{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:08:00Z","timestamp":1785413280415,"version":"3.56.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"FCT","doi-asserted-by":"publisher","award":["UID\/04046\/2023"],"award-info":[{"award-number":["UID\/04046\/2023"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003549","name":"Hungarian Scientific Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["00,064,203\/6003"],"award-info":[{"award-number":["00,064,203\/6003"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["LM2018132"],"award-info":[{"award-number":["LM2018132"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003827","name":"Hungarian Scientific Research Fund","doi-asserted-by":"publisher","award":["FK 135,327"],"award-info":[{"award-number":["FK 135,327"]}],"id":[{"id":"10.13039\/501100003827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["UID\/00100"],"award-info":[{"award-number":["UID\/00100"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cysticfibrosisjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cystic Fibrosis"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jcf.2026.03.019","type":"journal-article","created":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T10:49:41Z","timestamp":1775386181000},"page":"735-744","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of HE4 expression concerning epithelial-mesenchymal transition (EMT) in cystic fibrosis epithelial cells"],"prefix":"10.1016","volume":"25","author":[{"given":"Marianna","family":"P\u00f3csi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7851-2642","authenticated-orcid":false,"given":"Gy\u00f6rgy J\u00e1zon","family":"Balla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2890-0783","authenticated-orcid":false,"given":"Ferenc","family":"Fenyvesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gnes","family":"Ruszny\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Fejes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3397-2829","authenticated-orcid":false,"given":"Istv\u00e1n","family":"Balogh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5173-5280","authenticated-orcid":false,"suffix":"Jr.","given":"Milan","family":"Macek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0828-8630","authenticated-orcid":false,"given":"Margarida D.","family":"Amaral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"B\u00e9la","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcf.2026.03.019_bib0001","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMra043184","article-title":"Cystic fibrosis","volume":"352","author":"Rowe","year":"2005","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.jcf.2026.03.019_bib0002","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1365-2796.2006.01744.x","article-title":"Evidence for airway surface dehydration as the initiating event in CF airway disease","volume":"261","author":"Boucher","year":"2007","journal-title":"J Intern Med"},{"issue":"5","key":"10.1016\/j.jcf.2026.03.019_bib0003","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1055\/s-0029-1238909","article-title":"The clinical approach to lung disease in patients with cystic fibrosis","volume":"30","author":"O'Sullivan","year":"2009","journal-title":"Semin Respir Crit Care Med"},{"issue":"1\u20132","key":"10.1016\/j.jcf.2026.03.019_bib0004","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1385\/JMN:23:1-2:041","article-title":"CFTR and chaperones: processing and degradation","volume":"23","author":"Amaral","year":"2004","journal-title":"J Mol Neurosci"},{"issue":"9","key":"10.1016\/j.jcf.2026.03.019_bib0005","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.3390\/ijms21093133","article-title":"What role does CFTR play in development, differentiation, regeneration and cancer?","volume":"21","author":"Amaral","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"Pt 8","key":"10.1016\/j.jcf.2026.03.019_bib0006","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1113\/jphysiol.2009.182246","article-title":"Cystic fibrosis transmembrane conductance regulator trafficking modulates the barrier function of airway epithelial cell monolayers","volume":"588","author":"LeSimple","year":"2010","journal-title":"J Physiol"},{"issue":"6","key":"10.1016\/j.jcf.2026.03.019_bib0007","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1183\/09031936.00221711","article-title":"Improvement of defective cystic fibrosis airway epithelial wound repair after CFTR rescue","volume":"40","author":"Trinh","year":"2012","journal-title":"Eur Respir J"},{"issue":"3","key":"10.1016\/j.jcf.2026.03.019_bib0008","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/path.2118","article-title":"Human airway surface epithelial regeneration is delayed and abnormal in cystic fibrosis","volume":"211","author":"Hajj","year":"2007","journal-title":"J Pathol"},{"issue":"2","key":"10.1016\/j.jcf.2026.03.019_bib0009","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1093\/jnci\/djs481","article-title":"Cancer risk in cystic fibrosis: a 20-year nationwide study from the United States","volume":"105","author":"Maisonneuve","year":"2013","journal-title":"J Natl Cancer Inst"},{"issue":"32","key":"10.1016\/j.jcf.2026.03.019_bib0010","doi-asserted-by":"crossref","first-page":"4179","DOI":"10.1038\/onc.2015.483","article-title":"CFTR is a tumor suppressor gene in murine and human intestinal cancer","volume":"35","author":"Than","year":"2016","journal-title":"Oncogene"},{"issue":"12","key":"10.1016\/j.jcf.2026.03.019_bib0011","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1016\/j.bbamcr.2013.07.021","article-title":"Downregulation of CFTR promotes epithelial-to-mesenchymal transition and is associated with poor prognosis of breast cancer","volume":"1833","author":"Zhang","year":"2013","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"10.1016\/j.jcf.2026.03.019_bib0012","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ygeno.2015.07.005","article-title":"Transcriptome meta-analysis reveals common differential and global gene expression profiles in cystic fibrosis and other respiratory disorders and identifies CFTR regulators","volume":"106","author":"Clarke","year":"2015","journal-title":"Genomics"},{"issue":"10","key":"10.1016\/j.jcf.2026.03.019_bib0013","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/s41419-020-03119-z","article-title":"Mutant CFTR drives TWIST1 mediated epithelial-mesenchymal transition","volume":"11","author":"Quaresma","year":"2020","journal-title":"Cell Death Dis"},{"issue":"8","key":"10.1016\/j.jcf.2026.03.019_bib0014","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/d0132de3-56ca-4258-9119-bdab0ceb2cff","article-title":"Myofibroblast differentiation and enhanced TGF-B signaling in cystic fibrosis lung disease","volume":"8","author":"Harris","year":"2013","journal-title":"PLoS One"},{"issue":"15","key":"10.1016\/j.jcf.2026.03.019_bib0015","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241512412","article-title":"Epithelial-mesenchymal transition mechanisms in chronic airway diseases: a common process to target?","volume":"24","author":"Mottais","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcf.2026.03.019_bib0016","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1655479","article-title":"CFTR ion transport deficiency primes the epithelium for partial epithelial-mesenchymal transition in cystic fibrosis","volume":"16","author":"Rodrigues","year":"2025","journal-title":"Front Pharmacol"},{"issue":"3","key":"10.1016\/j.jcf.2026.03.019_bib0017","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.chest.2016.04.006","article-title":"Human epididymis protein 4: a novel serum inflammatory biomarker in cystic fibrosis","volume":"150","author":"Nagy","year":"2016","journal-title":"Chest"},{"issue":"17","key":"10.1016\/j.jcf.2026.03.019_bib0018","doi-asserted-by":"crossref","first-page":"6188","DOI":"10.3390\/jcm14176188","article-title":"Comparison of the effect of CFTR modulators elexacaftor\/tezacaftor\/ivacaftor and lumacaftor\/ivacaftor via Serum Human epididymis protein 4 concentration in p.Phe508del-CFTR homozygous Cystic Fibrosis patients","volume":"14","author":"P\u00f3csi","year":"2025","journal-title":"J Clin Med"},{"key":"10.1016\/j.jcf.2026.03.019_bib0019","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.592184","article-title":"Enhanced expression of Human epididymis protein 4 (HE4) reflecting pro-inflammatory status is regulated by CFTR in cystic fibrosis bronchial epithelial cells","volume":"12","author":"Bene","year":"2021","journal-title":"Front Pharmacol"},{"issue":"Pt 2","key":"10.1016\/j.jcf.2026.03.019_bib0020","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1113\/jphysiol.2005.096669","article-title":"Failure of cAMP agonists to activate rescued deltaF508 CFTR in CFBE41o- airway epithelial monolayers","volume":"569","author":"Bebok","year":"2005","journal-title":"J Physiol"},{"key":"10.1016\/j.jcf.2026.03.019_bib0021","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011598","article-title":"Expression of wild-type CFTR suppresses NF-kappaB-driven inflammatory signalling","volume":"5","author":"Hunter","year":"2010","journal-title":"PLoS One"},{"issue":"18","key":"10.1016\/j.jcf.2026.03.019_bib0022","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231810956","article-title":"The CFTR amplifier Nesolicaftor rescues TGF-\u03b21 inhibition of modulator-corrected F508del CFTR function","volume":"23","author":"Bengtson","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"11","key":"10.1016\/j.jcf.2026.03.019_bib0023","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/ppul.21079","article-title":"Transforming growth factor-beta(1) in bronchoalveolar lavage fluid from children with cystic fibrosis","volume":"44","author":"Harris","year":"2009","journal-title":"Pediatr Pulmonol"},{"issue":"1","key":"10.1016\/j.jcf.2026.03.019_bib0024","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jcf.2024.09.003","article-title":"Insights into epithelial-mesenchymal transition from cystic fibrosis rat models","volume":"24","author":"Rout-Pitt","year":"2025","journal-title":"J Cyst Fibros"},{"issue":"5","key":"10.1016\/j.jcf.2026.03.019_bib0025","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.jcf.2021.03.019","article-title":"Comparative meta-analysis of cystic fibrosis cell models suggests partial endothelial-to-mesenchymal transition","volume":"20","author":"Treps","year":"2021","journal-title":"J Cyst Fibros"},{"issue":"1","key":"10.1016\/j.jcf.2026.03.019_bib0026","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s12931-018-0834-8","article-title":"Epithelial mesenchymal transition (EMT): a universal process in lung diseases with implications for cystic fibrosis pathophysiology","volume":"19","author":"Rout-Pitt","year":"2018","journal-title":"Respir Res"},{"issue":"1","key":"10.1016\/j.jcf.2026.03.019_bib0027","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1038\/s41598-024-52341-8","article-title":"Single-cell RNA sequencing reveals the epithelial cell, fibroblast, and key gene alterations in chronic rhinosinusitis with nasal polyps","volume":"14","author":"Wang","year":"2024","journal-title":"Sci Rep"},{"issue":"17","key":"10.1016\/j.jcf.2026.03.019_bib0028","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241713384","article-title":"Modulation of plasmatic matrix metalloprotease 9: a promising new tool for understanding the variable clinical responses of patients with Cystic Fibrosis to Cystic Fibrosis transmembrane conductance regulator modulators","volume":"24","author":"Capraro","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.jcf.2026.03.019_bib0029","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.bbrc.2009.04.038","article-title":"Transforming growth factor-beta1 induces matrix metalloproteinase-9 expression in human meningeal cells via ERK and Smad pathways","volume":"383","author":"Okamoto","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"10.1016\/j.jcf.2026.03.019_bib0030","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nm.2989","article-title":"Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis","volume":"19","author":"LeBleu","year":"2013","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.jcf.2026.03.019_bib0031","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3390\/pathophysiology28010011","article-title":"Pathophysiology of lung disease and wound repair in cystic fibrosis","volume":"28","author":"Conese","year":"2021","journal-title":"Pathophysiology"},{"issue":"1","key":"10.1016\/j.jcf.2026.03.019_bib0032","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/1465-9921-10-100","article-title":"TGF-beta1 induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells is enhanced by IL-1beta but not abrogated by corticosteroids","volume":"10","author":"Doerner","year":"2009","journal-title":"Respir Res"},{"issue":"9","key":"10.1016\/j.jcf.2026.03.019_bib0033","doi-asserted-by":"crossref","DOI":"10.1242\/bio.043570","article-title":"Knockdown of HE4 suppresses aggressive cell growth and malignant progression of ovarian cancer by inhibiting the JAK\/STAT3 pathway","volume":"8","author":"Wang","year":"2019","journal-title":"Biol Open"}],"container-title":["Journal of Cystic Fibrosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156919932600086X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156919932600086X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:30:30Z","timestamp":1785411030000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156919932600086X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S156919932600086X"],"URL":"https:\/\/doi.org\/10.1016\/j.jcf.2026.03.019","relation":{},"ISSN":["1569-1993"],"issn-type":[{"value":"1569-1993","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigation of HE4 expression concerning epithelial-mesenchymal transition (EMT) in cystic fibrosis epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Cystic Fibrosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcf.2026.03.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of European Cystic Fibrosis Society.","name":"copyright","label":"Copyright"}]}}