"},{"issue":"1","key":"10.1016\/j.jcf.2018.12.010_bb0365","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2249.2008.03834.x","article-title":"The role of infections in autoimmune disease","volume":"155","author":"Ercolini","year":"2009","journal-title":"Clin Exp Immunol"}],"container-title":["Journal of Cystic Fibrosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199318309718?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199318309718?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:14:20Z","timestamp":1778620460000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569199318309718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":73,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S1569199318309718"],"URL":"https:\/\/doi.org\/10.1016\/j.jcf.2018.12.010","relation":{},"ISSN":["1569-1993"],"issn-type":[{"value":"1569-1993","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systemic levels of anti-PAD4 autoantibodies correlate with airway obstruction in cystic fibrosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Cystic Fibrosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcf.2018.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 European Cystic Fibrosis Society. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}