{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:35:31Z","timestamp":1792096531053,"version":"4.4.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cysticfibrosisjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cystic Fibrosis"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.jcf.2021.06.010","type":"journal-article","created":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T02:45:25Z","timestamp":1625885125000},"page":"26-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Preclinical atherosclerosis in cystic fibrosis: Two distinct presentations are related to pancreatic status"],"prefix":"10.1016","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0953-2188","authenticated-orcid":false,"given":"Jan Krzysztof","family":"Nowak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Wykr\u0119towicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edyta","family":"M\u0105dry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Krauze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u0142awomira","family":"Drzyma\u0142a-Czy\u017c","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrycja","family":"Krzy\u017canowska-Jankowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Sobkowiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4518-7070","authenticated-orcid":false,"given":"Joanna","family":"Go\u017adzik-Spychalska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szymon","family":"Kurek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Kononets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0503-6371","authenticated-orcid":false,"given":"Nataliya","family":"Kashirskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Lisowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaros\u0142aw","family":"Walkowiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcf.2021.06.010_bib0001","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1378\/chest.12-2444","article-title":"Joining the crowd: cystic fibrosis and cardiovascular disease risk factors","volume":"143","author":"Cross","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.jcf.2021.06.010_bib0002","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1183\/09031936.00044009","article-title":"Increased augmentation index in patients with cystic fibrosis","volume":"34","author":"Hull","year":"2009","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jcf.2021.06.010_bib0003","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1111\/echo.14375","article-title":"Elastic aortic properties in cystic fibrosis adults without cardiovascular risk factors: a case-control study","volume":"36","author":"Vizzardi","year":"2019","journal-title":"Echocardiography"},{"key":"10.1016\/j.jcf.2021.06.010_bib0004","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.jcf.2017.12.009","article-title":"Young patients with cystic fibrosis demonstrate subtle alterations of the cardiovascular system","volume":"17","author":"Eising","year":"2018","journal-title":"J Cyst Fibrosis"},{"key":"10.1016\/j.jcf.2021.06.010_bib0005","doi-asserted-by":"crossref","DOI":"10.4081\/monaldi.2019.1035","article-title":"Macro- and microvascular functions in cystic fibrosis adults without cardiovascular risk factors: a case-control study","volume":"89","author":"Vizzardi","year":"2019","journal-title":"Monaldi Arch Chest Dis"},{"key":"10.1016\/j.jcf.2021.06.010_bib0006","first-page":"233","article-title":"A devastating cardiovascular event in an adult cystic fibrosis patient: an unforeseen outcome of increasing life expectancy","volume":"25","author":"Hussain","year":"2018","journal-title":"Respir Med Case Rep"},{"key":"10.1016\/j.jcf.2021.06.010_bib0007","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1513\/AnnalsATS.201706-488OC","article-title":"Cardiovascular outcomes after a respiratory tract infection among adults with non-cystic fibrosis bronchiectasis: a general population-based study","volume":"15","author":"Navaratnam","year":"2018","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.jcf.2021.06.010_bib0008","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1007\/s11739-019-02104-5","article-title":"Focus on echocardiographic right ventricular strain analysis in cystic fibrosis adults without cardiovascular risk factors: a case-control study","volume":"14","author":"Sciatti","year":"2019","journal-title":"Intern Emerg Med"},{"key":"10.1016\/j.jcf.2021.06.010_bib0009","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.jcf.2019.04.001","article-title":"Cystic fibrosis dyslipidaemia: a cross-sectional study","volume":"18","author":"Nowak","year":"2019","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2021.06.010_bib0010","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18010185","article-title":"Determinants of Serum Glycerophospholipid Fatty Acids in Cystic Fibrosis","volume":"18","author":"Drzyma\u0142a-Czy\u017c","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcf.2021.06.010_bib0011","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1111\/j.1651-2227.2003.tb00512.x","article-title":"The predominance of omega-6 polyunsaturated fatty acids in cystic fibrosis despite low arachidonic acid levels","volume":"92","author":"Walkowiak","year":"2003","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jcf.2021.06.010_bib0012","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/MPG.0b013e3180690da9","article-title":"Polyunsaturated fatty acids in cystic fibrosis are related to nutrition and clinical expression of the disease","volume":"45","author":"Walkowiak","year":"2007","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jcf.2021.06.010_bib0013","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.atherosclerosis.2012.09.026","article-title":"Psoriasis is associated with increased intima-media thickness\u2013the Study of Health in Pomerania (SHIP)","volume":"225","author":"Troitzsch","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jcf.2021.06.010_bib0014","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.atherosclerosis.2017.11.024","article-title":"A genetic association study of carotid intima-media thickness (CIMT) and plaque in Mexican Americans and European Americans with rheumatoid arthritis","volume":"271","author":"Arya","year":"2018","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jcf.2021.06.010_bib0015","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.tcm.2019.10.001","article-title":"Inflammatory bowel disease and the risk for cardiovascular disease: does all inflammation lead to heart disease?","volume":"30","author":"Bigeh","year":"2020","journal-title":"Trends iCardiovasc Med"},{"key":"10.1016\/j.jcf.2021.06.010_bib0016","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.jpeds.2008.05.005","article-title":"Guidelines for diagnosis of cystic fibrosis in newborns through older adults: Cystic Fibrosis Foundation consensus report","volume":"153","author":"Farrell","year":"2008","journal-title":"J Pediatr"},{"key":"10.1016\/j.jcf.2021.06.010_bib0017","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jpeds.2004.06.033","article-title":"Assessment of maldigestion in cystic fibrosis","volume":"145","author":"Walkowiak","year":"2004","journal-title":"J Pediatr"},{"key":"10.1016\/j.jcf.2021.06.010_bib0018","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S1569-1993(02)00096-6","article-title":"Fecal elastase-1 cut-off levels in the assessment of exocrine pancreatic function in cystic fibrosis","volume":"1","author":"Walkowiak","year":"2002","journal-title":"J Cyst Fibros"},{"issue":"Suppl 2","key":"10.1016\/j.jcf.2021.06.010_bib0019","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1016\/S1569-1993(11)60006-4","article-title":"Best practice guidance for the diagnosis and management of cystic fibrosis-associated liver disease","volume":"10","author":"Debray","year":"2011","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2021.06.010_bib0020","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.2337\/dc10-1768","article-title":"Clinical care guidelines for cystic fibrosis-related diabetes: a position statement of the American Diabetes Association and a clinical practice guideline of the Cystic Fibrosis Foundation, endorsed by the Pediatric Endocrine Society","volume":"33","author":"Moran","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcf.2021.06.010_bib0021","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00408-017-0029-y","article-title":"Increased soluble VCAM-1 and normal P-selectin in cystic fibrosis: a cross-sectional study","volume":"195","author":"Nowak","year":"2017","journal-title":"Lung"},{"key":"10.1016\/j.jcf.2021.06.010_bib0022","article-title":"Mechanical factors in arterial aging: a clinical perspective","volume":"50","author":"Mf","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jcf.2021.06.010_bib0023","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1042\/cs1030371","article-title":"Determination of age-related increases in large artery stiffness by digital pulse contour analysis","volume":"103","author":"Millasseau","year":"2002","journal-title":"Clin Sci"},{"key":"10.1016\/j.jcf.2021.06.010_bib0024","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.amjhyper.2005.03.739","article-title":"Association of risk factors with increased pulse wave velocity detected by a novel method using dual-channel photoplethysmography","volume":"18","author":"Tsai","year":"2005","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.jcf.2021.06.010_bib0025","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00467-007-0693-x","article-title":"Pulse contour analysis: a valid assessment of central arterial stiffness in children?","volume":"23","author":"Simonetti","year":"2008","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.jcf.2021.06.010_bib0026","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1542\/peds.24.1.34","article-title":"Decreased aortic atherosclerosis in cystic fibrosis of the pancreas","volume":"24","author":"Holman","year":"1959","journal-title":"Pediatrics"},{"key":"10.1016\/j.jcf.2021.06.010_bib0027","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.freeradbiomed.2014.08.005","article-title":"Inflammation, oxidative stress, and cardiovascular disease risk factors in adults with cystic fibrosis","volume":"76","author":"Reverri","year":"2014","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jcf.2021.06.010_bib0028","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/MPG.0b013e318180af4f","article-title":"Exocrine pancreatic function testing in patients with cystic fibrosis and pancreatic sufficiency: a correlation study","volume":"48","author":"Weintraub","year":"2009","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jcf.2021.06.010_bib0029","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1097\/MPG.0b013e31817fb76b","article-title":"Serum linoleic acid status as a clinical indicator of essential fatty acid status in children with cystic fibrosis","volume":"47","author":"Maqbool","year":"2008","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jcf.2021.06.010_bib0030","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1177\/1535370218758605","article-title":"Low linoleic and high docosahexaenoic acids in a severe phenotype of transgenic cystic fibrosis mice","volume":"243","author":"Strandvik","year":"2018","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.jcf.2021.06.010_bib0031","doi-asserted-by":"crossref","DOI":"10.3390\/biom8040159","article-title":"Overview of bile acids signaling and perspective on the signal of ursodeoxycholic acid, the most hydrophilic bile acid, in the heart","volume":"8","author":"Hanafi","year":"2018","journal-title":"Biomolecules"},{"key":"10.1016\/j.jcf.2021.06.010_bib0032","article-title":"Ursodeoxycholic acid (UDCA) exerts anti-atherogenic effects by inhibiting RAGE signaling in diabetic atherosclerosis","volume":"11","author":"Chung","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jcf.2021.06.010_bib0033","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/ajh.2008.207","article-title":"Measurement of stiffness index by digital volume pulse analysis technique: clinical utility in cardiovascular disease risk stratification","volume":"21","author":"Gunarathne","year":"2008","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.jcf.2021.06.010_bib0034","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0135659","article-title":"Digital photoplethysmography for assessment of arterial stiffness: repeatability and comparison with applanation tonometry","volume":"10","author":"von Wowern","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jcf.2021.06.010_bib0035","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/08037050510034301","article-title":"Stiffness index derived from digital volume pulse as a marker of target organ damage in untreated hypertension","volume":"14","author":"Chen","year":"2005","journal-title":"Blood Press"},{"key":"10.1016\/j.jcf.2021.06.010_bib0036","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.clnu.2010.02.001","article-title":"Long chain n-3 PUFA-rich meal reduced postprandial measures of arterial stiffness","volume":"29","author":"Chong","year":"2010","journal-title":"Clin Nutr"},{"key":"10.1016\/j.jcf.2021.06.010_bib0037","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.preghy.2018.11.002","article-title":"Arterial stiffness in normal pregnancy as assessed by digital pulse wave analysis by photoplethysmography - a longitudinal study","volume":"15","author":"von Wowern","year":"2019","journal-title":"Pregnancy Hypertens"},{"key":"10.1016\/j.jcf.2021.06.010_bib0038","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/j.1440-1681.2007.04666.x","article-title":"Indices of vascular stiffness and wave reflection in relation to body mass index or body fat in healthy subjects","volume":"34","author":"Wykretowicz","year":"2007","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.jcf.2021.06.010_bib0039","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1183\/09031936.00212511","article-title":"Increased arterial stiffness in children with cystic fibrosis","volume":"39","author":"Buehler","year":"2012","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jcf.2021.06.010_bib0040","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1002\/ppul.24688","article-title":"Evaluation of increased arterial stiffness in pediatric patients with cystic fibrosis by augmentation index and pulse wave velocity analysis","volume":"55","author":"Kartal \u00d6zt\u00fcrk","year":"2020","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jcf.2021.06.010_bib0041","doi-asserted-by":"crossref","first-page":"e86183","DOI":"10.1172\/jci.insight.86183","article-title":"Acute administration of ivacaftor to people with cystic fibrosis and a G551D-CFTR mutation reveals smooth muscle abnormalities","volume":"1","author":"Adam","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.jcf.2021.06.010_bib0042","doi-asserted-by":"crossref","DOI":"10.3906\/sag-2002-61","article-title":"Prospective evaluation of vascular changes in acute respiratory infections in children with cystic fibrosis","author":"Kartal \u00d6zt\u00fcrk","year":"2020","journal-title":"Turk J Med Sci"},{"key":"10.1016\/j.jcf.2021.06.010_bib0043","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jcf.2012.07.004","article-title":"Dynamic vascular changes following intravenous antibiotics in patients with cystic fibrosis","volume":"12","author":"Hull","year":"2013","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2021.06.010_bib0044","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.echo.2007.11.011","volume":"21","author":"Stein","year":"2008","journal-title":"J Am Soc Echocardiogr"}],"container-title":["Journal of Cystic Fibrosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199321012947?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199321012947?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T21:45:37Z","timestamp":1761601537000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569199321012947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S1569199321012947"],"URL":"https:\/\/doi.org\/10.1016\/j.jcf.2021.06.010","relation":{},"ISSN":["1569-1993"],"issn-type":[{"value":"1569-1993","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preclinical atherosclerosis in cystic fibrosis: Two distinct presentations are related to pancreatic status","name":"articletitle","label":"Article Title"},{"value":"Journal of Cystic Fibrosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcf.2021.06.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 European Cystic Fibrosis Society. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}