{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:26:47Z","timestamp":1792895207800,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006259","name":"Teva Pharmaceutical Industries","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006259","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000292","name":"Cystic Fibrosis Trust","doi-asserted-by":"publisher","award":["VIA 061"],"award-info":[{"award-number":["VIA 061"]}],"id":[{"id":"10.13039\/501100000292","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000837","name":"University of Nottingham","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012618","name":"National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012618","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cysticfibrosisjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cystic Fibrosis"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.jcf.2021.11.014","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T17:29:18Z","timestamp":1638984558000},"page":"506-513","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Intestinal function and transit associate with gut microbiota dysbiosis in cystic fibrosis"],"prefix":"10.1016","volume":"21","author":[{"given":"Ryan","family":"Marsh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Gavillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"Hanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christabella","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandisa","family":"Mitchell-Whyte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giles","family":"Major","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan R","family":"Smyth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian","family":"Rivett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"van\u00a0der\u00a0Gast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcf.2021.11.014_bib0001","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a009753","article-title":"The cystic fibrosis intestine","volume":"3","author":"De Lisle","year":"2013","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.jcf.2021.11.014_bib0002","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrgastro.2015.226","article-title":"Cystic fibrosis from the gastroenterologist\u2019s perspective","volume":"13","author":"Ooi","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcf.2021.11.014_bib0003","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174463","article-title":"Abdominal symptoms in cystic fibrosis and their relation to genotype, history, clinical and laboratory findings","volume":"12","author":"Tabori","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jcf.2021.11.014_bib0004","first-page":"881","article-title":"A high prevalence of chronic gastrointestinal symptoms in adults with cystic fibrosis is detected using tools already validated in other GI disorders, United Eur","volume":"7","author":"Hayee","year":"2019","journal-title":"Gastroenterol J"},{"key":"10.1016\/j.jcf.2021.11.014_bib0005","article-title":"How can we relieve gastrointestinal symptoms in people with cystic fibrosis? An international qualitative survey","volume":"7","author":"Smith","year":"2020","journal-title":"BMJ Open Respir Res"},{"key":"10.1016\/j.jcf.2021.11.014_bib0006","doi-asserted-by":"crossref","DOI":"10.1128\/JB.00274-19","article-title":"Altered Stool Microbiota of Infants with Cystic Fibrosis Shows a Reduction in Genera Associated with Immune Programming from Birth","volume":"201","author":"Antosca","year":"2019","journal-title":"J Bacteriol"},{"key":"10.1016\/j.jcf.2021.11.014_bib0007","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1002\/ppul.24766","article-title":"Age and environmental exposures influence the fecal bacteriome of young children with cystic fibrosis","volume":"55","author":"Loman","year":"2020","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jcf.2021.11.014_bib0008","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12866-017-0968-8","article-title":"The altered gut microbiota in adults with cystic fibrosis","volume":"17","author":"Burke","year":"2017","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.jcf.2021.11.014_bib0009","doi-asserted-by":"crossref","first-page":"24857","DOI":"10.1038\/srep24857","article-title":"Disrupted progression of the intestinal microbiota with age in children with cystic fibrosis","volume":"6","author":"Nielsen","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcf.2021.11.014_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcf.2020.04.007","article-title":"Development of the gut microbiota in early life: The impact of cystic fibrosis and antibiotic treatment","author":"Kristensen","year":"2020","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2021.11.014_bib0011","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0208171","article-title":"Gut microbiota signatures in cystic fibrosis: Loss of host CFTR function drives the microbiota enterophenotype","volume":"13","author":"Vernocchi","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jcf.2021.11.014_bib0012","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cmet.2011.02.018","article-title":"The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon","volume":"13","author":"Donohoe","year":"2011","journal-title":"Cell Metab"},{"key":"10.1016\/j.jcf.2021.11.014_bib0013","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1073\/pnas.1322269111","article-title":"The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition","volume":"111","author":"Chang","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcf.2021.11.014_bib0014","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nature12726","article-title":"Metabolites produced by commensal bacteria promote peripheral regulatory T cell generation","volume":"504","author":"Arpaia","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jcf.2021.11.014_bib0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0198457","article-title":"Altered intestinal microbiota composition, antibiotic therapy and intestinal inflammation in children and adolescents with cystic fibrosis","volume":"13","author":"De Freitas","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jcf.2021.11.014_bib0016","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0116967","article-title":"Intestinal lesions are associated with altered intestinal microbiome and are more frequent in children and young adults with cystic fibrosis and cirrhosis","volume":"10","author":"Flass","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jcf.2021.11.014_bib0017","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13073-020-0710-2","article-title":"Interactions between the gut microbiome and host gene regulation in cystic fibrosis","volume":"12","author":"Dayama","year":"2020","journal-title":"Genome Med"},{"key":"10.1016\/j.jcf.2021.11.014_bib0018","doi-asserted-by":"crossref","first-page":"18593","DOI":"10.1038\/s41598-019-55028-7","article-title":"Gut Microbiota in Children With Cystic Fibrosis: A Taxonomic and Functional Dysbiosis","volume":"9","author":"Coffey","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcf.2021.11.014_bib0019","doi-asserted-by":"crossref","first-page":"e13883","DOI":"10.1111\/nmo.13883","article-title":"Motor dysfunction of the gut in cystic fibrosis","volume":"00","author":"Malagelada","year":"2020","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jcf.2021.11.014_bib0020","article-title":"Postprandial changes in gastrointestinal function and transit in cystic fibrosis assessed by Magnetic Resonance Imaging","author":"Ng","year":"2020","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2021.11.014_bib0021","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134802","article-title":"Methods for improving human gut microbiome data by reducing variability through sample processing and storage of stool","volume":"10","author":"Gorzelak","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jcf.2021.11.014_bib0022","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/ismej.2012.145","article-title":"Reducing bias in bacterial community analysis of lower respiratory infections","volume":"7","author":"Rogers","year":"2013","journal-title":"ISME J"},{"key":"10.1016\/j.jcf.2021.11.014_bib0023","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: High resolution sample inference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat Methods"},{"key":"10.1016\/j.jcf.2021.11.014_bib0024","first-page":"9","article-title":"PAST: Paleontological Statistics Software Package for Education and Data Analysis","volume":"4","author":"\u00d8yvind Hammer","year":"2001","journal-title":"Palaeontol Electron"},{"key":"10.1016\/j.jcf.2021.11.014_bib0025","series-title":"CANOCO reference manual and user's guide: software for ordination","author":"ter Braak","year":"2012"},{"key":"10.1016\/j.jcf.2021.11.014_bib0026","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s40168-020-00810-3","article-title":"Lung function and microbiota diversity in cystic fibrosis","volume":"8","author":"Cuthbertson","year":"2020","journal-title":"Microbiome"},{"key":"10.1016\/j.jcf.2021.11.014_bib0027","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1136\/gutjnl-2014-308896","article-title":"Siblings of patients with Crohn\u2019s disease exhibit a biologically relevant dysbiosis in mucosal microbial metacommunities","volume":"65","author":"Hedin","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.jcf.2021.11.014_bib0028","doi-asserted-by":"crossref","first-page":"17121","DOI":"10.1038\/nmicrobiol.2017.121","article-title":"Stress and stability: Applying the Anna Karenina principle to animal microbiomes","volume":"2","author":"Zaneveld","year":"2017","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.jcf.2021.11.014_bib0029","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3390\/jcm8050645","article-title":"Intestinal Inflammation in Children with Cystic Fibrosis Is Associated with Crohn\u2019s-Like Microbiota Disturbances","volume":"8","author":"Enaud","year":"2019","journal-title":"J Clin Med"},{"key":"10.1016\/j.jcf.2021.11.014_bib0030","article-title":"Serial analysis of the gut and respiratory microbiome","volume":"3","author":"Madan","year":"2012","journal-title":"MBio"},{"key":"10.1016\/j.jcf.2021.11.014_bib0031","doi-asserted-by":"crossref","first-page":"26985","DOI":"10.1038\/srep26985","article-title":"Microbiological profiles of sputum and gastric juice aspirates in Cystic Fibrosis patients","volume":"6","author":"Al-Momani","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcf.2021.11.014_bib0032","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jcf.2016.09.004","article-title":"Effect of probiotics on respiratory, gastrointestinal and nutritional outcomes in patients with cystic fibrosis: A systematic review","volume":"16","author":"Anderson","year":"2017","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2021.11.014_bib0033","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jcmgh.2019.07.006","article-title":"The Structure and Function of the Human Small Intestinal Microbiota: Current Understanding and Future Directions","volume":"9","author":"Kastl","year":"2020","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jcf.2021.11.014_bib0034","doi-asserted-by":"crossref","first-page":"22493","DOI":"10.1038\/srep22493","article-title":"Metagenomic evidence for taxonomic dysbiosis and functional imbalance in the gastrointestinal tracts of children with cystic fibrosis","volume":"6","author":"Manor","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcf.2021.11.014_bib0035","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/cid\/cit715","article-title":"Escherichia coli dysbiosis correlates with gastrointestinal dysfunction in children with cystic fibrosis","volume":"58","author":"Hoffman","year":"2014","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jcf.2021.11.014_bib0036","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41591-019-0714-x","article-title":"Fecal dysbiosis in infants with cystic fibrosis is associated with early linear growth failure","volume":"26","author":"Hayden","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.jcf.2021.11.014_bib0037","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jcf.2012.10.003","article-title":"Dysbiosis of bifidobacteria and Clostridium cluster XIVa in the cystic fibrosis fecal microbiota","volume":"12","author":"Duytschaever","year":"2013","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2021.11.014_bib0038","doi-asserted-by":"crossref","first-page":"8929","DOI":"10.3748\/wjg.v22.i40.8929","article-title":"Fecal microbiota in pouchitis and ulcerative colitis","volume":"22","author":"Li","year":"2016","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jcf.2021.11.014_bib0039","series-title":"Clostridium prazmowski 1880, 23AL","author":"Rainey","year":"2009"},{"key":"10.1016\/j.jcf.2021.11.014_bib0040","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/19490976.2018.1534512","article-title":"Opportunistic bacteria confer the ability to ferment prebiotic starch in the adult cystic fibrosis gut","volume":"10","author":"Wang","year":"2019","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jcf.2021.11.014_bib0041","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1016\/S0140-6736(16)00576-6","article-title":"Cystic fibrosis","volume":"388","author":"Elborn","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.jcf.2021.11.014_bib0042","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008251","article-title":"CFTR dysregulation drives active selection of the gut microbiome","volume":"16","author":"Meeker","year":"2020","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jcf.2021.11.014_bib0043","doi-asserted-by":"crossref","first-page":"16093","DOI":"10.1038\/nmicrobiol.2016.93","article-title":"Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut","volume":"1","author":"Roager","year":"2016","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.jcf.2021.11.014_bib0044","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1097\/MIB.0000000000000972","article-title":"A single species of clostridium Subcluster XIVa decreased in ulcerative colitis patients","volume":"22","author":"Takeshita","year":"2016","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jcf.2021.11.014_bib0045","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/ecco-jcc\/jjv203","article-title":"Donor Species Richness Determines Faecal Microbiota Transplantation Success in Inflammatory Bowel Disease","volume":"10","author":"Vermeire","year":"2016","journal-title":"J Crohn\u2019s Colitis"},{"key":"10.1016\/j.jcf.2021.11.014_bib0046","doi-asserted-by":"crossref","first-page":"6040","DOI":"10.1128\/IAI.72.10.6040-6049.2004","article-title":"Bacterial overgrowth in the cystic fibrosis transmembrane conductance regulator null mouse small intestine","volume":"72","author":"Norkina","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.jcf.2021.11.014_bib0047","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1152\/ajpgi.00548.2006","article-title":"Altered transit and bacterial overgrowth in the cystic fibrosis mouse small intestine","volume":"293","author":"De Lisle","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcf.2021.11.014_bib0048","first-page":"4","article-title":"Nutritional management of cystic fibrosis \u2013 an update for the 21st century","volume":"26","author":"Collins","year":"2018","journal-title":"Paediatr Respir Rev"},{"key":"10.1016\/j.jcf.2021.11.014_bib0049","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1073\/pnas.1714373115","article-title":"Adaptation of commensal proliferating Escherichia coli to the intestinal tract of young children with cystic fibrosis","volume":"115","author":"Matamouros","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcf.2021.11.014_bib0050","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1469-0691.2010.03256.x","article-title":"Antimicrobial susceptibility of Bacteroides fragilis group isolates in Europe: 20 years of experience","volume":"17","author":"Nagy","year":"2011","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jcf.2021.11.014_bib0051","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1097\/MPG.0000000000002864","article-title":"Reduced Intestinal Inflammation With Lumacaftor\/Ivacaftor in Adolescents With Cystic Fibrosis","volume":"71","author":"Tetard","year":"2020","journal-title":"J Pediatr Gastroenterol Nutr"}],"container-title":["Journal of Cystic Fibrosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156919932102155X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156919932102155X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:14:38Z","timestamp":1778620478000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156919932102155X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S156919932102155X"],"URL":"https:\/\/doi.org\/10.1016\/j.jcf.2021.11.014","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.08.24.21262265","asserted-by":"object"}]},"ISSN":["1569-1993"],"issn-type":[{"value":"1569-1993","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intestinal function and transit associate with gut microbiota dysbiosis in cystic fibrosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Cystic Fibrosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcf.2021.11.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V. on behalf of European Cystic Fibrosis Society.","name":"copyright","label":"Copyright"}]}}