{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:28:31Z","timestamp":1792625311210,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cysticfibrosisjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cystic Fibrosis"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jcf.2025.07.010","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T03:55:14Z","timestamp":1753242914000},"page":"886-893","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Validation of the CFAbd-Score.kid\u24b8, a Novel gastrointestinal patient reported outcome measure, specific for children with cystic fibrosis"],"prefix":"10.1016","volume":"24","author":[{"given":"Pauline","family":"Sadrieh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilith","family":"Bechinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Duckstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Barucha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7146-6997","authenticated-orcid":false,"given":"Lutz","family":"N\u00e4hrlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Eickmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"van Dullemen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kemp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit","family":"M\u00fchl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patience","family":"Eschenhagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Graepler-Mainka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Zagoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3780-7759","authenticated-orcid":false,"given":"Jochen G.","family":"Mainz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jcf.2025.07.010_bib0001","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1136\/thorax-2023-220100","article-title":"A refresh of the top 10 research priorities in cystic fibrosis","volume":"78","author":"Rowbotham","year":"2023","journal-title":"Thorax"},{"key":"10.1016\/j.jcf.2025.07.010_bib0002","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s40900-019-0159-x","article-title":"Adapting the James Lind Alliance priority setting process to better support patient participation: an example from cystic fibrosis","volume":"5","author":"Rowbotham","year":"2019","journal-title":"Res Involv Engagem"},{"key":"10.1016\/j.jcf.2025.07.010_bib0003","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2015.10","article-title":"Cystic fibrosis","volume":"1","author":"Ratjen","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"9","key":"10.1016\/j.jcf.2025.07.010_bib0004","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s00117-020-00729-8","article-title":"Abdominelle Manifestationen bei mukoviszidose","volume":"60","author":"Sommerburg","year":"2020","journal-title":"Radiologe"},{"issue":"3","key":"10.1016\/j.jcf.2025.07.010_bib0005","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s11894-021-00806-5","article-title":"Luminal gastrointestinal manifestations of cystic fibrosis","volume":"23","author":"J Burton","year":"2021","journal-title":"Curr. Gastroenterol. Rep."},{"issue":"2","key":"10.1016\/j.jcf.2025.07.010_bib0006","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jcf.2022.10.006","article-title":"Multicenter prospective study showing a high gastrointestinal symptom burden in cystic fibrosis","volume":"22","author":"Moshiree","year":"2023","journal-title":"J. Cyst. Fibros"},{"issue":"1","key":"10.1016\/j.jcf.2025.07.010_bib0007","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S2213-2600(19)30337-6","article-title":"The future of cystic fibrosis care: a global perspective","volume":"8","author":"Bell","year":"2020","journal-title":"Lancet Respir Med."},{"key":"10.1016\/j.jcf.2025.07.010_bib0008","unstructured":"Agency E.M. Kaftrio [updated 20\/08\/2022. Available from: https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/kaftrio."},{"issue":"4","key":"10.1016\/j.jcf.2025.07.010_bib0009","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s40271-019-00361-2","article-title":"Validity and reliability of a novel multimodal questionnaire for the assessment of abdominal symptoms in people with Cystic Fibrosis (CFAbd-Score)","volume":"12","author":"Jaudszus","year":"2019","journal-title":"Patient - Patient-Centered Outcomes Res."},{"issue":"5","key":"10.1016\/j.jcf.2025.07.010_bib0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174463","article-title":"Abdominal symptoms in cystic fibrosis and their relation to genotype, history, clinical and laboratory findings","volume":"12","author":"Tabori","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jcf.2025.07.010_bib0011","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17302-4","article-title":"Relation of ultrasound findings and abdominal symptoms obtained with the CFAbd-score in cystic fibrosis patients","volume":"7","author":"Tabori","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jcf.2025.07.010_bib0012","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.877118","article-title":"Elexacaftor-Tezacaftor-Ivacaftor treatment reduces abdominal symptoms in cystic fibrosis-early results obtained with the CF-specific CFAbd-score","volume":"13","author":"Mainz","year":"2022","journal-title":"Front Pharmacol."},{"issue":"3","key":"10.1016\/j.jcf.2025.07.010_bib0013","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.jcf.2023.10.001","article-title":"Reduction in abdominal symptoms (CFAbd-Score), faecal M2-pyruvate-kinase and Calprotectin over one year of treatment with Elexacaftor-Tezacaftor-Ivacaftor in people with CF aged \u226512 years - the RECOVER study","volume":"23","author":"Mainz","year":"2024","journal-title":"J. Cyst. Fibros"},{"issue":"2","key":"10.1016\/j.jcf.2025.07.010_bib0014","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.jcf.2022.10.003","article-title":"Elexacaftor\/tezacaftor\/ivacaftor and gastrointestinal outcomes in cystic fibrosis: report of promise-GI","volume":"22","author":"Schwarzenberg","year":"2023","journal-title":"J. Cyst. Fibros"},{"issue":"4","key":"10.1016\/j.jcf.2025.07.010_bib0015","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.jcf.2020.12.021","article-title":"Designing the GALAXY study: partnering with the cystic fibrosis community to optimize assessment of gastrointestinal symptoms","volume":"20","author":"Freeman","year":"2021","journal-title":"J. Cyst. Fibros"},{"issue":"4","key":"10.1016\/j.jcf.2025.07.010_bib0016","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.jcf.2021.07.002","article-title":"Utilization of electronic patient-reported outcome measures in cystic fibrosis research: application to the GALAXY study","volume":"20","author":"Sathe","year":"2021","journal-title":"J. Cyst. Fibros"},{"key":"10.1016\/j.jcf.2025.07.010_bib0017","unstructured":"Administration USDoHaHSFaD. Guidance for Industry: Patient-Reported Outcome Measures: Use in Medical Product Development to Support Labeling Claims 2009 10\/17\/2019."},{"issue":"4","key":"10.1016\/j.jcf.2025.07.010_bib0018","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s11136-010-9606-8","article-title":"The COSMIN checklist for assessing the methodological quality of studies on measurement properties of health status measurement instruments: an international Delphi study","volume":"19","author":"Mokkink","year":"2010","journal-title":"Qual. Life Res."},{"issue":"6","key":"10.1016\/j.jcf.2025.07.010_bib0019","doi-asserted-by":"crossref","first-page":"e226","DOI":"10.1016\/S1470-2045(16)30113-9","article-title":"New European guidance on patient-reported outcomes","volume":"17","author":"Venkatesan","year":"2016","journal-title":"Lancet Oncol."},{"issue":"4","key":"10.1016\/j.jcf.2025.07.010_bib0020","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.jval.2013.04.004","article-title":"Pediatric patient-reported outcome instruments for research to support medical product labeling: report of the ISPOR PRO good research practices for the assessment of children and adolescents task force","volume":"16","author":"Matza","year":"2013","journal-title":"Value Health"},{"issue":"8","key":"10.1016\/j.jcf.2025.07.010_bib0021","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.jval.2011.06.013","article-title":"Content validity\u2013establishing and reporting the evidence in newly developed patient-reported outcomes (PRO) instruments for medical product evaluation: ISPOR PRO Good Research Practices Task Force report: part 2\u2013assessing respondent understanding","volume":"14","author":"Patrick","year":"2011","journal-title":"Value Health"},{"issue":"8","key":"10.1016\/j.jcf.2025.07.010_bib0022","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.jval.2011.06.014","article-title":"Content validity\u2013establishing and reporting the evidence in newly developed patient-reported outcomes (PRO) instruments for medical product evaluation: ISPOR PRO good research practices task force report: part 1\u2013eliciting concepts for a new PRO instrument","volume":"14","author":"Patrick","year":"2011","journal-title":"Value Health"},{"issue":"6","key":"10.1016\/j.jcf.2025.07.010_bib0023","doi-asserted-by":"crossref","DOI":"10.3390\/jcm13061650","article-title":"Scoring abdominal symptoms in people with Cystic Fibrosis","volume":"13","author":"Tabori","year":"2024","journal-title":"J. Clin Med."},{"issue":"23(3)","key":"10.1016\/j.jcf.2025.07.010_bib0024","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.jcf.2023.10.001","article-title":"Reduction in abdominal symptoms (CFAbd-Score), faecal M2-pyruvate-kinase and Calprotectin over one year of treatment with Elexacaftor-Tezacaftor-Ivacaftor in people with CF aged \u226512 years - the RECOVER study","volume":"2024 May","author":"Mainz","year":"2024","journal-title":"J. Cyst. Fibros"},{"issue":"3","key":"10.1016\/j.jcf.2025.07.010_bib0025","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/MPG.0000000000003357","article-title":"Abdominal symptoms assessed with the CFAbd-score are associated with intestinal inflammation in patients with cystic fibrosis","volume":"74","author":"Jaudszus","year":"2022","journal-title":"J. Pediatr Gastroenterol. Nutr."},{"issue":"4","key":"10.1016\/j.jcf.2025.07.010_bib0026","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.jcf.2020.04.001","article-title":"Use of a mobile application for self-management of pancreatic enzyme replacement therapy is associated with improved gastro-intestinal related quality of life in children with Cystic Fibrosis","volume":"19","author":"Boon","year":"2020","journal-title":"J. Cyst. Fibros"},{"issue":"2","key":"10.1016\/j.jcf.2025.07.010_bib0027","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jcf.2023.01.010","article-title":"Diabetes is associated with increased burden of gastrointestinal symptoms in adults with cystic fibrosis","volume":"22","author":"Caley","year":"2023","journal-title":"J. Cyst. Fibros"},{"issue":"6","key":"10.1016\/j.jcf.2025.07.010_bib0028","doi-asserted-by":"crossref","DOI":"10.3390\/jcm13061650","article-title":"Scoring abdominal symptoms in people with Cystic Fibrosis","volume":"13","author":"Tabori","year":"2024","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.jcf.2025.07.010_bib0029","unstructured":"Kitzinger A. MetacomSymbole 2023 [Available from: https:\/\/www.metacom-symbole.de\/."},{"issue":"3","key":"10.1016\/j.jcf.2025.07.010_bib0030","first-page":"1","article-title":"mice: multivariate imputation by chained equations in R","volume":"45","author":"van Buuren","year":"2011","journal-title":"J. Stat. Softw."},{"issue":"7","key":"10.1016\/j.jcf.2025.07.010_bib0031","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1080\/17476348.2023.2228194","article-title":"Thinking outside the box: a review of gastrointestinal symptoms and complications in cystic fibrosis","volume":"17","author":"Yule","year":"2023","journal-title":"Expert Rev. Respir Med"},{"issue":"7","key":"10.1016\/j.jcf.2025.07.010_bib0032","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1007\/s11136-011-0036-z","article-title":"Psychometric evaluation of the Cystic Fibrosis questionnaire-revised in a national sample","volume":"21","author":"Quittner","year":"2012","journal-title":"Qual Life Res."},{"key":"10.1016\/j.jcf.2025.07.010_bib0033","unstructured":"Quittner A. Cystic Fibrosis Questionnaire-Revised Application - latest version: 0.17.9 https:\/\/cfqr.github.io\/2017."},{"issue":"12","key":"10.1016\/j.jcf.2025.07.010_bib0034","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0225004","article-title":"Assessing gastro-intestinal related quality of life in cystic fibrosis: validation of PedsQL GI in children and their parents","volume":"14","author":"Boon","year":"2019","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.jcf.2025.07.010_bib0035","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1080\/00365520510012208","article-title":"Development and validation of the Patient Assessment of Constipation Quality of Life questionnaire","volume":"40","author":"Marquis","year":"2005","journal-title":"Scand J. Gastroenterol."},{"issue":"6","key":"10.1016\/j.jcf.2025.07.010_bib0036","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.ejpain.2010.11.009","article-title":"Pain perceived in a national community sample of German children and adolescents","volume":"15","author":"Du","year":"2011","journal-title":"Eur. J. Pain"},{"issue":"10","key":"10.1016\/j.jcf.2025.07.010_bib0037","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.cgh.2009.07.002","article-title":"A community-based survey of abdominal pain prevalence, characteristics, and health care use among children","volume":"7","author":"Schwille","year":"2009","journal-title":"Clin Gastroenterol. Hepatol."}],"container-title":["Journal of Cystic Fibrosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199325015346?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199325015346?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T07:35:03Z","timestamp":1779953703000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569199325015346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S1569199325015346"],"URL":"https:\/\/doi.org\/10.1016\/j.jcf.2025.07.010","relation":{},"ISSN":["1569-1993"],"issn-type":[{"value":"1569-1993","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Validation of the CFAbd-Score.kid\u24b8, a Novel gastrointestinal patient reported outcome measure, specific for children with cystic fibrosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Cystic Fibrosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcf.2025.07.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of European Cystic Fibrosis Society.","name":"copyright","label":"Copyright"}]}}