{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:17:26Z","timestamp":1792275446208,"version":"4.4.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cysticfibrosisjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cystic Fibrosis"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.jcf.2021.03.005","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T22:35:17Z","timestamp":1617316517000},"page":"e46-e52","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Nasal high-flow therapy as an adjunct to exercise in patients with cystic fibrosis: A pilot feasibility trial"],"prefix":"10.1016","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5462-0083","authenticated-orcid":false,"given":"Giulia","family":"Spoletini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang Yng","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Pollard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Etherington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian J","family":"Clifton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G","family":"Peckham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcf.2021.03.005_bib0001","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1016\/S0140-6736(16)00576-6","article-title":"Cystic fibrosis","volume":"388","author":"Elborn","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.jcf.2021.03.005_bib0002","article-title":"Cystic Fibrosis Foundation consensus guidelines for the care of individuals with advanced cystic fibrosis lung disease","volume":"0","author":"Kapnadak","year":"2020","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2021.03.005_bib0003","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1378\/chest.80.4.392","article-title":"Exercise Conditioning and Cardiopulmonary Fitness in Cystic Fibrosis: the Effects of a Three-month Supervised Running Program","volume":"80","author":"Orenstein","year":"1981","journal-title":"Chest"},{"key":"10.1016\/j.jcf.2021.03.005_bib0004","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1067\/mpd.2000.103408","article-title":"A randomized controlled trial of a 3-year home exercise program in cystic fibrosis","volume":"136","author":"Schneiderman-Walker","year":"2000","journal-title":"J Pediatr"},{"key":"10.1016\/j.jcf.2021.03.005_bib0005","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD002768.pub3","article-title":"Physical exercise training for cystic fibrosis","author":"Radtke","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jcf.2021.03.005_bib0006","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1056\/NEJM199212173272504","article-title":"The Prognostic Value of Exercise Testing in Patients with Cystic Fibrosis","volume":"327","author":"Nixon","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcf.2021.03.005_bib0007","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1378\/chest.10-1508","article-title":"Bone health, daily physical activity, and exercise tolerance in patients with cystic fibrosis","volume":"140","author":"Tejero Garc\u00eda","year":"2011","journal-title":"Chest"},{"key":"10.1016\/j.jcf.2021.03.005_bib0008","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1164\/rccm.2112059","article-title":"Changes in pulmonary mechanics with increasing disease severity in children and young adults with cystic fibrosis","volume":"166","author":"Hart","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcf.2021.03.005_bib0009","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1111\/crj.12763","article-title":"Static hyperinflation is associated with ventilatory limitation and exercise tolerance in adult cystic fibrosis","volume":"12","author":"Stevens","year":"2018","journal-title":"Clin Respir J"},{"key":"10.1016\/j.jcf.2021.03.005_bib0010","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.rmed.2004.03.016","article-title":"Effect of respiratory rate on airway deadspace ventilation during exercise in cystic fibrosis","volume":"98","author":"Thin","year":"2004","journal-title":"Respir Med"},{"key":"10.1016\/j.jcf.2021.03.005_bib0011","first-page":"PA4866","volume":"48","author":"Hernandez Gonzalez","year":"2016"},{"key":"10.1016\/j.jcf.2021.03.005_bib0012","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1152\/japplphysiol.00391.2016","article-title":"Qualitative dimensions of exertional dyspnea in adults with cystic fibrosis","volume":"121","author":"Quon","year":"2016","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jcf.2021.03.005_bib0013","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1378\/chest.91.5.693","article-title":"Diffusion capacity and oxygen desaturation effects on exercise in patients with cystic fibrosis","volume":"91","author":"Lebecque","year":"1987","journal-title":"Chest"},{"key":"10.1016\/j.jcf.2021.03.005_bib0014","series-title":"Cochrane database syst. rev., chichester","article-title":"Oxygen therapy for cystic fibrosis","author":"Elphick","year":"2013"},{"key":"10.1016\/j.jcf.2021.03.005_bib0015","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1378\/chest.14-2871","article-title":"Heated humidified high-flow nasal oxygen in adults","volume":"148","author":"Spoletini","year":"2015","journal-title":"Chest"},{"key":"10.1016\/j.jcf.2021.03.005_bib0016","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.rmed.2016.08.004","article-title":"Effects of heated and humidified high flow gases during high-intensity constant-load exercise on severe COPD patients with ventilatory limitation","volume":"118","author":"Cirio","year":"2016","journal-title":"Respir Med"},{"key":"10.1016\/j.jcf.2021.03.005_bib0017","doi-asserted-by":"crossref","DOI":"10.1093\/ptj\/pzaa076","article-title":"High-flow oxygen therapy during exercise training in patients with chronic obstructive pulmonary disease and chronic hypoxemia: a multicenter randomized controlled trial","volume":"100","author":"Vitacca","year":"2020","journal-title":"Phys Ther"},{"key":"10.1016\/j.jcf.2021.03.005_bib0018","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1164\/ajrccm.166.1.at1102","article-title":"ATS statement guidelines for the six-minute walk test","volume":"166","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcf.2021.03.005_bib0019","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.rmed.2014.04.006","article-title":"Effects of noninvasive ventilation on treadmill 6-min walk distance and regional chest wall volumes in cystic fibrosis: randomized controlled trial","volume":"108","author":"Lima","year":"2014","journal-title":"Respir Med"},{"key":"10.1016\/j.jcf.2021.03.005_bib0020","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13613-018-0432-4","article-title":"High-flow nasal oxygen versus noninvasive ventilation in adult patients with cystic fibrosis: a randomized crossover physiological study","volume":"8","author":"Sklar","year":"2018","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.jcf.2021.03.005_bib0021","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0101-2018","article-title":"ERS statement on standardisation of cardiopulmonary exercise testing in chronic lung diseases","volume":"28","author":"Radtke","year":"2019","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.jcf.2021.03.005_bib0022","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1183\/09031936.00150414","article-title":"An official systematic review of the European Respiratory Society\/American Thoracic Society: measurement properties of field walking tests in chronic respiratory disease","volume":"44","author":"Singh","year":"2014","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jcf.2021.03.005_bib0023","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2220\/biomedres.24.309","article-title":"Ventilatory Responses to Six-minute Walk Test, Incremental Shuttle Walking Test, and Cycle Ergometer Test in Patients with Chronic Obstructive Pulmonary Disease","volume":"24","author":"SATAKE","year":"2003","journal-title":"Biomed Res"},{"key":"10.1016\/j.jcf.2021.03.005_bib0024","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/(SICI)1099-0496(199804)25:4<278::AID-PPUL8>3.0.CO;2-G","article-title":"A step in the right direction: assessing exercise tolerance in cystic fibrosis","volume":"25","author":"Balfour-Lynn","year":"1998","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jcf.2021.03.005_bib0025","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S1569-1993(02)00100-5","article-title":"Predictors of desaturation during formal hypoxic challenge in adult patients with cystic fibrosis","volume":"1","author":"Peckham","year":"2002","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2021.03.005_bib0026","first-page":"423","article-title":"Validation of a treadmill six-minute walk test protocol for the evaluation of patients with pulmonary arterial hypertension","volume":"35","author":"de Camargo","year":"2009","journal-title":"J Bras Pneumol"},{"key":"10.1016\/j.jcf.2021.03.005_bib0027","article-title":"Hallway versus treadmill 6-minute-walk tests in patients with chronic obstructive pulmonary disease","volume":"54","author":"de Almeida","year":"2009","journal-title":"Respir Care"},{"key":"10.1016\/j.jcf.2021.03.005_bib0028","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1097\/HJR.0b013e32833a1963","article-title":"Six-minute walking test done in a hallway or on a treadmill: how close do the two methods agree?","volume":"17","author":"Lenssen","year":"2010","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.jcf.2021.03.005_bib0029","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/jep.12629","article-title":"Minimal clinically important difference for change in 6-minute walk test distance of adults with pathology: a systematic review","volume":"23","author":"Bohannon","year":"2017","journal-title":"J Eval Clin Pract"},{"key":"10.1016\/j.jcf.2021.03.005_bib0030","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.jcrc.2018.10.004","article-title":"High-flow nasal therapy vs standard oxygen during breaks off noninvasive ventilation for acute respiratory failure: a pilot randomized controlled trial","volume":"48","author":"Spoletini","year":"2018","journal-title":"J Crit Care"},{"key":"10.1016\/j.jcf.2021.03.005_bib0031","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1007\/s00134-016-4277-8","article-title":"Use of high-flow nasal cannula oxygenation in ICU adults: a narrative review","volume":"42","author":"Papazian","year":"2016","journal-title":"Intensive Care Med"}],"container-title":["Journal of Cystic Fibrosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199321000540?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199321000540?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T21:46:14Z","timestamp":1761601574000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569199321000540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S1569199321000540"],"URL":"https:\/\/doi.org\/10.1016\/j.jcf.2021.03.005","relation":{},"ISSN":["1569-1993"],"issn-type":[{"value":"1569-1993","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nasal high-flow therapy as an adjunct to exercise in patients with cystic fibrosis: A pilot feasibility trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Cystic Fibrosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcf.2021.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V. on behalf of European Cystic Fibrosis Society.","name":"copyright","label":"Copyright"}]}}