{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T11:54:46Z","timestamp":1781783686521,"version":"3.54.5"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008385","name":"Cystic Fibrosis Research Foundation","doi-asserted-by":"publisher","award":["21\/2013"],"award-info":[{"award-number":["21\/2013"]}],"id":[{"id":"10.13039\/501100008385","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008385","name":"Cystic Fibrosis Research Foundation","doi-asserted-by":"publisher","award":["14\/2024"],"award-info":[{"award-number":["14\/2024"]}],"id":[{"id":"10.13039\/501100008385","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008385","name":"Cystic Fibrosis Research Foundation","doi-asserted-by":"publisher","award":["20\/2016"],"award-info":[{"award-number":["20\/2016"]}],"id":[{"id":"10.13039\/501100008385","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008385","name":"Cystic Fibrosis Research Foundation","doi-asserted-by":"publisher","award":["24\/2019"],"award-info":[{"award-number":["24\/2019"]}],"id":[{"id":"10.13039\/501100008385","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cysticfibrosisjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cystic Fibrosis"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jcf.2025.11.001","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T02:27:23Z","timestamp":1763519243000},"page":"319-327","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mutations with residual CFTR function are associated with better glucose tolerance and insulin secretion in people with Cystic fibrosis"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1493-9767","authenticated-orcid":false,"given":"Fabiana","family":"Ciciriello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Foppiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5732-2228","authenticated-orcid":false,"given":"Federica","family":"Sileo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4333-791X","authenticated-orcid":false,"given":"Federico","family":"Alghisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Chiara","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Elisabetta","family":"Claut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Bisogno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Lucanto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzina","family":"Lucidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4134-0557","authenticated-orcid":false,"given":"Alberto","family":"Battezzati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jcf.2025.11.001_bib0001","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41572-024-00538-6","article-title":"Cystic fibrosis","volume":"10","author":"Mall","year":"2024","journal-title":"Nat Rev Dis Primers"},{"issue":"9370","key":"10.1016\/j.jcf.2025.11.001_bib0002","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/S0140-6736(03)13368-5","article-title":"Effect of genotype on phenotype and mortality in cystic fibrosis: a retrospective cohort study","volume":"361","author":"McKone","year":"2003","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.jcf.2025.11.001_bib0003","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1210\/clinem\/dgac020","article-title":"New concepts in the pathogenesis of cystic fibrosis-related diabetes","volume":"107","author":"Moheet","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 2","key":"10.1016\/j.jcf.2025.11.001_bib0004","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.jcf.2019.08.016","article-title":"Cystic fibrosis related diabetes: pathophysiology, screening and diagnosis","volume":"18","author":"Granados","year":"2019","journal-title":"J Cyst Fibros"},{"issue":"2","key":"10.1016\/j.jcf.2025.11.001_bib0005","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jcf.2019.10.009","article-title":"Cystic fibrosis related diabetes in Europe: prevalence, risk factors and outcome; Olesen et al","volume":"19","author":"Olesen","year":"2020","journal-title":"J Cyst Fibros"},{"issue":"6","key":"10.1016\/j.jcf.2025.11.001_bib0006","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.2337\/dc23-0380","article-title":"Cystic Fibrosis-Related Diabetes Workshop: research priorities spanning disease pathophysiology, diagnosis, and outcomes","volume":"46","author":"Putman","year":"2023","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcf.2025.11.001_bib0007","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.702823","article-title":"The potential causes of cystic fibrosis-related diabetes","volume":"12","author":"Coderre","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"5","key":"10.1016\/j.jcf.2025.11.001_bib0008","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1210\/clinem\/dgz209","article-title":"In Situ analysis reveals that CFTR is expressed in only a small minority of \u03b2-cells in normal adult Human pancreas","volume":"105","author":"White","year":"2020","journal-title":"J Clin Endocrinol Metab."},{"issue":"8","key":"10.1016\/j.jcf.2025.11.001_bib0009","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S2213-2600(16)00023-0","article-title":"Progress in therapies for cystic fibrosis","volume":"4","author":"De Boeck","year":"2016","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jcf.2025.11.001_bib0010","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/j.jpeds.2016.09.063","article-title":"Applying cystic Fibrosis transmembrane conductance regulator genetics and CFTR2 data to facilitate diagnoses","volume":"181S","author":"Sosnay","year":"2017","journal-title":"J Pediatr"},{"issue":"2","key":"10.1016\/j.jcf.2025.11.001_bib0011","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jcf.2022.07.015","article-title":"Kerem E; ECFSPR with the list of contributing authors. Disease severity of people with cystic fibrosis carrying residual function mutations: data from the ECFS Patient Registry","volume":"22","author":"Mei Zahav","year":"2023","journal-title":"J Cyst Fibros"},{"issue":"11","key":"10.1016\/j.jcf.2025.11.001_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.dsx.2023.102899","article-title":"Advances in cystic fibrosis-related diabetes: current status and future directions","volume":"17","author":"Lurquin","year":"2023","journal-title":"Diabetes Metab Syndr"},{"issue":"8","key":"10.1016\/j.jcf.2025.11.001_bib0013","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1016\/S2213-2600(16)30188-6","article-title":"Classification of CFTR mutation classes","volume":"4","author":"Marson","year":"2016","journal-title":"Lancet Respir Med"},{"issue":"Suppl 27","key":"10.1016\/j.jcf.2025.11.001_bib0016","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/pedi.12732","article-title":"ISPAD Clinical Practice Consensus Guidelines 2018: management of cystic fibrosis-related diabetes in children and adolescents","volume":"19","author":"Moran","year":"2018","journal-title":"Pediatr Diabetes"},{"issue":"Suppl 4","key":"10.1016\/j.jcf.2025.11.001_bib0017","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1463-1326.2008.00946.x","article-title":"Beta-cell function assessment from modelling of oral tests: an effective approach","volume":"10","author":"Mari","year":"2008","journal-title":"Diabetes Obes Metab"},{"issue":"1","key":"10.1016\/j.jcf.2025.11.001_bib0018","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1530\/EJE-10-1003","article-title":"Identification of insulin secretory defects and insulin resistance during oral glucose tolerance test in a cohort of cystic fibrosis patients","volume":"165","author":"Battezzati","year":"2011","journal-title":"Eur J Endocrinol"},{"issue":"8","key":"10.1016\/j.jcf.2025.11.001_bib0019","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1210\/jc.2015-1512","article-title":"Age- and sex-dependent distribution of OGTT-related variables in a population of cystic fibrosis patients","volume":"100","author":"Battezzati","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"10.1016\/j.jcf.2025.11.001_bib0020","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1210\/jcem.85.7.6661","article-title":"Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans","volume":"85","author":"Katz","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.jcf.2025.11.001_bib0021","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2337\/diacare.24.3.539","article-title":"A model-based method for assessing insulin sensitivity from the oral glucose tolerance test","volume":"24","author":"Mari","year":"2001","journal-title":"Diabetes Care"},{"issue":"7","key":"10.1016\/j.jcf.2025.11.001_bib0022","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1002\/sim.7992","article-title":"Minimum sample size for developing a multivariable prediction model: PART II - binary and time-to-event outcomes","volume":"38","author":"Riley","year":"2019","journal-title":"Stat Med"},{"issue":"3","key":"10.1016\/j.jcf.2025.11.001_bib0023","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3390\/jpm13030469","article-title":"Distribution of OGTT-related variables in patients with cystic fibrosis from puberty to adulthood: an Italian multicenter study","volume":"13","author":"Foppiani","year":"2023","journal-title":"J Pers Med"},{"issue":"2","key":"10.1016\/j.jcf.2025.11.001_bib0024","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/ppul.24215","article-title":"Patients with cystic fibrosis having a residual function mutation: data from the Italian registry","volume":"54","author":"Salvatore","year":"2019","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jcf.2025.11.001_bib0025","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1269139","article-title":"Pancreas and islet morphology in cystic fibrosis: clues to the etiology of cystic fibrosis-related diabetes","volume":"14","author":"Malik","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jcf.2025.11.001_bib0026","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.1038\/ncomms5420","article-title":"Glucose-induced electrical activities and insulin secretion in pancreatic islet \u03b2-cells are modulated by CFTR","volume":"5","author":"Guo","year":"2014","journal-title":"Nat Commun"},{"issue":"10","key":"10.1016\/j.jcf.2025.11.001_bib0027","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1007\/s40618-021-01525-4","article-title":"Lumacaftor\/ivacaftor in cystic fibrosis: effects on glucose metabolism and insulin secretion","volume":"44","author":"Colombo","year":"2021","journal-title":"J Endocrinol Invest"},{"issue":"10","key":"10.1016\/j.jcf.2025.11.001_bib0028","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1007\/s00125-024-06220-6","article-title":"Insulin sensitivity, disposition index and insulin clearance in cystic fibrosis: a cross-sectional study","volume":"67","author":"Nielsen","year":"2024","journal-title":"Diabetologia"},{"issue":"4","key":"10.1016\/j.jcf.2025.11.001_bib0029","doi-asserted-by":"crossref","DOI":"10.1056\/EVIDoa2100052","article-title":"Potential identification of type 2 diabetes with elevated insulin clearance","volume":"1","author":"Sugiyama","year":"2022","journal-title":"NEJM Evid."},{"key":"10.1016\/j.jcf.2025.11.001_bib0030","article-title":"The role of genetic modifiers, inflammation and CFTR in the pathogenesis of cystic fibrosis related diabetes","volume":"27","author":"Hasan","year":"2021","journal-title":"J Clin Transl Endocrinol"}],"container-title":["Journal of Cystic Fibrosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156919932502497X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156919932502497X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T11:37:06Z","timestamp":1781782626000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156919932502497X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S156919932502497X"],"URL":"https:\/\/doi.org\/10.1016\/j.jcf.2025.11.001","relation":{},"ISSN":["1569-1993"],"issn-type":[{"value":"1569-1993","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mutations with residual CFTR function are associated with better glucose tolerance and insulin secretion in people with Cystic fibrosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Cystic Fibrosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcf.2025.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of European Cystic Fibrosis Society.","name":"copyright","label":"Copyright"}]}}