{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T05:15:58Z","timestamp":1789276558325,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cysticfibrosisjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cystic Fibrosis"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jcf.2025.02.001","type":"journal-article","created":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T17:11:31Z","timestamp":1739639491000},"page":"801-808","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cardiovascular function in people with cystic fibrosis on Elexacaftor\/Tezacaftor\/Ivacaftor: A cross-sectional, observational, single-centre study"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4907-257X","authenticated-orcid":false,"given":"Lauren J","family":"Clayton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6392-7944","authenticated-orcid":false,"given":"Anthony I","family":"Shepherd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6552-6471","authenticated-orcid":false,"given":"Jo","family":"Corbett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3974-2250","authenticated-orcid":false,"given":"Maria","family":"Perissiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Connett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Legg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7403-2097","authenticated-orcid":false,"given":"Mark","family":"Allenby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5249-5100","authenticated-orcid":false,"given":"Thomas","family":"Daniels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9048-9692","authenticated-orcid":false,"given":"Don S","family":"Urquhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0355-6357","authenticated-orcid":false,"given":"Kelly A","family":"Mackintosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0813-7477","authenticated-orcid":false,"given":"Melitta A","family":"McNarry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0674-8477","authenticated-orcid":false,"given":"Zoe L","family":"Saynor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcf.2025.02.001_bib0001","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jcf.2023.02.004","article-title":"Elexacaftor\/tezacaftor\/ivacaftor projected survival and long-term health outcomes in people with cystic fibrosis homozygous for F508del","volume":"22","author":"Lopez","year":"2023","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2025.02.001_bib0002","article-title":"Cardiovascular complications in cystic fibrosis: a review of the literature","author":"Poore","year":"2021","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2025.02.001_bib0003","unstructured":"World Health Organization. The top 10 causes of death 2020."},{"key":"10.1016\/j.jcf.2025.02.001_bib0004","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00174-2023","article-title":"Prevalence, risk factors and outcomes of cardiac disease in cystic fibrosis: a multinational retrospective cohort study","volume":"62","author":"Frost","year":"2023","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jcf.2025.02.001_bib0005","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1152\/ajpheart.00136.2016","article-title":"Evidence of microvascular dysfunction in patients with cystic fibrosis","volume":"310","author":"Rodriguez-Miguelez","year":"2016","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jcf.2025.02.001_bib0006","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1378\/chest.12-1934","article-title":"Evidence of vascular endothelial dysfunction in young patients with cystic fibrosis","volume":"143","author":"Poore","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.jcf.2025.02.001_bib0007","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/1629638","article-title":"Endothelial dysfunction in cystic fibrosis: role of oxidative stress","author":"Tucker","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jcf.2025.02.001_bib0008","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1016\/j.clnu.2019.12.029","article-title":"Overweight, obesity and significant weight gain in adult patients with cystic fibrosis association with lung function and cardiometabolic risk factors","volume":"39","author":"Bonhoure","year":"2020","journal-title":"Clin Nutr"},{"key":"10.1016\/j.jcf.2025.02.001_bib0009","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jcf.2021.11.012","article-title":"Effect of elexacaftor-tezacaftor-ivacaftor on body weight and metabolic parameters in adults with cystic fibrosis","volume":"21","author":"Petersen","year":"2022","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2025.02.001_bib0010","first-page":"2","article-title":"The heart in cystic fibrosis","volume":"95","author":"Bright-Thomas","year":"2002","journal-title":"J R Soc Med"},{"key":"10.1016\/j.jcf.2025.02.001_bib0011","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1113\/jphysiol.2010.188334","article-title":"Cardiomyocytes with disrupted CFTR function require CaMKII and Ca2+-activated Cl- channel activity to maintain contraction rate","volume":"588","author":"Sellers","year":"2010","journal-title":"J Physiol"},{"key":"10.1016\/j.jcf.2025.02.001_bib0012","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-63904-0","article-title":"Subclinical vascular, hemodynamic and arterial stiffness changes in adults with cystic fibrosis: cross-sectional observational study","volume":"14","author":"Pessoa","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcf.2025.02.001_bib0013","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.00879","article-title":"Cystic fibrosis transmembrane conductance regulator (CFTR) in Human lung microvascular endothelial cells controls oxidative stress, reactive oxygen-mediated cell signaling and inflammatory responses","volume":"11","author":"Khalaf","year":"2020","journal-title":"Front Physiol"},{"key":"10.1016\/j.jcf.2025.02.001_bib0014","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0130313","article-title":"Sphingosine-1-phosphate is a novel regulator of cystic fibrosis transmembrane conductance regulator (CFTR) activity","volume":"10","author":"Malik","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jcf.2025.02.001_bib0015","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1016\/j.bbadis.2017.08.011","article-title":"Mechanisms of endothelial cell dysfunction in cystic fibrosis","volume":"1863","author":"Totani","year":"2017","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.jcf.2025.02.001_bib0016","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jcf.2017.08.015","article-title":"Blood flow regulation and oxidative stress during submaximal cycling exercise in patients with cystic fibrosis","volume":"17","author":"Tucker","year":"2018","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2025.02.001_bib0017","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.echo.2011.06.004","article-title":"Myocardial strain assessment in cystic fibrosis","volume":"24","author":"Labombarda","year":"2011","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jcf.2025.02.001_bib0018","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1161\/CIRCULATIONAHA.109.192703","article-title":"Defining and setting national goals for cardiovascular health promotion and disease reduction: the american heart association's strategic impact goal through 2020 and beyond","volume":"121","author":"Lloyd-Jones","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jcf.2025.02.001_bib0019","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1002\/ppul.25038","article-title":"Physical activity in children and adolescents with cystic fibrosis: a systematic review and meta-analysis","volume":"55","author":"Puppo","year":"2020","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jcf.2025.02.001_bib0020","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1210\/er.2003-0012","article-title":"Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications","volume":"25","author":"Zhi","year":"2004","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jcf.2025.02.001_bib0021","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jcf.2021.01.007","article-title":"Challenges in the use of highly effective modulator treatment for cystic fibrosis","volume":"20","author":"Ramos","year":"2021","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2025.02.001_bib0022","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.jcf.2019.03.001","article-title":"Effects of Lumacaftor\/Ivacaftor on physical activity and exercise tolerance in three adults with cystic fibrosis","volume":"18","author":"Savi","year":"2019","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2025.02.001_bib0023","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1016\/j.jcf.2015.10.012","article-title":"CFTR potentiator therapy ameliorates impaired insulin secretion in CF patients with a gating mutation","volume":"15","author":"Tsabari","year":"2016","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2025.02.001_bib0024","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1152\/japplphysiol.00292.2019","article-title":"Beet\u201d the cold: beetroot juice supplementation improves peripheral blood flow, endothelial function, and anti-inflammatory status in individuals with Raynaud's phenomenon","volume":"127","author":"Shepherd","year":"2019","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jcf.2025.02.001_bib0025","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s00421-004-1300-5","article-title":"Reliability of peak VO2 and maximal cardiac output assessed using thoracic bioimpedance in children","volume":"94","author":"Welsman","year":"2005","journal-title":"Eur J Appl Physiol"},{"key":"10.1016\/j.jcf.2025.02.001_bib0026","article-title":"Peripheral muscle function and body composition in people with cystic fibrosis on Elexacaftor\/Tezacaftor\/Ivacaftor: a cross-sectional, observational, single-centre study","author":"Clayton","year":"2024","journal-title":"Under Rev"},{"key":"10.1016\/j.jcf.2025.02.001_bib0027","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1161\/CIRCULATIONAHA.107.743062","article-title":"Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample the framingham heart study","volume":"117","author":"Rosito","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jcf.2025.02.001_bib0028","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.clnu.2023.12.017","article-title":"ESPEN-ESPGHAN-ECFS guideline on nutrition care for cystic fibrosis","volume":"43","author":"Wilschanski","year":"2024","journal-title":"Clin Nutr"},{"key":"10.1016\/j.jcf.2025.02.001_bib0029","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1249\/MSS.0000000000001561","article-title":"Beyond cut points: accelerometer metrics that capture the physical activity profile","volume":"50","author":"Rowlands","year":"2018","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.jcf.2025.02.001_bib0030","article-title":"Flow-mediated dilation as a marker of endothelial dysfunction in pulmonary diseases: a narrative review","volume":"84","author":"Abagnale","year":"2023","journal-title":"Respir Med Res"},{"key":"10.1016\/j.jcf.2025.02.001_bib0031","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.ijcard.2012.09.047","article-title":"Flow-mediated dilation and cardiovascular risk prediction: a systematic review with meta-analysis","volume":"168","author":"Ras","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jcf.2025.02.001_bib0032","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1161\/CIRCULATIONAHA.108.765701","article-title":"Endothelial function predicts progression of carotid intima-media thickness","volume":"119","author":"Halcox","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jcf.2025.02.001_bib0033","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1159\/000226227","article-title":"Adjusting flow-mediated dilation for shear stress stimulus allows demonstration of endothelial dysfunction in a population with moderate cardiovascular risk","volume":"46","author":"Padilla","year":"2009","journal-title":"J Vasc Res"},{"key":"10.1016\/j.jcf.2025.02.001_bib0034","doi-asserted-by":"crossref","unstructured":"Ballermann B.J., Dardik A., Eng E., Liu A. Shear stress and the endothelium. 1998.","DOI":"10.1046\/j.1523-1755.1998.06720.x"},{"key":"10.1016\/j.jcf.2025.02.001_bib0035","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jpeds.2018.05.018","article-title":"Energy balance and mechanisms of weight gain with ivacaftor treatment of cystic fibrosis gating mutations","volume":"201","author":"Stallings","year":"2018","journal-title":"J Pediatr"},{"key":"10.1016\/j.jcf.2025.02.001_bib0036","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1136\/thorax.58.10.885","article-title":"Altered tissue distribution in adults with cystic fibrosis","volume":"58","author":"Bolton","year":"2003","journal-title":"Thorax"},{"key":"10.1016\/j.jcf.2025.02.001_bib0037","article-title":"Cardiometabolic risk factors in adults with cystic fibrosis undergoing elexacaftor\/tezacaftor\/ivacaftor therapy","author":"Gramegna","year":"2024","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2025.02.001_bib0038","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1152\/ajpgi.00344.2017","article-title":"Absence of leptin signaling allows fat accretion in cystic fibrosis mice","volume":"315","author":"Bederman","year":"2018","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jcf.2025.02.001_bib0039","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1038\/s41440-021-00718-x","article-title":"Serum leptin is associated with increased pulse pressure and the development of arterial stiffening in adult men: results of an eight-year follow-up study","volume":"44","author":"D'Elia","year":"2021","journal-title":"Hypertens Res"},{"key":"10.1016\/j.jcf.2025.02.001_bib0040","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1161\/CIRCRESAHA.120.314458","volume":"128","author":"Zhao","year":"2021","journal-title":"Circ Res"},{"key":"10.1016\/j.jcf.2025.02.001_bib0041","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.freeradbiomed.2014.08.005","article-title":"Inflammation, oxidative stress, and cardiovascular disease risk factors in adults with cystic fibrosis","volume":"76","author":"Reverri","year":"2014","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jcf.2025.02.001_bib0042","doi-asserted-by":"crossref","DOI":"10.1080\/02640414.2022.2115224","article-title":"Physical activity assessment and vascular function in adults with cystic fibrosis and their non-CF peers","author":"Shelley","year":"2022","journal-title":"J Sports Sci"}],"container-title":["Journal of Cystic Fibrosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199325000529?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199325000529?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:14:43Z","timestamp":1778822083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569199325000529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S1569199325000529"],"URL":"https:\/\/doi.org\/10.1016\/j.jcf.2025.02.001","relation":{},"ISSN":["1569-1993"],"issn-type":[{"value":"1569-1993","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiovascular function in people with cystic fibrosis on Elexacaftor\/Tezacaftor\/Ivacaftor: A cross-sectional, observational, single-centre study","name":"articletitle","label":"Article Title"},{"value":"Journal of Cystic Fibrosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcf.2025.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V. on behalf of European Cystic Fibrosis Society.","name":"copyright","label":"Copyright"}]}}