{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:19:40Z","timestamp":1790803180229,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100009309","name":"Northern Ireland Chest Heart and Stroke","doi-asserted-by":"publisher","award":["2014_15"],"award-info":[{"award-number":["2014_15"]}],"id":[{"id":"10.13039\/501100009309","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008303","name":"Department for Employment and Learning, Northern Ireland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008303","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cysticfibrosisjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cystic Fibrosis"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.jcf.2021.04.012","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:25:08Z","timestamp":1623111908000},"page":"682-691","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Microbial interaction: Prevotella spp. reduce P. aeruginosa induced inflammation in cystic fibrosis bronchial epithelial cells"],"prefix":"10.1016","volume":"20","author":[{"given":"Anne","family":"Bertelsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Stuart","family":"Elborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina C.","family":"Schock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcf.2021.04.012_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.prrv.2008.05.008","article-title":"Innate immune activation and cystic fibrosis","volume":"9","author":"Brennan","year":"2008","journal-title":"Paediatr Respir Rev"},{"key":"10.1016\/j.jcf.2021.04.012_bib0002","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1016\/S0140-6736(16)00576-6","article-title":"Cystic fibrosis","volume":"388","author":"Elborn","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.jcf.2021.04.012_bib0003","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1164\/rccm.200708-1151OC","article-title":"Detection of anaerobic bacteria in high numbers in sputum from patients with cystic fibrosis","volume":"177","author":"Tunney","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcf.2021.04.012_bib0004","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1128\/AAC.10.4.713","article-title":"Susceptibility of respiratory tract anaerobes to orally administered penicillins and cephalosporins","volume":"10","author":"Busch","year":"1976","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jcf.2021.04.012_bib0005","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1002\/art.39785","article-title":"Suppression of inflammatory arthritis by human gut-derived prevotella histicola in humanized mice","volume":"68","author":"Marietta","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jcf.2021.04.012_bib0006","doi-asserted-by":"crossref","first-page":"e31976","DOI":"10.1371\/journal.pone.0031976","article-title":"Divergent pro-inflammatory profile of human dendritic cells in response to commensal and pathogenic bacteria associated with the airway microbiota","volume":"7","author":"Larsen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jcf.2021.04.012_bib0007","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1164\/rccm.201512-2424OC","article-title":"Airway microbiota determines innate cell inflammatory or tissue remodeling profiles in lung transplantation","volume":"194","author":"Bernasconi","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcf.2021.04.012_bib0008","doi-asserted-by":"crossref","first-page":"e62917","DOI":"10.1371\/journal.pone.0062917","article-title":"Inflammation and airway microbiota during cystic fibrosis pulmonary exacerbations","volume":"8","author":"Zemanick","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jcf.2021.04.012_bib0009","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00242-2018","article-title":"Anaerobic bacteria cultured from cystic fibrosis airways correlate to milder disease: a multisite study","volume":"52","author":"Muhlebach","year":"2018","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jcf.2021.04.012_bib0010","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/2049-2618-1-19","article-title":"Enrichment of lung microbiome with supraglottic taxa is associated with increased pulmonary inflammation","volume":"1","author":"Segal","year":"2013","journal-title":"Microbiome"},{"key":"10.1016\/j.jcf.2021.04.012_bib0011","doi-asserted-by":"crossref","first-page":"16031","DOI":"10.1038\/nmicrobiol.2016.31","article-title":"Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype","volume":"1","author":"Segal","year":"2016","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.jcf.2021.04.012_bib0012","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jcf.2019.09.005","article-title":"Infection with Prevotella nigrescens induces TLR2 signalling and low levels of p65 mediated inflammation in cystic fibrosis bronchial epithelial cells","volume":"19","author":"Bertelsen","year":"2020","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2021.04.012_bib0013","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/imm.12760","article-title":"The immune response to Prevotella bacteria in chronic inflammatory disease","volume":"151","author":"Larsen","year":"2017","journal-title":"Immunology"},{"key":"10.1016\/j.jcf.2021.04.012_bib0014","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.1016\/S1569-1993(14)60252-6","article-title":"Prevotella histicola drives transcription of an elevated host response compared to P. nigrescens in cystic fibrosis bronchial epithelial cells","volume":"13","author":"Bertelsen","year":"2014","journal-title":"J Cystic Fibrosis"},{"key":"10.1016\/j.jcf.2021.04.012_bib0015","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/mi.2016.108","article-title":"The respiratory tract microbiome and lung inflammation: a two-way street","volume":"10","author":"Huffnagle","year":"2017","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jcf.2021.04.012_bib0016","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1099\/jmm.0.000500","article-title":"Evidence of persistence of Prevotella spp. in the cystic fibrosis lung","volume":"66","author":"Gilpin","year":"2017","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.jcf.2021.04.012_bib0017","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0235803","article-title":"Toll like Receptor signalling by Prevotella histicola activates alternative NF-kappaB signalling in Cystic Fibrosis bronchial epithelial cells compared to P. aeruginosa","volume":"15","author":"Bertelsen","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.jcf.2021.04.012_bib0018","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1042\/BST0370863","article-title":"Role of CFTR, Pseudomonas aeruginosa and Toll-like receptors in cystic fibrosis lung inflammation","volume":"37","author":"Buchanan","year":"2009","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.jcf.2021.04.012_bib0019","doi-asserted-by":"crossref","first-page":"e7259","DOI":"10.1371\/journal.pone.0007259","article-title":"Pseudomonas aeruginosa LPS or flagellin are sufficient to activate TLR-dependent signaling in murine alveolar macrophages and airway epithelial cells","volume":"4","author":"Raoust","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jcf.2021.04.012_bib0020","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2003.10.003","article-title":"TLR signaling pathways","volume":"16","author":"Takeda","year":"2004","journal-title":"Semin Immunol"},{"key":"10.1016\/j.jcf.2021.04.012_bib0021","doi-asserted-by":"crossref","first-page":"7151","DOI":"10.1128\/IAI.73.11.7151-7160.2005","article-title":"Human airway epithelial cells sense Pseudomonas aeruginosa infection via recognition of flagellin by Toll-like receptor 5","volume":"73","author":"Zhang","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.jcf.2021.04.012_bib0022","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00005-011-0113-6","article-title":"The cystic fibrosis neutrophil: a specialized yet potentially defective cell","volume":"59","author":"Hayes","year":"2011","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"10.1016\/j.jcf.2021.04.012_bib0023","doi-asserted-by":"crossref","first-page":"e89614","DOI":"10.1371\/journal.pone.0089614","article-title":"Adaptation of pseudomonas aeruginosa in cystic fibrosis airways influences virulence of staphylococcus aureus in vitro and murine models of co-infection","volume":"9","author":"Baldan","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jcf.2021.04.012_bib0024","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1378\/chest.11-2348","article-title":"Defective phagocytosis in airways disease","volume":"141","author":"Donnelly","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.jcf.2021.04.012_bib0025","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1177\/09680519050110040701","article-title":"Modulatory effects of sCD14 and LBP on LPS-host cell interactions","volume":"11","author":"Kitchens","year":"2005","journal-title":"J Endotoxin Res"},{"key":"10.1016\/j.jcf.2021.04.012_bib0026","doi-asserted-by":"crossref","first-page":"e6818","DOI":"10.1371\/journal.pone.0006818","article-title":"Serum lipopolysaccharide binding protein levels predict severity of lung injury and mortality in patients with severe sepsis","volume":"4","author":"Villar","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jcf.2021.04.012_bib0027","first-page":"L736","article-title":"Asthma and endotoxin: lipopolysaccharide-binding protein and soluble CD14 in bronchoalveolar compartment","volume":"270","author":"Dubin","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jcf.2021.04.012_bib0028","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/intimm\/dxq005","article-title":"Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells","volume":"22","author":"Tsukamoto","year":"2010","journal-title":"Int Immunol"},{"key":"10.1016\/j.jcf.2021.04.012_bib0029","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1099\/ijs.0.65656-0","article-title":"Prevotella histicola sp. nov., isolated from the human oral cavity","volume":"58","author":"Downes","year":"2008","journal-title":"Int J Syst Evol Microbiol"},{"key":"10.1016\/j.jcf.2021.04.012_bib0030","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1128\/AEM.66.5.2001-2005.2000","article-title":"Lactic acid permeabilizes gram-negative bacteria by disrupting the outer membrane","volume":"66","author":"Alakomi","year":"2000","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.jcf.2021.04.012_bib0031","doi-asserted-by":"crossref","first-page":"17044","DOI":"10.4238\/2015.December.16.5","article-title":"Lactic acid bacteria protect human intestinal epithelial cells from Staphylococcus aureus and Pseudomonas aeruginosa infections","volume":"14","author":"Affhan","year":"2015","journal-title":"Genet Mol Res"},{"key":"10.1016\/j.jcf.2021.04.012_bib0032","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1472-765X.2004.01608.x","article-title":"Characterization of a bacteriocin produced by Prevotella nigrescens ATCC 25261","volume":"39","author":"Kaewsrichan","year":"2004","journal-title":"Lett Appl Microbiol"},{"key":"10.1016\/j.jcf.2021.04.012_bib0033","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1472-765X.2009.02657.x","article-title":"The gene coding for nigrescin produced by Prevotella nigrescens ATCC 25261","volume":"49","author":"Teanpaisan","year":"2009","journal-title":"Lett Appl Microbiol"}],"container-title":["Journal of Cystic Fibrosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199321001223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199321001223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T21:44:36Z","timestamp":1761601476000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569199321001223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S1569199321001223"],"URL":"https:\/\/doi.org\/10.1016\/j.jcf.2021.04.012","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-40957\/v1","asserted-by":"object"}]},"ISSN":["1569-1993"],"issn-type":[{"value":"1569-1993","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microbial interaction: Prevotella spp. reduce P. aeruginosa induced inflammation in cystic fibrosis bronchial epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Cystic Fibrosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcf.2021.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 European Cystic Fibrosis Society. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}