{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T05:49:45Z","timestamp":1783662585170,"version":"3.55.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":731,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100008209","name":"University at Buffalo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008209","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005294","name":"Massachusetts General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005294","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010186","name":"Brooke Army Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010186","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006458","name":"Children's Hospital of Philadelphia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006458","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011022","name":"Vertex Pharmaceuticals Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011022","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006645","name":"Children's Hospital of Wisconsin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012423","name":"Children's Healthcare of Atlanta","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012423","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006939","name":"Emory University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006939","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030839","name":"Arkansas Children's Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030839","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007520","name":"Nationwide Children's Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007520","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1RR024134"],"award-info":[{"award-number":["UL1RR024134"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cysticfibrosisjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cystic Fibrosis"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.jcf.2023.04.010","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T08:04:16Z","timestamp":1688976256000},"page":"989-995","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Changes in nutrition and growth status in young children in the first 12 weeks of ivacaftor therapy"],"prefix":"10.1016","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2045-3002","authenticated-orcid":false,"given":"Alyssa","family":"Tindall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3290-7355","authenticated-orcid":false,"given":"Rosara","family":"Bass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asim","family":"Maqbool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia A.","family":"Stallings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcf.2023.04.010_bib0001","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1016\/j.clnu.2019.12.029","article-title":"Overweight, obesity and significant weight gain in adult patients with cystic fibrosis association with lung function and cardiometabolic risk factors","volume":"39","author":"Bonhoure","year":"2020","journal-title":"Clin Nutr"},{"key":"10.1016\/j.jcf.2023.04.010_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2018.05.018","article-title":"Energy balance and mechanisms of weight gain with ivacaftor treatment of cystic fibrosis gating mutations","volume":"201","author":"Stallings","year":"2018","journal-title":"J Pediatr"},{"issue":"Suppl 1","key":"10.1016\/j.jcf.2023.04.010_bib0003","first-page":"5","article-title":"Predicting basal metabolic rate,new standards and review of previous work","volume":"39","author":"Schofield","year":"1985","journal-title":"Hum Nutr Clin Nutr"},{"key":"10.1016\/j.jcf.2023.04.010_bib0004","series-title":"Anthropometric standardization reference manual","author":"Lohman","year":"1988"},{"key":"10.1016\/j.jcf.2023.04.010_bib0005","series-title":"WHO child growth standards length\/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age: methods and development","year":"2006"},{"key":"10.1016\/j.jcf.2023.04.010_bib0006","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3945\/ajcn.2009.28385","article-title":"Reference curves for triceps and subscapular skinfold thicknesses in US children and adolescents","volume":"91","author":"Addo","year":"2010","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jcf.2023.04.010_bib0007","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3945\/ajcn.116.142190","article-title":"Reference ranges for midupper arm circumference, upper arm muscle area, and upper arm fat area in US children and adolescents aged 1-20 y","volume":"105","author":"Addo","year":"2017","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jcf.2023.04.010_bib0008","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1515\/cclm-2014-1273","article-title":"Reference ranges of serum bile acids in children and adolescents","volume":"53","author":"Jahnel","year":"2015","journal-title":"Clin Chem Lab Med"},{"issue":"Suppl 1","key":"10.1016\/j.jcf.2023.04.010_bib0009","first-page":"268","article-title":"Range of serum bile acid concentrations in neonates, infants, older children, and in adults","volume":"7","author":"Polkowska","year":"2001","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.jcf.2023.04.010_bib0010","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jcf.2018.09.001","article-title":"IVACAFTOR restores FGF19 regulated bile acid homeostasis in cystic fibrosis patients with an S1251N or a G551D gating mutation","volume":"18","author":"van de Peppel","year":"2019","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2023.04.010_bib0011","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/S0016-5085(96)70024-0","article-title":"7 alpha-dehydroxylating bacteria enhance deoxycholic acid input and cholesterol saturation of bile in patients with gallstones","volume":"111","author":"Berr","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcf.2023.04.010_bib0012","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.3748\/wjg.v9.i7.1576","article-title":"High level of deoxycholic acid in human bile does not promote cholesterol gallstone formation","volume":"9","author":"Gustafsson","year":"2003","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jcf.2023.04.010_bib0013","first-page":"11","article-title":"Individual and group response of treatment with ivacaftor on airway and gut microbiota in people with CF and a S1251N mutation","author":"Kristensen","year":"2021","journal-title":"J Pers Med"},{"key":"10.1016\/j.jcf.2023.04.010_bib0014","doi-asserted-by":"crossref","first-page":"17834","DOI":"10.1038\/s41598-018-36364-6","article-title":"Impact of CFTR modulation with ivacaftor on gut microbiota and intestinal inflammation","volume":"8","author":"Ooi","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcf.2023.04.010_bib0015","article-title":"Ursodeoxycholic acid for cystic fibrosis-related liver disease","volume":"9","author":"Cheng","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jcf.2023.04.010_bib0016","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1080\/10408363.2019.1619159","article-title":"Clinical value of fecal calprotectin","volume":"56","author":"Ricciuto","year":"2019","journal-title":"Crit Rev Clin Lab Sci"},{"key":"10.1016\/j.jcf.2023.04.010_bib0017","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/S0022-3476(62)80065-1","article-title":"The fatty acid composition of the serum chylomicrons and adipose tissue of children with cystic fibrosis of the pancreas","volume":"60","author":"Kuo","year":"1962","journal-title":"J Pediatr"},{"key":"10.1016\/j.jcf.2023.04.010_bib0018","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1542\/peds.2004-2832","article-title":"Temporal associations among energy intake, plasma linoleic acid, and growth improvement in response to treatment initiation after diagnosis of cystic fibrosis","volume":"117","author":"Shoff","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.jcf.2023.04.010_bib0019","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1542\/peds.105.1.53","article-title":"Nutritional status of patients with cystic fibrosis with meconium ileus: a comparison with patients without meconium ileus and diagnosed early through neonatal screening","volume":"105","author":"Lai","year":"2000","journal-title":"Pediatrics"},{"key":"10.1016\/j.jcf.2023.04.010_bib0020","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/ajcn\/54.3.578","article-title":"Nutritional status of infants with cystic fibrosis associated with early diagnosis and intervention","volume":"54","author":"Marcus","year":"1991","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jcf.2023.04.010_bib0021","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1042\/CS20220450","article-title":"The fatty acid imbalance of cystic fibrosis exists at birth independent of feeding in pig and ferret models","volume":"136","author":"Uc","year":"2022","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.jcf.2023.04.010_bib0022","doi-asserted-by":"crossref","unstructured":"Maqbool A., Strandvik B. Dietary Fat and Fat Metabolism in Cystic Fibrosis. Nutrition in Cystic Fibrosis: a Guide for Clinicians New York, NY Springer's Nutrition and Health series; 2016.","DOI":"10.1007\/978-3-319-16387-1_3"},{"key":"10.1016\/j.jcf.2023.04.010_bib0023","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1067\/mpd.2001.118890","article-title":"Essential fatty acid deficiency in relation to genotype in patients with cystic fibrosis","volume":"139","author":"Strandvik","year":"2001","journal-title":"J Pediatr"},{"key":"10.1016\/j.jcf.2023.04.010_bib0024","doi-asserted-by":"crossref","first-page":"9202","DOI":"10.1073\/pnas.83.23.9202","article-title":"Pathological regulation of arachidonic acid release in cystic fibrosis: the putative basic defect","volume":"83","author":"Carlstedt-Duke","year":"1986","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcf.2023.04.010_bib0025","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1097\/MPG.0b013e31817fb76b","article-title":"Serum linoleic acid status as a clinical indicator of essential fatty acid status in children with cystic fibrosis","volume":"47","author":"Maqbool","year":"2008","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jcf.2023.04.010_bib0026","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/MPG.0b013e3180690da9","article-title":"Polyunsaturated fatty acids in cystic fibrosis are related to nutrition and clinical expression of the disease","volume":"45","author":"Walkowiak","year":"2007","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jcf.2023.04.010_bib0027","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jcf.2016.07.006","article-title":"The effects of ivacaftor on CF fatty acid metabolism: an analysis from the GOAL study","volume":"16","author":"O'Connor","year":"2017","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2023.04.010_bib0028","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.619442","article-title":"CFTR correctors and antioxidants partially normalize lipid imbalance but not abnormal basal inflammatory cytokine profile in CF bronchial epithelial cells","volume":"12","author":"Veltman","year":"2021","journal-title":"Front Physiol."}],"container-title":["Journal of Cystic Fibrosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199323001145?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199323001145?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T21:08:58Z","timestamp":1762031338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569199323001145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S1569199323001145"],"URL":"https:\/\/doi.org\/10.1016\/j.jcf.2023.04.010","relation":{},"ISSN":["1569-1993"],"issn-type":[{"value":"1569-1993","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Changes in nutrition and growth status in young children in the first 12 weeks of ivacaftor therapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Cystic Fibrosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcf.2023.04.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 European Cystic Fibrosis Society. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}