{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:28:55Z","timestamp":1788866935284,"version":"build-2803163510"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["R01 DK97830"],"award-info":[{"award-number":["R01 DK97830"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["UL1 TR000003"],"award-info":[{"award-number":["UL1 TR000003"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK97830"],"award-info":[{"award-number":["R01 DK97830"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1 TR000003"],"award-info":[{"award-number":["UL1 TR000003"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006458","name":"Children&apos;s Hospital of Philadelphia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006458","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cysticfibrosisjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cystic Fibrosis"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.jcf.2019.07.006","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T17:25:57Z","timestamp":1565285157000},"page":"310-315","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Dysregulated insulin in pancreatic insufficient cystic fibrosis with post-prandial hypoglycemia"],"prefix":"10.1016","volume":"19","author":[{"given":"Marissa J.","family":"Kilberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4164-6663","authenticated-orcid":false,"given":"Saba","family":"Sheikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darko","family":"Stefanovski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Kubrak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diva D.","family":"De Leon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Hadjiliadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald C.","family":"Rubenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Rickels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jcf.2019.07.006_bb0005","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1164\/ajrccm.162.3.9904075","article-title":"Trends in pulmonary function in patients with cystic fibrosis correlate with the degree of glucose intolerance at baseline","volume":"162","author":"Milla","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.jcf.2019.07.006_bb0010","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jpeds.2004.12.039","article-title":"Epidemiology of cystic fibrosis-related diabetes","volume":"146","author":"Marshall","year":"2005","journal-title":"J Pediatr"},{"issue":"5","key":"10.1016\/j.jcf.2019.07.006_bb0015","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/ppul.1142","article-title":"Presence of cystic fibrosis-related diabetes mellitus is tightly linked to poor lung function in patients with cystic fibrosis: data from the European epidemiologic registry of cystic fibrosis","volume":"32","author":"Koch","year":"2001","journal-title":"Pediatr Pulmonol"},{"issue":"9","key":"10.1016\/j.jcf.2019.07.006_bb0020","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/BF01957574","article-title":"Influence of the development of diabetes mellitus on clinical status in patients with cystic fibrosis","volume":"151","author":"Lanng","year":"1992","journal-title":"Eur J Pediatr"},{"issue":"1","key":"10.1016\/j.jcf.2019.07.006_bb0025","doi-asserted-by":"crossref","first-page":"134","DOI":"10.2337\/db16-0394","article-title":"Reduced \u03b2-cell secretory capacity in pancreatic-insufficient, but not pancreatic-sufficient, cystic fibrosis despite Normal glucose tolerance","volume":"66","author":"Sheikh","year":"2017","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.jcf.2019.07.006_bb0030","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/BF02072102","article-title":"Reduced pancreatic insulin release and reduced peripheral insulin sensitivity contribute to hyperglycaemia in cystic fibrosis","volume":"154","author":"Holl","year":"1995","journal-title":"Eur J Pediatr"},{"issue":"8","key":"10.1016\/j.jcf.2019.07.006_bb0035","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.98240","article-title":"Cystic fibrosis-related diabetes is caused by islet loss and inflammation","volume":"3","author":"Hart","year":"2018","journal-title":"JCI Insight"},{"issue":"4","key":"10.1016\/j.jcf.2019.07.006_bb0040","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jcf.2013.02.008","article-title":"Update on cystic fibrosis-related diabetes","volume":"12","author":"Kelly","year":"2013","journal-title":"J Cyst Fibros"},{"issue":"3","key":"10.1016\/j.jcf.2019.07.006_bb0045","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1530\/eje.1.02344","article-title":"Spontaneous hypoglycemia in patients with cystic fibrosis","volume":"156","author":"Battezzati","year":"2007","journal-title":"Eur J Endocrinol"},{"issue":"7","key":"10.1016\/j.jcf.2019.07.006_bb0050","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/pedi.12470","article-title":"Hypoglycemia is common in children with cystic fibrosis and seen predominantly in females","volume":"18","author":"Haliloglu","year":"2016","journal-title":"Pediatr Diabetes"},{"issue":"8","key":"10.1016\/j.jcf.2019.07.006_bb0055","doi-asserted-by":"crossref","first-page":"e121","DOI":"10.2337\/dc12-1859","article-title":"Hypoglycemia in adults with cystic fibrosis during oral glucose tolerance testing","volume":"36","author":"Hirsch","year":"2013","journal-title":"Diabetes Care"},{"issue":"4","key":"10.1016\/j.jcf.2019.07.006_bb0060","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.jcf.2017.11.015","article-title":"Hypoglycaemia in cystic fibrosis: an analysis of a single centre adult cystic fibrosis clinic","volume":"17","author":"Armaghanian","year":"2018","journal-title":"J Cyst Fibros"},{"issue":"3","key":"10.1016\/j.jcf.2019.07.006_bb0065","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jcf.2016.02.012","article-title":"Hypoglycaemia in cystic fibrosis in the absence of diabetes: a systematic review","volume":"15","author":"Armaghanian","year":"2016","journal-title":"J Cystic Fib"},{"issue":"4","key":"10.1016\/j.jcf.2019.07.006_bb0070","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.2337\/dc10-2286","article-title":"Prognostic relevance of hypoglycemia following an oral glucose challenge for cystic fibrosis\u2013related diabetes","volume":"34","author":"Radike","year":"2011","journal-title":"Diabetes Care"},{"issue":"4","key":"10.1016\/j.jcf.2019.07.006_bb0075","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.jcf.2018.03.009","article-title":"Prevalence of hypoglycemia during oral glucose tolerance testing in adults with cystic fibrosis and risk of developing cystic fibrosis-related diabetes","volume":"17","author":"Mannik","year":"2018","journal-title":"J Cyst Fibros"},{"issue":"10","key":"10.1016\/j.jcf.2019.07.006_bb0080","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/ppul.23237","article-title":"Elevation of one hour plasma glucose during oral glucose tolerance testing","volume":"50","author":"Sheikh","year":"2015","journal-title":"Pediatr Pulmonol"},{"issue":"7","key":"10.1016\/j.jcf.2019.07.006_bb0085","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1111\/pedi.12700","article-title":"Beta-cell secretory defects are present in pancreatic insufficient cystic fibrosis with 1-hour oral glucose tolerance test glucose >\/=155 mg\/dL","volume":"19","author":"Nyirjesy","year":"2018","journal-title":"Pediatr Diabetes"},{"issue":"7","key":"10.1016\/j.jcf.2019.07.006_bb0090","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1399-5448.2009.00632.x","article-title":"Oral glucose tolerance testing in children with cystic fibrosis","volume":"11","author":"Ode","year":"2010","journal-title":"Pediatr Diabetes"},{"key":"10.1016\/j.jcf.2019.07.006_bb0095","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.diabres.2016.08.013","article-title":"One-hourpost-load plasma glucose level during the OGTT predicts dysglycemia: observations from the 24year follow-up of the Israel Study of Glucose Intolerance, Obesity and Hypertension","volume":"120","author":"Bergman","year":"2016","journal-title":"Diabetes Res Clin Pract"},{"issue":"1","key":"10.1016\/j.jcf.2019.07.006_bb0100","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2337\/dc17-1351","article-title":"Enhanced predictive capability of a 1-hour oral glucose tolerance test: a prospective population-based cohort study","volume":"41","author":"Pareek","year":"2018","journal-title":"Diabetes Care"},{"issue":"5","key":"10.1016\/j.jcf.2019.07.006_bb0105","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1210\/jc.2012-3971","article-title":"Elevated 1-hour postload plasma glucose levels identify subjects with normal glucose tolerance but impaired beta-cell function, insulin resistance, and worse cardiovascular risk profile: the GENFIEV study","volume":"98","author":"Bianchi","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.jcf.2019.07.006_bb0110","doi-asserted-by":"crossref","first-page":"678","DOI":"10.2337\/db07-1124","article-title":"Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose tolerance","volume":"57","author":"Vollmer","year":"2008","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.jcf.2019.07.006_bb0115","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1530\/EJE-13-0941","article-title":"Specificity and sensitivity of commercially available assays for glucagon and oxyntomodulin measurement in humans","volume":"170","author":"Bak","year":"2014","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"10.1016\/j.jcf.2019.07.006_bb0120","doi-asserted-by":"crossref","first-page":"150","DOI":"10.2337\/diabetes.50.1.150","article-title":"Oral glucose tolerance test minimal model indexes of beta-cell function and insulin sensitivity","volume":"50","author":"Breda","year":"2001","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.jcf.2019.07.006_bb0125","doi-asserted-by":"crossref","first-page":"368","DOI":"10.2337\/diabetes.41.3.368","article-title":"Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance","volume":"41","author":"Van Cauter","year":"1992","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.jcf.2019.07.006_bb0130","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.2337\/dc12-2480","article-title":"Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and the Endocrine Society","volume":"36","author":"Seaquist","year":"2013","journal-title":"Diabetes Care"},{"issue":"10","key":"10.1016\/j.jcf.2019.07.006_bb0135","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1172\/JCI60610","article-title":"Abnormal endocrine pancreas function at birth in cystic fibrosis ferrets","volume":"122","author":"Olivier","year":"2012","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.jcf.2019.07.006_bb0140","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.diabres.2014.02.013","article-title":"Clinical characteristics of people experiencing biochemical hypoglycaemia during an oral glucose tolerance test: cross-sectional analyses from a UK multi-ethnic population","volume":"104","author":"Parekh","year":"2014","journal-title":"Diabetes Res Clin Pract"},{"issue":"1","key":"10.1016\/j.jcf.2019.07.006_bb0145","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1210\/jc.2008-1263","article-title":"Increased glucagon-like peptide-1 secretion and postprandial hypoglycemia in children after Nissen fundoplication","volume":"94","author":"Palladino","year":"2009","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of Cystic Fibrosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199319308276?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199319308276?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:17:22Z","timestamp":1777619842000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569199319308276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S1569199319308276"],"URL":"https:\/\/doi.org\/10.1016\/j.jcf.2019.07.006","relation":{},"ISSN":["1569-1993"],"issn-type":[{"value":"1569-1993","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dysregulated insulin in pancreatic insufficient cystic fibrosis with post-prandial hypoglycemia","name":"articletitle","label":"Article Title"},{"value":"Journal of Cystic Fibrosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcf.2019.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 European Cystic Fibrosis Society. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}