{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:06:08Z","timestamp":1790193968425,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002738","name":"Assistance Publique - H\u00f4pitaux de Paris","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100027380","name":"Foundation for Individual Rights in Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100027380","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cysticfibrosisjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cystic Fibrosis"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jcf.2025.06.001","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T23:38:32Z","timestamp":1750462712000},"page":"1051-1057","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Pregnancy and neonatal outcome following in utero exposure to CFTR modulators: A multicentre prospective case series"],"prefix":"10.1016","volume":"24","author":[{"given":"Sophie","family":"Gautier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3138-1654","authenticated-orcid":false,"given":"B\u00e9n\u00e9dicte","family":"Coulm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Andr\u00e9e","family":"Thompson-Bos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9626-3571","authenticated-orcid":false,"given":"Laurent","family":"Chouchana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Audousset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Elefant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Mankikian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0903-9828","authenticated-orcid":false,"given":"Pierre-Regis","family":"Burgel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2105-9784","authenticated-orcid":false,"given":"Charles","family":"Garabedian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8857-0910","authenticated-orcid":false,"given":"Beno\u00eet","family":"Marin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2635-3360","authenticated-orcid":false,"given":"Annie-Pierre","family":"Jonville - Bera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10212","key":"10.1016\/j.jcf.2025.06.001_bib0001","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1016\/S0140-6736(19)32597-8","article-title":"Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial","volume":"394","author":"Heijerman","year":"2019","journal-title":"Lancet North Am Ed"},{"issue":"3","key":"10.1016\/j.jcf.2025.06.001_bib0002","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.jcf.2021.07.019","article-title":"Pregnancy in cystic fibrosis: review of the literature and expert recommendations","volume":"21","author":"Jain","year":"2022","journal-title":"J Cyst Fibros"},{"issue":"9","key":"10.1016\/j.jcf.2025.06.001_bib0004","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.3390\/jcm9092706","article-title":"CFTR modulators: impact on fertility, pregnancy, and lactation in women with cystic fibrosis","volume":"9","author":"Taylor-Cousar","year":"2020","journal-title":"J Clin Med"},{"issue":"2","key":"10.1016\/j.jcf.2025.06.001_bib0005","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.chest.2024.09.019","article-title":"Impact of cystic fibrosis transmembrane conductance regulator modulators on maternal outcomes during and after pregnancy","volume":"167","author":"Jain","year":"2025","journal-title":"Chest"},{"issue":"6","key":"10.1016\/j.jcf.2025.06.001_bib0006","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.jcf.2018.05.009","article-title":"Measured fetal and neonatal exposure to Lumacaftor and Ivacaftor during pregnancy and while breastfeeding","volume":"17","author":"Trimble","year":"2018","journal-title":"J Cyst Fibros"},{"issue":"4","key":"10.1016\/j.jcf.2025.06.001_bib0007","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.jcf.2021.12.004","article-title":"Drug exposure to infants born to mothers taking Elexacaftor, Tezacaftor, and Ivacaftor","volume":"21","author":"Collins","year":"2022","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2025.06.001_bib0008","article-title":"Maternal, newborn and breast milk concentrations of elexacaftor\/tezacaftor\/ivacaftor in a F508del heterozygous woman with cystic fibrosis following successful pregnancy","volume":"10","author":"Ripani","year":"2023","journal-title":"Front Med (Lausanne)"},{"issue":"4","key":"10.1016\/j.jcf.2025.06.001_bib0009","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.jcf.2020.02.018","article-title":"Outcomes of pregnancy in women with cystic fibrosis (CF) taking CFTR modulators\u2013an international survey","volume":"19","author":"Nash","year":"2020","journal-title":"J Cyst Fibros"},{"issue":"3","key":"10.1016\/j.jcf.2025.06.001_bib0010","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jcf.2021.03.006","article-title":"Maternal and fetal outcomes following elexacaftor-tezacaftor-ivacaftor use during pregnancy and lactation","volume":"20","author":"Taylor-Cousar","year":"2021","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2025.06.001_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcf.2025.03.002","article-title":"CFTR modulators and pregnancy outcomes: early findings from a nationwide cohort study","author":"Chouchana","year":"2025","journal-title":"J Cyst Fibros"},{"issue":"8463","key":"10.1016\/j.jcf.2025.06.001_bib0012","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/S0140-6736(85)90918-3","article-title":"Adverse drug reaction monitoring: doing it the French way","volume":"326","author":"Moore","year":"1985","journal-title":"Lancet North Am Ed"},{"issue":"1","key":"10.1016\/j.jcf.2025.06.001_bib0013","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2515\/therapie\/2014004","article-title":"[Centre de r\u00e9f\u00e9rence sur les agents t\u00e9ratog\u00e8nes (CRAT): a pioneer center]","volume":"69","author":"Elefant","year":"2014","journal-title":"Therapie"},{"issue":"1","key":"10.1016\/j.jcf.2025.06.001_bib0014","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.reprotox.2008.05.064","article-title":"Using observational cohort data for studying drug effects on pregnancy outcome\u2014Methodological considerations","volume":"26","author":"Schaefer","year":"2008","journal-title":"Reprod Toxicol"},{"issue":"2","key":"10.1016\/j.jcf.2025.06.001_bib0015","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jgyn.2015.08.009","article-title":"Courbes de croissance in utero ajust\u00e9es et non ajust\u00e9es adapt\u00e9es \u00e0 la population fran\u00e7aise. I\u2013m\u00e9thodes de construction","volume":"45","author":"Ego","year":"2016","journal-title":"Journal De Gyn\u00e9cologie Obst\u00e9trique Et Biologie De La Reproduction,"},{"issue":"2","key":"10.1016\/j.jcf.2025.06.001_bib0016","doi-asserted-by":"crossref","first-page":"e2314","DOI":"10.1002\/bdr2.2314","article-title":"Updated EUROCAT guidelines for classification of cases with congenital anomalies","volume":"116","author":"Bergman","year":"2024","journal-title":"Birth Defects Research"},{"issue":"6","key":"10.1016\/j.jcf.2025.06.001_bib0017","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.therap.2022.01.020","article-title":"Pulmonary hemorrhage in a neonate born to a woman with cystic fibrosis treated with targeted cystic fibrosis transmembrane conductance regulator modulator elexacaftor-tezacaftor-ivacaftor during pregnancy","volume":"77","author":"Nuytten","year":"2022","journal-title":"Therapie"},{"key":"10.1016\/j.jcf.2025.06.001_bib0018","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ejmg.2014.03.002","article-title":"Birth defects epidemiology","volume":"57","author":"Carmichael","year":"2014","journal-title":"Eur. J. Med. Genet."},{"issue":"11","key":"10.1016\/j.jcf.2025.06.001_bib0019","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1369\/0022155414546190","article-title":"Cystic fibrosis transmembrane conductance regulator protein (CFTR) expression in the developing human brain: comparative immunohistochemical study between patients with normal and mutated CFTR","volume":"62","author":"Marcorelles","year":"2014","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.jcf.2025.06.001_bib0020","first-page":"88","article-title":"Epidemiology of neural tube defects","volume":"135","author":"Mitchell","year":"2005"},{"issue":"3","key":"10.1016\/j.jcf.2025.06.001_bib0021","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.jcf.2020.09.002","article-title":"Baseline Cystic fibrosis disease severity has an adverse impact on pregnancy and infant outcomes, but does not impact disease progression","volume":"20","author":"Cohen-Cymberknoh","year":"2021","journal-title":"J Cyst Fibros"},{"issue":"4","key":"10.1016\/j.jcf.2025.06.001_bib0022","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/ppul.24241","article-title":"Trends in epidemiology and outcomes of respiratory distress syndrome in the United States","volume":"54","author":"Donda","year":"2019","journal-title":"Pediatr Pulmonol"},{"issue":"9","key":"10.1016\/j.jcf.2025.06.001_bib0023","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.3390\/ijms21093133","article-title":"What role does CFTR play in development, differentiation, regeneration and cancer?","volume":"21","author":"Amaral","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.jcf.2025.06.001_bib0024","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1165\/rcmb.2022-0175LE","article-title":"Elexacaftor\/tezacaftor\/ivacaftor disrupts respiratory tract development in a murine fetal lung explant model","volume":"67","author":"Lhuillier","year":"2022","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jcf.2025.06.001_bib0025","doi-asserted-by":"crossref","unstructured":"Hadchouel-Duverg\u00e9, A., Lhuillier, M., Aoust, L., Dreano, E., Truchon, K.L., Delacourt, C., ... & Gaudelus, I.S. (2022). Airway morphogenesis in wild type and heterozygous F508del mouse embryonic lungs treated by Elexacaftor\/Tezacaftor\/Ivacaftor.","DOI":"10.1183\/13993003.congress-2022.4330"},{"issue":"3","key":"10.1016\/j.jcf.2025.06.001_bib0026","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jcf.2021.07.021","article-title":"Ivacaftor withdrawal syndrome: a potentially life-threatening consequence from a life-saving medication","volume":"21","author":"Clegg","year":"2022","journal-title":"J Cyst Fibros"},{"issue":"2","key":"10.1016\/j.jcf.2025.06.001_bib0027","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1016\/j.jcf.2017.09.006","article-title":"Ivacaftor withdrawal syndrome in cystic fibrosis patients with the G551D mutation","volume":"17","author":"Trimble","year":"2018","journal-title":"J Cyst Fibros"},{"issue":"6","key":"10.1016\/j.jcf.2025.06.001_bib0028","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.jcf.2022.10.004","article-title":"Congenital bilateral cataracts in newborns exposed to elexacaftor-tezacaftor-ivacaftor in utero and while breast feeding","volume":"21","author":"Jain","year":"2022","journal-title":"J Cyst Fibros"},{"issue":"12","key":"10.1016\/j.jcf.2025.06.001_bib0029","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1369\/jhc.2009.953455","article-title":"Expression and distribution of cystic fibrosis transmembrane conductance regulator in neurons of the human brain","volume":"57","author":"Guo","year":"2009","journal-title":"Journal of Histochemistry & Cytochemistry"},{"issue":"10448","key":"10.1016\/j.jcf.2025.06.001_bib0030","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0140-6736(24)01134-6","article-title":"Behavioural and sleep issues after initiation of elexacaftor\u2013tezacaftor\u2013ivacaftor in preschool-age children with cystic fibrosis","volume":"404","author":"Sermet-Gaudelus","year":"2024","journal-title":"Lancet North Am Ed"}],"container-title":["Journal of Cystic Fibrosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199325015152?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199325015152?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T07:35:56Z","timestamp":1779953756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569199325015152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S1569199325015152"],"URL":"https:\/\/doi.org\/10.1016\/j.jcf.2025.06.001","relation":{},"ISSN":["1569-1993"],"issn-type":[{"value":"1569-1993","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pregnancy and neonatal outcome following in utero exposure to CFTR modulators: A multicentre prospective case series","name":"articletitle","label":"Article Title"},{"value":"Journal of Cystic Fibrosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcf.2025.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of European Cystic Fibrosis Society.","name":"copyright","label":"Copyright"}]}}