{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T07:32:01Z","timestamp":1793518321550,"version":"4.5.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32GM007347"],"award-info":[{"award-number":["T32GM007347"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32GM007347"],"award-info":[{"award-number":["T32GM007347"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013017","name":"VANDERBILT UNIVERSITY MEDICAL CENTER","doi-asserted-by":"publisher","award":["T32GM007347"],"award-info":[{"award-number":["T32GM007347"]}],"id":[{"id":"10.13039\/100013017","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cysticfibrosisjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cystic Fibrosis"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.jcf.2021.07.005","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T08:15:38Z","timestamp":1627373738000},"page":"e1-e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Urinary tract infections in cystic fibrosis patients"],"prefix":"10.1016","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7791-1641","authenticated-orcid":false,"given":"Seth A.","family":"Reasoner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1901-5558","authenticated-orcid":false,"given":"Kyle T.","family":"Enriquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1874-1574","authenticated-orcid":false,"given":"Benjamin","family":"Abelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1947-5837","authenticated-orcid":false,"given":"Steven","family":"Scaglione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bennett","family":"Schneier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"O'Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Van Horn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4249-8997","authenticated-orcid":false,"given":"Maria","family":"Hadjifrangiskou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcf.2021.07.005_bib0001","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/nrurol.2017.20","article-title":"New and developing diagnostic technologies for urinary tract infections","volume":"14","author":"Davenport","year":"2017","journal-title":"Nat Rev Urol"},{"key":"10.1016\/j.jcf.2021.07.005_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.idc.2013.09.003","article-title":"Urinary tract infection syndromes. Occurrence, recurrence, bacteriology, risk factors, and disease burden","volume":"28","author":"Foxman","year":"2014","journal-title":"Infect Dis Clin North Am"},{"key":"10.1016\/j.jcf.2021.07.005_bib0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-019-02139-4","article-title":"Renal involvement and metabolic alterations in adults patients affected by cystic fibrosis","volume":"17","author":"Lai","year":"2019","journal-title":"J Transl Med"},{"key":"10.1016\/j.jcf.2021.07.005_bib0004","doi-asserted-by":"crossref","first-page":"921","DOI":"10.2215\/CJN.00750209","article-title":"Renal involvement in cystic fibrosis: diseases spectrum and clinical relevance","volume":"4","author":"Yahiaoui","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.jcf.2021.07.005_bib0005","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.1016\/j.lpm.2017.05.011","article-title":"Current and emerging comorbidities in cystic fibrosis","volume":"46","author":"Ronan","year":"2017","journal-title":"Press Med"},{"key":"10.1016\/j.jcf.2021.07.005_bib0006","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.jcf.2017.10.002","article-title":"New comorbidities in the changing face of cystic fibrosis care","volume":"16","author":"Bonk","year":"2017","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2021.07.005_bib0007","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/resp.13125","article-title":"A systematic review of the prevalence and impact of urinary incontinence in cystic fibrosis","volume":"23","author":"Frayman","year":"2018","journal-title":"Respirology"},{"key":"10.1016\/j.jcf.2021.07.005_bib0008","article-title":"Prevalence of pelvic incontinence in patients with cystic fibrosis","volume":"4","author":"Neemuchwala","year":"2017","journal-title":"Glob Pediatr Heal"},{"key":"10.1016\/j.jcf.2021.07.005_bib0009","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1002\/ppul.23544","article-title":"The CF gastrointestinal microbiome: structure and clinical impact","volume":"51","author":"Rogers","year":"2016","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jcf.2021.07.005_bib0010","first-page":"1","article-title":"Gut microbiota in children with cystic fibrosis: a taxonomic and functional dysbiosis","volume":"9","author":"Co","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcf.2021.07.005_bib0011","article-title":"Altered intestinal microbiota composition, antibiotic therapy and intestinal inflammation in children and adolescents with cystic fibrosis","volume":"13","author":"De","year":"2018","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jcf.2021.07.005_bib0012","first-page":"1","article-title":"The altered gut microbiota in adults with cystic fibrosis","volume":"17","author":"Burke","year":"2017","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.jcf.2021.07.005_bib0013","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/clpt.2008.89","article-title":"Development of a large-scale de-identified DNA biobank to enable personalized medicine","volume":"84","author":"Roden","year":"2008","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.jcf.2021.07.005_bib0014","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.jpeds.2016.09.064","article-title":"Diagnosis of cystic fibrosis: consensus guidelines from the cystic fibrosis foundation","volume":"181","author":"Farrell","year":"2017","journal-title":"J Pediatr"},{"key":"10.1016\/j.jcf.2021.07.005_bib0015","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/pedi.12732","article-title":"ISPAD clinical practice consensus guidelines 2018: management of cystic fibrosis-related diabetes in children and adolescents","volume":"19","author":"Moran","year":"2018","journal-title":"Pediatr Diab"},{"key":"10.1016\/j.jcf.2021.07.005_bib0016","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/MPG.0b013e3181a6e01d","article-title":"Defining DIOS and constipation in cystic fibrosis with a multicentre study on the incidence, characteristics, and treatment of DIOS","volume":"50","author":"Houwen","year":"2010","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jcf.2021.07.005_bib0017","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.jmb.2019.11.008","article-title":"Defining a molecular signature for uropathogenic versus urocolonizing Escherichia coli: the status of the field and new clinical opportunities","volume":"432","author":"Eberly","year":"2020","journal-title":"J Mol Biol"},{"key":"10.1016\/j.jcf.2021.07.005_bib0018","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1056\/NEJM199608153350703","article-title":"A Stergachis WES. A prospective study of risk factors for symptomatic urinary tract infection in young women","volume":"335","author":"Hooton","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcf.2021.07.005_bib0019","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S1047-2797(00)00072-7","article-title":"Urinary tract infection: Self-reported incidence and associated costs","volume":"10","author":"Foxman","year":"2000","journal-title":"Ann Epidemiol"},{"key":"10.1016\/j.jcf.2021.07.005_bib0020","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.UTI-0012-2012","article-title":"Gram-positive uropathogens, polymicrobial urinary tract infection, and the emerging microbiota of the urinary tract","volume":"4","author":"Kline","year":"2016","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.jcf.2021.07.005_bib0021","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12551-008-0002-3","article-title":"CFTR structure and function: Is there a role in the kidney?","volume":"1","author":"Souza-Menezes","year":"2009","journal-title":"Biophys Rev"},{"key":"10.1016\/j.jcf.2021.07.005_bib0022","first-page":"139","article-title":"Urinary metabolomics reveals unique metabolic signatures in infants with cystic fibrosis","volume":"176","author":"Koppa","year":"2019","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2021.07.005_bib0023","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1681\/ASN.2020010053","article-title":"Impaired renal HCO3- excretion in cystic fibrosis","volume":"31","author":"Berg","year":"2020","journal-title":"J Am Soc Nephrol"}],"container-title":["Journal of Cystic Fibrosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199321013035?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199321013035?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T21:44:45Z","timestamp":1761601485000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569199321013035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S1569199321013035"],"URL":"https:\/\/doi.org\/10.1016\/j.jcf.2021.07.005","relation":{},"ISSN":["1569-1993"],"issn-type":[{"value":"1569-1993","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Urinary tract infections in cystic fibrosis patients","name":"articletitle","label":"Article Title"},{"value":"Journal of Cystic Fibrosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcf.2021.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 European Cystic Fibrosis Society. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}