{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:16:42Z","timestamp":1792718202906,"version":"4.5.0"},"reference-count":64,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL143011"],"award-info":[{"award-number":["R01HL143011"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL151588"],"award-info":[{"award-number":["R01HL151588"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R44HL123299"],"award-info":[{"award-number":["R44HL123299"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL131012"],"award-info":[{"award-number":["R01HL131012"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010327","name":"Cincinnati Children\u2019s Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010327","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["CLEVEL16A0"],"award-info":[{"award-number":["CLEVEL16A0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["NAREN19R0"],"award-info":[{"award-number":["NAREN19R0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cysticfibrosisjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cystic Fibrosis"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.jcf.2024.07.002","type":"journal-article","created":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T00:12:40Z","timestamp":1720915960000},"page":"926-935","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Quantifying abnormal alveolar microstructure in cystic fibrosis lung disease via hyperpolarized 129Xe diffusion MRI"],"prefix":"10.1016","volume":"23","author":[{"given":"Abdullah S.","family":"Bdaiwi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6420-5190","authenticated-orcid":false,"given":"Alexandra M.","family":"Svoboda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle E.","family":"Murdock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2116-4982","authenticated-orcid":false,"given":"Alexandra","family":"Hendricks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md M.","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3278-2161","authenticated-orcid":false,"given":"Elizabeth L.","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9190-8087","authenticated-orcid":false,"given":"John J.","family":"Brewington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4356-9622","authenticated-orcid":false,"given":"Matthew M.","family":"Willmering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason C.","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5060-6401","authenticated-orcid":false,"given":"Laura L.","family":"Walkup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6195-9061","authenticated-orcid":false,"given":"Zackary I.","family":"Cleveland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jcf.2024.07.002_bib0001","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jcf.2022.01.009","article-title":"Worldwide rates of diagnosis and effective treatment for cystic fibrosis","volume":"21","author":"Guo","year":"2022","journal-title":"Journal of Cystic Fibrosis"},{"key":"10.1016\/j.jcf.2024.07.002_bib0002","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev-genom-090314-050024","article-title":"Cystic fibrosis and its management through established and emerging therapies","volume":"17","author":"Spielberg","year":"2016","journal-title":"Annual review of genomics human genetics"},{"issue":"9","key":"10.1016\/j.jcf.2024.07.002_bib0003","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1164\/rccm.201203-0507OC","article-title":"Sputum biomarkers of inflammation and lung function decline in children with cystic fibrosis","volume":"186","author":"Sagel","year":"2012","journal-title":"American journal of respiratory critical care medicine"},{"issue":"5","key":"10.1016\/j.jcf.2024.07.002_bib0004","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/jmri.27030","article-title":"Current state of the art MRI for the longitudinal assessment of cystic fibrosis","volume":"52","author":"Woods","year":"2020","journal-title":"Journal of Magnetic Resonance Imaging"},{"issue":"1","key":"10.1016\/j.jcf.2024.07.002_bib0005","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jpeds.2004.02.038","article-title":"High-resolution computed tomography in young patients with cystic fibrosis: distribution of abnormalities and correlation with pulmonary function tests","volume":"145","author":"Brody","year":"2004","journal-title":"J Pediatr"},{"issue":"2","key":"10.1016\/j.jcf.2024.07.002_bib0006","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1164\/ajrccm.152.2.7633722","article-title":"Comparison of computed density and macroscopic morphometry in pulmonary emphysema","volume":"152","author":"Gevenois","year":"1995","journal-title":"American journal of respiratory critical care medicine"},{"issue":"4","key":"10.1016\/j.jcf.2024.07.002_bib0007","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1164\/rccm.200907-1008OC","article-title":"Quantitative computed tomography measures of emphysema and airway wall thickness are related to respiratory symptoms","volume":"181","author":"Grydeland","year":"2010","journal-title":"American journal of respiratory critical care medicine"},{"issue":"8","key":"10.1016\/j.jcf.2024.07.002_bib0008","doi-asserted-by":"crossref","first-page":"e73142","DOI":"10.1371\/journal.pone.0073142","article-title":"Pulmonary emphysema in cystic fibrosis detected by densitometry on chest multidetector computed tomography","volume":"8","author":"Wielp\u00fctz","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.jcf.2024.07.002_bib0009","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0128062","article-title":"Emphysema is common in lungs of cystic fibrosis lung transplantation patients: a histopathological and computed tomography study","volume":"10","author":"Mets","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jcf.2024.07.002_bib0010","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1148\/radiol.2511081296","article-title":"Recurrent CT, cumulative radiation exposure, and associated radiation-induced cancer risks from CT of adults","volume":"251","author":"Sodickson","year":"2009","journal-title":"Radiology"},{"issue":"10","key":"10.1016\/j.jcf.2024.07.002_bib0011","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1016\/j.ejrad.2014.06.033","article-title":"Radiation dose reduction in chest CT\u2014Review of available options","volume":"83","author":"Kubo","year":"2014","journal-title":"Eur J Radiol"},{"issue":"19","key":"10.1016\/j.jcf.2024.07.002_bib0012","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1056\/NEJMoa1908639","article-title":"Elexacaftor\u2013tezacaftor\u2013ivacaftor for cystic fibrosis with a single Phe508del allele","volume":"381","author":"Middleton","year":"2019","journal-title":"New England Journal of Medicine"},{"issue":"10212","key":"10.1016\/j.jcf.2024.07.002_bib0013","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1016\/S0140-6736(19)32597-8","article-title":"Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial","volume":"394","author":"Heijerman","year":"2019","journal-title":"The Lancet"},{"issue":"12","key":"10.1016\/j.jcf.2024.07.002_bib0014","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1002\/nbm.3151","article-title":"Translational applications of hyperpolarized 3He and 129Xe","volume":"27","author":"Walkup","year":"2014","journal-title":"NMR Biomed"},{"key":"10.1016\/j.jcf.2024.07.002_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcf.2023.01.017","article-title":"Short-term structural and functional changes after airway clearance therapy in cystic fibrosis","author":"West","year":"2023","journal-title":"J Cyst Fibros"},{"issue":"4","key":"10.1016\/j.jcf.2024.07.002_bib0016","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/mrm.22697","article-title":"Diffusion-weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease","volume":"65","author":"Kaushik","year":"2011","journal-title":"Magn Reson Med"},{"issue":"3","key":"10.1016\/j.jcf.2024.07.002_bib0017","doi-asserted-by":"crossref","first-page":"e4639","DOI":"10.1002\/nbm.4639","article-title":"Improving hyperpolarized (129) Xe ADC mapping in pediatric and adult lungs with uncertainty propagation","volume":"35","author":"Bdaiwi","year":"2021","journal-title":"NMR Biomed"},{"key":"10.1016\/j.jcf.2024.07.002_bib0018","first-page":"1","article-title":"Diffusion weighted hyperpolarized 129Xe MRI of the lung with 2D and 3D (FLORET) spiral","author":"Bdaiwi","year":"2022","journal-title":"Magn Reson Med"},{"issue":"3","key":"10.1016\/j.jcf.2024.07.002_bib0019","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1002\/mrm.23056","article-title":"Lung morphometry with hyperpolarized 129Xe: theoretical background","volume":"67","author":"Sukstanskii","year":"2012","journal-title":"Magn Reson Med"},{"issue":"6","key":"10.1016\/j.jcf.2024.07.002_bib0020","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1002\/mrm.26960","article-title":"3D diffusion-weighted 129Xe MRI for whole lung morphometry","volume":"79","author":"Chan","year":"2018","journal-title":"Magn Reson Med"},{"issue":"1","key":"10.1016\/j.jcf.2024.07.002_bib0021","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/mrm.24224","article-title":"Measurement of 129Xe gas apparent diffusion coefficient anisotropy in an elastase-instilled rat model of emphysema","volume":"69","author":"Boudreau","year":"2013","journal-title":"Magn Reson Med"},{"issue":"4","key":"10.1016\/j.jcf.2024.07.002_bib0022","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1002\/mrm.28539","article-title":"Validating in vivo hyperpolarized 129Xe diffusion MRI and diffusion morphometry in the mouse lung","volume":"85","author":"Niedbalski","year":"2021","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jcf.2024.07.002_bib0023","series-title":"Cystic and cavitary lung diseases: focal and diffuse. mayo clinic proceedings","year":"2003"},{"issue":"1","key":"10.1016\/j.jcf.2024.07.002_bib0024","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1148\/radiol.2020192804","article-title":"Emphysema index based on hyperpolarized 3He or 129Xe diffusion MRI: performance and comparison with quantitative CT and pulmonary function tests","volume":"297","author":"Tafti","year":"2020","journal-title":"Radiology"},{"issue":"6","key":"10.1016\/j.jcf.2024.07.002_bib0025","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1002\/mp.12264","article-title":"Quantitative analysis of hyperpolarized 129Xe gas transfer MRI","volume":"44","author":"Wang","year":"2017","journal-title":"Med Phys"},{"issue":"8","key":"10.1016\/j.jcf.2024.07.002_bib0026","doi-asserted-by":"crossref","first-page":"e193","DOI":"10.1016\/j.acra.2019.10.016","article-title":"Generalized linear binning to compare hyperpolarized 129Xe ventilation maps derived from 3D radial gas exchange versus dedicated multislice gradient echo MRI","volume":"27","author":"He","year":"2020","journal-title":"Acad Radiol"},{"issue":"3","key":"10.1016\/j.jcf.2024.07.002_bib0027","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/mrm.29501","article-title":"Childhood to adulthood: Accounting for age dependence in healthy-reference distributions in 129Xe gas-exchange MRI","volume":"89","author":"Plummer","year":"2023","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jcf.2024.07.002_bib0028","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1183\/09031936.05.00034805","article-title":"ATS\/ERS task force: standardisation of spirometry","volume":"26","author":"Miller","year":"2005","journal-title":"Eur Respir J"},{"issue":"2","key":"10.1016\/j.jcf.2024.07.002_bib0029","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.mric.2015.01.003","article-title":"Hyperpolarized gas MR imaging: technique and applications","volume":"23","author":"Roos","year":"2015","journal-title":"Magnetic Resonance Imaging Clinics"},{"issue":"3","key":"10.1016\/j.jcf.2024.07.002_bib0030","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1183\/09031936.05.00035005","article-title":"Standardisation of the measurement of lung volumes","volume":"26","author":"Wanger","year":"2005","journal-title":"European respiratory journal"},{"key":"10.1016\/j.jcf.2024.07.002_bib0031","unstructured":"Loew W., Thomen R., Pratt R., Cleveland Z., Dumoulin C., Woods J., et al. A dual loop T\/R -Xenon coil for homogenous excitation with improved comfort and size ISMRM 2016."},{"key":"10.1016\/j.jcf.2024.07.002_bib0032","series-title":"Complex models and computational methods in statistics","first-page":"13","article-title":"Estimation approaches for the Apparent Diffusion Coefficient in Rice-distributed MR signals","author":"Baraldo","year":"2013"},{"issue":"1","key":"10.1016\/j.jcf.2024.07.002_bib0033","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/mrm.28703","article-title":"Finite element simulations of hyperpolarized gas DWI in micro-CT meshes of acinar airways: validating the cylinder and stretched exponential models of lung microstructural length scales","volume":"86","author":"Chan","year":"2021","journal-title":"Magn Reson Med"},{"issue":"5","key":"10.1016\/j.jcf.2024.07.002_bib0034","doi-asserted-by":"crossref","first-page":"1800821","DOI":"10.1183\/13993003.00821-2018","article-title":"Patterns of regional lung physiology in cystic fibrosis using ventilation magnetic resonance imaging and multiple-breath washout","volume":"52","author":"Smith","year":"2018","journal-title":"European Respiratory Journal"},{"issue":"3","key":"10.1016\/j.jcf.2024.07.002_bib0035","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1152\/japplphysiol.00409.2005","article-title":"Growth of the small airways and alveoli from childhood to the adult lung measured by aerosol-derived airway morphometry","volume":"100","author":"Zeman","year":"2006","journal-title":"J Appl Physiol"},{"issue":"2","key":"10.1016\/j.jcf.2024.07.002_bib0036","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1152\/japplphysiol.00541.2015","article-title":"Experimental evidence of age-related adaptive changes in human acinar airways","volume":"120","author":"Quirk","year":"2016","journal-title":"J Appl Physiol"},{"issue":"6","key":"10.1016\/j.jcf.2024.07.002_bib0037","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1002\/mrm.24595","article-title":"Lung morphometry using hyperpolarized 129Xe apparent diffusion coefficient anisotropy in chronic obstructive pulmonary disease","volume":"70","author":"Ouriadov","year":"2013","journal-title":"Magn Reson Med"},{"issue":"7","key":"10.1016\/j.jcf.2024.07.002_bib0038","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1002\/mp.12944","article-title":"Lung morphometry using hyperpolarized 129Xe multi-b diffusion MRI with compressed sensing in healthy subjects and patients with COPD","volume":"45","author":"Zhang","year":"2018","journal-title":"Med Phys"},{"issue":"3","key":"10.1016\/j.jcf.2024.07.002_bib0039","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1148\/radiol.11102226","article-title":"In vivo detection of acinar microstructural changes in early emphysema with 3He lung morphometry","volume":"260","author":"Quirk","year":"2011","journal-title":"Radiology"},{"key":"10.1016\/j.jcf.2024.07.002_bib0040","unstructured":"Juan Parra-Robles H.M., Ruth A Hartley, Christopher E Brightling, and Jim M Wild Quantification of lung microstructure in asthma using a 3He fractional diffusion approach. ISMRM; Milan, Italy 2014."},{"key":"10.1016\/j.jcf.2024.07.002_bib0041","unstructured":"Parra-Robles J. M.H, Wild J.M. Characterization of 3He Diffusion in Lungs Using a Stretched Exponential Model. ISMRM; Salt Lake City, Utah, USA 2013. p. 820."},{"issue":"6","key":"10.1016\/j.jcf.2024.07.002_bib0042","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0157177","article-title":"Characterizing lung disease in cystic fibrosis with magnetic resonance imaging and airway physiology","volume":"11","author":"Theilmann","year":"2016","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.jcf.2024.07.002_bib0043","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1513\/AnnalsATS.201812-880OC","article-title":"Cyst ventilation heterogeneity and alveolar airspace dilation as early disease markers in lymphangioleiomyomatosis","volume":"16","author":"Walkup","year":"2019","journal-title":"Ann Am Thorac Soc"},{"issue":"2","key":"10.1016\/j.jcf.2024.07.002_bib0044","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1164\/rccm.200901-0069OC","article-title":"Lung disease at diagnosis in infants with cystic fibrosis detected by newborn screening","volume":"180","author":"Sly","year":"2009","journal-title":"American journal of respiratory critical care medicine"},{"issue":"21","key":"10.1016\/j.jcf.2024.07.002_bib0045","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1056\/NEJMoa1301725","article-title":"Risk factors for bronchiectasis in children with cystic fibrosis","volume":"368","author":"Sly","year":"2013","journal-title":"New England Journal of Medicine"},{"issue":"2","key":"10.1016\/j.jcf.2024.07.002_bib0046","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S2213-2600(13)70026-2","article-title":"Early lung disease in cystic fibrosis","volume":"1","author":"Grasemann","year":"2013","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jcf.2024.07.002_bib0047","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1513\/pats.200703-044BR","article-title":"Sputum biomarkers of inflammation in cystic fibrosis lung disease","volume":"4","author":"Sagel","year":"2007","journal-title":"Proc Am Thorac Soc"},{"issue":"2","key":"10.1016\/j.jcf.2024.07.002_bib0048","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1164\/rccm.201205-0875OC","article-title":"Neutrophil elastase degrades cystic fibrosis transmembrane conductance regulator via calpains and disables channel function in vitro and in vivo","volume":"187","author":"Le Gars","year":"2013","journal-title":"American journal of respiratory critical care medicine"},{"issue":"5","key":"10.1016\/j.jcf.2024.07.002_bib0049","doi-asserted-by":"crossref","DOI":"10.1152\/ajplung.00435.2004","article-title":"Neutrophil elastase activates near-silent epithelial Na+ channels and increases airway epithelial Na+ transport","volume":"288","author":"Caldwell","year":"2005","journal-title":"American Journal of Physiology-Lung Cellular Molecular Physiology"},{"key":"10.1016\/j.jcf.2024.07.002_bib0050","series-title":"CFTR: cystic fibrosis and beyond","author":"Mall","year":"2014"},{"issue":"1","key":"10.1016\/j.jcf.2024.07.002_bib0051","doi-asserted-by":"crossref","first-page":"L3","DOI":"10.1152\/ajplung.00362.2007","article-title":"Mechanical ventilation uncouples synthesis and assembly of elastin and increases apoptosis in lungs of newborn mice. Prelude to defective alveolar septation during lung development?","volume":"294","author":"Bland","year":"2008","journal-title":"American Journal of Physiology-Lung Cellular and Molecular Physiology"},{"issue":"9","key":"10.1016\/j.jcf.2024.07.002_bib0052","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1164\/rccm.201311-1932OC","article-title":"Lack of neutrophil elastase reduces inflammation, mucus hypersecretion, and emphysema, but not mucus obstruction, in mice with cystic fibrosis\u2013like lung disease","volume":"189","author":"Gehrig","year":"2014","journal-title":"American Journal of Respiratory Critical Care Medicine"},{"issue":"4","key":"10.1016\/j.jcf.2024.07.002_bib0053","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/S0002-9440(10)63234-8","article-title":"Characteristic multiorgan pathology of cystic fibrosis in a long-living cystic fibrosis transmembrane regulator knockout murine model","volume":"164","author":"Durie","year":"2004","journal-title":"Am J Pathol"},{"issue":"10","key":"10.1016\/j.jcf.2024.07.002_bib0054","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1164\/rccm.200508-1330OC","article-title":"Cystic fibrosis transmembrane conductance regulator function is suppressed in cigarette smokers","volume":"173","author":"Cantin","year":"2006","journal-title":"American journal of respiratory critical care medicine"},{"issue":"2","key":"10.1016\/j.jcf.2024.07.002_bib0055","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1096\/fj.11-192377","article-title":"Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration","volume":"26","author":"Clunes","year":"2012","journal-title":"The FASEB Journal"},{"issue":"3","key":"10.1016\/j.jcf.2024.07.002_bib0056","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.bpg.2005.11.006","article-title":"Cystic fibrosis: nutritional consequences and management","volume":"20","author":"Dodge","year":"2006","journal-title":"Best practice research Clinical gastroenterology"},{"issue":"3","key":"10.1016\/j.jcf.2024.07.002_bib0057","first-page":"443","article-title":"Effects of starvation and refeeding on lung mechanics and morphometry","volume":"119","author":"Sahebjami","year":"1979","journal-title":"American Review of Respiratory Disease"},{"issue":"7","key":"10.1016\/j.jcf.2024.07.002_bib0058","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1164\/rccm.200405-651OC","article-title":"Early emphysema in patients with anorexia nervosa","volume":"170","author":"Coxson","year":"2004","journal-title":"American journal of respiratory critical care medicine"},{"issue":"12","key":"10.1016\/j.jcf.2024.07.002_bib0059","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1164\/rccm.201609-1954OC","article-title":"Restoring cystic fibrosis transmembrane conductance regulator function reduces airway bacteria and inflammation in people with cystic fibrosis and chronic lung infections","volume":"195","author":"Hisert","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.jcf.2024.07.002_bib0060","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1513\/AnnalsATS.201907-493OC","article-title":"Changes in airway microbiome and inflammation with ivacaftor treatment in patients with cystic fibrosis and the G551D mutation","volume":"17","author":"Harris","year":"2020","journal-title":"Ann Am Thorac Soc"},{"issue":"6","key":"10.1016\/j.jcf.2024.07.002_bib0061","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1002\/ppul.25285","article-title":"Cystic fibrosis patients of minority race and ethnicity less likely eligible for CFTR modulators based on CFTR genotype","volume":"56","author":"McGarry","year":"2021","journal-title":"Pediatr Pulmonol"},{"issue":"2","key":"10.1016\/j.jcf.2024.07.002_bib0062","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jcf.2016.07.008","article-title":"Hyperpolarized 129Xe for investigation of mild cystic fibrosis lung disease in pediatric patients","volume":"16","author":"Thomen","year":"2017","journal-title":"Journal of Cystic Fibrosis"},{"issue":"2","key":"10.1016\/j.jcf.2024.07.002_bib0063","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1148\/radiol.13120005","article-title":"Effect of lung inflation level on hyperpolarized 3He apparent diffusion coefficient measurements in never-smokers","volume":"268","author":"Halaweish","year":"2013","journal-title":"Radiology"},{"key":"10.1016\/j.jcf.2024.07.002_bib0064","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1590\/S0100-879X1999000600006","article-title":"Reference values for lung function tests: I. Static volumes","volume":"32","author":"Neder","year":"1999","journal-title":"Brazilian journal of medical and biological research"}],"container-title":["Journal of Cystic Fibrosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199324007860?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199324007860?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:13:36Z","timestamp":1788246816000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569199324007860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":64,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S1569199324007860"],"URL":"https:\/\/doi.org\/10.1016\/j.jcf.2024.07.002","relation":{},"ISSN":["1569-1993"],"issn-type":[{"value":"1569-1993","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantifying abnormal alveolar microstructure in cystic fibrosis lung disease via hyperpolarized 129Xe diffusion MRI","name":"articletitle","label":"Article Title"},{"value":"Journal of Cystic Fibrosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcf.2024.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 European Cystic Fibrosis Society. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}