{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:47:57Z","timestamp":1790326077957,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"vor","delay-in-days":37,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cysticfibrosisjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cystic Fibrosis"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.jcf.2019.08.013","type":"journal-article","created":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T04:54:01Z","timestamp":1572756841000},"page":"S88-S94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"S2","title":["Puberty in cystic fibrosis"],"prefix":"10.1016","volume":"18","author":[{"given":"Bracha","family":"Goldsweig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1516-7455","authenticated-orcid":false,"given":"Beth","family":"Kaminski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniket","family":"Sidhaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M.","family":"Blackman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jcf.2019.08.013_bb0005","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1136\/archdischild-2014-307963","article-title":"Recent advances in the understanding and management of delayed puberty","volume":"101","author":"Wei","year":"2016","journal-title":"Arch Dis Child"},{"issue":"1","key":"10.1016\/j.jcf.2019.08.013_bb0010","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S2352-4642(18)30306-7","article-title":"Is there a causal relationship between obesity and puberty?","volume":"3","author":"Reinehr","year":"2019","journal-title":"Lancet Child Adolesc Health"},{"key":"10.1016\/j.jcf.2019.08.013_bb0015","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/S0022-3476(64)80151-7","article-title":"Growth patterns in children with cystic fibrosis","volume":"65","author":"Sproul","year":"1964","journal-title":"J Pediart"},{"issue":"2","key":"10.1016\/j.jcf.2019.08.013_bb0020","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/BF00473404","article-title":"The physical development of children with cystic fibrosis","volume":"113","author":"Kreissl","year":"1972","journal-title":"Z Kinderheilkd"},{"issue":"179","key":"10.1016\/j.jcf.2019.08.013_bb0025","first-page":"479","article-title":"Cystic fibrosis in adolescents and adults","volume":"45","author":"Mitchell-Heggs","year":"1976","journal-title":"Q J Med"},{"issue":"5","key":"10.1016\/j.jcf.2019.08.013_bb0030","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1001\/archpedi.1981.02130290020009","article-title":"The reproductive endocrine system in cystic fibrosis","volume":"135","author":"Reiter","year":"1981","journal-title":"Am J Dis Child"},{"issue":"4","key":"10.1016\/j.jcf.2019.08.013_bb0035","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1001\/archpedi.1984.02140420054017","article-title":"Short stature and pubertal delay in male adolescents with cystic fibrosis. Androgen treatment","volume":"138","author":"Landon","year":"1984","journal-title":"Am J Dis Child"},{"issue":"3","key":"10.1016\/j.jcf.2019.08.013_bb0040","first-page":"445","article-title":"Developmental delays and pulmonary disease severity in cystic fibrosis","volume":"58","author":"Mahaney","year":"1986","journal-title":"Hum Biol"},{"issue":"9","key":"10.1016\/j.jcf.2019.08.013_bb0045","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1177\/000992289803700910","article-title":"Nutrition and pulmonary function predictors of delayed puberty in adolescent males with cystic fibrosis","volume":"37","author":"Boas","year":"1998","journal-title":"Clin Pediatr (Phila)"},{"issue":"3","key":"10.1016\/j.jcf.2019.08.013_bb0050","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S0022-3476(76)80537-9","article-title":"Course of cystic fibrosis in 95 patients","volume":"89","author":"Stern","year":"1976","journal-title":"J Pediatr"},{"issue":"12","key":"10.1016\/j.jcf.2019.08.013_bb0055","first-page":"1139","article-title":"Menarchal determinants in cystic fibrosis","volume":"134","author":"Moshang","year":"1980","journal-title":"Am J Dis Child"},{"issue":"3","key":"10.1016\/j.jcf.2019.08.013_bb0060","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0197-0070(83)80367-2","article-title":"Menstrual dysfunction in cystic fibrosis","volume":"4","author":"Neinstein","year":"1983","journal-title":"J Adolesc Health Care"},{"issue":"1","key":"10.1016\/j.jcf.2019.08.013_bb0065","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1542\/peds.99.1.29","article-title":"Delayed puberty in girls with cystic fibrosis despite good clinical status","volume":"99","author":"Johannesson","year":"1997","journal-title":"Pediatrics"},{"issue":"9","key":"10.1016\/j.jcf.2019.08.013_bb0070","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/j.1651-2227.2003.tb02571.x","article-title":"Pubertal growth and development in cystic fibrosis: a retrospective review","volume":"92","author":"Aswani","year":"2003","journal-title":"Acta Paediatr"},{"issue":"6","key":"10.1016\/j.jcf.2019.08.013_bb0075","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1177\/0148607181005006501","article-title":"Oral correction of essential fatty acid deficiency in cystic fibrosis","volume":"5","author":"Landon","year":"1981","journal-title":"J Parenter Enteral Nutr"},{"issue":"7","key":"10.1016\/j.jcf.2019.08.013_bb0080","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1440-1754.2005.00635.x","article-title":"Pubertal development and its influences on bone mineral density in Australian children and adolescents with cystic fibrosis","volume":"41","author":"Buntain","year":"2005","journal-title":"J Paediatr Child Health"},{"issue":"4","key":"10.1016\/j.jcf.2019.08.013_bb0085","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.jocd.2008.07.002","article-title":"Deficits in bone mineral content in children and adolescents with cystic fibrosis are related to height deficits","volume":"11","author":"Kelly","year":"2008","journal-title":"J Clin Densitom"},{"issue":"8","key":"10.1016\/j.jcf.2019.08.013_bb0090","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1136\/archdischild-2011-301069","article-title":"Growth during puberty in cystic fibrosis: a retrospective evaluation of a French cohort","volume":"97","author":"Bournez","year":"2012","journal-title":"Arch Dis Child"},{"issue":"1","key":"10.1016\/j.jcf.2019.08.013_bb0095","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1172\/JCI118080","article-title":"Expression and localization of the cystic fibrosis transmembrane conductance regulator mRNA and its protein in rat brain","volume":"96","author":"Mulberg","year":"1995","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.jcf.2019.08.013_bb0100","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/00001756-199801050-00028","article-title":"Cystic fibrosis transmembrane conductance regulator expression in human hypothalamus","volume":"9","author":"Mulberg","year":"1998","journal-title":"Neuroreport"},{"issue":"3","key":"10.1016\/j.jcf.2019.08.013_bb0105","doi-asserted-by":"crossref","first-page":"C563","DOI":"10.1152\/ajpcell.1999.277.3.C563","article-title":"CFTR is functionally active in GnRH-expressing GT1-7 hypothalamic neurons","volume":"277","author":"Weyler","year":"1999","journal-title":"Am J Physiol"},{"issue":"6","key":"10.1016\/j.jcf.2019.08.013_bb0110","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1136\/jmg.2005.032839","article-title":"The cystic fibrosis transmembrane conductance regulator (Cftr) modulates the timing of puberty in mice","volume":"43","author":"Jin","year":"2006","journal-title":"J Med Genet"},{"issue":"5","key":"10.1016\/j.jcf.2019.08.013_bb0115","first-page":"906","article-title":"Differential cellular expression of cystic fibrosis transmembrane regulator in human reproductive tissues. Clues for the infertility in patients with cystic fibrosis","volume":"144","author":"Tizzano","year":"1994","journal-title":"Am J Pathol"},{"issue":"2","key":"10.1016\/j.jcf.2019.08.013_bb0120","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1056\/NEJM196807112790203","article-title":"Reproductive failure in males with cystic fibrosis","volume":"279","author":"Kaplan","year":"1968","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.jcf.2019.08.013_bb0125","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1542\/pir.25-6-194","article-title":"Physiologic growth and development during adolescence","volume":"25","author":"Rosen","year":"2004","journal-title":"Pediatr Rev"},{"key":"10.1016\/j.jcf.2019.08.013_bb0130","series-title":"Pediatric endocrinology","article-title":"Puberty and its disorders in the female","author":"Rosenfield","year":"2008"},{"issue":"1","key":"10.1016\/j.jcf.2019.08.013_bb0135","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0022-3476(95)70265-2","article-title":"Pubertal staging in boys","volume":"127","author":"Biro","year":"1995","journal-title":"J Pediatr"},{"key":"10.1016\/j.jcf.2019.08.013_bb0140","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1542\/pir.32.7.281","article-title":"Normal pubertal development: part II: clinical aspects of puberty","volume":"32","author":"Bordini","year":"2011","journal-title":"Pediatr Rev"},{"issue":"4","key":"10.1016\/j.jcf.2019.08.013_bb0145","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1542\/peds.99.4.505","article-title":"Secondary sexual characteristics and menses in young girls seen in office practice: a study from the pediatric research in office settings network","volume":"99","author":"Herman-Giddens","year":"1997","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.jcf.2019.08.013_bb0150","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1210\/jcem.87.4.8395","article-title":"Delayed puberty: analysis of a large case series from an academic center","volume":"87","author":"Sedlmeyer","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.jcf.2019.08.013_bb0155","first-page":"186","article-title":"Psychological development as related to puberty, body height and severity of illness in adolescents with cystic fibrosis","volume":"27","author":"Sinnema","year":"1991","journal-title":"Isr J Med Sci"},{"issue":"10","key":"10.1016\/j.jcf.2019.08.013_bb0160","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa040388","article-title":"Recombinant human leptin in women with hypothalamic amenorrhea","volume":"351","author":"Welt","year":"2004","journal-title":"N Engl J Med"},{"issue":"249","key":"10.1016\/j.jcf.2019.08.013_bb0165","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1136\/adc.46.249.695","article-title":"Height and weight at menarche and a hypothesis of menarche","volume":"46","author":"Frisch","year":"1971","journal-title":"Arch Dis Child"},{"issue":"9","key":"10.1016\/j.jcf.2019.08.013_bb0170","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1111\/j.1651-2227.2003.tb02587.x","article-title":"Growth failure and diabetes in cystic fibrosis: have you considered turner syndrome?","volume":"92","author":"Steppberger","year":"2003","journal-title":"Acta Paediatr"},{"issue":"3","key":"10.1016\/j.jcf.2019.08.013_bb0175","first-page":"120","article-title":"Mosaic Klinefelter syndrome in an adult with cystic fibrosis","volume":"150","author":"Shwachman","year":"1982","journal-title":"Johns Hopkins Med J"},{"issue":"4","key":"10.1016\/j.jcf.2019.08.013_bb0180","doi-asserted-by":"crossref","first-page":"183","DOI":"10.6065\/apem.2013.18.4.183","article-title":"Boys with precocious or early puberty: incidence of pathological brain magnetic resonance imaging findings and factors related to newly developed brain lesions","volume":"18","author":"Choi","year":"2013","journal-title":"Ann Pediatr Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.jcf.2019.08.013_bb0185","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/BF02088471","article-title":"Validation of a self-administered instrument to assess stage of adolescent development","volume":"9","author":"Morris","year":"1980","journal-title":"J Youth Adolesc"},{"issue":"7","key":"10.1016\/j.jcf.2019.08.013_bb0190","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1210\/jc.2012-4243","article-title":"Metabolic effects of oral versus transdermal 17\u03b2-estradiol (E\u2082): a randomized clinical trial in girls with turner syndrome","volume":"98","author":"Torres-Santiago","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"10.1016\/j.jcf.2019.08.013_bb0195","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1136\/adc.65.10.1109","article-title":"Final height in boys with untreated constitutional delay in growth and puberty","volume":"65","author":"Crowne","year":"1990","journal-title":"Arch Dis Child"},{"issue":"10","key":"10.1016\/j.jcf.2019.08.013_bb0200","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1007\/BF01958760","article-title":"Final height in girls with untreated constitutional delay in growth and puberty","volume":"150","author":"Crowne","year":"1991","journal-title":"Eur J Pediatr"},{"issue":"1","key":"10.1016\/j.jcf.2019.08.013_bb0205","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1210\/er.2015-1026","article-title":"Growth and the growth hormone-insulin like growth factor 1 axis in children with chronic inflammation: current evidence, gaps in knowledge, and future directions","volume":"37","author":"Wong","year":"2016","journal-title":"Endocr Rev"},{"issue":"12","key":"10.1016\/j.jcf.2019.08.013_bb0210","article-title":"Recombinant growth hormone therapy for cystic fibrosis in children and young adults","author":"Thaker","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"10.1016\/j.jcf.2019.08.013_bb0215","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-3177","article-title":"Adult consequences of self-limited delayed puberty","volume":"139","author":"Zhu","year":"2017","journal-title":"Pediatrics"},{"issue":"3","key":"10.1016\/j.jcf.2019.08.013_bb0220","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/jbmr.3320","article-title":"Genetically determined later puberty impacts lowered bone mineral density in childhood and adulthood","volume":"33","author":"Cousminer","year":"2018","journal-title":"J Bone Miner Res"},{"issue":"9","key":"10.1016\/j.jcf.2019.08.013_bb0225","doi-asserted-by":"crossref","DOI":"10.1001\/jamapediatrics.2017.1769","article-title":"Association between linear growth and bone accrual in a diverse cohort of children and adolescents","volume":"171","author":"McCormack","year":"2017","journal-title":"JAMA Pediatr"},{"issue":"3","key":"10.1016\/j.jcf.2019.08.013_bb0230","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1359\/JBMR.051106","article-title":"BMD and body composition in children and young patients affected by cystic fibrosis","volume":"21","author":"Bianchi","year":"2006","journal-title":"J Bone Miner Res"},{"issue":"3","key":"10.1016\/j.jcf.2019.08.013_bb0235","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jocd.2015.06.013","article-title":"Executive summary of the 2015 ISCD position development conference on advanced measures from DXA and QCT: fracture prediction beyond BMD","volume":"18","author":"Shepherd","year":"2015","journal-title":"J Clin Densitom"},{"issue":"2","key":"10.1016\/j.jcf.2019.08.013_bb0240","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s12325-018-0860-4","article-title":"Efficacy and safety of CFTR corrector and potentiator combination therapy in patients with cystic fibrosis for the F508del-CFTR homozygous mutation: a systematic review and meta-analysis","volume":"36","author":"Wu","year":"2019","journal-title":"Adv Ther"},{"issue":"1","key":"10.1016\/j.jcf.2019.08.013_bb0245","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/ppul.23033","article-title":"Overweight and obesity in patients with cystic fibrosis: a center-based analysis","volume":"50","author":"Hanna","year":"2015","journal-title":"Pediatr Pulmonol"},{"issue":"S2","key":"10.1016\/j.jcf.2019.08.013_bb0246","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1016\/j.jcf.2019.08.010","article-title":"Growth failure and treatment in cystic fibrosis","volume":"18","author":"Le","year":"2019","journal-title":"J Cyst Fibros"},{"issue":"S2","key":"10.1016\/j.jcf.2019.08.013_bb0247","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.1016\/j.jcf.2019.08.022","article-title":"Vitamin D deficiency and its treatment in cystic fibrosis","volume":"18","author":"Daley","year":"2019","journal-title":"J Cyst Fibros"}],"container-title":["Journal of Cystic Fibrosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199319308665?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199319308665?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T21:40:43Z","timestamp":1761601243000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569199319308665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":51,"alternative-id":["S1569199319308665"],"URL":"https:\/\/doi.org\/10.1016\/j.jcf.2019.08.013","relation":{},"ISSN":["1569-1993"],"issn-type":[{"value":"1569-1993","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Puberty in cystic fibrosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Cystic Fibrosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcf.2019.08.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier B.V. on behalf of European Cystic Fibrosis Society.","name":"copyright","label":"Copyright"}]}}