{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T19:57:40Z","timestamp":1769198260453,"version":"3.49.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["DASENB17A0"],"award-info":[{"award-number":["DASENB17A0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["SANDERS16Y5"],"award-info":[{"award-number":["SANDERS16Y5"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","cysticfibrosisjournal.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cystic Fibrosis"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.jcf.2019.12.005","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T23:17:07Z","timestamp":1576883827000},"page":"527-533","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Rapid lung function decline in adults with early-stage cystic fibrosis lung disease"],"prefix":"10.1016","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9811-8004","authenticated-orcid":false,"given":"Elliott C.","family":"Dasenbrook","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliza K.","family":"Fink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Schechter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6265-6249","authenticated-orcid":false,"given":"Don B.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie J.","family":"Millar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2637-9293","authenticated-orcid":false,"given":"David J.","family":"Pasta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Mayer-Hamblett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcf.2019.12.005_bib0001","series-title":"Patient registry 2016 annual data report","year":"2017"},{"issue":"7","key":"10.1016\/j.jcf.2019.12.005_bib0002","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1164\/rccm.201507-1348ED","article-title":"The evidence for long-term benefits of restoration of CFTR function continues to grow","volume":"192","author":"Boyle","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"10.1016\/j.jcf.2019.12.005_bib0003","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.jpeds.2014.06.061","article-title":"Improvements in lung function and height among cohorts of 6-year-olds with cystic fibrosis from 1994 to 2012","volume":"165","author":"VanDevanter","year":"2014","journal-title":"J Pediatr"},{"issue":"10","key":"10.1016\/j.jcf.2019.12.005_bib0004","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1513\/AnnalsATS.201404-166OC","article-title":"Cystic fibrosis foundation pulmonary guideline. pharmacologic approaches to prevention and eradication of initial pseudomonas aeruginosa infection","volume":"11","author":"Mogayzel","year":"2014","journal-title":"Ann Am Thorac Soc"},{"issue":"2","key":"10.1016\/j.jcf.2019.12.005_bib0005","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jcf.2008.09.007","article-title":"High treatment burden in adults with cystic fibrosis: challenges to disease self-management","volume":"8","author":"Sawicki","year":"2009","journal-title":"J Cyst Fibros"},{"issue":"5","key":"10.1016\/j.jcf.2019.12.005_bib0006","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jcf.2012.03.009","article-title":"Risk factors for rate of decline in FEV1 in adults with cystic fibrosis","volume":"11","author":"Konstan","year":"2012","journal-title":"J Cyst Fibros"},{"issue":"S30","key":"10.1016\/j.jcf.2019.12.005_bib0007","first-page":"365","article-title":"Characteristic changes in lung function decline from adolescence to young adulthood","volume":"42","author":"VandenBranden","year":"2007","journal-title":"Pediatr Pulmonol"},{"issue":"5","key":"10.1016\/j.jcf.2019.12.005_bib0008","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1164\/rccm.201001-0092OC","article-title":"Effects of gender and age at diagnosis on disease progression in long-term survivors of cystic fibrosis","volume":"182","author":"Nick","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcf.2019.12.005_bib0009","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jpeds.2015.08.042","article-title":"Forced expiratory volume in 1 Second variability helps identify patients with cystic fibrosis at risk of greater loss of lung function","volume":"169","author":"Morgan","year":"2016","journal-title":"J Pediatr"},{"key":"10.1016\/j.jcf.2019.12.005_bib0010","doi-asserted-by":"crossref","DOI":"10.1513\/AnnalsATS.201511-781OC","article-title":"The cystic fibrosis foundation patient registry: design and methods of a national observational disease registry","author":"Knapp","year":"2016","journal-title":"Ann Am Thorac Soc"},{"issue":"8","key":"10.1016\/j.jcf.2019.12.005_bib0011","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1164\/rccm.200802-327OC","article-title":"Persistent methicillin-resistant Staphylococcus aureus and rate of FEV1 decline in cystic fibrosis","volume":"178","author":"Dasenbrook","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"10.1016\/j.jcf.2019.12.005_bib0012","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1183\/09031936.00080312","article-title":"Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations","volume":"40","author":"Quanjer","year":"2012","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1016\/j.jcf.2019.12.005_bib0013","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1513\/AnnalsATS.201808-564PS","article-title":"Control of confounding and reporting of results in causal inference studies. Guidance for authors from editors of respiratory, sleep, and critical care journals","volume":"16","author":"Lederer","year":"2019","journal-title":"Ann Am Thorac Soc"},{"issue":"2","key":"10.1016\/j.jcf.2019.12.005_bib0014","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1513\/AnnalsATS.201705-357OC","article-title":"Risk factors for gaps in care during transfer from pediatric to adult cystic fibrosis programs in the United States","volume":"15","author":"Sawicki","year":"2018","journal-title":"Ann Am Thorac Soc"},{"issue":"3","key":"10.1016\/j.jcf.2019.12.005_bib0015","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1542\/peds.2009-2791","article-title":"Cystic fibrosis and transition to adult medical care","volume":"125","author":"Tuchman","year":"2010","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.jcf.2019.12.005_bib0016","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.jcf.2017.10.003","article-title":"Lung function decline is delayed but not decreased in patients with cystic fibrosis and the R117H gene mutation","volume":"17","author":"Wagener","year":"2018","journal-title":"J Cyst Fibros"},{"issue":"3","key":"10.1016\/j.jcf.2019.12.005_bib0017","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1136\/thoraxjnl-2014-206750","article-title":"Short-term and long-term response to pulmonary exacerbation treatment in cystic fibrosis","volume":"71","author":"Heltshe","year":"2016","journal-title":"Thorax"},{"issue":"12","key":"10.1016\/j.jcf.2019.12.005_bib0018","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1089\/jwh.2014.4985","article-title":"Gender differences in outcomes of patients with cystic fibrosis","volume":"23","author":"Harness-Brumley","year":"2014","journal-title":"J Women\u2019s Health"},{"key":"10.1016\/j.jcf.2019.12.005_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcf.2018.03.001","article-title":"Cystic fibrosis patient registries: a valuable source for clinical research","author":"Dasenbrook","year":"2018","journal-title":"J Cyst Fibros"}],"container-title":["Journal of Cystic Fibrosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199319309841?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199319309841?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T21:12:56Z","timestamp":1593033176000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569199319309841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S1569199319309841"],"URL":"https:\/\/doi.org\/10.1016\/j.jcf.2019.12.005","relation":{},"ISSN":["1569-1993"],"issn-type":[{"value":"1569-1993","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rapid lung function decline in adults with early-stage cystic fibrosis lung disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Cystic Fibrosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcf.2019.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}