{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:33:48Z","timestamp":1786991628056,"version":"build-2736575974"},"reference-count":15,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000082","name":"Cystic Fibrosis Canada","doi-asserted-by":"publisher","award":["904018"],"award-info":[{"award-number":["904018"]}],"id":[{"id":"10.13039\/501100000082","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cysticfibrosisjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cystic Fibrosis"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jcf.2025.03.004","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T16:40:21Z","timestamp":1741711221000},"page":"816-818","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Vitality is associated with systemic inflammation in cystic fibrosis adults on elexacaftor\/tezacaftor\/ivacaftor"],"prefix":"10.1016","volume":"24","author":[{"given":"Jacob","family":"Gravelle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9671-9383","authenticated-orcid":false,"given":"Sameer","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1785-3870","authenticated-orcid":false,"given":"Bradley S.","family":"Quon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jcf.2025.03.004_bib0001","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jpainsymman.2007.06.005","article-title":"Self-reported physical and psychological symptom burden in adults with cystic fibrosis","volume":"35","author":"Sawicki","year":"2008","journal-title":"J Pain Symptom Manag"},{"issue":"3","key":"10.1016\/j.jcf.2025.03.004_bib0002","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jcf.2018.03.003","article-title":"Prevalence of severe fatigue among adults with cystic fibrosis: a single center study","volume":"17","author":"Nap-Van Der Vlist","year":"2018","journal-title":"J Cyst Fibros"},{"issue":"2","key":"10.1016\/j.jcf.2025.03.004_bib0003","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1007\/s12035-015-9090-9","article-title":"The neuro-immune pathophysiology of central and peripheral fatigue in systemic Immune-inflammatory and Neuro-immune diseases","volume":"53","author":"Morris","year":"2016","journal-title":"Mol Neurobiol"},{"issue":"1","key":"10.1016\/j.jcf.2025.03.004_bib0004","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1186\/s13075-015-0784-1","article-title":"Fatigue in chronic inflammation - a link to pain pathways","volume":"17","author":"Louati","year":"2015","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"10.1016\/j.jcf.2025.03.004_bib0005","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2014-000041","article-title":"Fatigue in rheumatoid arthritis; a persistent problem: a large longitudinal study","volume":"1","author":"Van Steenbergen","year":"2015","journal-title":"RMD Open"},{"issue":"6","key":"10.1016\/j.jcf.2025.03.004_bib0006","doi-asserted-by":"crossref","first-page":"2202029","DOI":"10.1183\/13993003.02029-2022","article-title":"Long-term safety and efficacy of elexacaftor\/tezacaftor\/ivacaftor in people with cystic fibrosis and at least one F508del allele: 144-week interim results from a 192-week open-label extension study","volume":"62","author":"Daines","year":"2023","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jcf.2025.03.004_bib0007","doi-asserted-by":"crossref","first-page":"1179208","DOI":"10.3389\/fphar.2023.1179208","article-title":"Effects of elexacaftor\/tezacaftor\/ivacaftor therapy on mental health of patients with cystic fibrosis","volume":"14","author":"Piehler","year":"2023","journal-title":"Front Pharmacol"},{"issue":"8","key":"10.1016\/j.jcf.2025.03.004_bib0008","doi-asserted-by":"crossref","DOI":"10.1136\/thorax-2022-219943","article-title":"Effect of elexacaftor\/tezacaftor\/ivacaftor on airway and systemic inflammation in cystic fibrosis - PubMed","volume":"78","author":"Casey","year":"2023","journal-title":"Thorax"},{"issue":"7","key":"10.1016\/j.jcf.2025.03.004_bib0009","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1007\/s11136-011-0036-z","article-title":"Psychometric evaluation of the cystic fibrosis questionnaire-revised in a national sample","volume":"21","author":"Quittner","year":"2012","journal-title":"Qual Life Res"},{"key":"10.1016\/j.jcf.2025.03.004_bib0010","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fimmu.2017.00021","article-title":"Role of inflammation in human fatigue: relevance of multidimensional assessments and potential neuronal mechanisms","volume":"8","author":"Karshikoff","year":"2017","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.jcf.2025.03.004_bib0011","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat Rev Neurosci"},{"issue":"4","key":"10.1016\/j.jcf.2025.03.004_bib0012","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1177\/1479972312464236","article-title":"Fatigue in cystic fibrosis: a novel prospective study investigating subjective and objective factors associated with fatigue","volume":"9","author":"Jarad","year":"2012","journal-title":"Chron Respir Dis"},{"issue":"7","key":"10.1016\/j.jcf.2025.03.004_bib0013","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1136\/ard.2006.065763","article-title":"Functional assessment of chronic illness therapy-fatigue scale is valid in patients with psoriatic arthritis","volume":"66","author":"Chandran","year":"2007","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"10.1016\/j.jcf.2025.03.004_bib0014","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1378\/chest.128.4.2347","article-title":"Development and validation of the cystic fibrosis questionnaire in the United States","volume":"128","author":"Quittner","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.jcf.2025.03.004_bib0015","article-title":"P168 Determining the relationship between vitality and C-reactive protein in those initiating elexacaftor\/tezacaftor\/ivacaftor","volume":"22: S116","author":"Gravelle","year":"2023","journal-title":"J Cyst Fibros"}],"container-title":["Journal of Cystic Fibrosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199325000736?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199325000736?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:15:38Z","timestamp":1778822138000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569199325000736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S1569199325000736"],"URL":"https:\/\/doi.org\/10.1016\/j.jcf.2025.03.004","relation":{},"ISSN":["1569-1993"],"issn-type":[{"value":"1569-1993","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitality is associated with systemic inflammation in cystic fibrosis adults on elexacaftor\/tezacaftor\/ivacaftor","name":"articletitle","label":"Article Title"},{"value":"Journal of Cystic Fibrosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcf.2025.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of European Cystic Fibrosis Society.","name":"copyright","label":"Copyright"}]}}