{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:30:48Z","timestamp":1787236248349,"version":"build-2736575974"},"reference-count":146,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"vor","delay-in-days":731,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100006282","name":"Koning Boudewijnstichting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006282","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cysticfibrosisjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cystic Fibrosis"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.jcf.2019.07.005","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T17:07:14Z","timestamp":1565197634000},"page":"752-761","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["The role of endothelial cells in cystic fibrosis"],"prefix":"10.1016","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0442-6538","authenticated-orcid":false,"given":"M.","family":"Declercq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Treps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Carmeliet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9264-6153","authenticated-orcid":false,"given":"P.","family":"Witters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"80","key":"10.1016\/j.jcf.2019.07.005_bb0005","doi-asserted-by":"crossref","first-page":"1073 LP","DOI":"10.1126\/science.2570460","article-title":"Identification of the cystic fibrosis gene: genetic analysis","volume":"245","author":"Kerem","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.jcf.2019.07.005_bb0010","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1126\/science.1712984","article-title":"Demonstration that CFTR is a chloride channel by alteration of its anion selectivity","volume":"253","author":"Anderson","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.jcf.2019.07.005_bb0015","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1126\/science.2475911","article-title":"Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA","volume":"245","author":"Riordan","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.jcf.2019.07.005_bb0020","doi-asserted-by":"crossref","first-page":"C1555","DOI":"10.1152\/ajpcell.1998.275.6.C1555","article-title":"Characterization of CFTR expression and chloride channel activity in human endothelia","volume":"275","author":"Tousson","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0025","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1113\/jphysiol.2005.085019","article-title":"Disruption of CFTR chloride channel alters mechanical properties and cAMP-dependent cl- transport of mouse aortic smooth muscle cells","volume":"568","author":"Robert","year":"2005","journal-title":"J Physiol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0030","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1089\/scd.2011.0041","article-title":"Hematopoietic stem\/progenitor cells express functional mitochondrial energy-dependent cystic fibrosis transmembrane conductance regulator","volume":"21","author":"Piro","year":"2012","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.jcf.2019.07.005_bb0035","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1165\/rcmb.2012-0502OC","article-title":"Optimal complement-mediated phagocytosis of Pseudomonas aeruginosa by monocytes is cystic fibrosis transmembrane conductance regulator-dependent","volume":"49","author":"Van De Weert-van Leeuwen","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0040","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1096\/fj.10-159921","article-title":"Cystic fibrosis transmembrane conductance regulator (CFTR) expression in human platelets: impact on mediators and mechanisms of the inflammatory response","volume":"24","author":"Mattoscio","year":"2010","journal-title":"FASEB J"},{"key":"10.1016\/j.jcf.2019.07.005_bb0045","doi-asserted-by":"crossref","first-page":"C1114","DOI":"10.1152\/ajpcell.00400.2002","article-title":"HCO-3-dependent soluble adenylyl cyclase activates cystic fibrosis transmembrane conductance regulator in corneal endothelium","volume":"284","author":"Sun","year":"2003","journal-title":"AJP Cell Physiol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0050","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/bja\/aeh163","article-title":"Physiology of the endothelium","volume":"93","author":"Galley","year":"2004","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.jcf.2019.07.005_bb0055","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.7150\/ijbs.7502","article-title":"The vascular endothelium and human diseases","volume":"9","author":"Rajendran","year":"2013","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.jcf.2019.07.005_bb0060","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1042\/CS20100476","article-title":"Aging and vascular endothelial function in humans","volume":"120","author":"Seals","year":"2011","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.jcf.2019.07.005_bb0065","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.freeradbiomed.2014.08.005","article-title":"Inflammation, oxidative stress, and cardiovascular disease risk factors in adults with cystic fibrosis","volume":"76","author":"Reverri","year":"2014","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jcf.2019.07.005_bb0070","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1378\/chest.12-2444","article-title":"Joining the crowd: cystic fibrosis and cardiovascular disease risk factors","volume":"143","author":"Cross","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.jcf.2019.07.005_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2350-8-S1-S2","article-title":"Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham heart study","volume":"8","author":"Vasan","year":"2007","journal-title":"BMC Med Genet"},{"issue":"Suppl","key":"10.1016\/j.jcf.2019.07.005_bb0080","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1258\/jrsm.2010.s11010","article-title":"Ischaemic heart disease--a new issue in cystic fibrosis?","volume":"103","author":"Perrin","year":"2010","journal-title":"J R Soc Med"},{"key":"10.1016\/j.jcf.2019.07.005_bb0085","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1016\/j.jcf.2016.09.010","article-title":"Coronary artery disease in cystic fibrosis: an emerging concern?","volume":"15","author":"Skolnik","year":"2016","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2019.07.005_bb0090","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.thromres.2017.08.022","article-title":"Venous thromboembolism in children with cystic fibrosis: retrospective incidence and intrapopulation risk factors","volume":"158","author":"Knight-Perry","year":"2017","journal-title":"Thromb Res"},{"key":"10.1016\/j.jcf.2019.07.005_bb0095","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1183\/09031936.00186908","article-title":"Pulmonary vascular dysfunction in endstage cystic fibrosis: role of NF-\u03baB and endothelin-1","volume":"34","author":"Henno","year":"2009","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jcf.2019.07.005_bb0100","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1378\/chest.115.5.1321","article-title":"Pulmonary hypertension and cardiac function in adult cystic fibrosis: role of hypoxemia","volume":"115","author":"Fraser","year":"1999","journal-title":"Chest"},{"key":"10.1016\/j.jcf.2019.07.005_bb0105","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1164\/rccm.201407-1382OC","article-title":"Pulmonary hypertension in cystic fibrosis with advanced lung disease","volume":"190","author":"Hayes","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcf.2019.07.005_bb0110","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1161\/01.CIR.0000102381.57477.50","article-title":"Endothelial dysfunction in pulmonary hypertension","volume":"109","author":"Rohit","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jcf.2019.07.005_bb0115","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12931-017-0505-1","article-title":"The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD)","volume":"18","author":"Green","year":"2017","journal-title":"Respir Res"},{"key":"10.1016\/j.jcf.2019.07.005_bb0120","doi-asserted-by":"crossref","DOI":"10.1177\/2045894018758528","article-title":"COPD as an endothelial disorder: endothelial injury linking lesions in the lungs and other organs? (2017 Grover conference series)","volume":"8","author":"Polverino","year":"2018","journal-title":"Pulm Circ"},{"key":"10.1016\/j.jcf.2019.07.005_bb0125","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/S2213-2600(16)30105-9","article-title":"Pulmonary artery enlargement and cystic fibrosis pulmonary exacerbations: a cohort study","volume":"4","author":"Wells","year":"2016","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jcf.2019.07.005_bb0130","first-page":"e11","article-title":"Liver disease in cystic fibrosis presents as non-cirrhotic portal hypertension","volume":"16","author":"Witters","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0135","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fendo.2018.00020","article-title":"Cystic fibrosis-related diabetes","volume":"9","author":"Kayani","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jcf.2019.07.005_bb0140","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s11154-010-9134-4","article-title":"Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications","volume":"11","author":"Tabit","year":"2010","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.jcf.2019.07.005_bb0145","doi-asserted-by":"crossref","first-page":"302","DOI":"10.2174\/1874192401004010302","article-title":"The endothelium and its role in regulating vascular tone","volume":"4","author":"Sandoo","year":"2010","journal-title":"Open Cardiovasc Med J"},{"key":"10.1016\/j.jcf.2019.07.005_bb0150","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/157016112798829760","article-title":"The role of nitric oxide on endothelial function","volume":"10","author":"Tousoulis","year":"2012","journal-title":"Curr Vasc Pharmacol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0155","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1093\/eurheartj\/ehq340","article-title":"Assessment of atherosclerosis: the role of flow-mediated dilatation","volume":"31","author":"Charakida","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jcf.2019.07.005_bb0160","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1378\/chest.12-1934","article-title":"Evidence of vascular endothelial dysfunction in young patients with cystic fibrosis","volume":"143","author":"Poore","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.jcf.2019.07.005_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcf.2019.03.011","article-title":"Assessment of endothelial function is reproducible in patients with cystic fibrosis","author":"Derella","year":"2019","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2019.07.005_bb0170","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1152\/ajpheart.00136.2016","article-title":"Evidence of microvascular dysfunction in patients with cystic fibrosis","volume":"310","author":"Rodriguez-Miguelez","year":"2016","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0175","doi-asserted-by":"crossref","first-page":"H1486","DOI":"10.1152\/ajpheart.00301.2018","article-title":"Sildenafil improves vascular endothelial function in patients with cystic fibrosis","volume":"315","author":"Rodriguez-Miguelez","year":"2018","journal-title":"Am J Physiol Circ Physiol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0180","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1152\/japplphysiol.00629.2018","article-title":"Tetrahydrobiopterin improves endothelial function in patients with cystic fibrosis","volume":"126","author":"Jeong","year":"2018","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0185","first-page":"3243","article-title":"Mechanisms of endothelial cell dysfunction in cystic fibrosis","volume":"2017","author":"Totani","year":"1863","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.jcf.2019.07.005_bb0190","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1136\/adc.75.4.319","article-title":"Reduced upper airway nitric oxide in cystic fibrosis","volume":"75","author":"Balfour-Lynn","year":"1996","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jcf.2019.07.005_bb0195","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1136\/adc.75.4.323","article-title":"Exhaled nitric oxide in paediatric asthma and cystic fibrosis","author":"Lundberg","year":"1996","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jcf.2019.07.005_bb0200","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/(SICI)1099-0496(199709)24:3<173::AID-PPUL2>3.0.CO;2-O","article-title":"Decreased concentration of exhaled nitric oxide (NO) in patients with cystic","volume":"24","author":"Grasemann","year":"1997","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0205","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1378\/chest.117.4.1085","article-title":"Nasal and exhaled nitric oxide is reduced in adult patients with cystic fibrosis and does not correlate with cystic fibrosis genotype","volume":"117","author":"Thomas","year":"2000","journal-title":"Chest"},{"key":"10.1016\/j.jcf.2019.07.005_bb0210","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1136\/thorax.56.2.151","article-title":"Exhaled nitric oxide is reduced in infants with cystic fibrosis","volume":"56","author":"Elphick","year":"2001","journal-title":"Thorax"},{"key":"10.1016\/j.jcf.2019.07.005_bb0215","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1136\/thx.2003.017327","article-title":"Exhaled breath condensate pH and exhaled nitric oxide in allergic asthma and in cystic fibrosis","volume":"60","author":"Ojoo","year":"2005","journal-title":"Thorax"},{"key":"10.1016\/j.jcf.2019.07.005_bb0220","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jcf.2017.05.005","article-title":"Lower exhaled nitric oxide in infants with cystic fibrosis compared to healthy controls","volume":"17","author":"Korten","year":"2018","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2019.07.005_bb0225","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1569-1993(03)00061-4","article-title":"Exhaled nitric oxide increases following admission for intravenous antibiotics in children with cystic fibrosis","volume":"2","author":"Jaff\u00e9","year":"2003","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2019.07.005_bb0230","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/(SICI)1096-9896(199803)184:3<323::AID-PATH2>3.0.CO;2-2","article-title":"Lack of inducible nitric oxide synthase in bronchial epithelium: a possible mechanism of susceptibility to infection in cystic fibrosis","volume":"184","author":"Meng","year":"1998","journal-title":"JPathol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0235","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jcf.2005.05.008","article-title":"Nitric oxide in cystic fibrosis","volume":"4","author":"de Winter-de Groot","year":"2005","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2019.07.005_bb0240","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1136\/adc.78.1.49","article-title":"Nitric oxide metabolites in cystic","volume":"78","author":"Grasemann","year":"1998","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jcf.2019.07.005_bb0245","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0003-9861(02)00427-7","article-title":"Nitric oxide and protein nitration in the cystic fibrosis airway","volume":"406","author":"Morrissey","year":"2002","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jcf.2019.07.005_bb0250","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0014-2999(89)90217-3","article-title":"Reduced endothelium-dependent relaxation of cystic fibrosis pulmonary arteries","volume":"163","author":"Xuan","year":"1989","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0255","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1042\/cs1010507","article-title":"Individuals with cystic fibrosis do not display impaired endothelial function or evidence of oxidative damage in endothelial cells exposed to serum","volume":"101","author":"McGrath","year":"2001","journal-title":"Clin Sci"},{"key":"10.1016\/j.jcf.2019.07.005_bb0260","series-title":"Sputum Endothelin-1 Is Increased in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease","first-page":"1288","author":"Chalmers","year":"1999"},{"key":"10.1016\/j.jcf.2019.07.005_bb0265","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1111\/j.1651-2227.2000.tb00407.x","article-title":"Plasma immunoreactive endothelin levels in children with cystic fibrosis","volume":"89","author":"Siahanidou","year":"2000","journal-title":"Acta Paediatr Int J Paediatr"},{"key":"10.1016\/j.jcf.2019.07.005_bb0270","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00005-014-0310-1","article-title":"The role of endothelin-1 and endothelin receptor antagonists in inflammatory response and sepsis","volume":"63","author":"Kowalczyk","year":"2015","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"issue":"1","key":"10.1016\/j.jcf.2019.07.005_bb0275","doi-asserted-by":"crossref","first-page":"11","DOI":"10.33549\/physiolres.930000.49.11","article-title":"Age-related endothelial dysfunction with respect to nitric oxide, endothelium-derived hyperpolarizing factor and cyclooxygenase products","volume":"49","author":"Matz","year":"2000","journal-title":"Physiol Res"},{"key":"10.1016\/j.jcf.2019.07.005_bb0280","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/00004872-200301000-00002","article-title":"Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes","volume":"21","author":"Aronson","year":"2003","journal-title":"J Hypertens"},{"key":"10.1016\/j.jcf.2019.07.005_bb0285","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1161\/01.CIR.0000048894.99865.02","article-title":"Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part III: cellular and molecular clues to heart and arterial aging","volume":"107","author":"Lakatta","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jcf.2019.07.005_bb0290","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1183\/09031936.00044009","article-title":"Increased augmentation index in patients with cystic fibrosis","volume":"34","author":"Hull","year":"2009","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jcf.2019.07.005_bb0295","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1183\/09031936.00212511","article-title":"Increased arterial stiffness in children with cystic fibrosis","volume":"39","author":"Buehler","year":"2012","journal-title":"Eur Respir J"},{"issue":"Supple","key":"10.1016\/j.jcf.2019.07.005_bb0300","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.1016\/S1569-1993(14)60334-9","article-title":"Arterial stiffness in an ageing cystic fibrosis (CF) population attending the all wales adult cystic fibrosis centre (AWACFC)","volume":"13","author":"Choudhury","year":"2014","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2019.07.005_bb0305","first-page":"1","article-title":"Young patients with cystic fibrosis demonstrate subtle alterations of the cardiovascular system","author":"Eising","year":"2018","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2019.07.005_bb0310","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1183\/09031936.00155209","article-title":"Premature vascular ageing in cystic fibrosis","volume":"34","author":"MacNee","year":"2009","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jcf.2019.07.005_bb0315","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jcf.2013.10.009","article-title":"Genotype-specific alterations in vascular smooth muscle cell function in cystic fibrosis piglets","volume":"13","author":"Guo","year":"2014","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2019.07.005_bb0320","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1152\/japplphysiol.00120.2017","article-title":"The endothelium in hypoxic pulmonary vasoconstriction","volume":"123","author":"Grimmer","year":"2017","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0325","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1152\/physrev.00035.2003","article-title":"Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis","volume":"84","author":"Bazzoni","year":"2004","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jcf.2019.07.005_bb0330","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1189\/jlb.0904554","article-title":"Active participation of endothelial cells in inflammation","volume":"77","author":"Cook-Mills","year":"2005","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0335","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0002-9394(14)73367-7","article-title":"A morphologic and fluorophotometric analysis of the corneal endothelium in type I diabetes mellitus and cystic fibrosis","volume":"100","author":"Lass","year":"1985","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0340","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1086\/675989","article-title":"Loss of cystic fibrosis transmembrane conductance regulator impairs lung endothelial cell barrier function and increases susceptibility to microvascular damage from cigarette smoke","volume":"4","author":"Brown","year":"2014","journal-title":"Pulm Circ"},{"key":"10.1016\/j.jcf.2019.07.005_bb0345","doi-asserted-by":"crossref","first-page":"487508","DOI":"10.1155\/2015\/487508","article-title":"Role of sphingolipids in the pathobiology of lung inflammation","volume":"2015","author":"Ghidoni","year":"2015","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.jcf.2019.07.005_bb0350","doi-asserted-by":"crossref","first-page":"35258","DOI":"10.1074\/jbc.M105442200","article-title":"Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate","volume":"276","author":"Boujaoude","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jcf.2019.07.005_bb0355","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/nm1748","article-title":"Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis","volume":"14","author":"Teichgr\u00e4ber","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.jcf.2019.07.005_bb0360","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1165\/rcmb.2008-0264OC","article-title":"CFTR regulation of intracellular pH and ceramides is required for lung endothelial cell apoptosis","volume":"41","author":"Noe","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0365","doi-asserted-by":"crossref","first-page":"674968","DOI":"10.1155\/2011\/674968","article-title":"Ceramide in cystic fibrosis: a potential new target for therapeutic intervention","volume":"2011","author":"Wojewodka","year":"2011","journal-title":"J Lipids"},{"key":"10.1016\/j.jcf.2019.07.005_bb0370","doi-asserted-by":"crossref","first-page":"L1000","DOI":"10.1152\/ajplung.00298.2016","article-title":"Correction of lung inflammation in a F508del CFTR murine cystic fibrosis model by the sphingosine-1-phosphate lyase inhibitor LX2931","volume":"311","author":"Veltman","year":"2016","journal-title":"Am J Physiol Cell Mol Physiol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0375","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.nano.2017.08.012","article-title":"Polymer hydration and stiffness at biointerfaces and related cellular processes","volume":"14","author":"Kerch","year":"2018","journal-title":"Nanomed Nanotechnol Biol Med"},{"key":"10.1016\/j.jcf.2019.07.005_bb0380","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/j.nano.2015.03.013","article-title":"Cystic fibrosis transmembrane conductance regulator is involved in polyphenol-induced swelling of the endothelial glycocalyx","volume":"11","author":"Peters","year":"2015","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jcf.2019.07.005_bb0385","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00424-007-0212-8","article-title":"The endothelial glycocalyx: composition, functions, and visualization","volume":"454","author":"Reitsma","year":"2007","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.jcf.2019.07.005_bb0390","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1002\/hep.28817","article-title":"The cystic fibrosis transmembrane conductance regulator controls biliary epithelial inflammation and permeability by regulating Src tyrosine kinase activity","volume":"64","author":"Fiorotto","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jcf.2019.07.005_bb0395","doi-asserted-by":"crossref","first-page":"27390","DOI":"10.1038\/srep27390","article-title":"The cystic fibrosis transmembrane conductance regulator (CFTR) uses its C-terminus to regulate the A2B adenosine receptor","volume":"6","author":"Watson","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcf.2019.07.005_bb0400","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1038\/labinvest.2012.123","article-title":"NHERF1 and CFTR restore tight junction organisation and function in cystic fibrosis airway epithelial cells: role of ezrin and the RhoA\/ROCK pathway","volume":"92","author":"Castellani","year":"2012","journal-title":"Lab Invest"},{"key":"10.1016\/j.jcf.2019.07.005_bb0405","first-page":"4396","article-title":"CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation through the ZONAB pathway","volume":"127","author":"Ruan","year":"2014","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jcf.2019.07.005_bb0410","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1016\/S0002-9440(10)64133-8","article-title":"Regulation of gap junctional communication by a pro-inflammatory cytokine in cystic fibrosis transmembrane conductance regulator-expressing but not cystic fibrosis airway cells","volume":"158","author":"Chanson","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0415","article-title":"Control of vascular permeability by adhesion molecules","volume":"3","author":"Sarelius","year":"2014","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.jcf.2019.07.005_bb0420","doi-asserted-by":"crossref","first-page":"L731","DOI":"10.1152\/ajplung.00309.2014","article-title":"Pulmonary epithelial barrier function: some new players and mechanisms","volume":"308","author":"Brune","year":"2015","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0425","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/0167-5699(93)90267-O","article-title":"Circulating adhesion molecules in disease","volume":"14","author":"Gearing","year":"1993","journal-title":"Immunol Today"},{"key":"10.1016\/j.jcf.2019.07.005_bb0430","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/ppul.20563","article-title":"Inflammatory markers of lung disease in adult patients with cystic fibrosis","volume":"42","author":"Levy","year":"2007","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0435","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1164\/ajrccm.157.4.9704134","article-title":"Circulating adhesion molecules in cystic fibrosis","volume":"157","author":"De Rose","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcf.2019.07.005_bb0440","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00408-017-0029-y","article-title":"Increased soluble VCAM-1 and Normal P-selectin in cystic fibrosis: a Cross-sectional study","volume":"195","author":"Nowak","year":"2017","journal-title":"Lung"},{"key":"10.1016\/j.jcf.2019.07.005_bb0445","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1055\/s-0037-1616736","article-title":"Endothelial perturbation in cystic fibrosis","volume":"86","author":"Romano","year":"2001","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jcf.2019.07.005_bb0450","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jcf.2009.12.004","article-title":"Platelet proinflammatory activity in clinically stable patients with CF starts in early childhood","volume":"9","author":"Sturm","year":"2010","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2019.07.005_bb0455","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.bcp.2009.04.029","article-title":"Inflammatory cytokines in vascular dysfunction and vascular disease","volume":"78","author":"Sprague","year":"2009","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0460","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1538-7836.2004.00683.x","article-title":"Increased soluble CD40 ligand levels in cystic fibrosis","volume":"2","author":"Falco","year":"2004","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jcf.2019.07.005_bb0465","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.cyto.2013.03.029","article-title":"Effects of treatment in the levels of circulating cytokines and growth factors in cystic fibrosis and dialyzed patients by multi-analytical determination with a biochip array platform","volume":"62","author":"Tirelli","year":"2013","journal-title":"Cytokine"},{"key":"10.1016\/j.jcf.2019.07.005_bb0470","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/ppul.21428","article-title":"Elevated vascular endothelial growth factor is correlated with elevated erythropoietin in stable, young cystic fibrosis patients","volume":"46","author":"Watts","year":"2011","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0475","article-title":"Higher Interleukin-7 serum concentrations in patients with cystic fibrosis correlate with impaired lung function","author":"Seyfarth","year":"2018","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2019.07.005_bb0480","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1164\/rccm.200802-232OC","article-title":"Effect of systemic inflammation on inspiratory and limb muscle strength and bulk in cystic fibrosis","volume":"180","author":"Dufresne","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcf.2019.07.005_bb0485","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1164\/ajrccm.157.6.9704086","article-title":"Circulating immunoreactive interleukin-6 in cystic fibrosis","volume":"157","author":"Nixon","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcf.2019.07.005_bb0490","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-015-0651-2","article-title":"Flaxseed modulates inflammatory and oxidative stress biomarkers in cystic fibrosis: a pilot study","volume":"15","author":"Turowski","year":"2015","journal-title":"BMC Complement Altern Med"},{"key":"10.1016\/j.jcf.2019.07.005_bb0495","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s00408-016-9925-9","article-title":"Decreased TGF-\u03b21 and VEGF release in cystic fibrosis platelets: further evidence for platelet defects in cystic fibrosis","volume":"194","author":"Maloney","year":"2016","journal-title":"Lung"},{"key":"10.1016\/j.jcf.2019.07.005_bb0500","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/ppul.21430","article-title":"Plasma TGF-beta(1) in pediatric cystic fibrosis: potential biomarker of lung disease and response to therapy","volume":"46","author":"Harris","year":"2011","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0505","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ehj.2014.11.005","article-title":"C-reactive protein, inflammation and coronary heart disease","volume":"67","author":"Shrivastava","year":"2015","journal-title":"Egypt Hear J"},{"key":"10.1016\/j.jcf.2019.07.005_bb0510","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jcf.2017.08.015","article-title":"Blood flow regulation and oxidative stress during submaximal cycling exercise in patients with cystic fibrosis","volume":"17","author":"Tucker","year":"2018","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2019.07.005_bb0515","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.jacc.2009.03.076","article-title":"The CD40\/CD40 ligand system. Linking inflammation with atherothrombosis","volume":"54","author":"Antoniades","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0520","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1177\/039463200802100410","article-title":"Tumor necrosis factor-alpha in airway secretions from cystic fibrosis patients upregulate endothelial adhesion molecules and induce airway epithelial cell apoptosis: implications for cystic fibrosis lung disease","volume":"21","author":"Mitola","year":"2008","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0525","first-page":"3501","article-title":"CFTR ameliorates high glucose-induced oxidative stress and inflammation by mediating the NF-\u03baB and MAPK signaling pathways in endothelial cells","volume":"41","author":"Fei","year":"2018","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.jcf.2019.07.005_bb0530","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1164\/rccm.200409-1207OC","article-title":"Endothelial activation and increased heparan sulfate expression in cystic fibrosis","volume":"172","author":"Solic","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcf.2019.07.005_bb0535","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jcf.2015.03.003","article-title":"Inflammation in cystic fibrosis lung disease: pathogenesis and therapy","volume":"14","author":"Cantin","year":"2015","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2019.07.005_bb0540","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1515\/hsz-2015-0271","article-title":"Neutrophils in cystic fibrosis","volume":"397","author":"Laval","year":"2016","journal-title":"Biol Chem"},{"key":"10.1016\/j.jcf.2019.07.005_bb0545","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1093\/qjmed\/hcv067","article-title":"CFTR regulates acute inflammatory responses in macrophages","volume":"108","author":"Gao","year":"2015","journal-title":"QJM An Int J Med"},{"key":"10.1016\/j.jcf.2019.07.005_bb0550","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1164\/rccm.201510-1922OC","article-title":"Mutations of cystic fibrosis transmembrane conductance regulator gene cause a monocyte-selective adhesion deficiency","volume":"193","author":"Sorio","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcf.2019.07.005_bb0555","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12950-015-0107-y","article-title":"CFTR knockdown induces proinflammatory changes in intestinal epithelial cells","volume":"12","author":"Crites","year":"2015","journal-title":"J Inflamm"},{"key":"10.1016\/j.jcf.2019.07.005_bb0560","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20170680","article-title":"CFTR protects against vascular inflammation and atherogenesis in apolipoprotein E-deficient mice","volume":"37","author":"Li","year":"2017","journal-title":"Biosci Rep"},{"key":"10.1016\/j.jcf.2019.07.005_bb0565","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00281-011-0285-5","article-title":"Endothelium - role in regulation of coagulation and inflammation","volume":"34","author":"van Hinsbergh","year":"2012","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0570","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/ppul.20158","article-title":"Prevalence of thrombophilia and catheter-related thrombosis in cystic fibrosis","volume":"39","author":"Barker","year":"2005","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0575","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/ppul.20181","article-title":"Thrombophilia in children with cystic fibrosis","volume":"39","author":"Balfour-Lynn","year":"2005","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0580","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jcf.2006.02.003","article-title":"Catheter-related thrombosis associated with elevated factor VIII levels in cystic fibrosis","volume":"5","author":"Serisier","year":"2006","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2019.07.005_bb0585","doi-asserted-by":"crossref","first-page":"4635 LP","DOI":"10.1182\/blood-2004-06-2098","article-title":"Platelet activation in cystic fibrosis","volume":"105","author":"O'Sullivan","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jcf.2019.07.005_bb0590","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jpeds.2005.11.032","article-title":"Cystic fibrosis as a risk factor for recurrent venous thrombosis at a pediatric tertiary care hospital","volume":"148","author":"Raffini","year":"2006","journal-title":"J Pediatr"},{"key":"10.1016\/j.jcf.2019.07.005_bb0595","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jcf.2014.05.015","article-title":"Central venous thrombosis and thrombophilia in cystic fibrosis: a prospective study","volume":"14","author":"Munck","year":"2015","journal-title":"J Cyst Fibros"},{"issue":"03","key":"10.1016\/j.jcf.2019.07.005_bb0610","first-page":"449","article-title":"The role of platelets in inflammation","volume":"114","author":"Thomas","year":"2015","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jcf.2019.07.005_bb0615","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1164\/rccm.200508-1243PP","article-title":"The inflammatory role of platelets in cystic fibrosis","volume":"173","author":"O'Sullivan","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcf.2019.07.005_bb0620","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1023\/B:MCBI.0000044378.09409.b5","article-title":"Reactive oxygen species as mediators of angiogenesis signaling. Role of NAD(P)H oxidase","volume":"264","author":"Ushio-Fukai","year":"2004","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.jcf.2019.07.005_bb0625","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2017.05.005","article-title":"Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases","volume":"100","author":"Incalza","year":"2018","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0630","first-page":"690","article-title":"Oxidative stress and antioxidant therapy in cystic fibrosis","volume":"2012","author":"Galli","year":"1822","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.jcf.2019.07.005_bb0635","doi-asserted-by":"crossref","first-page":"20515","DOI":"10.1073\/pnas.0911412106","article-title":"The antioxidant role of thiocyanate in the pathogenesis of cystic fibrosis and other inflammation-related diseases","volume":"106","author":"Xu","year":"2009","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.jcf.2019.07.005_bb0640","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s10863-016-9663-y","article-title":"Characterization of mitochondrial function in cells with impaired cystic fibrosis transmembrane conductance regulator (CFTR) function","volume":"48","author":"Atlante","year":"2016","journal-title":"J Bioenerg Biomembr"},{"key":"10.1016\/j.jcf.2019.07.005_bb0645","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.redox.2012.11.007","article-title":"CFTR activity and mitochondrial function","volume":"1","author":"Valdivieso","year":"2013","journal-title":"Redox Biol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0650","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1093\/emboj\/cdg194","article-title":"CFTR directly mediates nucleotide-regulated glutathione flux","volume":"22","author":"Kogan","year":"2003","journal-title":"EMBO J"},{"key":"10.1016\/j.jcf.2019.07.005_bb0655","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.freeradbiomed.2012.01.001","article-title":"CFTR is the primary known apical glutathione transporter involved in cigarette smoke-induced adaptive responses in the lung","volume":"52","author":"Gould","year":"2012","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jcf.2019.07.005_bb0660","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1152\/physrev.00001.2017","article-title":"Endothelial cell metabolism","volume":"98","author":"Eelen","year":"2018","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jcf.2019.07.005_bb0665","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nature04478","article-title":"Angiogenesis in life, disease and medicine","volume":"438","author":"Carmeliet","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jcf.2019.07.005_bb0670","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1378\/chest.128.2.729","article-title":"Massive hemoptysis in cystic fibrosis","volume":"128","author":"Flume","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.jcf.2019.07.005_bb0675","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1148\/rg.2018170122","article-title":"An Interventionalist's guide to hemoptysis in cystic fibrosis","volume":"38","author":"Monroe","year":"2018","journal-title":"RadioGraphics"},{"key":"10.1016\/j.jcf.2019.07.005_bb0680","doi-asserted-by":"crossref","first-page":"1173 LP","DOI":"10.1183\/09031936.97.10051173","article-title":"Bronchial vascular congestion and angiogenesis","volume":"10","author":"Charan","year":"1997","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jcf.2019.07.005_bb0685","first-page":"296","article-title":"Bouck. N. Elevated inducer of angiogenesis and increased microvascular density suggest a role for neovascularization in cystic fibrosis","volume":"23","author":"Crawford","year":"1997","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0690","doi-asserted-by":"crossref","first-page":"1553 LP","DOI":"10.1183\/09031936.00164212","article-title":"CFTR dysfunction induces vascular endothelial growth factor synthesis in airway epithelium","volume":"42","author":"Martin","year":"2013","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jcf.2019.07.005_bb0695","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ejcts.2007.04.006","article-title":"Vascular endothelial growth factor increases pulmonary vascular permeability in cystic fibrosis patients undergoing lung transplantation","volume":"32","author":"Krenn","year":"2007","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jcf.2019.07.005_bb0700","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1016\/S1569-1993(11)60006-4","article-title":"Best practice guidance for the diagnosis and management of cystic fibrosis-associated liver disease","volume":"10","author":"Debray","year":"2011","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2019.07.005_bb0705","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1161\/CIRCRESAHA.112.279109","article-title":"Formation of the collateral circulation is regulated by vascular endothelial growth factor-a and a disintegrin and metalloprotease family members 10 and 17","volume":"111","author":"Lucitti","year":"2012","journal-title":"Circ Res"},{"key":"10.1016\/j.jcf.2019.07.005_bb0710","doi-asserted-by":"crossref","first-page":"L314","DOI":"10.1152\/ajplung.00382.2014","article-title":"EG-VEGF, BV8, and their receptor expression in human bronchi and their modification in cystic fibrosis: impact of CFTR mutation (delF508)","volume":"309","author":"Chauvet","year":"2015","journal-title":"Am J Physiol Cell Mol Physiol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0715","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1164\/ajrccm.161.6.9905022","article-title":"Serum vascular endothelial growth factor is elevated in cystic fibrosis and decreases with treatment of acute pulmonary exacerbation","volume":"161","author":"McColley","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcf.2019.07.005_bb0720","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.bbrc.2007.02.166","article-title":"Intrinsic pro-angiogenic status of cystic fibrosis airway epithelial cells","volume":"356","author":"Verhaeghe","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jcf.2019.07.005_bb0725","first-page":"a011056","article-title":"PlGF: a multitasking cytokine with disease-restricted activity","volume":"2","author":"Dewerchin","year":"2019","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.jcf.2019.07.005_bb0730","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.exger.2017.06.007","article-title":"Vascular ageing: underlying mechanisms and clinical implications","volume":"109","author":"Laina","year":"2018","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0735","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1113\/JP270841","article-title":"Diabetes and ageing-induced vascular inflammation","volume":"594","author":"El","year":"2016","journal-title":"J Physiol"},{"key":"10.1016\/j.jcf.2019.07.005_bb0740","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3389\/fcvm.2017.00065","article-title":"Angiogenesis, cancer, and vascular aging","volume":"4","author":"Moriya","year":"2017","journal-title":"Front Cardiovasc Med"}],"container-title":["Journal of Cystic Fibrosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199319308264?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199319308264?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T21:41:53Z","timestamp":1761601313000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569199319308264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":146,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["S1569199319308264"],"URL":"https:\/\/doi.org\/10.1016\/j.jcf.2019.07.005","relation":{},"ISSN":["1569-1993"],"issn-type":[{"value":"1569-1993","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of endothelial cells in cystic fibrosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Cystic Fibrosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcf.2019.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 European Cystic Fibrosis Society. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}