{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:36:49Z","timestamp":1780497409030,"version":"3.54.1"},"reference-count":55,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["HL007106"],"award-info":[{"award-number":["HL007106"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["HL144290"],"award-info":[{"award-number":["HL144290"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["HL165964"],"award-info":[{"award-number":["HL165964"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 DK065988"],"award-info":[{"award-number":["P30 DK065988"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["BENGTS23A0"],"award-info":[{"award-number":["BENGTS23A0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["WRENNA21F0"],"award-info":[{"award-number":["WRENNA21F0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["TARRAN20I0"],"award-info":[{"award-number":["TARRAN20I0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["SASSAN010"],"award-info":[{"award-number":["SASSAN010"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["HL163445"],"award-info":[{"award-number":["HL163445"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","doi-asserted-by":"publisher","award":["AI155107"],"award-info":[{"award-number":["AI155107"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005562","name":"North Carolina Biotechnology Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005562","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cysticfibrosisjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cystic Fibrosis"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jcf.2025.08.014","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T11:05:51Z","timestamp":1756292751000},"page":"1173-1183","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Neutrophil store-operated Ca2+ entry: A correctable biomarker of cystic fibrosis lung disease progression"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0706-3377","authenticated-orcid":false,"given":"Joe A","family":"Wrennall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9301-5695","authenticated-orcid":false,"given":"Matthew GS","family":"Biggart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3177-3992","authenticated-orcid":false,"given":"Charles D","family":"Bengtson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Flori","family":"Sassano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8598-2642","authenticated-orcid":false,"given":"Robert","family":"Tarran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcf.2025.08.014_bib0001","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1016\/S0140-6736(16)00576-6","article-title":"Cystic fibrosis","volume":"388","author":"Elborn","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.jcf.2025.08.014_bib0002","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1067\/mpd.2002.129847","article-title":"Induced sputum inflammatory measures correlate with lung function in children with cystic fibrosis","volume":"141","author":"Sagel","year":"2002","journal-title":"J Pediatr"},{"key":"10.1016\/j.jcf.2025.08.014_bib0003","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1136\/thx.2009.134106","article-title":"Airway remodelling and its relationship to inflammation in cystic fibrosis","volume":"66","author":"Regamey","year":"2011","journal-title":"Thorax"},{"key":"10.1016\/j.jcf.2025.08.014_bib0004","article-title":"Inflammation and its genesis in cystic fibrosis","volume":"50 Suppl 40","author":"Nichols","year":"2015","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jcf.2025.08.014_bib0005","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1378\/chest.07-1631","article-title":"Airway inflammation in cystic fibrosis","volume":"133","author":"Elizur","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.jcf.2025.08.014_bib0006","doi-asserted-by":"crossref","DOI":"10.1183\/23120541.00204-2022","article-title":"Dutch Cystic Fibrosis Registry Steering G. Long-term effectiveness of dual CFTR modulator treatment of cystic fibrosis","volume":"8","author":"Muilwijk","year":"2022","journal-title":"ERJ Open Res"},{"key":"10.1016\/j.jcf.2025.08.014_bib0007","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1164\/rccm.201503-0578OC","article-title":"Sustained benefit from ivacaftor demonstrated by combining clinical trial and cystic fibrosis patient registry data","volume":"192","author":"Sawicki","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcf.2025.08.014_bib0008","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1164\/rccm.202310-1836OC","article-title":"Pharmacological improvement of Cystic fibrosis transmembrane conductance regulator function rescues airway epithelial homeostasis and host defense in children with Cystic Fibrosis","volume":"209","author":"Loske","year":"2024","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcf.2025.08.014_bib0009","doi-asserted-by":"crossref","DOI":"10.1136\/thorax-2022-219943","article-title":"Effect of elexacaftor\/tezacaftor\/ivacaftor on airway and systemic inflammation in cystic fibrosis","author":"Casey","year":"2023","journal-title":"Thorax"},{"key":"10.1016\/j.jcf.2025.08.014_bib0010","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3389\/fphys.2018.00113","article-title":"Neutrophil: A cell with many roles in inflammation or several cell types?","volume":"9","author":"Rosales","year":"2018","journal-title":"Front Physiol"},{"key":"10.1016\/j.jcf.2025.08.014_bib0011","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/jleuko\/qiad033","article-title":"Neutrophil defect and lung pathogen selection in cystic fibrosis","volume":"113","author":"Jennings","year":"2023","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jcf.2025.08.014_bib0012","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.4049\/jimmunol.1800076","article-title":"Dysregulated calcium homeostasis in cystic fibrosis neutrophils leads to deficient antimicrobial responses","volume":"201","author":"Robledo-Avila","year":"2018","journal-title":"J Immunol"},{"key":"10.1016\/j.jcf.2025.08.014_bib0013","doi-asserted-by":"crossref","first-page":"10260","DOI":"10.1021\/bi060490t","article-title":"CFTR expression in human neutrophils and the phagolysosomal chlorination defect in cystic fibrosis","volume":"45","author":"Painter","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.jcf.2025.08.014_bib0014","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/jlb.64.1.98","article-title":"Neutrophil degranulation and phospholipase D activation are enhanced if the Na+\/H+ antiport is blocked","volume":"64","author":"Gewirtz","year":"1998","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jcf.2025.08.014_bib0015","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.jcf.2021.01.012","article-title":"Neutrophil dysfunction in cystic fibrosis","volume":"20","author":"Yonker","year":"2021","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2025.08.014_bib0016","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1189\/jlb.2MR1114-573R","article-title":"Store-operated calcium signaling in neutrophils","volume":"98","author":"Clemens","year":"2015","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jcf.2025.08.014_bib0017","article-title":"Calcium signalling and related ion channels in neutrophil recruitment and function","volume":"48 Suppl 2","author":"Immler","year":"2018","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.jcf.2025.08.014_bib0018","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jcf.2022.07.003","article-title":"Super resolution microscopy analysis reveals increased Orai1 activity in asthma and cystic fibrosis lungs","volume":"22","author":"Goriounova","year":"2023","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2025.08.014_bib0019","article-title":"Identification of BPIFA1\/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor","volume":"8","author":"Wu","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcf.2025.08.014_bib0020","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00668-2018","article-title":"SPLUNC1 degradation by the cystic fibrosis mucosal environment drives airway surface liquid dehydration","volume":"52","author":"Webster","year":"2018","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jcf.2025.08.014_bib0021","series-title":"American Thoracic Society 2021 International Conference. San Diego: American Journal of Respiratory and Critical Care Medicine","article-title":"ELD607, a novel anti-Orai1 peptide reduces pulmonary inflammation","author":"Ahmad","year":"2021"},{"key":"10.1016\/j.jcf.2025.08.014_bib0022","doi-asserted-by":"crossref","DOI":"10.1164\/rccm.201903-0615OC","article-title":"Chronic E-cigarette use increases neutrophil elastase and matrix metalloprotease levels in the lung","author":"Ghosh","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcf.2025.08.014_bib0023","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1165\/rcmb.2020-0452OC","article-title":"A SPLUNC1 peptidomimetic inhibits Orai1 and reduces inflammation in a murine allergic asthma model","volume":"66","author":"Wrennall","year":"2022","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jcf.2025.08.014_bib0024","doi-asserted-by":"crossref","DOI":"10.1164\/rccm.201710-2033OC","article-title":"Chronic E-cigarette exposure alters the Human bronchial epithelial proteome","author":"Ghosh","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcf.2025.08.014_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2024.102945","article-title":"ELD607 specifically traffics Orai1 to the lysosome leading to inhibition of store operated calcium entry","volume":"123","author":"Goriounova","year":"2024","journal-title":"Cell Calcium"},{"key":"10.1016\/j.jcf.2025.08.014_bib0026","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.exphem.2008.02.009","article-title":"A cascade of Ca(2+)\/calmodulin-dependent protein kinases regulates the differentiation and functional activation of murine neutrophils","volume":"36","author":"Gaines","year":"2008","journal-title":"Exp Hematol"},{"key":"10.1016\/j.jcf.2025.08.014_bib0027","first-page":"4025","article-title":"17beta-Estradiol inhibits Ca2+-dependent homeostasis of airway surface liquid volume in human cystic fibrosis airway epithelia","volume":"118","author":"Coakley","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jcf.2025.08.014_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2020.102281","article-title":"Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels","volume":"91","author":"Zhang","year":"2020","journal-title":"Cell Calcium"},{"key":"10.1016\/j.jcf.2025.08.014_bib0029","doi-asserted-by":"crossref","first-page":"10202","DOI":"10.1074\/jbc.M410617200","article-title":"Cystic fibrosis airway epithelial Ca2+ i signaling: the mechanism for the larger agonist-mediated Ca2+ i signals in human cystic fibrosis airway epithelia","volume":"280","author":"Ribeiro","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jcf.2025.08.014_bib0030","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0001-2024","article-title":"Neutrophil serine proteases in cystic fibrosis: role in disease pathogenesis and rationale as a therapeutic target","volume":"33","author":"Mall","year":"2024","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.jcf.2025.08.014_bib0031","article-title":"Function and regulation of GPR84 in human neutrophils","author":"Forsman","year":"2023","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jcf.2025.08.014_bib0032","first-page":"1","article-title":"GPR84 regulates pulmonary inflammation by modulating neutrophil functions","author":"Wang","year":"2023","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.jcf.2025.08.014_bib0033","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/361315a0","article-title":"Inositol trisphosphate and calcium signalling","volume":"361","author":"Berridge","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.jcf.2025.08.014_bib0034","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1242\/jcs.02836","article-title":"Apical localization of ITPK1 enhances its ability to be a modifier gene product in a murine tracheal cell model of cystic fibrosis","volume":"119","author":"Yang","year":"2006","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jcf.2025.08.014_bib0035","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ncb2045","article-title":"A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells","volume":"12","author":"Srikanth","year":"2010","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jcf.2025.08.014_bib0036","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1182\/blood.2021014699","article-title":"Neutrophil dysfunction in the pathogenesis of cystic fibrosis","volume":"139","author":"Wang","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.jcf.2025.08.014_bib0037","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.freeradbiomed.2019.03.007","article-title":"Peroxiredoxin expression and redox status in neutrophils and HL-60 cells","volume":"135","author":"de Souza","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jcf.2025.08.014_bib0038","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.bbamcr.2011.11.014","article-title":"Peroxiredoxin 6 translocates to the plasma membrane during neutrophil activation and is required for optimal NADPH oxidase activity","volume":"1823","author":"Ambruso","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jcf.2025.08.014_bib0039","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00408-025-00806-6","article-title":"The role of triple CFTR modulator therapy in reducing systemic inflammation in cystic fibrosis","volume":"203","author":"Garcia","year":"2025","journal-title":"Lung"},{"key":"10.1016\/j.jcf.2025.08.014_bib0040","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ceca.2019.01.003","article-title":"CRAC channel regulation of innate immune cells in health and disease","volume":"78","author":"Clemens","year":"2019","journal-title":"Cell Calcium"},{"key":"10.1016\/j.jcf.2025.08.014_bib0041","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1136\/bmj.1.5953.306","article-title":"Normal haematological values: sex difference in neutrophil count","volume":"1","author":"Bain","year":"1975","journal-title":"Br Med J"},{"key":"10.1016\/j.jcf.2025.08.014_bib0042","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1177\/0960327118793188","article-title":"Sex-specific differences in the regulation of inducible nitric oxide synthase by bisphenol A in neutrophils","volume":"38","author":"Ratajczak-Wrona","year":"2019","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.jcf.2025.08.014_bib0043","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1182\/blood-2003-02-0649","article-title":"Sex-specific alterations in neutrophil apoptosis: the role of estradiol and progesterone","volume":"102","author":"Molloy","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.jcf.2025.08.014_bib0044","doi-asserted-by":"crossref","first-page":"L304","DOI":"10.1152\/ajplung.00016.2009","article-title":"Modulation of endocytic trafficking and apical stability of CFTR in primary human airway epithelial cultures","volume":"298","author":"Cholon","year":"2010","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jcf.2025.08.014_bib0045","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1182\/blood-2009-05-224659","article-title":"Orai1 regulates intracellular calcium, arrest, and shape polarization during neutrophil recruitment in shear flow","volume":"115","author":"Schaff","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jcf.2025.08.014_bib0046","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.ceca.2008.03.002","article-title":"Store-operated Ca2+ channels formed by TRPC1, TRPC6 and Orai1 and non-store-operated channels formed by TRPC3 are involved in the regulation of NADPH oxidase in HL-60 granulocytes","volume":"44","author":"Brechard","year":"2008","journal-title":"Cell Calcium"},{"key":"10.1016\/j.jcf.2025.08.014_bib0047","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1002\/eji.201445337","article-title":"Orai1 controls C5a-induced neutrophil recruitment in inflammation","volume":"45","author":"Sogkas","year":"2015","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jcf.2025.08.014_bib0048","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.jaci.2015.09.047","article-title":"Preserved effector functions of human ORAI1- and STIM1-deficient neutrophils","volume":"137","author":"Elling","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jcf.2025.08.014_bib0049","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1007\/s00424-016-1880-z","article-title":"Molecular mechanisms underlying inhibition of STIM1-Orai1-mediated Ca(2+) entry induced by 2-aminoethoxydiphenyl borate","volume":"468","author":"Wei","year":"2016","journal-title":"Pflug. Arch"},{"key":"10.1016\/j.jcf.2025.08.014_bib0050","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature04702","article-title":"A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function","volume":"441","author":"Feske","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jcf.2025.08.014_bib0051","doi-asserted-by":"crossref","first-page":"4274","DOI":"10.1096\/fj.11-187682","article-title":"Enhanced Ca2+ entry due to Orai1 plasma membrane insertion increases IL-8 secretion by cystic fibrosis airways","volume":"25","author":"Balghi","year":"2011","journal-title":"FASEB J"},{"key":"10.1016\/j.jcf.2025.08.014_bib0052","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.cca.2020.05.015","article-title":"Laboratory biomarkers for lung disease severity and progression in cystic fibrosis","volume":"508","author":"Bene","year":"2020","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jcf.2025.08.014_bib0053","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1164\/rccm.202308-1393OC","article-title":"Specific inhibition of Orai1-mediated calcium signalling resolves inflammation and clears bacteria in an acute Respiratory distress syndrome model","volume":"209","author":"Ahmad","year":"2024","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcf.2025.08.014_bib0054","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1056\/NEJM199503303321303","article-title":"Effect of high-dose ibuprofen in patients with cystic fibrosis","volume":"332","author":"Konstan","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcf.2025.08.014_bib0055","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.03502-2020","article-title":"Targeting cystic fibrosis inflammation in the age of CFTR modulators: focus on macrophages","volume":"57","author":"Gillan","year":"2021","journal-title":"Eur Respir J"}],"container-title":["Journal of Cystic Fibrosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199325015735?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199325015735?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T07:36:08Z","timestamp":1779953768000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569199325015735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":55,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S1569199325015735"],"URL":"https:\/\/doi.org\/10.1016\/j.jcf.2025.08.014","relation":{},"ISSN":["1569-1993"],"issn-type":[{"value":"1569-1993","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neutrophil store-operated Ca2+ entry: A correctable biomarker of cystic fibrosis lung disease progression","name":"articletitle","label":"Article Title"},{"value":"Journal of Cystic Fibrosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcf.2025.08.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of European Cystic Fibrosis Society.","name":"copyright","label":"Copyright"}]}}